Rochais C

General

Full name : Rochais Christophe

First name : Christophe

Mail : UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Medicament de Normandie), F-14032 Caen

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Country : France

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References (24)

Title : Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation - Malek_2022_Molecules_28_
Author(s) : Malek R , Simakov A , Davis A , Maj M , Bernard PJ , Wnorowski A , Martin H , Marco-Contelles J , Chabchoub F , Dallemagne P , Rochais C , Jozwiak K , Ismaili L
Ref : Molecules , 28 : , 2022
PubMedID: 36615267

Title : Advances in prodrug design for Alzheimer's disease: the state of the art - Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325
Author(s) : Travers-Lesage V , Mignani SM , Dallemagne P , Rochais C
Ref : Expert Opin Drug Discov , 17 :325 , 2022
PubMedID: 35089846

Title : Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy - Lecoutey_2021_Molecules_26_
Author(s) : Lecoutey C , Legay R , Davis A , Sopkova-de Oliveira Santos J , Dallemagne P , Rochais C
Ref : Molecules , 26 : , 2021
PubMedID: 33926141

Title : Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease - Chretien_2021_Br.J.Clin.Pharmacol_87_2830
Author(s) : Chretien B , Jourdan JP , Davis A , Fedrizzi S , Bureau R , Sassier M , Rochais C , Alexandre J , Lelong-Boulouard V , Dolladille C , Dallemagne P
Ref : British Journal of Clinical Pharmacology , 87 :2830 , 2021
PubMedID: 33274491

Title : Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT(6) receptor antagonist with therapeutic interest in Alzheimer's disease - Toublet_2020_Eur.J.Med.Chem_210_113059
Author(s) : Toublet FX , Lalut J , Hatat B , Lecoutey C , Davis A , Since M , Corvaisier S , Freret T , Sopkova-de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C
Ref : Eur Journal of Medicinal Chemistry , 210 :113059 , 2020
PubMedID: 33310288

Title : Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment - Adnet_2020_Pharmaceutics_12_
Author(s) : Adnet T , Groo AC , Picard C , Davis A , Corvaisier S , Since M , Bounoure F , Rochais C , Pluart LL , Dallemagne P , Malzert-Freon A
Ref : Pharmaceutics , 12 : , 2020
PubMedID: 32168767

Title : First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease - Guieu_2020_Molecules_26_
Author(s) : Guieu B , Lecoutey C , Legay R , Davis A , Sopkova de Oliveira Santos J , Altomare CD , Catto M , Rochais C , Dallemagne P
Ref : Molecules , 26 : , 2020
PubMedID: 33375412

Title : Donecopride, a Swiss army knife with potential against Alzheimer's disease - Rochais_2020_Br.J.Pharmacol_177_1988
Author(s) : Rochais C , Lecoutey C , Hamidouche K , Giannoni P , Gaven F , Cem E , Mignani S , Baranger K , Freret T , Bockaert J , Rivera S , Boulouard M , Dallemagne P , Claeysen S
Ref : British Journal of Pharmacology , 177 :1988 , 2020
PubMedID: 31881553

Title : Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease - Lalut_2020_Sci.Rep_10_3014
Author(s) : Lalut J , Payan H , Davis A , Lecoutey C , Legay R , Sopkova-de Oliveira Santos J , Claeysen S , Dallemagne P , Rochais C
Ref : Sci Rep , 10 :3014 , 2020
PubMedID: 32080261

Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_
Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C
Ref : Molecules , 24 : , 2019
PubMedID: 31370232

Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234
Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C
Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019
PubMedID: 30447434
Gene_locus related to this paper: torca-ACHE

Title : A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease - Hatat_2019_Front.Aging.Neurosci_11_148
Author(s) : Hatat B , Yahiaoui S , Lecoutey C , Davis A , Freret T , Boulouard M , Claeysen S , Rochais C , Dallemagne P
Ref : Front Aging Neurosci , 11 :148 , 2019
PubMedID: 31316368

Title : Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors - Lecoutey_2012_MedChemComm_3_627
Author(s) : Lecoutey C , Rochais C , Genest D , Butt-Gueulle S , Ballandonne C , Corvaisier S , Dulin F , Lepailleur A , Sopkova-de , Dallemagne P
Ref : Medchemcomm , 33 :627 , 2018
PubMedID:

Title : Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment - Jourdan_2017_ChemMedChem_12_913
Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P
Ref : ChemMedChem , 12 :913 , 2017
PubMedID: 28342294

Title : Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment - Lalut_2017_Future.Med.Chem_9_781
Author(s) : Lalut J , Karila D , Dallemagne P , Rochais C
Ref : Future Med Chem , 9 :781 , 2017
PubMedID: 28504917

Title : Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment - Jourdan_2016_Eur.J.Med.Chem_114_365
Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P
Ref : Eur Journal of Medicinal Chemistry , 114 :365 , 2016
PubMedID: 27046230

Title : Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography - Lalut_2016_Eur.J.Med.Chem_116_90
Author(s) : Lalut J , Tournier BB , Cailly T , Lecoutey C , Corvaisier S , Davis A , Ballandonne C , Since M , Millet P , Fabis F , Dallemagne P , Rochais C
Ref : Eur Journal of Medicinal Chemistry , 116 :90 , 2016
PubMedID: 27060761

Title : Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease - Yahiaoui_2016_Eur.J.Med.Chem_121_283
Author(s) : Yahiaoui S , Hamidouche K , Ballandonne C , Davis A , de Oliveira Santos JS , Freret T , Boulouard M , Rochais C , Dallemagne P
Ref : Eur Journal of Medicinal Chemistry , 121 :283 , 2016
PubMedID: 27266998

Title : Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride - Rochais_2015_J.Med.Chem_58_3172
Author(s) : Rochais C , Lecoutey C , Gaven F , Giannoni P , Hamidouche K , Hedou D , Dubost E , Genest D , Yahiaoui S , Freret T , Bouet V , Dauphin F , Sopkova de Oliveira Santos J , Ballandonne C , Corvaisier S , Malzert-Freon A , Legay R , Boulouard M , Claeysen S , Dallemagne P
Ref : Journal of Medicinal Chemistry , 58 :3172 , 2015
PubMedID: 25793650

Title : Therapeutic Potential of 5-HT6 Receptor Agonists - Karila_2015_J.Med.Chem_58_7901
Author(s) : Karila D , Freret T , Bouet V , Boulouard M , Dallemagne P , Rochais C
Ref : Journal of Medicinal Chemistry , 58 :7901 , 2015
PubMedID: 26099069

Title : Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances - Quiedeville_2015_Behav.Brain.Res_293_10
Author(s) : Quiedeville A , Boulouard M , Hamidouche K , Da Silva Costa-Aze V , Nee G , Rochais C , Dallemagne P , Fabis F , Freret T , Bouet V
Ref : Behavioural Brain Research , 293 :10 , 2015
PubMedID: 26187692

Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825
Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P
Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014
PubMedID: 25157130

Title : Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice - Freret_2012_Behav.Brain.Res_230_304
Author(s) : Freret T , Bouet V , Quiedeville A , Nee G , Dallemagne P , Rochais C , Boulouard M
Ref : Behavioural Brain Research , 230 :304 , 2012
PubMedID: 22348892

Title : Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library - Sopkova-de_2010_J.Chem.Inf.Model_50_422
Author(s) : Sopkova-de Oliveira Santos J , Lesnard A , Agondanou JH , Dupont N , Godard AM , Stiebing S , Rochais C , Fabis F , Dallemagne P , Bureau R , Rault S
Ref : J Chem Inf Model , 50 :422 , 2010
PubMedID: 20196555