Full name : Leader Haim N
First name : Haim N
Mail : Weizmann Institute of Science, Department of Materials and Interfaces 76100 Rehovot
Zip Code :
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Country : Israel
Email : haimleader@gmail.com
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Comment
| Title : Utilization of diverse organophosphorus pollutants by marine bacteria - Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119 |
| Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Eliason O , Sperfeld M , Leader H , Castelli A , Fumagalli L , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS |
| Ref : Proc Natl Acad Sci U S A , 119 :e2203604119 , 2022 |
| Abstract : |
| PubMedSearch : Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119 |
| PubMedID: 35917352 |
| Title : Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria - Despotovic_2021_Biorxiv__ |
| Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Leader H , Castelli A , Fumagalli A , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS |
| Ref : Biorxiv , : , 2020 |
| Abstract : |
| PubMedSearch : Despotovic_2021_Biorxiv__ |
| PubMedID: |
| Title : A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents - Despotovic_2019_Protein.Eng.Des.Sel_32_169 |
| Author(s) : Despotovic D , Aharon E , Dubovetskyi A , Leader H , Ashani Y , Tawfik DS |
| Ref : Protein Engineering Des Sel , 32 :169 , 2019 |
| Abstract : |
| PubMedSearch : Despotovic_2019_Protein.Eng.Des.Sel_32_169 |
| PubMedID: 31612205 |
| Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711 |
| Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 90 :2711 , 2016 |
| Abstract : |
| PubMedSearch : Goldsmith_2016_Arch.Toxicol_90_2711 |
| PubMedID: 26612364 |
| Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252 |
| Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M |
| Ref : Chemico-Biological Interactions , 259 :252 , 2016 |
| Abstract : |
| PubMedSearch : Ashani_2016_Chem.Biol.Interact_259_252 |
| PubMedID: 27163850 |
| Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45 |
| Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS |
| Ref : Toxicol Lett , 231 :45 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.Lett_231_45 |
| PubMedID: 25195526 |
| Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257 |
| Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T |
| Ref : Archives of Toxicology , 88 :1257 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Arch.Toxicol_88_1257 |
| PubMedID: 24477626 |
| Title : Engineering v-type nerve agents detoxifying enzymes using computationally focused libraries - Cherny_2013_ACS.Chem.Biol_8_2394 |
| Author(s) : Cherny I , Greisen P, Jr. , Ashani Y , Khare SD , Oberdorfer G , Leader H , Baker D , Tawfik DS |
| Ref : ACS Chemical Biology , 8 :2394 , 2013 |
| Abstract : |
| PubMedSearch : Cherny_2013_ACS.Chem.Biol_8_2394 |
| PubMedID: 24041203 |
| Title : Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification - Goldsmith_2012_Chem.Biol_19_456 |
| Author(s) : Goldsmith M , Ashani Y , Simo Y , Ben-David M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Chemical Biology , 19 :456 , 2012 |
| Abstract : |
| PubMedSearch : Goldsmith_2012_Chem.Biol_19_456 |
| PubMedID: 22520752 |
| Title : Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Khare_2012_Nat.Chem.Biol_8_294 |
| Author(s) : Khare SD , Kipnis Y , Greisen P, Jr. , Takeuchi R , Ashani Y , Goldsmith M , Song Y , Gallaher JL , Silman I , Leader H , Sussman JL , Stoddard BL , Tawfik DS , Baker D |
| Ref : Nat Chemical Biology , 8 :294 , 2012 |
| Abstract : |
| PubMedSearch : Khare_2012_Nat.Chem.Biol_8_294 |
| PubMedID: 22306579 |
| Title : Directed evolution of hydrolases for prevention of G-type nerve agent intoxication - Gupta_2011_Nat.Chem.Biol_7_120 |
| Author(s) : Gupta RD , Goldsmith M , Ashani Y , Simo Y , Mullokandov G , Bar H , Ben-David M , Leader H , Margalit R , Silman I , Sussman JL , Tawfik DS |
| Ref : Nat Chemical Biology , 7 :120 , 2011 |
| Abstract : |
| PubMedSearch : Gupta_2011_Nat.Chem.Biol_7_120 |
| PubMedID: 21217689 |
| Title : In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases - Ashani_2011_Toxicol.Lett_206_24 |
| Author(s) : Ashani Y , Goldsmith M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Toxicol Lett , 206 :24 , 2011 |
| Abstract : |
| PubMedSearch : Ashani_2011_Toxicol.Lett_206_24 |
| PubMedID: 21807078 |
| Title : Pro-2-PAM therapy for central and peripheral cholinesterases - Demar_2010_Chem.Biol.Interact_187_191 |
| Author(s) : DeMar JC , Clarkson ED , Ratcliffe RH , Campbell AJ , Thangavelu SG , Herdman CA , Leader H , Schulz SM , Marek E , Medynets MA , Ku TC , Evans SA , Khan FA , Owens RR , Nambiar MP , Gordon RK |
| Ref : Chemico-Biological Interactions , 187 :191 , 2010 |
| Abstract : |
| PubMedSearch : Demar_2010_Chem.Biol.Interact_187_191 |
| PubMedID: 20156430 |
| Title : Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers - Ashani_2010_Chem.Biol.Interact_187_362 |
| Author(s) : Ashani Y , Gupta RD , Goldsmith M , Silman I , Sussman JL , Tawfik DS , Leader H |
| Ref : Chemico-Biological Interactions , 187 :362 , 2010 |
| Abstract : |
| PubMedSearch : Ashani_2010_Chem.Biol.Interact_187_362 |
| PubMedID: 20303930 |
| Title : Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators - Ashani_2003_Biochem.Pharmacol_66_191 |
| Author(s) : Ashani Y , Bhattacharjee AK , Leader H , Saxena A , Doctor BP |
| Ref : Biochemical Pharmacology , 66 :191 , 2003 |
| Abstract : |
| PubMedSearch : Ashani_2003_Biochem.Pharmacol_66_191 |
| PubMedID: 12826262 |
| Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase - Luo_2003_Biochem.Pharmacol_66_387 |
| Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A |
| Ref : Biochemical Pharmacology , 66 :387 , 2003 |
| Abstract : |
| PubMedSearch : Luo_2003_Biochem.Pharmacol_66_387 |
| PubMedID: 12907237 |
| Title : Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors - Leader_2002_J.Med.Chem_45_902 |
| Author(s) : Leader H , Wolfe AD , Chiang PK , Gordon RK |
| Ref : Journal of Medicinal Chemistry , 45 :902 , 2002 |
| Abstract : |
| PubMedSearch : Leader_2002_J.Med.Chem_45_902 |
| PubMedID: 11831902 |
| Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129 |
| Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP |
| Ref : Chemico-Biological Interactions , 119-120 :129 , 1999 |
| Abstract : |
| PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129 |
| PubMedID: 10421446 |
| Title : Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases - Leader_1999_Biochem.Pharmacol_58_503 |
| Author(s) : Leader H , Vincze A , Manisterski B , Rothschild N , Dosoretz C , Ashani Y |
| Ref : Biochemical Pharmacology , 58 :503 , 1999 |
| Abstract : |
| PubMedSearch : Leader_1999_Biochem.Pharmacol_58_503 |
| PubMedID: 10424771 |
| Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195 |
| Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y |
| Ref : FEBS Letters , 438 :195 , 1998 |
| Abstract : |
| PubMedSearch : Amitai_1998_FEBS.Lett_438_195 |
| PubMedID: 9827544 |
| Title : Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands - |
| Author(s) : Luo C , Ashani Y , Saxena A , Leader H , Maxwell DM , Taylor P , Doctor BP |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :215 , 1998 |
| PubMedID: |
| Title : Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates - Ashani_1998_Biochem.Pharmacol_55_159 |
| Author(s) : Ashani Y , Leader H , Rothschild N , Dosoretz C |
| Ref : Biochemical Pharmacology , 55 :159 , 1998 |
| Abstract : |
| PubMedSearch : Ashani_1998_Biochem.Pharmacol_55_159 |
| PubMedID: 9448738 |
| Title : Sequestration of Toxic Phosphorylated Oximes by Stoichiometric and Catalytic Scavengers - |
| Author(s) : Leader H , Vincze A , Rothschild N , Dosoretz C , Ashani Y |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :305 , 1998 |
| PubMedID: |
| Title : Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta- hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen - Brown_1993_J.Pharm.Sci_82_563 |
| Author(s) : Brown ND , Leader H , Phillips LR , Smejkal RM , Gordon RK , Chiang PK |
| Ref : J Pharm Sci , 82 :563 , 1993 |
| Abstract : |
| PubMedSearch : Brown_1993_J.Pharm.Sci_82_563 |
| PubMedID: 8331525 |
| Title : Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2- cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues) - Leader_1992_J.Med.Chem_35_1290 |
| Author(s) : Leader H , Gordon RK , Baumgold J , Boyd VL , Newman AH , Smejkal RM , Chiang PK |
| Ref : Journal of Medicinal Chemistry , 35 :1290 , 1992 |
| Abstract : |
| PubMedSearch : Leader_1992_J.Med.Chem_35_1290 |
| PubMedID: 1560441 |
| Title : Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters - Raveh_1992_Biochem.Pharmacol_44_397 |
| Author(s) : Raveh L , Segall Y , Leader H , Rothschild N , Levanon D , Henis Y , Ashani Y |
| Ref : Biochemical Pharmacology , 44 :397 , 1992 |
| Abstract : |
| PubMedSearch : Raveh_1992_Biochem.Pharmacol_44_397 |
| PubMedID: 1322669 |
| Title : Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats - Brown_1991_J.Chromatogr_563_466 |
| Author(s) : Brown ND , Phillips LR , Leader H , Chiang PK |
| Ref : Journal of Chromatography , 563 :466 , 1991 |
| Abstract : |
| PubMedSearch : Brown_1991_J.Chromatogr_563_466 |
| PubMedID: 2056011 |
| Title : Aprophit: an irreversible antagonist for muscarinic receptors - Newman_1990_Biochem.Pharmacol_40_1357 |
| Author(s) : Newman AH , Covington J , Oleshansky M , Jackson BW , Weissman BA , Leader H , Chiang PK |
| Ref : Biochemical Pharmacology , 40 :1357 , 1990 |
| Abstract : |
| PubMedSearch : Newman_1990_Biochem.Pharmacol_40_1357 |
| PubMedID: 2403389 |
| Title : Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates - Leader_1989_J.Med.Chem_32_1522 |
| Author(s) : Leader H , Smejkal RM , Payne CS , Padilla FN , Doctor BP , Gordon RK , Chiang PK |
| Ref : Journal of Medicinal Chemistry , 32 :1522 , 1989 |
| Abstract : |
| PubMedSearch : Leader_1989_J.Med.Chem_32_1522 |
| PubMedID: 2738887 |
| Title : In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide - Ashani_1983_J.Med.Chem_26_145 |
| Author(s) : Ashani Y , Leader H , Raveh L , Bruckstein R , Spiegelstein M |
| Ref : Journal of Medicinal Chemistry , 26 :145 , 1983 |
| Abstract : |
| PubMedSearch : Ashani_1983_J.Med.Chem_26_145 |
| PubMedID: 6827532 |
| Title : Sugar-oximes, new potential antidotes against organophosphorus poisoning - Rachaman_1979_Arzneimittelforschung_29_875 |
| Author(s) : Rachaman ES , Ashani Y , Leader H , Granoth I , Edery H , Porath G |
| Ref : Arzneimittelforschung , 29 :875 , 1979 |
| Abstract : |
| PubMedSearch : Rachaman_1979_Arzneimittelforschung_29_875 |
| PubMedID: 582776 |