| Title : Biocatalytic Heteroaromatic Amide Formation in Water Enabled by a Catalytic Tetrad and Two Access Tunnels - Zukic_2024_ACS.Catal_14_8913 |
| Author(s) : Zukic E , Mokos D , Weber M , Stix N , Ditrich K , Ferrario V , Muller H , Willrodt C , Gruber K , Daniel B , Kroutil W |
| Ref : ACS Catal , 14 :8913 , 2024 |
| Abstract : |
| PubMedSearch : Zukic_2024_ACS.Catal_14_8913 |
| PubMedID: 38868102 |
| Gene_locus related to this paper: sphmc-SpL |
| Title : Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX - Hetmann_2023_Sci.Rep_13_11783 |
| Author(s) : Hetmann M , Langner C , Durmaz V , Cespugli M , Kochl K , Krassnigg A , Blaschitz K , Groiss S , Loibner M , Ruau D , Zatloukal K , Gruber K , Steinkellner G , Gruber CC |
| Ref : Sci Rep , 13 :11783 , 2023 |
| Abstract : |
| PubMedSearch : Hetmann_2023_Sci.Rep_13_11783 |
| PubMedID: 37479788 |
| Title : Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes - Grabner_2022_J.Am.Chem.Soc__ |
| Author(s) : Grabner GF , Guttenberger N , Mayer N , Migglautsch-Sulzer AK , Lembacher-Fadum C , Fawzy N , Bulfon D , Hofer P , Zullig T , Hartig L , Kulminskaya N , Chalhoub G , Schratter M , Radner FPW , Preiss-Landl K , Masser S , Lass A , Zechner R , Gruber K , Oberer M , Breinbauer R , Zimmermann R |
| Ref : Journal of the American Chemical Society , : , 2022 |
| Abstract : |
| PubMedSearch : Grabner_2022_J.Am.Chem.Soc__ |
| PubMedID: 35362954 |
| Title : Residue-Specific Incorporation of the Non-Canonical Amino Acid Norleucine Improves Lipase Activity on Synthetic Polyesters - Haernvall_2022_Front.Bioeng.Biotechnol_10_769830 |
| Author(s) : Haernvall K , Fladischer P , Schoeffmann H , Zitzenbacher S , Pavkov-Keller T , Gruber K , Schick M , Yamamoto M , Kuenkel A , Ribitsch D , Guebitz GM , Wiltschi B |
| Ref : Front Bioeng Biotechnol , 10 :769830 , 2022 |
| Abstract : |
| PubMedSearch : Haernvall_2022_Front.Bioeng.Biotechnol_10_769830 |
| PubMedID: 35155387 |
| Gene_locus related to this paper: theet-q3ch51 |
| Title : PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes - Wallace_2017_Appl.Microbiol.Biotechnol_101_2291 |
| Author(s) : Wallace PW , Haernvall K , Ribitsch D , Zitzenbacher S , Schittmayer M , Steinkellner G , Gruber K , Guebitz GM , Birner-Gruenberger R |
| Ref : Applied Microbiology & Biotechnology , 101 :2291 , 2017 |
| Abstract : |
| PubMedSearch : Wallace_2017_Appl.Microbiol.Biotechnol_101_2291 |
| PubMedID: 27872998 |
| Title : Engineering of the zinc-binding domain of an esterase from Clostridium botulinum towards increased activity on polyesters - Biundo_2017_Catal.Sci.Technol_7_1440 |
| Author(s) : Biundo A , Steinkellner G , Gruber K , Spreitzhofer T , Ribitsch D , Guebitz GM |
| Ref : Catal Sci Technol , 7 :1440 , 2017 |
| Abstract : |
| PubMedSearch : Biundo_2017_Catal.Sci.Technol_7_1440 |
| PubMedID: |
| Gene_locus related to this paper: clobh-A51055 |
| Title : Small cause, large effect: Structural characterization of cutinases from Thermobifida cellulosilytica - Ribitsch_2017_Biotechnol.Bioeng_114_2481 |
| Author(s) : Ribitsch D , Hromic A , Zitzenbacher S , Zartl B , Gamerith C , Pellis A , Jungbauer A , Lyskowski A , Steinkellner G , Gruber K , Tscheliessnig R , Herrero Acero E , Guebitz GM |
| Ref : Biotechnol Bioeng , 114 :2481 , 2017 |
| Abstract : |
| PubMedSearch : Ribitsch_2017_Biotechnol.Bioeng_114_2481 |
| PubMedID: 28671263 |
| Gene_locus related to this paper: thefu-q6a0i4 , thefu-q6a0i3 |
| Title : Hydrolysis of synthetic polyesters by Clostridium botulinum esterases - Perz_2016_Biotechnol.Bioeng_113_1024 |
| Author(s) : Perz V , Baumschlager A , Bleymaier K , Zitzenbacher S , Hromic A , Steinkellner G , Pairitsch A , Lyskowski A , Gruber K , Sinkel C , Kuper U , Ribitsch D , Guebitz GM |
| Ref : Biotechnol Bioeng , 113 :1024 , 2016 |
| Abstract : |
| PubMedSearch : Perz_2016_Biotechnol.Bioeng_113_1024 |
| PubMedID: 26524601 |
| Gene_locus related to this paper: clobh-A5I3I2 , clobh-A51055 |
| Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016 |
| Abstract : |
| PubMedSearch : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
| PubMedID: 26869448 |
| Gene_locus related to this paper: yeast-mgll |
| Title : Characterization of a poly(butylene adipate-co-terephthalate)-hydrolyzing lipase from Pelosinus fermentans - Biundo_2016_Appl.Microbiol.Biotechnol_100_1753 |
| Author(s) : Biundo A , Hromic A , Pavkov-Keller T , Gruber K , Quartinello F , Haernvall K , Perz V , Arrell MS , Zinn M , Ribitsch D , Guebitz GM |
| Ref : Applied Microbiology & Biotechnology , 100 :1753 , 2016 |
| Abstract : |
| PubMedSearch : Biundo_2016_Appl.Microbiol.Biotechnol_100_1753 |
| PubMedID: 26490551 |
| Gene_locus related to this paper: 9firm-a0a0a0ymq9 |
| Title : An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic-Aromatic Polyesters - Perz_2016_Environ.Sci.Technol_50_2899 |
| Author(s) : Perz V , Hromic A , Baumschlager A , Steinkellner G , Pavkov-Keller T , Gruber K , Bleymaier K , Zitzenbacher S , Zankel A , Mayrhofer C , Sinkel C , Kueper U , Schlegel K , Ribitsch D , Guebitz GM |
| Ref : Environ Sci Technol , 50 :2899 , 2016 |
| Abstract : |
| PubMedSearch : Perz_2016_Environ.Sci.Technol_50_2899 |
| PubMedID: 26878094 |
| Gene_locus related to this paper: 9clot-r5t6k9 |
| Title : Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels - Bezerra_2015_Sci.Rep_5_8769 |
| Author(s) : Bezerra GA , Dobrovetsky E , Seitova A , Fedosyuk S , Dhe-Paganon S , Gruber K |
| Ref : Sci Rep , 5 :8769 , 2015 |
| Abstract : |
| PubMedSearch : Bezerra_2015_Sci.Rep_5_8769 |
| PubMedID: 25740212 |
| Gene_locus related to this paper: human-DPP10 |
| Title : Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis - Herrero_2013_Biotechnol.Bioeng_110_2581 |
| Author(s) : Herrero Acero E , Ribitsch D , Dellacher A , Zitzenbacher S , Marold A , Steinkellner G , Gruber K , Schwab H , Guebitz GM |
| Ref : Biotechnol Bioeng , 110 :2581 , 2013 |
| Abstract : |
| PubMedSearch : Herrero_2013_Biotechnol.Bioeng_110_2581 |
| PubMedID: 23592055 |
| Title : Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase - Rengachari_2013_J.Biol.Chem_288_31093 |
| Author(s) : Rengachari S , Aschauer P , Schittmayer M , Mayer N , Gruber K , Breinbauer R , Birner-Gruenberger R , Dreveny I , Oberer M |
| Ref : Journal of Biological Chemistry , 288 :31093 , 2013 |
| Abstract : |
| PubMedSearch : Rengachari_2013_J.Biol.Chem_288_31093 |
| PubMedID: 24014019 |
| Gene_locus related to this paper: bac25-mglp |
| Title : Fusion of binding domains to Thermobifida cellulosilytica cutinase to tune sorption characteristics and enhancing PET hydrolysis - Ribitsch_2013_Biomacromolecules_14_1769 |
| Author(s) : Ribitsch D , Yebra AO , Zitzenbacher S , Wu J , Nowitsch S , Steinkellner G , Greimel K , Doliska A , Oberdorfer G , Gruber CC , Gruber K , Schwab H , Stana-Kleinschek K , Herrero Acero E , Guebitz GM |
| Ref : Biomacromolecules , 14 :1769 , 2013 |
| Abstract : |
| PubMedSearch : Ribitsch_2013_Biomacromolecules_14_1769 |
| PubMedID: 23718548 |
| Gene_locus related to this paper: thefu-q6a0i4 |
| Title : Tailoring a stabilized variant of hydroxynitrile lyase from Arabidopsis thaliana - Okrob_2012_Chembiochem_13_797 |
| Author(s) : Okrob D , Metzner J , Wiechert W , Gruber K , Pohl M |
| Ref : Chembiochem , 13 :797 , 2012 |
| Abstract : |
| PubMedSearch : Okrob_2012_Chembiochem_13_797 |
| PubMedID: 22378361 |
| Gene_locus related to this paper: arath-HNL |
| Title : Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases - Bezerra_2012_PLoS.One_7_e43019 |
| Author(s) : Bezerra GA , Dobrovetsky E , Dong A , Seitova A , Crombett L , Shewchuk LM , Hassell AM , Sweitzer SM , Sweitzer TD , McDevitt PJ , Johanson KO , Kennedy-Wilson KM , Cossar D , Bochkarev A , Gruber K , Dhe-Paganon S |
| Ref : PLoS ONE , 7 :e43019 , 2012 |
| Abstract : |
| PubMedSearch : Bezerra_2012_PLoS.One_7_e43019 |
| PubMedID: 22952628 |
| Gene_locus related to this paper: human-DPP7 |
| Title : Extracellular serine proteases from Stenotrophomonas maltophilia: Screening, isolation and heterologous expression in E. coli - Ribitsch_2012_J.Biotechnol_157_140 |
| Author(s) : Ribitsch D , Heumann S , Karl W , Gerlach J , Leber R , Birner-Gruenberger R , Gruber K , Eiteljoerg I , Remler P , Siegert P , Lange J , Maurer KH , Berg G , Guebitz GM , Schwab H |
| Ref : J Biotechnol , 157 :140 , 2012 |
| Abstract : |
| PubMedSearch : Ribitsch_2012_J.Biotechnol_157_140 |
| PubMedID: 21983234 |
| Title : A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA) - Ribitsch_2012_Polymers_4_617 |
| Author(s) : Ribitsch D , Herrero Acero E , Greimel K , Dellacher A , Zitzenbacher S , Marold A , Rodriguez RD , Steinkellner G , Gruber K , Schwab H , Guebitz GM |
| Ref : Polymers , 4 :617 , 2012 |
| Abstract : |
| PubMedSearch : Ribitsch_2012_Polymers_4_617 |
| PubMedID: |
| Gene_locus related to this paper: 9actn-h6wx58 |
| Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
| Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012 |
| Abstract : |
| PubMedSearch : Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
| PubMedID: 22561231 |
| Gene_locus related to this paper: bac25-mglp |
| Title : Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels - Bezerra_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_214 |
| Author(s) : Bezerra GA , Dobrovetsky E , Seitova A , Dhe-Paganon S , Gruber K |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 68 :214 , 2012 |
| Abstract : |
| PubMedSearch : Bezerra_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_68_214 |
| PubMedID: 22298003 |
| Gene_locus related to this paper: human-DPP10 |
| Title : Hydroxynitrile lyases with alpha\/beta-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms - Andexer_2012_Chembiochem_13_1932 |
| Author(s) : Andexer JN , Staunig N , Eggert T , Kratky C , Pohl M , Gruber K |
| Ref : Chembiochem , 13 :1932 , 2012 |
| Abstract : |
| PubMedSearch : Andexer_2012_Chembiochem_13_1932 |
| PubMedID: 22851196 |
| Gene_locus related to this paper: arath-HNL |
| Title : Enzymatic Surface Hydrolysis of PET: Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida. - Herrero-Acero_2011_Macromolecules_44_4632 |
| Author(s) : Herrero Acero E , Ribitsch D , Steinkellner G , Gruber K , Greimel K , Eiteljoerg I , Trotscha E , Wei R , Zimmermann W , Zinn M , Cavaco-Paulo A , Freddi G , Schwab H , Guebitz G |
| Ref : Macromolecules , 44 :4632 , 2011 |
| Abstract : |
| PubMedSearch : Herrero-Acero_2011_Macromolecules_44_4632 |
| PubMedID: |
| Gene_locus related to this paper: bacsu-pnbae , thefu-q6a0i4 , thefu-q6a0i3 |
| Title : Epoxide-hydrolase-initiated hydrolysis\/rearrangement cascade of a methylene-interrupted bis-epoxide yields chiral THF moieties without involvement of a cyclase - Ueberbacher_2009_Chembiochem_10_1697 |
| Author(s) : Ueberbacher BT , Oberdorfer G , Gruber K , Faber K |
| Ref : Chembiochem , 10 :1697 , 2009 |
| Abstract : |
| PubMedSearch : Ueberbacher_2009_Chembiochem_10_1697 |
| PubMedID: 19496106 |
| Title : Substrate binding in the FAD-dependent hydroxynitrile lyase from almond provides insight into the mechanism of cyanohydrin formation and explains the absence of dehydrogenation activity - Dreveny_2009_Biochemistry_48_3370 |
| Author(s) : Dreveny I , Andryushkova AS , Glieder A , Gruber K , Kratky C |
| Ref : Biochemistry , 48 :3370 , 2009 |
| Abstract : |
| PubMedSearch : Dreveny_2009_Biochemistry_48_3370 |
| PubMedID: 19256550 |
| Title : Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha\/beta-hydrolase fold - Guterl_2009_J.Biotechnol_141_166 |
| Author(s) : Guterl JK , Andexer JN , Sehl T , von Langermann J , Frindi-Wosch I , Rosenkranz T , Fitter J , Gruber K , Kragl U , Eggert T , Pohl M |
| Ref : J Biotechnol , 141 :166 , 2009 |
| Abstract : |
| PubMedSearch : Guterl_2009_J.Biotechnol_141_166 |
| PubMedID: 19433222 |
| Gene_locus related to this paper: arath-HNL , hevbr-hnl , manes-hnl |
| Title : Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis - Schmidt_2008_J.Biol.Chem_283_21827 |
| Author(s) : Schmidt A , Gruber K , Kratky C , Lamzin VS |
| Ref : Journal of Biological Chemistry , 283 :21827 , 2008 |
| Abstract : |
| PubMedSearch : Schmidt_2008_J.Biol.Chem_283_21827 |
| PubMedID: 18524775 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Inverting enantioselectivity of Burkholderia gladioli esterase EstB by directed and designed evolution - Ivancic_2007_J.Biotechnol_129_109 |
| Author(s) : Ivancic M , Valinger G , Gruber K , Schwab H |
| Ref : J Biotechnol , 129 :109 , 2007 |
| Abstract : |
| PubMedSearch : Ivancic_2007_J.Biotechnol_129_109 |
| PubMedID: 17147964 |
| Title : Serine scanning: a tool to prove the consequences of N-glycosylation of proteins - Weis_2007_J.Biotechnol_129_50 |
| Author(s) : Weis R , Gaisberger R , Gruber K , Glieder A |
| Ref : J Biotechnol , 129 :50 , 2007 |
| Abstract : |
| PubMedSearch : Weis_2007_J.Biotechnol_129_50 |
| PubMedID: 17224199 |
| Title : Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using thio-disguised precursors and oxynitrilase catalysis - Fechter_2007_Chemistry_13_3369 |
| Author(s) : Fechter MH , Gruber K , Avi M , Skranc W , Schuster C , Pochlauer P , Klepp KO , Griengl H |
| Ref : Chemistry , 13 :3369 , 2007 |
| Abstract : |
| PubMedSearch : Fechter_2007_Chemistry_13_3369 |
| PubMedID: 17226866 |
| Title : Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis - Gartler_2007_J.Biotechnol_129_87 |
| Author(s) : Gartler G , Kratky C , Gruber K |
| Ref : J Biotechnol , 129 :87 , 2007 |
| Abstract : |
| PubMedSearch : Gartler_2007_J.Biotechnol_129_87 |
| PubMedID: 17250917 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : A biocatalytic Henry reaction--the hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol reactions - |
| Author(s) : Purkarthofer T , Gruber K , Gruber-Khadjawi M , Waich K , Skranc W , Mink D , Griengl H |
| Ref : Angew Chem Int Ed Engl , 45 :3454 , 2006 |
| PubMedID: 16634109 |
| Title : Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate - Stranzl_2004_J.Biol.Chem_279_3699 |
| Author(s) : Stranzl GR , Gruber K , Steinkellner G , Zangger K , Schwab H , Kratky C |
| Ref : Journal of Biological Chemistry , 279 :3699 , 2004 |
| Abstract : |
| PubMedSearch : Stranzl_2004_J.Biol.Chem_279_3699 |
| PubMedID: 14597632 |
| Gene_locus related to this paper: manes-hnl |
| Title : Reaction mechanism of hydroxynitrile lyases of the alpha\/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236 - Gruber_2004_J.Biol.Chem_279_20501 |
| Author(s) : Gruber K , Gartler G , Krammer B , Schwab H , Kratky C |
| Ref : Journal of Biological Chemistry , 279 :20501 , 2004 |
| Abstract : |
| PubMedSearch : Gruber_2004_J.Biol.Chem_279_20501 |
| PubMedID: 14998991 |
| Gene_locus related to this paper: hevbr-hnl |
| Title : Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis - |
| Author(s) : Glieder A , Weis R , Skranc W , Poechlauer P , Dreveny I , Majer S , Wubbolts M , Schwab H , Gruber K |
| Ref : Angew Chem Int Ed Engl , 42 :4815 , 2003 |
| PubMedID: 14562357 |
| Title : The active site of hydroxynitrile lyase from Prunus amygdalus: modeling studies provide new insights into the mechanism of cyanogenesis - Dreveny_2002_Protein.Sci_11_292 |
| Author(s) : Dreveny I , Kratky C , Gruber K |
| Ref : Protein Science , 11 :292 , 2002 |
| Abstract : |
| PubMedSearch : Dreveny_2002_Protein.Sci_11_292 |
| PubMedID: 11790839 |
| Title : Elucidation of the mode of substrate binding to hydroxynitrile lyase from Hevea brasiliensis - Gruber_2001_Proteins_44_26 |
| Author(s) : Gruber K |
| Ref : Proteins , 44 :26 , 2001 |
| Abstract : |
| PubMedSearch : Gruber_2001_Proteins_44_26 |
| PubMedID: 11354003 |
| Title : The hydroxynitrile lyase from almond: a lyase that looks like an oxidoreductase - Dreveny_2001_Structure_9_803 |
| Author(s) : Dreveny I , Gruber K , Glieder A , Thompson A , Kratky C |
| Ref : Structure , 9 :803 , 2001 |
| Abstract : |
| PubMedSearch : Dreveny_2001_Structure_9_803 |
| PubMedID: 11566130 |
| Title : Atomic resolution crystal structure of hydroxynitrile lyase from Hevea brasiliensis - Gruber_1999_Biol.Chem_380_993 |
| Author(s) : Gruber K , Gugganig M , Wagner UG , Kratky C |
| Ref : Biol Chem , 380 :993 , 1999 |
| Abstract : |
| PubMedSearch : Gruber_1999_Biol.Chem_380_993 |
| PubMedID: 10494852 |
| Title : Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis - Zuegg_1999_Protein.Sci_8_1990 |
| Author(s) : Zuegg J , Gruber K , Gugganig M , Wagner UG , Kratky C |
| Ref : Protein Science , 8 :1990 , 1999 |
| Abstract : |
| PubMedSearch : Zuegg_1999_Protein.Sci_8_1990 |
| PubMedID: 10548044 |
| Gene_locus related to this paper: hevbr-hnl |