Felder CC

General

Full name : Felder Christian C

First name : Christian C

Mail : Lilly Research Labs Drop 0510, Lilly Corporate Center, Indianapolis, IN 46285

Zip Code :

City :

Country : USA

Email : felder@lilly.com

Phone : I 317 276 1380

Fax : 1 317 276 7600

Website :

Directory :

References (49)

Title : M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss - Bradley_2017_J.Clin.Invest_127_487
Author(s) : Bradley SJ , Bourgognon JM , Sanger HE , Verity N , Mogg AJ , White DJ , Butcher AJ , Moreno JA , Molloy C , Macedo-Hatch T , Edwards JM , Wess J , Pawlak R , Read DJ , Sexton PM , Broad LM , Steinert JR , Mallucci GR , Christopoulos A , Felder CC , Tobin AB
Ref : J Clinical Investigation , 127 :487 , 2017
PubMedID: 27991860

Title : Characterization of PCS1055, a novel muscarinic M4 receptor antagonist - Croy_2016_Eur.J.Pharmacol_782_70
Author(s) : Croy CH , Chan WY , Castetter AM , Watt ML , Quets AT , Felder CC
Ref : European Journal of Pharmacology , 782 :70 , 2016
PubMedID: 27085897

Title : M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine - Witkin_2014_J.Pharmacol.Exp.Ther_351_448
Author(s) : Witkin JM , Overshiner C , Li X , Catlow JT , Wishart GN , Schober DA , Heinz BA , Nikolayev A , Tolstikov VV , Anderson WH , Higgs RE , Kuo MS , Felder CC
Ref : Journal of Pharmacology & Experimental Therapeutics , 351 :448 , 2014
PubMedID: 25187432

Title : Activation and allosteric modulation of a muscarinic acetylcholine receptor - Kruse_2013_Nature_504_101
Author(s) : Kruse AC , Ring AM , Manglik A , Hu J , Hu K , Eitel K , Hubner H , Pardon E , Valant C , Sexton PM , Christopoulos A , Felder CC , Gmeiner P , Steyaert J , Weis WI , Garcia KC , Wess J , Kobilka BK
Ref : Nature , 504 :101 , 2013
PubMedID: 24256733

Title : Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects - Valant_2012_Mol.Pharmacol_81_41
Author(s) : Valant C , Felder CC , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 81 :41 , 2012
PubMedID: 21989256

Title : Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor - Suratman_2011_Br.J.Pharmacol_162_1659
Author(s) : Suratman S , Leach K , Sexton P , Felder CC , Loiacono R , Christopoulos A
Ref : British Journal of Pharmacology , 162 :1659 , 2011
PubMedID: 21198541

Title : The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor - Leach_2011_Mol.Pharmacol_79_855
Author(s) : Leach K , Davey AE , Felder CC , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 79 :855 , 2011
PubMedID: 21300722

Title : Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms - Nawaratne_2010_J.Biol.Chem_285_19012
Author(s) : Nawaratne V , Leach K , Felder CC , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 285 :19012 , 2010
PubMedID: 20406819

Title : Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties - Leach_2010_Neuropsychopharmacology_35_855
Author(s) : Leach K , Loiacono RE , Felder CC , McKinzie DL , Mogg A , Shaw DB , Sexton PM , Christopoulos A
Ref : Neuropsychopharmacology , 35 :855 , 2010
PubMedID: 19940843

Title : Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia - Shekhar_2008_Am.J.Psychiatry_165_1033
Author(s) : Shekhar A , Potter WZ , Lightfoot J , Lienemann J , Dube S , Mallinckrodt C , Bymaster FP , McKinzie DL , Felder CC
Ref : Am J Psychiatry , 165 :1033 , 2008
PubMedID: 18593778

Title : New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug) - Nawaratne_2008_Mol.Pharmacol_74_1119
Author(s) : Nawaratne V , Leach K , Suratman N , Loiacono RE , Felder CC , Armbruster BN , Roth BL , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 74 :1119 , 2008
PubMedID: 18628403

Title : Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia - Chan_2008_Proc.Natl.Acad.Sci.U.S.A_105_10978
Author(s) : Chan WY , McKinzie DL , Bose S , Mitchell SN , Witkin JM , Thompson RC , Christopoulos A , Lazareno S , Birdsall NJ , Bymaster FP , Felder CC
Ref : Proc Natl Acad Sci U S A , 105 :10978 , 2008
PubMedID: 18678919

Title : Generation and analysis of muscarinic acetylcholine receptor knockout mice. -
Author(s) : Duttaroy A , Yamada M , Gomeza J , Zhang W , Miyakawa T , Makita R , Bymaster FP , Felder CC , Deng CX , Wess J
Ref : Cholinergic Mechanisms, CRC Press :63 , 2004
PubMedID:

Title : New evidence for the involvement of muscarinic cholinergic receptors in psychoses. -
Author(s) : Bymaster FP , McKinzie DL , Felder CC
Ref : Cholinergic Mechanisms, CRC Press :331 , 2004
PubMedID:

Title : Muscarinic mechanisms of antipsychotic atypicality - Bymaster_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_1125
Author(s) : Bymaster FP , Felder CC , Tzavara E , Nomikos GG , Calligaro DO , McKinzie DL
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 27 :1125 , 2003
PubMedID: 14642972

Title : Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity - Bymaster_2003_Eur.J.Neurosci_17_1403
Author(s) : Bymaster FP , Carter PA , Yamada M , Gomeza J , Wess J , Hamilton SE , Nathanson NM , McKinzie DL , Felder CC
Ref : European Journal of Neuroscience , 17 :1403 , 2003
PubMedID: 12713643

Title : Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review - Wess_2003_Life.Sci_72_2047
Author(s) : Wess J , Duttaroy A , Gomeza J , Zhang W , Yamada M , Felder CC , Bernardini N , Reeh PW
Ref : Life Sciences , 72 :2047 , 2003
PubMedID: 12628455

Title : M1 muscarinic receptor signaling in mouse hippocampus and cortex - Porter_2002_Brain.Res_944_82
Author(s) : Porter AC , Bymaster FP , DeLapp NW , Yamada M , Wess J , Hamilton SE , Nathanson NM , Felder CC
Ref : Brain Research , 944 :82 , 2002
PubMedID: 12106668

Title : Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice - Duttaroy_2002_Mol.Pharmacol_62_1084
Author(s) : Duttaroy A , Gomeza J , Gan JW , Siddiqui N , Basile AS , Harman WD , Smith PL , Felder CC , Levey AI , Wess J
Ref : Molecular Pharmacology , 62 :1084 , 2002
PubMedID: 12391271

Title : Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents - Bymaster_2002_Mol.Psychiatry_7 Suppl 1_S57
Author(s) : Bymaster FP , Felder CC
Ref : Mol Psychiatry , 7 Suppl 1 :S57 , 2002
PubMedID: 11986996

Title : Poster: The M1 muscarinic receptor subtype mediates Gq coupling in mouse hippocampus and pre-frontal cortex -
Author(s) : Porter AC , Bymaster FP , Nathanson NM , Hamilton SE , Carter PA , DeLapp NW , Felder CC
Ref : Life Sciences , 68 :2624 , 2001
PubMedID:

Title : Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo - Bymaster_2001_Brain.Res_916_165
Author(s) : Bymaster FP , Carter PA , DeLapp NW , Calligaro DO , Felder CC
Ref : Brain Research , 916 :165 , 2001
PubMedID: 11597604

Title : Poster: Evaluation of muscarinic agonist-induced analgesia in muscarinic receptor knockout mice -
Author(s) : Duttaroy A , Gomeza J , Gan JW , Basile AS , Harman WD , Smith PL , Felder CC , Levey AI , Wess J
Ref : Life Sciences , 68 :2631 , 2001
PubMedID:

Title : Poster: Enhanced sensitivity to the locomotor-activating and disrupting effects of phencyclidine in M4 muscarinic receptor knock-out mice -
Author(s) : Felder CC , Bymaster FP , Wess J , Zhang L , Shaw DB , McKinzie DL
Ref : Life Sciences , 68 :2636 , 2001
PubMedID:

Title : Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism - Salamone_2001_Life.Sci_68(22-23)_2579
Author(s) : Salamone JD , Correa M , Carlson BB , Wisniecki A , Mayorga AJ , Nisenbaum E , Nisenbaum L , Felder CC
Ref : Life Sciences , 68 :2579 , 2001
PubMedID: 11392629

Title : Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice - Bymaster_2001_Life.Sci_68(22-23)_2473
Author(s) : Bymaster FP , Carter PA , Zhang L , Falcone JF , Stengel PW , Cohen ML , Shannon HE , Gomeza J , Wess J , Felder CC
Ref : Life Sciences , 68 :2473 , 2001
PubMedID: 11392615

Title : The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex - Perry_2001_Biol.Psychiatry_49_716
Author(s) : Perry KW , Nisenbaum LK , George CA , Shannon HE , Felder CC , Bymaster FP
Ref : Biological Psychiatry , 49 :716 , 2001
PubMedID: 11313039

Title : Elucidating the role of muscarinic receptors in psychosis - Felder_2001_Life.Sci_68(22-23)_2605
Author(s) : Felder CC , Porter AC , Skillman TL , Zhang L , Bymaster FP , Nathanson NM , Hamilton SE , Gomeza J , Wess J , McKinzie DL
Ref : Life Sciences , 68 :2605 , 2001
PubMedID: 11392633

Title : Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice - Gomeza_2001_Life.Sci_68(22-23)_2457
Author(s) : Gomeza J , Zhang L , Kostenis E , Felder CC , Bymaster FP , Brodkin J , Shannon HE , Xia B , Duttaroy A , Deng CX , Wess J
Ref : Life Sciences , 68 :2457 , 2001
PubMedID: 11392613

Title : A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data - Kennedy_2001_Int.J.Geriatr.Psychiatry_16 Suppl 1_S33
Author(s) : Kennedy JS , Bymaster FP , Schuh L , Calligaro DO , Nomikos G , Felder CC , Bernauer M , Kinon BJ , Baker RW , Hay D , Roth HJ , Dossenbach M , Kaiser C , Beasley CM , Holcombe JH , Effron MB , Breier A
Ref : Int J Geriatr Psychiatry , 16 Suppl 1 :S33 , 2001
PubMedID: 11748788

Title : Therapeutic opportunities for muscarinic receptors in the central nervous system -
Author(s) : Felder CC , Bymaster FP , Ward JS , DeLapp NC
Ref : Journal of Medicinal Chemistry , 43 :4333 , 2000
PubMedID: 11087557

Title : Poster: Comparison of GTP-gamma-35S and 3H-NMS binding in CHO cells stably expressing human M1-M5 muscarinic receptors using scintillation proximity assays -
Author(s) : Sawyer BD , Silbernagel A , McKinzie JB , Falcone J , DeLapp NW , Felder CC
Ref : Life Sciences , 64 :568 , 1999
PubMedID:

Title : Poster: A study of M1 receptor coupling to inhibitory G proteins in CHO cells via GTPS binding determined with anti-G protein antibodies -
Author(s) : DeLapp NW , McClure D , McKinzie J , Silbernagel A , Sawyer BD , Felder CC
Ref : Life Sciences , 64 :569 , 1999
PubMedID:

Title : Poster: Muscarinic receptor-activated arachidonic acid release is enhanced by cytokines in A2058 human melanoma cells -
Author(s) : Wood MW , Briley EM , Felder CC
Ref : Life Sciences , 64 :566 , 1999
PubMedID:

Title : Poster: An anti-G protein scintillation proximity assay for M1-M5 receptor-mediated GTPS binding -
Author(s) : McKinzie JH , Sawyer BD , Felder CC , Falcone J , Silbernagel A , McClure D , DeLapp NW
Ref : Life Sciences , 64 :570 , 1999
PubMedID:

Title : 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives - Jeppesen_1999_J.Med.Chem_42_1999
Author(s) : Jeppesen L , Olesen PH , Hansen L , Sheardown MJ , Thomsen C , Rasmussen T , Jensen AF , Christensen MS , Rimvall K , Ward JS , Whitesitt CA , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE , Sauerberg P
Ref : Journal of Medicinal Chemistry , 42 :1999 , 1999
PubMedID: 10354408

Title : Poster: New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof -
Author(s) : Jeppesen L , Sauerberg P , Olesen PH , Sheardown MJ , Thomsen C , Rasmussen T , Fink-Jensen A , Christensen MS , Ward JS , Whitesitt C , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE
Ref : Life Sciences , 64 :555 , 1999
PubMedID:

Title : Muscarinic receptor-activated arachidonic acid release is enhanced by cytokines in A2058 human melanoma cells -
Author(s) : Felder CC , Joon JH , Briley EM , Wood MW
Ref : Journal de Physiologie (Paris) , 92 :431 , 1998
PubMedID:

Title : Cytosolic phospholipase A2 (cPLA2) distribution in murine brain and functional studies indicate that cPLA2 does not participate in muscarinic receptor-mediated signaling in neurons -
Author(s) : Lamar T , Lautens LL , Chiou XG , Sharp JD , Young III WS , Sprague DL , Ross LS , Felder CC
Ref : Journal de Physiologie (Paris) , 92 :454 , 1998
PubMedID:

Title : Muscarinic receptor activated Ca2+ channels in non-excitable cells - Singer-Lahat_1996_Prog.Brain.Res_109_195
Author(s) : Singer-Lahat D , Rojas E , Felder CC
Ref : Prog Brain Res , 109 :195 , 1996
PubMedID: 9009707

Title : Independent induction of morphological transformation of CHO cells by receptor-activated cyclic AMP synthesis or by receptor-operated calcium influx - Singer-Lahat_1996_Biochem.Pharmacol_51_495
Author(s) : Singer-Lahat D , Ma AL , Felder CC
Ref : Biochemical Pharmacology , 51 :495 , 1996
PubMedID: 8619896

Title : Muscarinic acetylcholine receptor subtypes associated with release of Alzheimer amyloid precursor derivatives activate multiple signal transduction pathways - Felder_1993_Ann.N.Y.Acad.Sci_695_15
Author(s) : Felder CC , Ma AL , Briley EM , Axelrod J
Ref : Annals of the New York Academy of Sciences , 695 :15 , 1993
PubMedID: 8239275

Title : Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx - Felder_1993_Proc.Natl.Acad.Sci.U.S.A_90_1706
Author(s) : Felder CC , MacArthur L , Ma AL , Gusovsky F , Kohn EC
Ref : Proc Natl Acad Sci U S A , 90 :1706 , 1993
PubMedID: 7680475

Title : Receptor-coupled amyloid precursor protein processing - Nitsch_1993_Ann.N.Y.Acad.Sci_695_122
Author(s) : Nitsch RM , Slack BE , Farber SA , Borghesani PR , Schulz JG , Kim C , Felder CC , Growdon JH , Wurtman RJ
Ref : Annals of the New York Academy of Sciences , 695 :122 , 1993
PubMedID: 8239269

Title : The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release - Felder_1991_J.Pharmacol.Exp.Ther_257_967
Author(s) : Felder CC , Ma AL , Liotta LA , Kohn EC
Ref : Journal of Pharmacology & Experimental Therapeutics , 257 :967 , 1991
PubMedID: 1646332

Title : Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture - Kanterman_1990_Neurosci.Lett_118_235
Author(s) : Kanterman RY , Ma AL , Briley EM , Axelrod J , Felder CC
Ref : Neuroscience Letters , 118 :235 , 1990
PubMedID: 2125713

Title : Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor - Felder_1989_FEBS.Lett_245_75
Author(s) : Felder CC , Ma AL , Conklin BR
Ref : FEBS Letters , 245 :75 , 1989
PubMedID: 2466702

Title : Poster: Carbachol stimulation causes inhibition of mitogenesis and cell elongation in CHO cells transfected with muscarinrc receptor genes -
Author(s) : Conklin BR , Brann MR , Buckley NJ , Bonner TI , Ma AL , Felder CC , Axelrod J
Ref : Trends in Pharmacological Sciences , Suppl :117 , 1989
PubMedID:

Title : A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis - Felder_1989_J.Biol.Chem_264_20356
Author(s) : Felder CC , Kanterman RY , Ma AL , Axelrod J
Ref : Journal of Biological Chemistry , 264 :20356 , 1989
PubMedID: 2555356