| Title : Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT(4) receptors with potential interest in the treatment of Alzheimer's disease - Rochais_2024_Eur.J.Med.Chem_280_116975 |
| Author(s) : Rochais C , Lecoutey C , Lalut J , Davis A , Duval E , Gaven F , Largilliere S , Nee G , Corvaisier S , Sopkova de Oliveira Santos J , Since M , Freret T , Legrand R , Callizot N , Claeysen S , Boulouard M , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 280 :116975 , 2024 |
| Abstract : |
| PubMedSearch : Rochais_2024_Eur.J.Med.Chem_280_116975 |
| PubMedID: 39454222 |
| Title : Donecopride, a Swiss army knife with potential against Alzheimer's disease - Rochais_2020_Br.J.Pharmacol_177_1988 |
| Author(s) : Rochais C , Lecoutey C , Hamidouche K , Giannoni P , Gaven F , Cem E , Mignani S , Baranger K , Freret T , Bockaert J , Rivera S , Boulouard M , Dallemagne P , Claeysen S |
| Ref : British Journal of Pharmacology , 177 :1988 , 2020 |
| Abstract : |
| PubMedSearch : Rochais_2020_Br.J.Pharmacol_177_1988 |
| PubMedID: 31881553 |
| Title : Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease - Lalut_2020_Sci.Rep_10_3014 |
| Author(s) : Lalut J , Payan H , Davis A , Lecoutey C , Legay R , Sopkova-de Oliveira Santos J , Claeysen S , Dallemagne P , Rochais C |
| Ref : Sci Rep , 10 :3014 , 2020 |
| Abstract : |
| PubMedSearch : Lalut_2020_Sci.Rep_10_3014 |
| PubMedID: 32080261 |
| Title : Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT(6) receptor antagonist with therapeutic interest in Alzheimer's disease - Toublet_2020_Eur.J.Med.Chem_210_113059 |
| Author(s) : Toublet FX , Lalut J , Hatat B , Lecoutey C , Davis A , Since M , Corvaisier S , Freret T , Sopkova-de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 210 :113059 , 2020 |
| Abstract : |
| PubMedSearch : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| PubMedID: 33310288 |
| Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
| Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Toublet_2019_Molecules_24_ |
| PubMedID: 31370232 |
| Title : A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease - Hatat_2019_Front.Aging.Neurosci_11_148 |
| Author(s) : Hatat B , Yahiaoui S , Lecoutey C , Davis A , Freret T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Front Aging Neurosci , 11 :148 , 2019 |
| Abstract : |
| PubMedSearch : Hatat_2019_Front.Aging.Neurosci_11_148 |
| PubMedID: 31316368 |
| Title : Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride - Rochais_2015_J.Med.Chem_58_3172 |
| Author(s) : Rochais C , Lecoutey C , Gaven F , Giannoni P , Hamidouche K , Hedou D , Dubost E , Genest D , Yahiaoui S , Freret T , Bouet V , Dauphin F , Sopkova de Oliveira Santos J , Ballandonne C , Corvaisier S , Malzert-Freon A , Legay R , Boulouard M , Claeysen S , Dallemagne P |
| Ref : Journal of Medicinal Chemistry , 58 :3172 , 2015 |
| Abstract : |
| PubMedSearch : Rochais_2015_J.Med.Chem_58_3172 |
| PubMedID: 25793650 |
| Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014 |
| Abstract : |
| PubMedSearch : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedID: 25157130 |