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Substrate Report for: CHEMBL1784957

Carbamate cholinesterase inhibitor. Conjugation of the phenol derived from rivastigmine with d-amphetamine


General
Type Drug, Pro-drug, Carbamate, Derivative of Rivastigmine
Chemical_Nomenclature [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-[(2S)-1-phenylpropan-2-yl]carbamate
Canonical SMILES CC(CC1=CC=CC=C1)NC(=O)OC2=CC=CC(=C2)C(C)N(C)C
InChI InChI=1S/C20H26N2O2/c1-15(13-17-9-6-5-7-10-17)21-20(23)24-19-12-8-11-18(14-19)16(2)22(3)4/h5-12,14-16H,13H2,1-4H3,(H,21,23)/t15-,16-/m0/s1
InChIKey HKJROXHSAHRDAO-HOTGVXAUSA-N
Other name(s) CHEMBL1784957 ; SCHEMBL7897597 ; CHEMBL1789758 ; BDBM50345811 ; 3-((S)-1-(dimethylamino)ethyl)phenyl(S)-1-phenylpropan-2-ylcarbamate hydrochloride
________________________________________________________________________________________________
MW|326.4
Formula|C20H26N2O2
CAS_number|
PubChem|25205011
UniChem|HKJROXHSAHRDAO-HOTGVXAUSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: CHEMBL1784957
    Title: Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition
    Verheijen JC, Wiig KA, Du S, Connors SL, Martin AN, Ferreira JP, Slepnev VI, Kochendorfer U
    Ref: Bioorganic & Medicinal Chemistry Lett, 19:3243, 2009 : PubMed