| Title : Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors - Leader_2002_J.Med.Chem_45_902 |
| Author(s) : Leader H , Wolfe AD , Chiang PK , Gordon RK |
| Ref : Journal of Medicinal Chemistry , 45 :902 , 2002 |
| PubMedID: 11831902 |
| Title : 6,7,8,9-Tetrahydro-3-methyl-1H-pyrano-[4,3-b]quinolin-1-one - Hua_1999_Acta.Crystallogr.C_55 ( Pt 10)_1698 |
| Author(s) : Hua DH , Chen Y , Sin HS , Robinson PD , Meyers CY , Perchellet EM , Perchellet JP , Chiang PK , Biellmann JF |
| Ref : Acta Crystallographica C , 55 ( Pt 10) :1698 , 1999 |
| PubMedID: 10573829 |
| Title : Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal bovine serum acetylcholinesterase - Wolfe_1993_Mol.Pharmacol_44_1152 |
| Author(s) : Wolfe AD , Chiang PK , Doctor BP , Fryar N , Rhee JP , Saeed M |
| Ref : Molecular Pharmacology , 44 :1152 , 1993 |
| PubMedID: 8264551 |
| Title : Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta- hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen - Brown_1993_J.Pharm.Sci_82_563 |
| Author(s) : Brown ND , Leader H , Phillips LR , Smejkal RM , Gordon RK , Chiang PK |
| Ref : J Pharm Sci , 82 :563 , 1993 |
| PubMedID: 8331525 |
| Title : Relationship of three-dimensional structure of muscarinic antagonists to antimuscarinic activity: structure of thiodeacylaprophen hydrochloride - Karle_1992_Acta.Crystallogr.B_48_208 |
| Author(s) : Karle JM , Karle IL , Gordon RK , Chiang PK |
| Ref : Acta Crystallographica B , 48 :208 , 1992 |
| PubMedID: 1515109 |
| Title : Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2- cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues) - Leader_1992_J.Med.Chem_35_1290 |
| Author(s) : Leader H , Gordon RK , Baumgold J , Boyd VL , Newman AH , Smejkal RM , Chiang PK |
| Ref : Journal of Medicinal Chemistry , 35 :1290 , 1992 |
| PubMedID: 1560441 |
| Title : Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats - Brown_1991_J.Chromatogr_563_466 |
| Author(s) : Brown ND , Phillips LR , Leader H , Chiang PK |
| Ref : Journal of Chromatography , 563 :466 , 1991 |
| PubMedID: 2056011 |
| Title : Structural comparison of the potent antimuscarinic agent azaprophen hydrochloride with aprophen hydrochloride and structurally related antimuscarinic agents - Karle_1990_Acta.Crystallogr.B_46_215 |
| Author(s) : Karle JM , Karle IL , Chiang PK |
| Ref : Acta Crystallographica B , 46 :215 , 1990 |
| PubMedID: 2344395 |
| Title : Aprophit: an irreversible antagonist for muscarinic receptors - Newman_1990_Biochem.Pharmacol_40_1357 |
| Author(s) : Newman AH , Covington J , Oleshansky M , Jackson BW , Weissman BA , Leader H , Chiang PK |
| Ref : Biochemical Pharmacology , 40 :1357 , 1990 |
| PubMedID: 2403389 |
| Title : Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates - Leader_1989_J.Med.Chem_32_1522 |
| Author(s) : Leader H , Smejkal RM , Payne CS , Padilla FN , Doctor BP , Gordon RK , Chiang PK |
| Ref : Journal of Medicinal Chemistry , 32 :1522 , 1989 |
| PubMedID: 2738887 |
| Title : Reversal of inhibition of prolactin secretion in cultured pituitary cells by muscarinic antagonists - Beach_1988_J.Pharmacol.Exp.Ther_246_548 |
| Author(s) : Beach JE , Smallridge RC , Chiang PK , Fein HG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 246 :548 , 1988 |
| PubMedID: 3404446 |
| Title : Effects of muscarinic pharmacophores on the cholinergic regulation of catecholamine secretion from perfused adrenal glands - Nakazato_1988_Arch.Int.Pharmacodyn.Ther_293_209 |
| Author(s) : Nakazato Y , Oleshansky MA , Chiang PK |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 293 :209 , 1988 |
| PubMedID: 3421778 |
| Title : Desethylaprophen: a metabolite of aprophen with antimuscarinic activities - Brown_1988_J.Pharm.Sci_77_145 |
| Author(s) : Brown ND , Smejkal RM , Breuer E , Doctor BP , Chiang PK |
| Ref : J Pharm Sci , 77 :145 , 1988 |
| PubMedID: 3258910 |
| Title : 6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent - Carroll_1987_J.Med.Chem_30_805 |
| Author(s) : Carroll FI , Abraham P , Parham K , Griffith RC , Ahmad A , Richard MM , Padilla FN , Witkin JM , Chiang PK |
| Ref : Journal of Medicinal Chemistry , 30 :805 , 1987 |
| PubMedID: 3494849 |
| Title : Comparison of in vitro actions with behavioral effects of antimuscarinic agents - Witkin_1987_J.Pharmacol.Exp.Ther_242_796 |
| Author(s) : Witkin JM , Gordon RK , Chiang PK |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 242 :796 , 1987 |
| PubMedID: 3498817 |
| Title : Enzymatic synthesis of a false cholinergic neurotransmitter: diethylaminoethyl acetate as a muscarinic agonist analog of acetylcholine - Miura_1986_Gen.Pharmacol_17_477 |
| Author(s) : Miura GA , Chiang PK , Gordon RK , Doctor BP , Twine CE , Philip A , Kepler JA , Carroll FI |
| Ref : General Pharmacology , 17 :477 , 1986 |
| PubMedID: 2875921 |
| Title : Disposition of aprophen in rats - Aarbakke_1986_J.Pharm.Pharmacol_38_928 |
| Author(s) : Aarbakke J , Miura GA , Brown ND , Gray RR , Gordon RK , Doctor BP , Chiang PK |
| Ref : J Pharm Pharmacol , 38 :928 , 1986 |
| PubMedID: 2880971 |