| Title : From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease - Brown_2021_Cell_184_5886 |
| Author(s) : Brown AJH , Bradley SJ , Marshall FH , Brown GA , Bennett KA , Brown J , Cansfield JE , Cross DM , de Graaf C , Hudson BD , Dwomoh L , Dias JM , Errey JC , Hurrell E , Liptrot J , Mattedi G , Molloy C , Nathan PJ , Okrasa K , Osborne G , Patel JC , Pickworth M , Robertson N , Shahabi S , Bundgaard C , Phillips K , Broad LM , Goonawardena AV , Morairty SR , Browning M , Perini F , Dawson GR , Deakin JFW , Smith RT , Sexton PM , Warneck J , Vinson M , Tasker T , Tehan BG , Teobald B , Christopoulos A , Langmead CJ , Jazayeri A , Cooke RM , Rucktooa P , Congreve MS , Weir M , Tobin AB |
| Ref : Cell , 184 :5886 , 2021 |
| Abstract : |
| PubMedSearch : Brown_2021_Cell_184_5886 |
| PubMedID: 34822784 |
| Title : Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor - Avlani_2010_Mol.Pharmacol_78_94 |
| Author(s) : Avlani VA , Langmead CJ , Guida E , Wood MD , Tehan BG , Herdon HJ , Watson JM , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 78 :94 , 2010 |
| Abstract : |
| PubMedSearch : Avlani_2010_Mol.Pharmacol_78_94 |
| PubMedID: 20413650 |
| Title : Evaluation of expression and function of the H+\/myo-inositol transporter HMIT - Di Daniel_2009_BMC.Cell.Biol_10_54 |
| Author(s) : Di Daniel E , Mok MH , Mead E , Mutinelli C , Zambello E , Caberlotto LL , Pell TJ , Langmead CJ , Shah AJ , Duddy G , Kew JN , Maycox PR |
| Ref : BMC Cell Biol , 10 :54 , 2009 |
| Abstract : |
| PubMedSearch : Di Daniel_2009_BMC.Cell.Biol_10_54 |
| PubMedID: 19607714 |
| Title : Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation - Thomas_2009_J.Pharmacol.Exp.Ther_331_1086 |
| Author(s) : Thomas RL , Langmead CJ , Wood MD , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :1086 , 2009 |
| Abstract : |
| PubMedSearch : Thomas_2009_J.Pharmacol.Exp.Ther_331_1086 |
| PubMedID: 19767446 |
| Title : Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors - Lebon_2009_Mol.Pharmacol_75_331 |
| Author(s) : Lebon G , Langmead CJ , Tehan BG , Hulme EC |
| Ref : Molecular Pharmacology , 75 :331 , 2009 |
| Abstract : |
| PubMedSearch : Lebon_2009_Mol.Pharmacol_75_331 |
| PubMedID: 19001633 |
| Title : G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists - Thomas_2008_J.Pharmacol.Exp.Ther_327_365 |
| Author(s) : Thomas RL , Mistry R , Langmead CJ , Wood MD , Challiss RA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :365 , 2008 |
| Abstract : |
| PubMedSearch : Thomas_2008_J.Pharmacol.Exp.Ther_327_365 |
| PubMedID: 18664591 |
| Title : Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors - May_2007_Mol.Pharmacol_72_463 |
| Author(s) : May LT , Avlani VA , Langmead CJ , Herdon HJ , Wood MD , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 72 :463 , 2007 |
| Abstract : |
| PubMedSearch : May_2007_Mol.Pharmacol_72_463 |
| PubMedID: 17525129 |
| Title : Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands - Goodwin_2007_Mol.Pharmacol_72_1484 |
| Author(s) : Goodwin JA , Hulme EC , Langmead CJ , Tehan BG |
| Ref : Molecular Pharmacology , 72 :1484 , 2007 |
| Abstract : |
| PubMedSearch : Goodwin_2007_Mol.Pharmacol_72_1484 |
| PubMedID: 17848601 |
| Title : Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist - Langmead_2006_Mol.Pharmacol_69_236 |
| Author(s) : Langmead CJ , Fry VA , Forbes IT , Branch CL , Christopoulos A , Wood MD , Herdon HJ |
| Ref : Molecular Pharmacology , 69 :236 , 2006 |
| Abstract : |
| PubMedSearch : Langmead_2006_Mol.Pharmacol_69_236 |
| PubMedID: 16207821 |