Leader H

General

Full name : Leader Haim N

First name : Haim N

Mail : Weizmann Institute of Science, Department of Materials and Interfaces 76100 Rehovot

Zip Code :

City :

Country : Israel

Email : haimleader@gmail.com

Phone :

Fax :

Website :

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Comment

References (32)

Title : Utilization of diverse organophosphorus pollutants by marine bacteria - Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119
Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Eliason O , Sperfeld M , Leader H , Castelli A , Fumagalli L , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS
Ref : Proc Natl Acad Sci U S A , 119 :e2203604119 , 2022
Abstract :
PubMedSearch : Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119
PubMedID: 35917352

Title : Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria - Despotovic_2021_Biorxiv__
Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Leader H , Castelli A , Fumagalli A , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS
Ref : Biorxiv , : , 2020
Abstract :
PubMedSearch : Despotovic_2021_Biorxiv__
PubMedID:

Title : A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents - Despotovic_2019_Protein.Eng.Des.Sel_32_169
Author(s) : Despotovic D , Aharon E , Dubovetskyi A , Leader H , Ashani Y , Tawfik DS
Ref : Protein Engineering Des Sel , 32 :169 , 2019
Abstract :
PubMedSearch : Despotovic_2019_Protein.Eng.Des.Sel_32_169
PubMedID: 31612205

Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252
Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M
Ref : Chemico-Biological Interactions , 259 :252 , 2016
Abstract :
PubMedSearch : Ashani_2016_Chem.Biol.Interact_259_252
PubMedID: 27163850

Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711
Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F
Ref : Archives of Toxicology , 90 :2711 , 2016
Abstract :
PubMedSearch : Goldsmith_2016_Arch.Toxicol_90_2711
PubMedID: 26612364

Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257
Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T
Ref : Archives of Toxicology , 88 :1257 , 2014
Abstract :
PubMedSearch : Worek_2014_Arch.Toxicol_88_1257
PubMedID: 24477626

Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45
Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS
Ref : Toxicol Lett , 231 :45 , 2014
Abstract :
PubMedSearch : Worek_2014_Toxicol.Lett_231_45
PubMedID: 25195526

Title : Engineering v-type nerve agents detoxifying enzymes using computationally focused libraries - Cherny_2013_ACS.Chem.Biol_8_2394
Author(s) : Cherny I , Greisen P, Jr. , Ashani Y , Khare SD , Oberdorfer G , Leader H , Baker D , Tawfik DS
Ref : ACS Chemical Biology , 8 :2394 , 2013
Abstract :
PubMedSearch : Cherny_2013_ACS.Chem.Biol_8_2394
PubMedID: 24041203

Title : Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification - Goldsmith_2012_Chem.Biol_19_456
Author(s) : Goldsmith M , Ashani Y , Simo Y , Ben-David M , Leader H , Silman I , Sussman JL , Tawfik DS
Ref : Chemical Biology , 19 :456 , 2012
Abstract :
PubMedSearch : Goldsmith_2012_Chem.Biol_19_456
PubMedID: 22520752

Title : Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Khare_2012_Nat.Chem.Biol_8_294
Author(s) : Khare SD , Kipnis Y , Greisen P, Jr. , Takeuchi R , Ashani Y , Goldsmith M , Song Y , Gallaher JL , Silman I , Leader H , Sussman JL , Stoddard BL , Tawfik DS , Baker D
Ref : Nat Chemical Biology , 8 :294 , 2012
Abstract :
PubMedSearch : Khare_2012_Nat.Chem.Biol_8_294
PubMedID: 22306579

Title : Directed evolution of hydrolases for prevention of G-type nerve agent intoxication - Gupta_2011_Nat.Chem.Biol_7_120
Author(s) : Gupta RD , Goldsmith M , Ashani Y , Simo Y , Mullokandov G , Bar H , Ben-David M , Leader H , Margalit R , Silman I , Sussman JL , Tawfik DS
Ref : Nat Chemical Biology , 7 :120 , 2011
Abstract :
PubMedSearch : Gupta_2011_Nat.Chem.Biol_7_120
PubMedID: 21217689

Title : In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases - Ashani_2011_Toxicol.Lett_206_24
Author(s) : Ashani Y , Goldsmith M , Leader H , Silman I , Sussman JL , Tawfik DS
Ref : Toxicol Lett , 206 :24 , 2011
Abstract :
PubMedSearch : Ashani_2011_Toxicol.Lett_206_24
PubMedID: 21807078

Title : Pro-2-PAM therapy for central and peripheral cholinesterases - Demar_2010_Chem.Biol.Interact_187_191
Author(s) : DeMar JC , Clarkson ED , Ratcliffe RH , Campbell AJ , Thangavelu SG , Herdman CA , Leader H , Schulz SM , Marek E , Medynets MA , Ku TC , Evans SA , Khan FA , Owens RR , Nambiar MP , Gordon RK
Ref : Chemico-Biological Interactions , 187 :191 , 2010
Abstract :
PubMedSearch : Demar_2010_Chem.Biol.Interact_187_191
PubMedID: 20156430

Title : Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers - Ashani_2010_Chem.Biol.Interact_187_362
Author(s) : Ashani Y , Gupta RD , Goldsmith M , Silman I , Sussman JL , Tawfik DS , Leader H
Ref : Chemico-Biological Interactions , 187 :362 , 2010
Abstract :
PubMedSearch : Ashani_2010_Chem.Biol.Interact_187_362
PubMedID: 20303930

Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase. -
Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A
Ref : Cholinergic Mechanisms, CRC Press :627 , 2004
PubMedID:

Title : Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase - Luo_2003_Biochem.Pharmacol_66_387
Author(s) : Luo C , Leader H , Radic Z , Maxwell DM , Taylor P , Doctor BP , Saxena A
Ref : Biochemical Pharmacology , 66 :387 , 2003
Abstract :
PubMedSearch : Luo_2003_Biochem.Pharmacol_66_387
PubMedID: 12907237

Title : Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators - Ashani_2003_Biochem.Pharmacol_66_191
Author(s) : Ashani Y , Bhattacharjee AK , Leader H , Saxena A , Doctor BP
Ref : Biochemical Pharmacology , 66 :191 , 2003
Abstract :
PubMedSearch : Ashani_2003_Biochem.Pharmacol_66_191
PubMedID: 12826262

Title : Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors - Leader_2002_J.Med.Chem_45_902
Author(s) : Leader H , Wolfe AD , Chiang PK , Gordon RK
Ref : Journal of Medicinal Chemistry , 45 :902 , 2002
Abstract :
PubMedSearch : Leader_2002_J.Med.Chem_45_902
PubMedID: 11831902

Title : Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases - Leader_1999_Biochem.Pharmacol_58_503
Author(s) : Leader H , Vincze A , Manisterski B , Rothschild N , Dosoretz C , Ashani Y
Ref : Biochemical Pharmacology , 58 :503 , 1999
Abstract :
PubMedSearch : Leader_1999_Biochem.Pharmacol_58_503
PubMedID: 10424771

Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129
Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :129 , 1999
Abstract :
PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129
PubMedID: 10421446

Title : Sequestration of Toxic Phosphorylated Oximes by Stoichiometric and Catalytic Scavengers -
Author(s) : Leader H , Vincze A , Rothschild N , Dosoretz C , Ashani Y
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :305 , 1998
PubMedID:

Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195
Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y
Ref : FEBS Letters , 438 :195 , 1998
Abstract :
PubMedSearch : Amitai_1998_FEBS.Lett_438_195
PubMedID: 9827544

Title : Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands -
Author(s) : Luo C , Ashani Y , Saxena A , Leader H , Maxwell DM , Taylor P , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :215 , 1998
PubMedID:

Title : Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates - Ashani_1998_Biochem.Pharmacol_55_159
Author(s) : Ashani Y , Leader H , Rothschild N , Dosoretz C
Ref : Biochemical Pharmacology , 55 :159 , 1998
Abstract :
PubMedSearch : Ashani_1998_Biochem.Pharmacol_55_159
PubMedID: 9448738

Title : Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta- hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen - Brown_1993_J.Pharm.Sci_82_563
Author(s) : Brown ND , Leader H , Phillips LR , Smejkal RM , Gordon RK , Chiang PK
Ref : J Pharm Sci , 82 :563 , 1993
Abstract :
PubMedSearch : Brown_1993_J.Pharm.Sci_82_563
PubMedID: 8331525

Title : Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2- cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues) - Leader_1992_J.Med.Chem_35_1290
Author(s) : Leader H , Gordon RK , Baumgold J , Boyd VL , Newman AH , Smejkal RM , Chiang PK
Ref : Journal of Medicinal Chemistry , 35 :1290 , 1992
Abstract :
PubMedSearch : Leader_1992_J.Med.Chem_35_1290
PubMedID: 1560441

Title : Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters - Raveh_1992_Biochem.Pharmacol_44_397
Author(s) : Raveh L , Segall Y , Leader H , Rothschild N , Levanon D , Henis Y , Ashani Y
Ref : Biochemical Pharmacology , 44 :397 , 1992
Abstract :
PubMedSearch : Raveh_1992_Biochem.Pharmacol_44_397
PubMedID: 1322669

Title : Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats - Brown_1991_J.Chromatogr_563_466
Author(s) : Brown ND , Phillips LR , Leader H , Chiang PK
Ref : Journal of Chromatography , 563 :466 , 1991
Abstract :
PubMedSearch : Brown_1991_J.Chromatogr_563_466
PubMedID: 2056011

Title : Aprophit: an irreversible antagonist for muscarinic receptors - Newman_1990_Biochem.Pharmacol_40_1357
Author(s) : Newman AH , Covington J , Oleshansky M , Jackson BW , Weissman BA , Leader H , Chiang PK
Ref : Biochemical Pharmacology , 40 :1357 , 1990
Abstract :
PubMedSearch : Newman_1990_Biochem.Pharmacol_40_1357
PubMedID: 2403389

Title : Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates - Leader_1989_J.Med.Chem_32_1522
Author(s) : Leader H , Smejkal RM , Payne CS , Padilla FN , Doctor BP , Gordon RK , Chiang PK
Ref : Journal of Medicinal Chemistry , 32 :1522 , 1989
Abstract :
PubMedSearch : Leader_1989_J.Med.Chem_32_1522
PubMedID: 2738887

Title : In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide - Ashani_1983_J.Med.Chem_26_145
Author(s) : Ashani Y , Leader H , Raveh L , Bruckstein R , Spiegelstein M
Ref : Journal of Medicinal Chemistry , 26 :145 , 1983
Abstract :
PubMedSearch : Ashani_1983_J.Med.Chem_26_145
PubMedID: 6827532

Title : Sugar-oximes, new potential antidotes against organophosphorus poisoning - Rachaman_1979_Arzneimittelforschung_29_875
Author(s) : Rachaman ES , Ashani Y , Leader H , Granoth I , Edery H , Porath G
Ref : Arzneimittelforschung , 29 :875 , 1979
Abstract :
PubMedSearch : Rachaman_1979_Arzneimittelforschung_29_875
PubMedID: 582776