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Substrate Report for: Acetonecyanohydrin

General
Type Cyanide
Chemical_Nomenclature 2-hydroxy-2-methylpropanenitrile
Canonical SMILES CC(C)(C#N)O
InChI InChI=1S/C4H7NO/c1-4(2,6)3-5/h6H,1-2H3
InChIKey MWFMGBPGAXYFAR-UHFFFAOYSA-N
Other name(s) 2-Hydroxy-2-methylpropanenitrile ; 2-Hydroxyisobutyronitrile ; 2-Methyllactonitrile ; Acetone cyanhydrin
________________________________________________________________________________________________
MW|85.10
Formula|C4H7NO
CAS_number|75-86-5
PubChem|6406
UniChem|MWFMGBPGAXYFAR-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Acetone_cyanohydrin

Target
Families | Acetonecyanohydrin ligand of proteins in family: Hydroxynitrile_lyase
Stucture | 3 structures: 1E8D, 1SC9, 1SCQ
Protein | manes-hnl

References:
Search PubMed for references concerning: Acetonecyanohydrin
    Title: The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo
    Soler-Martin C, Riera J, Seoane A, Cutillas B, Ambrosio S, Boadas-Vaello P, Llorens J
    Ref: Neurotoxicology & Teratology, 32:289, 2010 : PubMed

            

    Title: Reaction mechanism of hydroxynitrile lyases of the alpha/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236
    Gruber K, Gartler G, Krammer B, Schwab H, Kratky C
    Ref: Journal of Biological Chemistry, 279:20501, 2004 : PubMed

            

    Title: Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta
    Lauble H, Miehlich B, Forster S, Kobler C, Wajant H, Effenberger F
    Ref: Protein Science, 11:65, 2002 : PubMed