Full name : Rochais Christophe
First name : Christophe
Mail : UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Medicament de Normandie), F-14032 Caen
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Country : France
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Title : Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT(4) receptors with potential interest in the treatment of Alzheimer's disease - Rochais_2024_Eur.J.Med.Chem_280_116975 |
Author(s) : Rochais C , Lecoutey C , Lalut J , Davis A , Duval E , Gaven F , Largilliere S , Nee G , Corvaisier S , Sopkova de Oliveira Santos J , Since M , Freret T , Legrand R , Callizot N , Claeysen S , Boulouard M , Dallemagne P |
Ref : Eur Journal of Medicinal Chemistry , 280 :116975 , 2024 |
Abstract : |
PubMedSearch : Rochais_2024_Eur.J.Med.Chem_280_116975 |
PubMedID: 39454222 |
Title : Studies on the mechanisms of action of MR33317 - Neumann_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
Author(s) : Neumann J , Hesse C , Yahiaoui S , Dallemagne P , Rochais C , Hofmann B , Gergs U |
Ref : Naunyn Schmiedebergs Arch Pharmacol , : , 2024 |
Abstract : |
PubMedSearch : Neumann_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
PubMedID: 38856912 |
Title : Advances in prodrug design for Alzheimer's disease: the state of the art - Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
Author(s) : Travers-Lesage V , Mignani SM , Dallemagne P , Rochais C |
Ref : Expert Opin Drug Discov , 17 :325 , 2022 |
Abstract : |
PubMedSearch : Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
PubMedID: 35089846 |
Title : Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation - Malek_2022_Molecules_28_ |
Author(s) : Malek R , Simakov A , Davis A , Maj M , Bernard PJ , Wnorowski A , Martin H , Marco-Contelles J , Chabchoub F , Dallemagne P , Rochais C , Jozwiak K , Ismaili L |
Ref : Molecules , 28 : , 2022 |
Abstract : |
PubMedSearch : Malek_2022_Molecules_28_ |
PubMedID: 36615267 |
Title : Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease - Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
Author(s) : Chretien B , Jourdan JP , Davis A , Fedrizzi S , Bureau R , Sassier M , Rochais C , Alexandre J , Lelong-Boulouard V , Dolladille C , Dallemagne P |
Ref : British Journal of Clinical Pharmacology , 87 :2830 , 2021 |
Abstract : |
PubMedSearch : Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
PubMedID: 33274491 |
Title : Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy - Lecoutey_2021_Molecules_26_ |
Author(s) : Lecoutey C , Legay R , Davis A , Sopkova-de Oliveira Santos J , Dallemagne P , Rochais C |
Ref : Molecules , 26 : , 2021 |
Abstract : |
PubMedSearch : Lecoutey_2021_Molecules_26_ |
PubMedID: 33926141 |
Title : Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease - Lalut_2020_Sci.Rep_10_3014 |
Author(s) : Lalut J , Payan H , Davis A , Lecoutey C , Legay R , Sopkova-de Oliveira Santos J , Claeysen S , Dallemagne P , Rochais C |
Ref : Sci Rep , 10 :3014 , 2020 |
Abstract : |
PubMedSearch : Lalut_2020_Sci.Rep_10_3014 |
PubMedID: 32080261 |
Title : Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT(6) receptor antagonist with therapeutic interest in Alzheimer's disease - Toublet_2020_Eur.J.Med.Chem_210_113059 |
Author(s) : Toublet FX , Lalut J , Hatat B , Lecoutey C , Davis A , Since M , Corvaisier S , Freret T , Sopkova-de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
Ref : Eur Journal of Medicinal Chemistry , 210 :113059 , 2020 |
Abstract : |
PubMedSearch : Toublet_2020_Eur.J.Med.Chem_210_113059 |
PubMedID: 33310288 |
Title : Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment - Adnet_2020_Pharmaceutics_12_ |
Author(s) : Adnet T , Groo AC , Picard C , Davis A , Corvaisier S , Since M , Bounoure F , Rochais C , Pluart LL , Dallemagne P , Malzert-Freon A |
Ref : Pharmaceutics , 12 : , 2020 |
Abstract : |
PubMedSearch : Adnet_2020_Pharmaceutics_12_ |
PubMedID: 32168767 |
Title : First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease - Guieu_2020_Molecules_26_ |
Author(s) : Guieu B , Lecoutey C , Legay R , Davis A , Sopkova de Oliveira Santos J , Altomare CD , Catto M , Rochais C , Dallemagne P |
Ref : Molecules , 26 : , 2020 |
Abstract : |
PubMedSearch : Guieu_2020_Molecules_26_ |
PubMedID: 33375412 |
Title : Donecopride, a Swiss army knife with potential against Alzheimer's disease - Rochais_2020_Br.J.Pharmacol_177_1988 |
Author(s) : Rochais C , Lecoutey C , Hamidouche K , Giannoni P , Gaven F , Cem E , Mignani S , Baranger K , Freret T , Bockaert J , Rivera S , Boulouard M , Dallemagne P , Claeysen S |
Ref : British Journal of Pharmacology , 177 :1988 , 2020 |
Abstract : |
PubMedSearch : Rochais_2020_Br.J.Pharmacol_177_1988 |
PubMedID: 31881553 |
Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234 |
Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C |
Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019 |
Abstract : |
PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234 |
PubMedID: 30447434 |
Gene_locus related to this paper: torca-ACHE |
Title : A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease - Hatat_2019_Front.Aging.Neurosci_11_148 |
Author(s) : Hatat B , Yahiaoui S , Lecoutey C , Davis A , Freret T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
Ref : Front Aging Neurosci , 11 :148 , 2019 |
Abstract : |
PubMedSearch : Hatat_2019_Front.Aging.Neurosci_11_148 |
PubMedID: 31316368 |
Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
Ref : Molecules , 24 : , 2019 |
Abstract : |
PubMedSearch : Toublet_2019_Molecules_24_ |
PubMedID: 31370232 |
Title : Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors - Lecoutey_2012_MedChemComm_3_627 |
Author(s) : Lecoutey C , Rochais C , Genest D , Butt-Gueulle S , Ballandonne C , Corvaisier S , Dulin F , Lepailleur A , Sopkova-de , Dallemagne P |
Ref : Medchemcomm , 33 :627 , 2018 |
Abstract : |
PubMedSearch : Lecoutey_2012_MedChemComm_3_627 |
PubMedID: |
Title : Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment - Jourdan_2017_ChemMedChem_12_913 |
Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
Ref : ChemMedChem , 12 :913 , 2017 |
Abstract : |
PubMedSearch : Jourdan_2017_ChemMedChem_12_913 |
PubMedID: 28342294 |
Title : Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment - Lalut_2017_Future.Med.Chem_9_781 |
Author(s) : Lalut J , Karila D , Dallemagne P , Rochais C |
Ref : Future Med Chem , 9 :781 , 2017 |
Abstract : |
PubMedSearch : Lalut_2017_Future.Med.Chem_9_781 |
PubMedID: 28504917 |
Title : Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease - Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
Author(s) : Yahiaoui S , Hamidouche K , Ballandonne C , Davis A , de Oliveira Santos JS , Freret T , Boulouard M , Rochais C , Dallemagne P |
Ref : Eur Journal of Medicinal Chemistry , 121 :283 , 2016 |
Abstract : |
PubMedSearch : Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
PubMedID: 27266998 |
Title : Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment - Jourdan_2016_Eur.J.Med.Chem_114_365 |
Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
Ref : Eur Journal of Medicinal Chemistry , 114 :365 , 2016 |
Abstract : |
PubMedSearch : Jourdan_2016_Eur.J.Med.Chem_114_365 |
PubMedID: 27046230 |
Title : Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography - Lalut_2016_Eur.J.Med.Chem_116_90 |
Author(s) : Lalut J , Tournier BB , Cailly T , Lecoutey C , Corvaisier S , Davis A , Ballandonne C , Since M , Millet P , Fabis F , Dallemagne P , Rochais C |
Ref : Eur Journal of Medicinal Chemistry , 116 :90 , 2016 |
Abstract : |
PubMedSearch : Lalut_2016_Eur.J.Med.Chem_116_90 |
PubMedID: 27060761 |
Title : Therapeutic Potential of 5-HT6 Receptor Agonists - Karila_2015_J.Med.Chem_58_7901 |
Author(s) : Karila D , Freret T , Bouet V , Boulouard M , Dallemagne P , Rochais C |
Ref : Journal of Medicinal Chemistry , 58 :7901 , 2015 |
Abstract : |
PubMedSearch : Karila_2015_J.Med.Chem_58_7901 |
PubMedID: 26099069 |
Title : Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances - Quiedeville_2015_Behav.Brain.Res_293_10 |
Author(s) : Quiedeville A , Boulouard M , Hamidouche K , Da Silva Costa-Aze V , Nee G , Rochais C , Dallemagne P , Fabis F , Freret T , Bouet V |
Ref : Behavioural Brain Research , 293 :10 , 2015 |
Abstract : |
PubMedSearch : Quiedeville_2015_Behav.Brain.Res_293_10 |
PubMedID: 26187692 |
Title : Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride - Rochais_2015_J.Med.Chem_58_3172 |
Author(s) : Rochais C , Lecoutey C , Gaven F , Giannoni P , Hamidouche K , Hedou D , Dubost E , Genest D , Yahiaoui S , Freret T , Bouet V , Dauphin F , Sopkova de Oliveira Santos J , Ballandonne C , Corvaisier S , Malzert-Freon A , Legay R , Boulouard M , Claeysen S , Dallemagne P |
Ref : Journal of Medicinal Chemistry , 58 :3172 , 2015 |
Abstract : |
PubMedSearch : Rochais_2015_J.Med.Chem_58_3172 |
PubMedID: 25793650 |
Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014 |
Abstract : |
PubMedSearch : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
PubMedID: 25157130 |
Title : Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice - Freret_2012_Behav.Brain.Res_230_304 |
Author(s) : Freret T , Bouet V , Quiedeville A , Nee G , Dallemagne P , Rochais C , Boulouard M |
Ref : Behavioural Brain Research , 230 :304 , 2012 |
Abstract : |
PubMedSearch : Freret_2012_Behav.Brain.Res_230_304 |
PubMedID: 22348892 |
Title : Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library - Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
Author(s) : Sopkova-de Oliveira Santos J , Lesnard A , Agondanou JH , Dupont N , Godard AM , Stiebing S , Rochais C , Fabis F , Dallemagne P , Bureau R , Rault S |
Ref : J Chem Inf Model , 50 :422 , 2010 |
Abstract : |
PubMedSearch : Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
PubMedID: 20196555 |