| Title : In situ identification of cellular drug targets in mammalian tissue - Pang_2022_Cell_185_1793 |
| Author(s) : Pang Z , Schafroth MA , Ogasawara D , Wang Y , Nudell V , Lal NK , Yang D , Wang K , Herbst DM , Ha J , Guijas C , Blankman JL , Cravatt BF , Ye L |
| Ref : Cell , 185 :1793 , 2022 |
| Abstract : |
| PubMedSearch : Pang_2022_Cell_185_1793 |
| PubMedID: 35483372 |
| Title : Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators - Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| Author(s) : Clapper JR , Henry CL , Niphakis MJ , Knize AM , Coppola AR , Simon GM , Ngo N , Herbst RA , Herbst DM , Reed AW , Cisar JS , Weber OD , Viader A , Alexander JP , Cunningham ML , Jones TK , Fraser IP , Grice CA , Ezekowitz RAB , O'Neill GP , Blankman JL |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :494 , 2018 |
| Abstract : |
| PubMedSearch : Clapper_2018_J.Pharmacol.Exp.Ther_367_494 |
| PubMedID: 30305428 |
| Title : Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders - Cisar_2018_J.Med.Chem_61_9062 |
| Author(s) : Cisar JS , Weber OD , Clapper JR , Blankman JL , Henry CL , Simon GM , Alexander JP , Jones TK , Ezekowitz RAB , O'Neill GP , Grice CA |
| Ref : Journal of Medicinal Chemistry , 61 :9062 , 2018 |
| Abstract : |
| PubMedSearch : Cisar_2018_J.Med.Chem_61_9062 |
| PubMedID: 30067909 |
| Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361 |
| Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N |
| Ref : Neuron , 83 :361 , 2014 |
| Abstract : |
| PubMedSearch : Naydenov_2014_Neuron_83_361 |
| PubMedID: 25033180 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome - Thomas_2013_Cell.Rep_5_508 |
| Author(s) : Thomas G , Betters JL , Lord CC , Brown AL , Marshall S , Ferguson D , Sawyer J , Davis MA , Melchior JT , Blume LC , Howlett AC , Ivanova PT , Milne SB , Myers DS , Mrak I , Leber V , Heier C , Taschler U , Blankman JL , Cravatt BF , Lee RG , Crooke RM , Graham MJ , Zimmermann R , Brown HA , Brown JM |
| Ref : Cell Rep , 5 :508 , 2013 |
| Abstract : |
| PubMedSearch : Thomas_2013_Cell.Rep_5_508 |
| PubMedID: 24095738 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC - Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| Author(s) : Blankman JL , Long JZ , Trauger SA , Siuzdak G , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 110 :1500 , 2013 |
| Abstract : |
| PubMedSearch : Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| PubMedID: 23297193 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Chemical probes of endocannabinoid metabolism - Blankman_2013_Pharmacol.Rev_65_849 |
| Author(s) : Blankman JL , Cravatt BF |
| Ref : Pharmacol Rev , 65 :849 , 2013 |
| Abstract : |
| PubMedSearch : Blankman_2013_Pharmacol.Rev_65_849 |
| PubMedID: 23512546 |
| Gene_locus related to this paper: human-MGLL |
| Title : Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects - Chen_2013_Hum.Mutat_34_1672 |
| Author(s) : Chen DH , Naydenov A , Blankman JL , Mefford HC , Davis M , Sul Y , Barloon AS , Bonkowski E , Wolff J , Matsushita M , Smith C , Cravatt BF , Mackie K , Raskind WH , Stella N , Bird TD |
| Ref : Hum Mutat , 34 :1672 , 2013 |
| Abstract : |
| PubMedSearch : Chen_2013_Hum.Mutat_34_1672 |
| PubMedID: 24027063 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation - Straiker_2011_Br.J.Pharmacol_164_1672 |
| Author(s) : Straiker A , Wager-Miller J , Hu SS , Blankman JL , Cravatt BF , Mackie K |
| Ref : British Journal of Pharmacology , 164 :1672 , 2011 |
| Abstract : |
| PubMedSearch : Straiker_2011_Br.J.Pharmacol_164_1672 |
| PubMedID: 21564090 |
| Title : Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation - Nomura_2011_Science_334_809 |
| Author(s) : Nomura DK , Morrison BE , Blankman JL , Long JZ , Kinsey SG , Marcondes MC , Ward AM , Hahn YK , Lichtman AH , Conti B , Cravatt BF |
| Ref : Science , 334 :809 , 2011 |
| Abstract : |
| PubMedSearch : Nomura_2011_Science_334_809 |
| PubMedID: 22021672 |
| Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420 |
| Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal of Neuroscience , 31 :13420 , 2011 |
| Abstract : |
| PubMedSearch : Pan_2011_J.Neurosci_31_13420 |
| PubMedID: 21940435 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847 |
| Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal de Physiologie , 589 :4847 , 2011 |
| Abstract : |
| PubMedSearch : Zhong_2011_J.Physiol_589_4847 |
| PubMedID: 21911610 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951 |
| Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N |
| Ref : Nat Neurosci , 13 :951 , 2010 |
| Abstract : |
| PubMedSearch : Marrs_2010_Nat.Neurosci_13_951 |
| PubMedID: 20657592 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Endocannabinoid overload - Lichtman_2010_Mol.Pharmacol_78_993 |
| Author(s) : Lichtman AH , Blankman JL , Cravatt BF |
| Ref : Molecular Pharmacology , 78 :993 , 2010 |
| Abstract : |
| PubMedSearch : Lichtman_2010_Mol.Pharmacol_78_993 |
| PubMedID: 20952498 |
| Title : Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system - Schlosburg_2010_Nat.Neurosci_13_1113 |
| Author(s) : Schlosburg JE , Blankman JL , Long JZ , Nomura DK , Pan B , Kinsey SG , Nguyen PT , Ramesh D , Booker L , Burston JJ , Thomas EA , Selley DE , Sim-Selley LJ , Liu QS , Lichtman AH , Cravatt BF |
| Ref : Nat Neurosci , 13 :1113 , 2010 |
| Abstract : |
| PubMedSearch : Schlosburg_2010_Nat.Neurosci_13_1113 |
| PubMedID: 20729846 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |
| Title : Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling - Hoover_2008_Bioorg.Med.Chem.Lett_18_5838 |
| Author(s) : Hoover HS , Blankman JL , Niessen S , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5838 , 2008 |
| Abstract : |
| PubMedSearch : Hoover_2008_Bioorg.Med.Chem.Lett_18_5838 |
| PubMedID: 18657971 |
| Title : Activation of the endocannabinoid system by organophosphorus nerve agents - Nomura_2008_Nat.Chem.Biol_4_373 |
| Author(s) : Nomura DK , Blankman JL , Simon GM , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Nat Chemical Biology , 4 :373 , 2008 |
| Abstract : |
| PubMedSearch : Nomura_2008_Nat.Chem.Biol_4_373 |
| PubMedID: 18438404 |
| Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347 |
| Author(s) : Blankman JL , Simon GM , Cravatt BF |
| Ref : Chemical Biology , 14 :1347 , 2007 |
| Abstract : |
| PubMedSearch : Blankman_2007_Chem.Biol_14_1347 |
| PubMedID: 18096503 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases - |
| Author(s) : Li W , Blankman JL , Cravatt BF |
| Ref : Journal of the American Chemical Society , 129 :9594 , 2007 |
| PubMedID: 17629278 |