ABD-1970
General
Type : Carbamate,Trifluoro,Piperazine,Azabicyclo
Chemical_Nomenclature : 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[4-chloro-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl]methyl]piperazine-1-carboxylate
Canonical SMILES : C1CC2CN(CC1O2)C3=C(C=CC(=C3)Cl)CN4CCN(CC4)C(=O)OC(C(F)(F)F)C(F)(F)F
InChI : InChI=1S\/C21H24ClF6N3O3\/c22-14-2-1-13(17(9-14)31-11-15-3-4-16(12-31)33-15)10-29-5-7-30(8-6-29)19(32)34-18(20(23,24)25)21(26,27)28\/h1-2,9,15-16,18H,3-8,10-12H2
InChIKey : CXSFVTMRWPSLGO-UHFFFAOYSA-N
Other name(s) : CHEMBL4517565,SCHEMBL18064890,GTPL11816
MW : 515.9
Formula : C21H24ClF6N3O3
CAS_number : 2010154-82-0
PubChem : 122530045
UniChem : CXSFVTMRWPSLGO-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : ABD-1970 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein : human-MGLL
References (1)
| Title : Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators - Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| Author(s) : Clapper JR , Henry CL , Niphakis MJ , Knize AM , Coppola AR , Simon GM , Ngo N , Herbst RA , Herbst DM , Reed AW , Cisar JS , Weber OD , Viader A , Alexander JP , Cunningham ML , Jones TK , Fraser IP , Grice CA , Ezekowitz RAB , O'Neill GP , Blankman JL |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :494 , 2018 |
| Abstract : Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| ESTHER : Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| PubMedSearch : Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| PubMedID: 30305428 |