Title : A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation - League_2024_Front.Immunol_15_1374301 |
Author(s) : League AF , Yadav-Samudrala BJ , Kolagani R , Cline CA , Jacobs IR , Manke J , Niphakis MJ , Cravatt BF , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
Ref : Front Immunol , 15 :1374301 , 2024 |
Abstract : |
PubMedSearch : League_2024_Front.Immunol_15_1374301 |
PubMedID: 38835765 |
Gene_locus related to this paper: human-MGLL |
Title : Attenuating ABHD17 enhances S- palmitoylation, membrane localization and signal transduction of NOD2 and Crohn's disease-associated variants - Dixon_2023_bioRxiv__ |
Author(s) : Dixon CL , Martin NR , Niphakis MJ , Cravatt BF , Fairn GD |
Ref : Biorxiv , : , 2023 |
Abstract : |
PubMedSearch : Dixon_2023_bioRxiv__ |
PubMedID: 38187608 |
Title : Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron - Keller_2023_Nat.Chem.Biol__ |
Author(s) : Keller LJ , Nguyen TH , Liu LJ , Hurysz BM , Lakemeyer M , Guerra M , Gelsinger DJ , Chanin R , Ngo N , Lum KM , Faucher F , Ipock P , Niphakis MJ , Bhatt AS , O'Donoghue AJ , Huang KC , Bogyo M |
Ref : Nat Chemical Biology , : , 2023 |
Abstract : |
PubMedSearch : Keller_2023_Nat.Chem.Biol__ |
PubMedID: 37349583 |
Title : Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms - Xu_2022_Cells_11_ |
Author(s) : Xu C , Yadav-Samudrala BJ , Nath B , Mistry T , Jiang W , Niphakis MJ , Cravatt BF , Mukhopadhyay S , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
Ref : Cells , 11 : , 2022 |
Abstract : |
PubMedSearch : Xu_2022_Cells_11_ |
PubMedID: 35269478 |
Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
Ref : Nat Chemical Biology , : , 2021 |
Abstract : |
PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
PubMedID: 33927411 |
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
Title : Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host - Onguka_2021_Cell.Chem.Biol__ |
Author(s) : Onguka O , Babin BM , Lakemeyer M , Foe IT , Amara N , Terrell SM , Lum KM , Cieplak P , Niphakis MJ , Long JZ , Bogyo M |
Ref : Cell Chemical Biology , : , 2021 |
Abstract : |
PubMedSearch : Onguka_2021_Cell.Chem.Biol__ |
PubMedID: 34043961 |
Gene_locus related to this paper: toxgo-TgASH3 , toxgo-TgASH2 , toxgo-s4ug63 , toxgo-a0a125yz56 |
Title : Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat - League_2021_Front.Neurol_12_651272 |
Author(s) : League AF , Gorman BL , Hermes DJ , Johnson CT , Jacobs IR , Yadav-Samudrala BJ , Poklis JL , Niphakis MJ , Cravatt BF , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
Ref : Front Neurol , 12 :651272 , 2021 |
Abstract : |
PubMedSearch : League_2021_Front.Neurol_12_651272 |
PubMedID: 34484091 |
Gene_locus related to this paper: human-MGLL |
Title : AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice - Erikci_2020_J.Biol.Chem_295_5891 |
Author(s) : Erikci Ertunc M , Kok BP , Parsons WH , Wang JG , Tan D , Donaldson CJ , Pinto AFM , Vaughan JM , Ngo N , Lum KM , Henry CL , Coppola AR , Niphakis MJ , Cravatt BF , Saez E , Saghatelian A |
Ref : Journal of Biological Chemistry , 295 :5891 , 2020 |
Abstract : |
PubMedSearch : Erikci_2020_J.Biol.Chem_295_5891 |
PubMedID: 32152231 |
Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805 |
Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA |
Ref : Cell Rep , 31 :107805 , 2020 |
Abstract : |
PubMedSearch : Mizrak_2020_Cell.Rep_31_107805 |
PubMedID: 32579931 |
Gene_locus related to this paper: human-NOTUM |
Title : The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain - Thompson_2020_J.Pharmacol.Exp.Ther_373_230 |
Author(s) : Thompson AL , Grenald SA , Ciccone HA , BassiriRad N , Niphakis MJ , Cravatt BF , Largent-Milnes TM , Vanderah TW |
Ref : Journal of Pharmacology & Experimental Therapeutics , 373 :230 , 2020 |
Abstract : |
PubMedSearch : Thompson_2020_J.Pharmacol.Exp.Ther_373_230 |
PubMedID: 32054717 |
Gene_locus related to this paper: human-MGLL |
Title : Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators - Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
Author(s) : Clapper JR , Henry CL , Niphakis MJ , Knize AM , Coppola AR , Simon GM , Ngo N , Herbst RA , Herbst DM , Reed AW , Cisar JS , Weber OD , Viader A , Alexander JP , Cunningham ML , Jones TK , Fraser IP , Grice CA , Ezekowitz RAB , O'Neill GP , Blankman JL |
Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :494 , 2018 |
Abstract : |
PubMedSearch : Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
PubMedID: 30305428 |
Title : Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy - Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
Author(s) : Curry ZA , Wilkerson JL , Bagdas D , Kyte SL , Patel N , Donvito G , Mustafa MA , Poklis JL , Niphakis MJ , Hsu KL , Cravatt BF , Gewirtz DA , Damaj MI , Lichtman AH |
Ref : Journal of Pharmacology & Experimental Therapeutics , 366 :169 , 2018 |
Abstract : |
PubMedSearch : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
PubMedID: 29540562 |
Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80 |
Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH |
Ref : Neuropharmacology , 125 :80 , 2017 |
Abstract : |
PubMedSearch : Owens_2017_Neuropharmacol_125_80 |
PubMedID: 28673548 |
Title : The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice - Wilkerson_2017_Neuropharmacol_114_156 |
Author(s) : Wilkerson JL , Ghosh S , Mustafa M , Abdullah RA , Niphakis MJ , Cabrera R , Maldonado RL , Cravatt BF , Lichtman AH |
Ref : Neuropharmacology , 114 :156 , 2017 |
Abstract : |
PubMedSearch : Wilkerson_2017_Neuropharmacol_114_156 |
PubMedID: 27890602 |
Title : Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure - Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
Author(s) : Buczynski MW , Herman MA , Hsu KL , Natividad LA , Irimia C , Polis IY , Pugh H , Chang JW , Niphakis MJ , Cravatt BF , Roberto M , Parsons LH |
Ref : Proc Natl Acad Sci U S A , 113 :1086 , 2016 |
Abstract : |
PubMedSearch : Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
PubMedID: 26755579 |
Title : Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice - Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
Author(s) : Owens RA , Ignatowska-Jankowska B , Mustafa M , Beardsley PM , Wiley JL , Jali A , Selley DE , Niphakis MJ , Cravatt BF , Lichtman AH |
Ref : Journal of Pharmacology & Experimental Therapeutics , 358 :306 , 2016 |
Abstract : |
PubMedSearch : Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
PubMedID: 27307500 |
Title : The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model - Wilkerson_2016_J.Pharmacol.Exp.Ther_357_145 |
Author(s) : Wilkerson JL , Niphakis MJ , Grim TW , Mustafa MA , Abdullah RA , Poklis JL , Dewey WL , Akbarali H , Banks ML , Wise LE , Cravatt BF , Lichtman AH |
Ref : Journal of Pharmacology & Experimental Therapeutics , 357 :145 , 2016 |
Abstract : |
PubMedSearch : Wilkerson_2016_J.Pharmacol.Exp.Ther_357_145 |
PubMedID: 26791602 |
Title : Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model - Limebeer_2016_Behav.Neurosci_130_261 |
Author(s) : Limebeer CL , Rock EM , Puvanenthirarajah N , Niphakis MJ , Cravatt BF , Parker LA |
Ref : Behavioral Neuroscience , 130 :261 , 2016 |
Abstract : |
PubMedSearch : Limebeer_2016_Behav.Neurosci_130_261 |
PubMedID: 26974857 |
Title : Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain - Burston_2016_Br.J.Pharmacol_173_3134 |
Author(s) : Burston JJ , Mapp PI , Sarmad S , Barrett DA , Niphakis MJ , Cravatt BF , Walsh DA , Chapman V |
Ref : British Journal of Pharmacology , 173 :3134 , 2016 |
Abstract : |
PubMedSearch : Burston_2016_Br.J.Pharmacol_173_3134 |
PubMedID: 27501482 |
Title : Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats - Wills_2016_Neuropsychopharmacology_41_1865 |
Author(s) : Wills KL , Petrie GN , Millett G , Limebeer CL , Rock EM , Niphakis MJ , Cravatt BF , Parker LA |
Ref : Neuropsychopharmacology , 41 :1865 , 2016 |
Abstract : |
PubMedSearch : Wills_2016_Neuropsychopharmacology_41_1865 |
PubMedID: 26647976 |
Title : Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex - Sticht_2016_Neuropharmacol_102_92 |
Author(s) : Sticht MA , Limebeer CL , Rafla BR , Abdullah RA , Poklis JL , Ho W , Niphakis MJ , Cravatt BF , Sharkey KA , Lichtman AH , Parker LA |
Ref : Neuropharmacology , 102 :92 , 2016 |
Abstract : |
PubMedSearch : Sticht_2016_Neuropharmacol_102_92 |
PubMedID: 26541329 |
Title : Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus - Parker_2015_Psychopharmacology.(Berl)_232_583 |
Author(s) : Parker LA , Niphakis MJ , Downey R , Limebeer CL , Rock EM , Sticht MA , Morris H , Abdullah RA , Lichtman AH , Cravatt BF |
Ref : Psychopharmacology (Berl) , 232 :583 , 2015 |
Abstract : |
PubMedSearch : Parker_2015_Psychopharmacology.(Berl)_232_583 |
PubMedID: 25085768 |
Gene_locus related to this paper: human-MGLL |
Title : Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases - Cognetta_2015_Chem.Biol_22_928 |
Author(s) : Cognetta AB, 3rd , Niphakis MJ , Lee HC , Martini ML , Hulce JJ , Cravatt BF |
Ref : Chemical Biology , 22 :928 , 2015 |
Abstract : |
PubMedSearch : Cognetta_2015_Chem.Biol_22_928 |
PubMedID: 26120000 |
Title : Delta9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice - Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
Author(s) : Wiebelhaus JM , Grim TW , Owens RA , Lazenka MF , Sim-Selley LJ , Abdullah RA , Niphakis MJ , Vann RE , Cravatt BF , Wiley JL , Negus SS , Lichtman AH |
Ref : Journal of Pharmacology & Experimental Therapeutics , 352 :195 , 2015 |
Abstract : |
PubMedSearch : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
PubMedID: 25398241 |
Title : Endocannabinoids modulate cortical development by configuring Slit2\/Robo1 signalling - Alpar_2014_Nat.Commun_5_4421 |
Author(s) : Alpar A , Tortoriello G , Calvigioni D , Niphakis MJ , Milenkovic I , Bakker J , Cameron GA , Hanics J , Morris CV , Fuzik J , Kovacs GG , Cravatt BF , Parnavelas JG , Andrews WD , Hurd YL , Keimpema E , Harkany T |
Ref : Nat Commun , 5 :4421 , 2014 |
Abstract : |
PubMedSearch : Alpar_2014_Nat.Commun_5_4421 |
PubMedID: 25030704 |
Title : In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects - Ignatowska-Jankowska_2014_Br.J.Pharmacol_171_1392 |
Author(s) : Ignatowska-Jankowska BM , Ghosh S , Crowe MS , Kinsey SG , Niphakis MJ , Abdullah RA , Tao Q , ST ON , Walentiny DM , Wiley JL , Cravatt BF , Lichtman AH |
Ref : British Journal of Pharmacology , 171 :1392 , 2014 |
Abstract : |
PubMedSearch : Ignatowska-Jankowska_2014_Br.J.Pharmacol_171_1392 |
PubMedID: 23848221 |
Gene_locus related to this paper: human-MGLL |
Title : Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells - Kambe_2014_J.Am.Chem.Soc_136_10777 |
Author(s) : Kambe T , Correia BE , Niphakis MJ , Cravatt BF |
Ref : Journal of the American Chemical Society , 136 :10777 , 2014 |
Abstract : |
PubMedSearch : Kambe_2014_J.Am.Chem.Soc_136_10777 |
PubMedID: 25045785 |
Title : Enzyme inhibitor discovery by activity-based protein profiling - Niphakis_2014_Annu.Rev.Biochem_83_341 |
Author(s) : Niphakis MJ , Cravatt BF |
Ref : Annual Review of Biochemistry , 83 :341 , 2014 |
Abstract : |
PubMedSearch : Niphakis_2014_Annu.Rev.Biochem_83_341 |
PubMedID: 24905785 |
Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr. |
Ref : Journal of the American Chemical Society , 136 :2659 , 2014 |
Abstract : |
PubMedSearch : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
PubMedID: 24447064 |
Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda |
Title : Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors - Niphakis_2013_ACS.Chem.Neurosci_4_1322 |
Author(s) : Niphakis MJ , Cognetta AB, 3rd , Chang JW , Buczynski MW , Parsons LH , Byrne F , Burston JJ , Chapman V , Cravatt BF |
Ref : ACS Chem Neurosci , 4 :1322 , 2013 |
Abstract : |
PubMedSearch : Niphakis_2013_ACS.Chem.Neurosci_4_1322 |
PubMedID: 23731016 |
Gene_locus related to this paper: human-MGLL |
Title : Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice - Ramesh_2013_Neuropsychopharmacology_38_1039 |
Author(s) : Ramesh D , Gamage TF , Vanuytsel T , Owens RA , Abdullah RA , Niphakis MJ , Shea-Donohue T , Cravatt BF , Lichtman AH |
Ref : Neuropsychopharmacology , 38 :1039 , 2013 |
Abstract : |
PubMedSearch : Ramesh_2013_Neuropsychopharmacology_38_1039 |
PubMedID: 23303065 |
Gene_locus related to this paper: human-MGLL |
Title : Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) - Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
Author(s) : Nagano JM , Hsu KL , Whitby LR , Niphakis MJ , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder P , Srinivasan P , Gonzalez TD , Rosen H , Bahnson BJ , Cravatt BF |
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :839 , 2013 |
Abstract : |
PubMedSearch : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
PubMedID: 23260346 |
Title : Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells - Hulce_2013_Nat.Methods_10_259 |
Author(s) : Hulce JJ , Cognetta AB, 3rd , Niphakis MJ , Tully SE , Cravatt BF |
Ref : Nat Methods , 10 :259 , 2013 |
Abstract : |
PubMedSearch : Hulce_2013_Nat.Methods_10_259 |
PubMedID: 23396283 |
Title : Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition - Chang_2013_ACS.Chem.Biol_8_1590 |
Author(s) : Chang JW , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF |
Ref : ACS Chemical Biology , 8 :1590 , 2013 |
Abstract : |
PubMedSearch : Chang_2013_ACS.Chem.Biol_8_1590 |
PubMedID: 23701408 |
Title : O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors - Niphakis_2012_ACS.Chem.Neurosci_3_418 |
Author(s) : Niphakis MJ , Johnson DS , Ballard TE , Stiff C , Cravatt BF |
Ref : ACS Chem Neurosci , 3 :418 , 2012 |
Abstract : |
PubMedSearch : Niphakis_2012_ACS.Chem.Neurosci_3_418 |
PubMedID: 22860211 |
Gene_locus related to this paper: human-MGLL |
Title : Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates - Chang_2012_Chem.Biol_19_579 |
Author(s) : Chang JW , Niphakis MJ , Lum KM , Cognetta AB, 3rd , Wang C , Matthews ML , Niessen S , Buczynski MW , Parsons LH , Cravatt BF |
Ref : Chemical Biology , 19 :579 , 2012 |
Abstract : |
PubMedSearch : Chang_2012_Chem.Biol_19_579 |
PubMedID: 22542104 |
Gene_locus related to this paper: human-MGLL |