Besansky NJ

References (3)

Title : Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences - Lawniczak_2010_Science_330_512
Author(s) : Lawniczak MK , Emrich SJ , Holloway AK , Regier AP , Olson M , White B , Redmond S , Fulton L , Appelbaum E , Godfrey J , Farmer C , Chinwalla A , Yang SP , Minx P , Nelson J , Kyung K , Walenz BP , Garcia-Hernandez E , Aguiar M , Viswanathan LD , Rogers YH , Strausberg RL , Saski CA , Lawson D , Collins FH , Kafatos FC , Christophides GK , Clifton SW , Kirkness EF , Besansky NJ
Ref : Science , 330 :512 , 2010
Abstract : The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.
ESTHER : Lawniczak_2010_Science_330_512
PubMedSearch : Lawniczak_2010_Science_330_512
PubMedID: 20966253
Gene_locus related to this paper: anoga-Q7PVF9 , anoga-q7q837 , 9dipt-a0a182ksz6 , anost-a0a182xxz0 , anost-a0a182xzf1 , anoga-q7q887

Title : Speciation within Anopheles gambiae--the glass is half full - della Torre_2002_Science_298_115
Author(s) : della Torre A , Costantini C , Besansky NJ , Caccone A , Petrarca V , Powell JR , Coluzzi M
Ref : Science , 298 :115 , 2002
Abstract : Restrictions to gene flow among molecular forms of the mosquito Anopheles gambiae sensu stricto reveal an ongoing speciation process affecting the epidemiology of malaria in sub-Saharan Africa.
ESTHER : della Torre_2002_Science_298_115
PubMedSearch : della Torre_2002_Science_298_115
PubMedID: 12364784

Title : Inversions and gene order shuffling in Anopheles gambiae and A. funestus - Sharakhov_2002_Science_298_182
Author(s) : Sharakhov IV , Serazin AC , Grushko OG , Dana A , Lobo N , Hillenmeyer ME , Westerman R , Romero-Severson J , Costantini C , Sagnon N , Collins FH , Besansky NJ
Ref : Science , 298 :182 , 2002
Abstract : In tropical Africa, Anopheles funestus is one of the three most important malaria vectors. We physically mapped 157 A. funestus complementary DNAs (cDNAs) to the polytene chromosomes of this species. Sequences of the cDNAs were mapped in silico to the A. gambiae genome as part of a comparative genomic study of synteny, gene order, and sequence conservation between A. funestus and A. gambiae. These species are in the same subgenus and diverged about as recently as humans and chimpanzees. Despite nearly perfect preservation of synteny, we found substantial shuffling of gene order along corresponding chromosome arms. Since the divergence of these species, at least 70 chromosomal inversions have been fixed, the highest rate of rearrangement of any eukaryote studied to date. The high incidence of paracentric inversions and limited colinearity suggests that locating genes in one anopheline species based on gene order in another may be limited to closely related taxa.
ESTHER : Sharakhov_2002_Science_298_182
PubMedSearch : Sharakhov_2002_Science_298_182
PubMedID: 12364797