DeLapp NW

General

Full name : DeLapp Neil W

First name : Neil W

Mail : Retired from Cardiovascular Research, Eli Lilly and Company, Indianapolis, Indiana

Zip Code :

City :

Country : USA

Email :

Phone :

Fax :

Website :

Directory :

Comment

References (28)

Title : M1 muscarinic receptor signaling in mouse hippocampus and cortex - Porter_2002_Brain.Res_944_82
Author(s) : Porter AC , Bymaster FP , DeLapp NW , Yamada M , Wess J , Hamilton SE , Nathanson NM , Felder CC
Ref : Brain Research , 944 :82 , 2002
Abstract :
PubMedSearch : Porter_2002_Brain.Res_944_82
PubMedID: 12106668

Title : The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance - Rasmussen_2001_Schizophr.Res_49_193
Author(s) : Rasmussen T , Fink-Jensen A , Sauerberg P , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP
Ref : Schizophr Res , 49 :193 , 2001
Abstract :
PubMedSearch : Rasmussen_2001_Schizophr.Res_49_193
PubMedID: 11343877

Title : Poster: The M1 muscarinic receptor subtype mediates Gq coupling in mouse hippocampus and pre-frontal cortex -
Author(s) : Porter AC , Bymaster FP , Nathanson NM , Hamilton SE , Carter PA , DeLapp NW , Felder CC
Ref : Life Sciences , 68 :2624 , 2001
PubMedID:

Title : Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo - Bymaster_2001_Brain.Res_916_165
Author(s) : Bymaster FP , Carter PA , DeLapp NW , Calligaro DO , Felder CC
Ref : Brain Research , 916 :165 , 2001
Abstract :
PubMedSearch : Bymaster_2001_Brain.Res_916_165
PubMedID: 11597604

Title : Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine - Bymaster_2001_Eur.J.Pharmacol_430_341
Author(s) : Bymaster FP , Falcone JF , Bauzon D , Kennedy JS , Schenck K , DeLapp NW , Cohen ML
Ref : European Journal of Pharmacology , 430 :341 , 2001
Abstract :
PubMedSearch : Bymaster_2001_Eur.J.Pharmacol_430_341
PubMedID: 11711053

Title : Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice - Rasmussen_2000_Eur.J.Pharmacol_402_241
Author(s) : Rasmussen T , Sauerberg P , Nielsen EB , Swedberg MD , Thomsen C , Sheardown MJ , Jeppesen L , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Shannon HE , Bymaster FP , Fink-Jensen A
Ref : European Journal of Pharmacology , 402 :241 , 2000
Abstract :
PubMedSearch : Rasmussen_2000_Eur.J.Pharmacol_402_241
PubMedID: 10958890

Title : Poster: New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof -
Author(s) : Jeppesen L , Sauerberg P , Olesen PH , Sheardown MJ , Thomsen C , Rasmussen T , Fink-Jensen A , Christensen MS , Ward JS , Whitesitt C , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE
Ref : Life Sciences , 64 :555 , 1999
PubMedID:

Title : 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives - Jeppesen_1999_J.Med.Chem_42_1999
Author(s) : Jeppesen L , Olesen PH , Hansen L , Sheardown MJ , Thomsen C , Rasmussen T , Jensen AF , Christensen MS , Rimvall K , Ward JS , Whitesitt CA , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE , Sauerberg P
Ref : Journal of Medicinal Chemistry , 42 :1999 , 1999
Abstract :
PubMedSearch : Jeppesen_1999_J.Med.Chem_42_1999
PubMedID: 10354408

Title : Poster: Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice -
Author(s) : Zhang L , Shannon HE , Bymaster FP , DeLapp NW , Womer DE , Mitch CH , Ward JS , Olesen PH , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Life Sciences , 64 :587 , 1999
PubMedID:

Title : Poster: Comparison of GTP-gamma-35S and 3H-NMS binding in CHO cells stably expressing human M1-M5 muscarinic receptors using scintillation proximity assays -
Author(s) : Sawyer BD , Silbernagel A , McKinzie JB , Falcone J , DeLapp NW , Felder CC
Ref : Life Sciences , 64 :568 , 1999
PubMedID:

Title : Poster: A study of M1 receptor coupling to inhibitory G proteins in CHO cells via GTPS binding determined with anti-G protein antibodies -
Author(s) : DeLapp NW , McClure D , McKinzie J , Silbernagel A , Sawyer BD , Felder CC
Ref : Life Sciences , 64 :569 , 1999
PubMedID:

Title : Poster: Muscarinic receptor characterization and neurochemical effects of the antipsychotic-like muscarinic agonist PTAC -
Author(s) : Bymaster FP , Shannon HE , DeLapp NW , Calligaro DO , Perry KW , Zhang W , Rasmussen K , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Life Sciences , 64 :579 , 1999
PubMedID:

Title : Poster: Behavioral and electrophysiological effects of the antipsychotic-like muscarinic agonist PTAC -
Author(s) : Shannon HE , Bymaster FP , Rasmussen K , DeLapp NW , Calligaro DO , Perry KW , Mitch CH , Ward JS , Fink-Jensen A , Olesen PH , Rasmussen T , Sheardown M , Swedberg MD , Jeppesen L , Sauerberg P
Ref : Life Sciences , 64 :587 , 1999
PubMedID:

Title : Potential role of muscarinic receptors in schizophrenia - Bymaster_1999_Life.Sci_64(6-7)_527
Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Ward JS , Calligaro DO , Mitch CH , Whitesitt CA , Ludvigsen TS , Sheardown MJ , Swedberg MD , Rasmussen T , Olesen PH , Jeppesen L , Sauerberg P , Fink-Jensen A
Ref : Life Sciences , 64 :527 , 1999
Abstract :
PubMedSearch : Bymaster_1999_Life.Sci_64(6-7)_527
PubMedID: 10069519

Title : Poster: An anti-G protein scintillation proximity assay for M1-M5 receptor-mediated GTPS binding -
Author(s) : McKinzie JH , Sawyer BD , Felder CC , Falcone J , Silbernagel A , McClure D , DeLapp NW
Ref : Life Sciences , 64 :570 , 1999
PubMedID:

Title : Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats - Shannon_1999_J.Pharmacol.Exp.Ther_290_901
Author(s) : Shannon HE , Hart JC , Bymaster FP , Calligaro DO , DeLapp NW , Mitch CH , Ward JS , Fink-Jensen A , Sauerberg P , Jeppesen L , Sheardown MJ , Swedberg MD
Ref : Journal of Pharmacology & Experimental Therapeutics , 290 :901 , 1999
Abstract :
PubMedSearch : Shannon_1999_J.Pharmacol.Exp.Ther_290_901
PubMedID: 10411607

Title : Poster: Muscarinic agonists with antipsychotic-like activity. Structure activity-relationships of 1,2,5-thiadiazole analogues with functioally dopamine antagonist activity -
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE
Ref : Life Sciences , 64 :555 , 1999
PubMedID:

Title : Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats - Fink-Jensen_1998_Neuroreport_9_3481
Author(s) : Fink-Jensen A , Kristensen P , Shannon HE , Calligaro DO , DeLapp NW , Whitesitt CA , Ward JS , Thomsen C , Rasmusseen T , Sheardown MJ , Jeppesen L , Sauerberg P , Bymaster FP
Ref : Neuroreport , 9 :3481 , 1998
Abstract :
PubMedSearch : Fink-Jensen_1998_Neuroreport_9_3481
PubMedID: 9855303

Title : Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane - Bymaster_1998_Eur.J.Pharmacol_356_109
Author(s) : Bymaster FP , Shannon HE , Rasmussen K , DeLapp NW , Mitch CH , Ward JS , Calligaro DO , Ludvigsen TS , Sheardown MJ , Olesen PH , Swedberg MD , Sauerberg P , Fink-Jensen A
Ref : European Journal of Pharmacology , 356 :109 , 1998
Abstract :
PubMedSearch : Bymaster_1998_Eur.J.Pharmacol_356_109
PubMedID: 9774240

Title : Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity - Sauerberg_1998_J.Med.Chem_41_4378
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Rasmussen T , Swedberg MD , Sheardown MJ , Fink-Jensen A , Thomsen C , Thogersen H , Rimvall K , Ward JS , Calligaro DO , DeLapp NW , Bymaster FP , Shannon HE
Ref : Journal of Medicinal Chemistry , 41 :4378 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_J.Med.Chem_41_4378
PubMedID: 9784113

Title : Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation - Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897
Author(s) : Sauerberg P , Jeppesen L , Olesen PH , Sheardown MJ , Fink-Jensen A , Rasmussen T , Rimvall K , Shannon HE , Bymaster FP , DeLapp NW , Calligaro DO , Ward JS , Whitesitt CA , Thomsen C
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2897 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_Bioorg.Med.Chem.Lett_8_2897
PubMedID: 9873644

Title : Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity - Sauerberg_1998_J.Med.Chem_41_109
Author(s) : Sauerberg P , Olesen PH , Sheardown MJ , Rimvall K , Thogersen H , Shannon HE , Sawyer BD , Ward JS , Bymaster FP , DeLapp NW , Calligaro DO , Swedberg MD
Ref : Journal of Medicinal Chemistry , 41 :109 , 1998
Abstract :
PubMedSearch : Sauerberg_1998_J.Med.Chem_41_109
PubMedID: 9438027

Title : Butylthio[2.2.2] (NNC 11-1053\/LY297802): an orally active muscarinic agonist analgesic - Swedberg_1997_J.Pharmacol.Exp.Ther_281_876
Author(s) : Swedberg MD , Sheardown MJ , Sauerberg P , Olesen PH , Suzdak PD , Hansen KT , Bymaster FP , Ward JS , Mitch CH , Calligaro DO , DeLapp NW , Shannon HE
Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :876 , 1997
Abstract :
PubMedSearch : Swedberg_1997_J.Pharmacol.Exp.Ther_281_876
PubMedID: 9152397

Title : Poster: An immunoblot assay for PTX ADP-ribosylation of brain and spinal cord Gi\/0 proteins -
Author(s) : DeLapp NW , Womer DE , Shannon HE
Ref : Life Sciences , 60 :1179 , 1997
PubMedID:

Title : Pharmacology of butylthio[2.2.2] (LY297802\/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity - Shannon_1997_J.Pharmacol.Exp.Ther_281_884
Author(s) : Shannon HE , Sheardown MJ , Bymaster FP , Calligaro DO , DeLapp NW , Gidda J , Mitch CH , Sawyer BD , Stengel PW , Ward JS , Wong DT , Olesen PH , Suzdak PD , Sauerberg P , Swedberg MD
Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :884 , 1997
Abstract :
PubMedSearch : Shannon_1997_J.Pharmacol.Exp.Ther_281_884
PubMedID: 9152398

Title : Muscarinic agonist inhibition of rat striatal adenylate cyclase is enhanced by dopamine stimulation - DeLapp_1996_Life.Sci_59_565
Author(s) : DeLapp NW , Eckols K , Shannon HE
Ref : Life Sciences , 59 :565 , 1996
Abstract :
PubMedSearch : DeLapp_1996_Life.Sci_59_565
PubMedID: 8761345

Title : The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells - Eckols_1995_Life.Sci_57_1183
Author(s) : Eckols K , Bymaster FP , Mitch CH , Shannon HE , Ward JS , DeLapp NW
Ref : Life Sciences , 57 :1183 , 1995
Abstract :
PubMedSearch : Eckols_1995_Life.Sci_57_1183
PubMedID: 7674807

Title : Poster: The M1 agonist xanomeline potently stimulates APPs release from CHO-m1 cells -
Author(s) : DeLapp NW , Eckols K , Bymaster FP , Mitch CH , Shannon HE , Ward JS
Ref : Life Sciences , 56(11-12) :1024 , 1995
PubMedID: