Full name : Challiss RA John
First name : RA John
Mail : Department of Cell Physiology and Pharmacology, University of Leicester, Room 404, Henry Wellcome Building, Lancaster Road, Leicester, LE1 9HN
Zip Code :
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Country : United Kingdom
Email : jc36@leicester.ac.uk
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Comment
| Title : Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation - Thomas_2009_J.Pharmacol.Exp.Ther_331_1086 |
| Author(s) : Thomas RL , Langmead CJ , Wood MD , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :1086 , 2009 |
| Abstract : |
| PubMedSearch : Thomas_2009_J.Pharmacol.Exp.Ther_331_1086 |
| PubMedID: 19767446 |
| Title : G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists - Thomas_2008_J.Pharmacol.Exp.Ther_327_365 |
| Author(s) : Thomas RL , Mistry R , Langmead CJ , Wood MD , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :365 , 2008 |
| Abstract : |
| PubMedSearch : Thomas_2008_J.Pharmacol.Exp.Ther_327_365 |
| PubMedID: 18664591 |
| Title : Regulation of cyclic AMP response-element binding-protein (CREB) by Gq\/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells - Rosethorne_2008_Biochem.Pharmacol_75_942 |
| Author(s) : Rosethorne EM , Nahorski SR , Challiss RA |
| Ref : Biochemical Pharmacology , 75 :942 , 2008 |
| Abstract : |
| PubMedSearch : Rosethorne_2008_Biochem.Pharmacol_75_942 |
| PubMedID: 18036509 |
| Title : Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons - Nelson_2008_J.Neurochem_107_602 |
| Author(s) : Nelson CP , Nahorski SR , Challiss RA |
| Ref : Journal of Neurochemistry , 107 :602 , 2008 |
| Abstract : |
| PubMedSearch : Nelson_2008_J.Neurochem_107_602 |
| PubMedID: 18665913 |
| Title : The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons - Willets_2007_J.Neurochem_103_2268 |
| Author(s) : Willets JM , Nelson CP , Nahorski SR , Challiss RA |
| Ref : Journal of Neurochemistry , 103 :2268 , 2007 |
| Abstract : |
| PubMedSearch : Willets_2007_J.Neurochem_103_2268 |
| PubMedID: 17908240 |
| Title : A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism - Dowling_2006_J.Pharmacol.Exp.Ther_317_1134 |
| Author(s) : Dowling MR , Willets JM , Budd DC , Charlton SJ , Nahorski SR , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 317 :1134 , 2006 |
| Abstract : |
| PubMedSearch : Dowling_2006_J.Pharmacol.Exp.Ther_317_1134 |
| PubMedID: 16489127 |
| Title : Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor - Nelson_2006_J.Pharmacol.Exp.Ther_316_279 |
| Author(s) : Nelson CP , Nahorski SR , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 316 :279 , 2006 |
| Abstract : |
| PubMedSearch : Nelson_2006_J.Pharmacol.Exp.Ther_316_279 |
| PubMedID: 16188951 |
| Title : Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons - Willets_2005_J.Biol.Chem_280_18950 |
| Author(s) : Willets JM , Nahorski SR , Challiss RA |
| Ref : Journal of Biological Chemistry , 280 :18950 , 2005 |
| Abstract : |
| PubMedSearch : Willets_2005_J.Biol.Chem_280_18950 |
| PubMedID: 15743771 |
| Title : Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion - Young_2005_Mol.Cell.Neurosci_30_48 |
| Author(s) : Young KW , Billups D , Nelson CP , Johnston N , Willets JM , Schell MJ , Challiss RA , Nahorski SR |
| Ref : Molecular & Cellular Neurosciences , 30 :48 , 2005 |
| Abstract : |
| PubMedSearch : Young_2005_Mol.Cell.Neurosci_30_48 |
| PubMedID: 15996483 |
| Title : Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors - Bartlett_2005_J.Biol.Chem_280_21837 |
| Author(s) : Bartlett PJ , Young KW , Nahorski SR , Challiss RA |
| Ref : Journal of Biological Chemistry , 280 :21837 , 2005 |
| Abstract : |
| PubMedSearch : Bartlett_2005_J.Biol.Chem_280_21837 |
| PubMedID: 15788407 |
| Title : Imaging of muscarinic acetylcholine receptor signaling in hippocampal neurons: evidence for phosphorylation-dependent and -independent regulation by G-protein-coupled receptor kinases - Willets_2004_J.Neurosci_24_4157 |
| Author(s) : Willets JM , Nash MS , Challiss RA , Nahorski SR |
| Ref : Journal of Neuroscience , 24 :4157 , 2004 |
| Abstract : |
| PubMedSearch : Willets_2004_J.Neurosci_24_4157 |
| PubMedID: 15115810 |
| Title : NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C activation in single cerebellar granule neurons - Young_2004_J.Neurochem_89_1537 |
| Author(s) : Young KW , Garro MA , Challiss RA , Nahorski SR |
| Ref : Journal of Neurochemistry , 89 :1537 , 2004 |
| Abstract : |
| PubMedSearch : Young_2004_J.Neurochem_89_1537 |
| PubMedID: 15189357 |
| Title : Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to facilitate Ca2+ release in hippocampal neurons - Nash_2004_J.Biol.Chem_279_49036 |
| Author(s) : Nash MS , Willets JM , Billups B , Challiss RA , Nahorski SR |
| Ref : Journal of Biological Chemistry , 279 :49036 , 2004 |
| Abstract : |
| PubMedSearch : Nash_2004_J.Biol.Chem_279_49036 |
| PubMedID: 15342646 |
| Title : Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland - Nelson_2004_J.Pharmacol.Exp.Ther_310_1255 |
| Author(s) : Nelson CP , Gupta P , Napier CM , Nahorski SR , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 310 :1255 , 2004 |
| Abstract : |
| PubMedSearch : Nelson_2004_J.Pharmacol.Exp.Ther_310_1255 |
| PubMedID: 15140916 |
| Title : Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling - Willets_2003_Mol.Pharmacol_64_1059 |
| Author(s) : Willets JM , Mistry R , Nahorski SR , Challiss RA |
| Ref : Molecular Pharmacology , 64 :1059 , 2003 |
| Abstract : |
| PubMedSearch : Willets_2003_Mol.Pharmacol_64_1059 |
| PubMedID: 14573754 |
| Title : Characterization of an N-terminal secreted domain of the type-1 human metabotropic glutamate receptor produced by a mammalian cell line - Selkirk_2002_J.Neurochem_80_346 |
| Author(s) : Selkirk JV , Challiss RA , Rhodes A , McIlhinney RA |
| Ref : Journal of Neurochemistry , 80 :346 , 2002 |
| Abstract : |
| PubMedSearch : Selkirk_2002_J.Neurochem_80_346 |
| PubMedID: 11905408 |
| Title : Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells - Willets_2002_J.Biol.Chem_277_15523 |
| Author(s) : Willets JM , Challiss RA , Nahorski SR |
| Ref : Journal of Biological Chemistry , 277 :15523 , 2002 |
| Abstract : |
| PubMedSearch : Willets_2002_J.Biol.Chem_277_15523 |
| PubMedID: 11856737 |
| Title : Conformational analysis of cyclophostin and designed analogs in comparison with the potent IP3 receptor agonist adenophostin A - Iwata_2001_Drug.Des.Discov_17_253 |
| Author(s) : Iwata Y , de Kort M , Challiss RA , van der Marel GA , van Boom JH , Miyamoto S |
| Ref : Drug Des Discov , 17 :253 , 2001 |
| Abstract : |
| PubMedSearch : Iwata_2001_Drug.Des.Discov_17_253 |
| PubMedID: 11469755 |
| Title : G(q\/11) and G(i\/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype - Akam_2001_Br.J.Pharmacol_132_950 |
| Author(s) : Akam EC , Challiss RA , Nahorski SR |
| Ref : British Journal of Pharmacology , 132 :950 , 2001 |
| Abstract : |
| PubMedSearch : Akam_2001_Br.J.Pharmacol_132_950 |
| PubMedID: 11181437 |
| Title : G protein-coupled receptor kinases 3 and 6 use different pathways to desensitize the endogenous M3 muscarinic acetylcholine receptor in human SH-SY5Y cells - Willets_2001_Mol.Pharmacol_60_321 |
| Author(s) : Willets JM , Challiss RA , Kelly E , Nahorski SR |
| Ref : Molecular Pharmacology , 60 :321 , 2001 |
| Abstract : |
| PubMedSearch : Willets_2001_Mol.Pharmacol_60_321 |
| PubMedID: 11455019 |
| Title : Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation - Young_1999_Biochem.J_343 Pt 1_45 |
| Author(s) : Young KW , Challiss RA , Nahorski SR , Mackrill JJ |
| Ref : Biochemical Journal , 343 Pt 1 :45 , 1999 |
| Abstract : |
| PubMedSearch : Young_1999_Biochem.J_343 Pt 1_45 |
| PubMedID: 10493910 |
| Title : Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors - Waugh_1999_Biochem.J_338 ( Pt 1)_175 |
| Author(s) : Waugh MG , Challiss RA , Berstein G , Nahorski SR , Tobin AB |
| Ref : Biochemical Journal , 338 ( Pt 1) :175 , 1999 |
| Abstract : |
| PubMedSearch : Waugh_1999_Biochem.J_338 ( Pt 1)_175 |
| PubMedID: 9931314 |
| Title : Cross talk between m3-muscarinic and beta(2)-adrenergic receptors at the level of receptor phosphorylation and desensitization - Budd_1999_Mol.Pharmacol_56_813 |
| Author(s) : Budd DC , Challiss RA , Young KW , Tobin AB |
| Ref : Molecular Pharmacology , 56 :813 , 1999 |
| Abstract : |
| PubMedSearch : Budd_1999_Mol.Pharmacol_56_813 |
| PubMedID: 10496966 |
| Title : Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus - Boxall_1998_Br.J.Pharmacol_124_1615 |
| Author(s) : Boxall DK , Ford AP , Choppin A , Nahorski SR , Challiss RA , Eglen RM |
| Ref : British Journal of Pharmacology , 124 :1615 , 1998 |
| Abstract : |
| PubMedSearch : Boxall_1998_Br.J.Pharmacol_124_1615 |
| PubMedID: 9756376 |
| Title : Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells - Willars_1998_J.Biol.Chem_273_5037 |
| Author(s) : Willars GB , Nahorski SR , Challiss RA |
| Ref : Journal of Biological Chemistry , 273 :5037 , 1998 |
| Abstract : |
| PubMedSearch : Willars_1998_J.Biol.Chem_273_5037 |
| PubMedID: 9478953 |
| Title : Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines - Mackrill_1997_Biochem.J_327 ( Pt 1)_251 |
| Author(s) : Mackrill JJ , Challiss RA , O'Connell D A , Lai FA , Nahorski SR |
| Ref : Biochemical Journal , 327 ( Pt 1) :251 , 1997 |
| Abstract : |
| PubMedSearch : Mackrill_1997_Biochem.J_327 ( Pt 1)_251 |
| PubMedID: 9355760 |
| Title : Divalent cation entry in cultured rat cerebellar granule cells measured using Mn2+ quench of fura 2 fluorescence - Simpson_1995_Eur.J.Neurosci_7_831 |
| Author(s) : Simpson PB , Challiss RA , Nahorski SR |
| Ref : European Journal of Neuroscience , 7 :831 , 1995 |
| Abstract : |
| PubMedSearch : Simpson_1995_Eur.J.Neurosci_7_831 |
| PubMedID: 7613620 |
| Title : Muscarinic acetylcholine receptor subtypes in smooth muscle - Eglen_1994_Trends.Pharmacol.Sci_15_114 |
| Author(s) : Eglen RM , Reddy H , Watson N , Challiss RA |
| Ref : Trends in Pharmacological Sciences , 15 :114 , 1994 |
| Abstract : |
| PubMedSearch : Eglen_1994_Trends.Pharmacol.Sci_15_114 |
| PubMedID: 8016895 |
| Title : Chronic activation of muscarinic and metabotropic glutamate receptors down-regulates type I inositol 1,4,5-trisphosphate receptor expression in cerebellar granule cells - Simpson_1994_J.Neurochem_63_2369 |
| Author(s) : Simpson PB , Challiss RA , Nahorski SR |
| Ref : Journal of Neurochemistry , 63 :2369 , 1994 |
| Abstract : |
| PubMedSearch : Simpson_1994_J.Neurochem_63_2369 |
| PubMedID: 7964761 |
| Title : Depolarization and agonist-stimulated changes in inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate mass accumulation in rat cerebral cortex - Challiss_1991_J.Neurochem_57_1042 |
| Author(s) : Challiss RA , Nahorski SR |
| Ref : Journal of Neurochemistry , 57 :1042 , 1991 |
| Abstract : |
| PubMedSearch : Challiss_1991_J.Neurochem_57_1042 |
| PubMedID: 1861143 |
| Title : Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle - Chilvers_1991_Biochem.J_275 ( Pt 2)_373 |
| Author(s) : Chilvers ER , Batty IH , Challiss RA , Barnes PJ , Nahorski SR |
| Ref : Biochemical Journal , 275 ( Pt 2) :373 , 1991 |
| Abstract : |
| PubMedSearch : Chilvers_1991_Biochem.J_275 ( Pt 2)_373 |
| PubMedID: 1850985 |
| Title : Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices - Kennedy_1990_Biochem.J_267_781 |
| Author(s) : Kennedy ED , Challiss RA , Ragan CI , Nahorski SR |
| Ref : Biochemical Journal , 267 :781 , 1990 |
| Abstract : |
| PubMedSearch : Kennedy_1990_Biochem.J_267_781 |
| PubMedID: 2339988 |
| Title : Neurotransmitter and depolarization-stimulated accumulation of inositol 1,3,4,5-tetrakisphosphate mass in rat cerebral cortex slices - Challiss_1990_J.Neurochem_54_2138 |
| Author(s) : Challiss RA , Nahorski SR |
| Ref : Journal of Neurochemistry , 54 :2138 , 1990 |
| Abstract : |
| PubMedSearch : Challiss_1990_J.Neurochem_54_2138 |
| PubMedID: 1971012 |
| Title : Lithium reduces the accumulation of inositol polyphosphate second messengers following cholinergic stimulation of cerebral cortex slices - Kennedy_1989_J.Neurochem_53_1652 |
| Author(s) : Kennedy ED , Challiss RA , Nahorski SR |
| Ref : Journal of Neurochemistry , 53 :1652 , 1989 |
| Abstract : |
| PubMedSearch : Kennedy_1989_J.Neurochem_53_1652 |
| PubMedID: 2795023 |
| Title : Mass changes of inositol(1,4,5)trisphosphate in trachealis muscle following agonist stimulation - Chilvers_1989_Eur.J.Pharmacol_164_587 |
| Author(s) : Chilvers ER , Challiss RA , Barnes PJ , Nahorski SR |
| Ref : European Journal of Pharmacology , 164 :587 , 1989 |
| Abstract : |
| PubMedSearch : Chilvers_1989_Eur.J.Pharmacol_164_587 |
| PubMedID: 2548874 |