Gruber K

References (39)

Title : Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX - Hetmann_2023_Sci.Rep_13_11783
Author(s) : Hetmann M , Langner C , Durmaz V , Cespugli M , Kochl K , Krassnigg A , Blaschitz K , Groiss S , Loibner M , Ruau D , Zatloukal K , Gruber K , Steinkellner G , Gruber CC
Ref : Sci Rep , 13 :11783 , 2023
PubMedID: 37479788

Title : Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes - Grabner_2022_J.Am.Chem.Soc__
Author(s) : Grabner GF , Guttenberger N , Mayer N , Migglautsch-Sulzer AK , Lembacher-Fadum C , Fawzy N , Bulfon D , Hofer P , Zullig T , Hartig L , Kulminskaya N , Chalhoub G , Schratter M , Radner FPW , Preiss-Landl K , Masser S , Lass A , Zechner R , Gruber K , Oberer M , Breinbauer R , Zimmermann R
Ref : Journal of the American Chemical Society , : , 2022
PubMedID: 35362954

Title : Residue-Specific Incorporation of the Non-Canonical Amino Acid Norleucine Improves Lipase Activity on Synthetic Polyesters - Haernvall_2022_Front.Bioeng.Biotechnol_10_769830
Author(s) : Haernvall K , Fladischer P , Schoeffmann H , Zitzenbacher S , Pavkov-Keller T , Gruber K , Schick M , Yamamoto M , Kuenkel A , Ribitsch D , Guebitz GM , Wiltschi B
Ref : Front Bioeng Biotechnol , 10 :769830 , 2022
PubMedID: 35155387
Gene_locus related to this paper: theet-q3ch51

Title : PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes - Wallace_2017_Appl.Microbiol.Biotechnol_101_2291
Author(s) : Wallace PW , Haernvall K , Ribitsch D , Zitzenbacher S , Schittmayer M , Steinkellner G , Gruber K , Guebitz GM , Birner-Gruenberger R
Ref : Applied Microbiology & Biotechnology , 101 :2291 , 2017
PubMedID: 27872998

Title : Engineering of the zinc-binding domain of an esterase from Clostridium botulinum towards increased activity on polyesters - Biundo_2017_Catal.Sci.Technol_7_1440
Author(s) : Biundo A , Steinkellner G , Gruber K , Spreitzhofer T , Ribitsch D , Guebitz GM
Ref : Catal Sci Technol , 7 :1440 , 2017
PubMedID:
Gene_locus related to this paper: clobh-A51055

Title : Small cause, large effect: Structural characterization of cutinases from Thermobifida cellulosilytica - Ribitsch_2017_Biotechnol.Bioeng_114_2481
Author(s) : Ribitsch D , Hromic A , Zitzenbacher S , Zartl B , Gamerith C , Pellis A , Jungbauer A , Lyskowski A , Steinkellner G , Gruber K , Tscheliessnig R , Herrero Acero E , Guebitz GM
Ref : Biotechnol Bioeng , 114 :2481 , 2017
PubMedID: 28671263
Gene_locus related to this paper: thefu-q6a0i4 , thefu-q6a0i3

Title : Characterization of a poly(butylene adipate-co-terephthalate)-hydrolyzing lipase from Pelosinus fermentans - Biundo_2016_Appl.Microbiol.Biotechnol_100_1753
Author(s) : Biundo A , Hromic A , Pavkov-Keller T , Gruber K , Quartinello F , Haernvall K , Perz V , Arrell MS , Zinn M , Ribitsch D , Guebitz GM
Ref : Applied Microbiology & Biotechnology , 100 :1753 , 2016
PubMedID: 26490551
Gene_locus related to this paper: 9firm-a0a0a0ymq9

Title : An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic-Aromatic Polyesters - Perz_2016_Environ.Sci.Technol_50_2899
Author(s) : Perz V , Hromic A , Baumschlager A , Steinkellner G , Pavkov-Keller T , Gruber K , Bleymaier K , Zitzenbacher S , Zankel A , Mayrhofer C , Sinkel C , Kueper U , Schlegel K , Ribitsch D , Guebitz GM
Ref : Environ Sci Technol , 50 :2899 , 2016
PubMedID: 26878094
Gene_locus related to this paper: 9clot-r5t6k9

Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462
Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M
Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016
PubMedID: 26869448
Gene_locus related to this paper: yeast-mgll

Title : Hydrolysis of synthetic polyesters by Clostridium botulinum esterases - Perz_2016_Biotechnol.Bioeng_113_1024
Author(s) : Perz V , Baumschlager A , Bleymaier K , Zitzenbacher S , Hromic A , Steinkellner G , Pairitsch A , Lyskowski A , Gruber K , Sinkel C , Kuper U , Ribitsch D , Guebitz GM
Ref : Biotechnol Bioeng , 113 :1024 , 2016
PubMedID: 26524601
Gene_locus related to this paper: clobh-A5I3I2 , clobh-A51055

Title : Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels - Bezerra_2015_Sci.Rep_5_8769
Author(s) : Bezerra GA , Dobrovetsky E , Seitova A , Fedosyuk S , Dhe-Paganon S , Gruber K
Ref : Sci Rep , 5 :8769 , 2015
PubMedID: 25740212
Gene_locus related to this paper: human-DPP10

Title : Fusion of binding domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis - Ribitsch_2013_Biomacromolecules_14_1769
Author(s) : Ribitsch D , Yebra AO , Zitzenbacher S , Wu J , Nowitsch S , Steinkellner G , Greimel K , Doliska A , Oberdorfer G , Gruber CC , Gruber K , Schwab H , Stana-Kleinschek K , Herrero Acero E , Guebitz GM
Ref : Biomacromolecules , 14 :1769 , 2013
PubMedID: 23718548
Gene_locus related to this paper: thefu-q6a0i4

Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093
Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M
Ref : Journal of Biological Chemistry , 288 :31093 , 2013
PubMedID: 24014019
Gene_locus related to this paper: bac25-mglp

Title : Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis - Herrero_2013_Biotechnol.Bioeng_110_2581
Author(s) : Herrero Acero E , Ribitsch D , Dellacher A , Zitzenbacher S , Marold A , Steinkellner G , Gruber K , Schwab H , Guebitz GM
Ref : Biotechnol Bioeng , 110 :2581 , 2013
PubMedID: 23592055

Title : Hydroxynitrile lyases with alpha\/beta-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms - Andexer_2012_Chembiochem_13_1932
Author(s) : Andexer JN , Staunig N , Eggert T , Kratky C , Pohl M , Gruber K
Ref : Chembiochem , 13 :1932 , 2012
PubMedID: 22851196
Gene_locus related to this paper: arath-HNL

Title : Extracellular serine proteases from Stenotrophomonas maltophilia: Screening, isolation and heterologous expression in E. coli - Ribitsch_2012_J.Biotechnol_157_140
Author(s) : Ribitsch D , Heumann S , Karl W , Gerlach J , Leber R , Birner-Gruenberger R , Gruber K , Eiteljoerg I , Remler P , Siegert P , Lange J , Maurer KH , Berg G , Guebitz GM , Schwab H
Ref : J Biotechnol , 157 :140 , 2012
PubMedID: 21983234

Title : Tailoring a stabilized variant of hydroxynitrile lyase from Arabidopsis thaliana - Okrob_2012_Chembiochem_13_797
Author(s) : Okrob D , Metzner J , Wiechert W , Gruber K , Pohl M
Ref : Chembiochem , 13 :797 , 2012
PubMedID: 22378361
Gene_locus related to this paper: arath-HNL

Title : Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases - Bezerra_2012_PLoS.One_7_e43019
Author(s) : Bezerra GA , Dobrovetsky E , Dong A , Seitova A , Crombett L , Shewchuk LM , Hassell AM , Sweitzer SM , Sweitzer TD , McDevitt PJ , Johanson KO , Kennedy-Wilson KM , Cossar D , Bochkarev A , Gruber K , Dhe-Paganon S
Ref : PLoS ONE , 7 :e43019 , 2012
PubMedID: 22952628
Gene_locus related to this paper: human-DPP7

Title : Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels - Bezerra_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_214
Author(s) : Bezerra GA , Dobrovetsky E , Seitova A , Dhe-Paganon S , Gruber K
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 68 :214 , 2012
PubMedID: 22298003
Gene_locus related to this paper: human-DPP10

Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012
Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M
Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012
PubMedID: 22561231
Gene_locus related to this paper: bac25-mglp

Title : A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA) - Ribitsch_2012_Polymers_4_617
Author(s) : Ribitsch D , Herrero Acero E , Greimel K , Dellacher A , Zitzenbacher S , Marold A , Rodriguez RD , Steinkellner G , Gruber K , Schwab H , Guebitz GM
Ref : Polymers , 4 :617 , 2012
PubMedID:
Gene_locus related to this paper: 9actn-h6wx58

Title : Enzymatic Surface Hydrolysis of PET: Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida. - Herrero-Acero_2011_Macromolecules_44_4632
Author(s) : Herrero Acero E , Ribitsch D , Steinkellner G , Gruber K , Greimel K , Eiteljoerg I , Trotscha E , Wei R , Zimmermann W , Zinn M , Cavaco-Paulo A , Freddi G , Schwab H , Guebitz G
Ref : Macromolecules , 44 :4632 , 2011
PubMedID:
Gene_locus related to this paper: bacsu-pnbae , thefu-q6a0i4 , thefu-q6a0i3

Title : Epoxide-hydrolase-initiated hydrolysis\/rearrangement cascade of a methylene-interrupted bis-epoxide yields chiral THF moieties without involvement of a cyclase - Ueberbacher_2009_Chembiochem_10_1697
Author(s) : Ueberbacher BT , Oberdorfer G , Gruber K , Faber K
Ref : Chembiochem , 10 :1697 , 2009
PubMedID: 19496106

Title : Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha\/beta-hydrolase fold - Guterl_2009_J.Biotechnol_141_166
Author(s) : Guterl JK , Andexer JN , Sehl T , von Langermann J , Frindi-Wosch I , Rosenkranz T , Fitter J , Gruber K , Kragl U , Eggert T , Pohl M
Ref : J Biotechnol , 141 :166 , 2009
PubMedID: 19433222
Gene_locus related to this paper: arath-HNL , hevbr-hnl , manes-hnl

Title : Substrate binding in the FAD-dependent hydroxynitrile lyase from almond provides insight into the mechanism of cyanohydrin formation and explains the absence of dehydrogenation activity - Dreveny_2009_Biochemistry_48_3370
Author(s) : Dreveny I , Andryushkova AS , Glieder A , Gruber K , Kratky C
Ref : Biochemistry , 48 :3370 , 2009
PubMedID: 19256550

Title : Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis - Schmidt_2008_J.Biol.Chem_283_21827
Author(s) : Schmidt A , Gruber K , Kratky C , Lamzin VS
Ref : Journal of Biological Chemistry , 283 :21827 , 2008
PubMedID: 18524775
Gene_locus related to this paper: hevbr-hnl

Title : Serine scanning: a tool to prove the consequences of N-glycosylation of proteins - Weis_2007_J.Biotechnol_129_50
Author(s) : Weis R , Gaisberger R , Gruber K , Glieder A
Ref : J Biotechnol , 129 :50 , 2007
PubMedID: 17224199

Title : Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using thio-disguised precursors and oxynitrilase catalysis - Fechter_2007_Chemistry_13_3369
Author(s) : Fechter MH , Gruber K , Avi M , Skranc W , Schuster C , Pochlauer P , Klepp KO , Griengl H
Ref : Chemistry , 13 :3369 , 2007
PubMedID: 17226866

Title : Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis - Gartler_2007_J.Biotechnol_129_87
Author(s) : Gartler G , Kratky C , Gruber K
Ref : J Biotechnol , 129 :87 , 2007
PubMedID: 17250917
Gene_locus related to this paper: hevbr-hnl

Title : Inverting enantioselectivity of Burkholderia gladioli esterase EstB by directed and designed evolution - Ivancic_2007_J.Biotechnol_129_109
Author(s) : Ivancic M , Valinger G , Gruber K , Schwab H
Ref : J Biotechnol , 129 :109 , 2007
PubMedID: 17147964

Title : A biocatalytic Henry reaction--the hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol reactions -
Author(s) : Purkarthofer T , Gruber K , Gruber-Khadjawi M , Waich K , Skranc W , Mink D , Griengl H
Ref : Angew Chem Int Ed Engl , 45 :3454 , 2006
PubMedID: 16634109

Title : Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate - Stranzl_2004_J.Biol.Chem_279_3699
Author(s) : Stranzl GR , Gruber K , Steinkellner G , Zangger K , Schwab H , Kratky C
Ref : Journal of Biological Chemistry , 279 :3699 , 2004
PubMedID: 14597632
Gene_locus related to this paper: manes-hnl

Title : Reaction mechanism of hydroxynitrile lyases of the alpha\/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236 - Gruber_2004_J.Biol.Chem_279_20501
Author(s) : Gruber K , Gartler G , Krammer B , Schwab H , Kratky C
Ref : Journal of Biological Chemistry , 279 :20501 , 2004
PubMedID: 14998991
Gene_locus related to this paper: hevbr-hnl

Title : Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis -
Author(s) : Glieder A , Weis R , Skranc W , Poechlauer P , Dreveny I , Majer S , Wubbolts M , Schwab H , Gruber K
Ref : Angew Chem Int Ed Engl , 42 :4815 , 2003
PubMedID: 14562357

Title : The active site of hydroxynitrile lyase from Prunus amygdalus: modeling studies provide new insights into the mechanism of cyanogenesis - Dreveny_2002_Protein.Sci_11_292
Author(s) : Dreveny I , Kratky C , Gruber K
Ref : Protein Science , 11 :292 , 2002
PubMedID: 11790839

Title : The hydroxynitrile lyase from almond: a lyase that looks like an oxidoreductase - Dreveny_2001_Structure_9_803
Author(s) : Dreveny I , Gruber K , Glieder A , Thompson A , Kratky C
Ref : Structure , 9 :803 , 2001
PubMedID: 11566130

Title : Elucidation of the mode of substrate binding to hydroxynitrile lyase from Hevea brasiliensis - Gruber_2001_Proteins_44_26
Author(s) : Gruber K
Ref : Proteins , 44 :26 , 2001
PubMedID: 11354003

Title : Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis - Zuegg_1999_Protein.Sci_8_1990
Author(s) : Zuegg J , Gruber K , Gugganig M , Wagner UG , Kratky C
Ref : Protein Science , 8 :1990 , 1999
PubMedID: 10548044
Gene_locus related to this paper: hevbr-hnl

Title : Atomic resolution crystal structure of hydroxynitrile lyase from Hevea brasiliensis - Gruber_1999_Biol.Chem_380_993
Author(s) : Gruber K , Gugganig M , Wagner UG , Kratky C
Ref : Biol Chem , 380 :993 , 1999
PubMedID: 10494852