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Substrate Report for: Ciclesonide

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. It is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21-desisobutyryl-ciclesonide (des-ciclesonide). Des-ciclesonide has anti-inflammatory activity with affinity for the glucocorticoid receptor



General
Type: Not A/B H target, Pro-Drug, Butyrate, Drug
Chemical_Nomenclature: (R)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
Canonical SMILES:
InChI:
InChIKey:
Other name(s): Omnaris ; Alvesco ; Zetonna ; DB01410
MW: 540.69
Formula: C32H44O7
CAS_number: 126544-47-6
PubChem: 6918155
UniChem:
IUPHAR:
Wikipedia: Ciclesonide

Target families
Ciclesonide ligand of proteins in family: Carb_B_Chordata
No structure

Protein target
Enzyme: human-CES1

References
Search PubMed for references concerning: Ciclesonide
    Title: The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue
    Mutch E, Nave R, McCracken N, Zech K, Williams FM
    Ref: Biochemical Pharmacology, 73:1657, 2007 : PubMed