Full name : Felder Christian C
First name : Christian C
Mail : Lilly Research Labs Drop 0510, Lilly Corporate Center, Indianapolis, IN 46285
Zip Code :
City :
Country : USA
Email : felder@lilly.com
Phone : I 317 276 1380
Fax : 1 317 276 7600
Website :
Directory :
Comment
| Title : M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss - Bradley_2017_J.Clin.Invest_127_487 |
| Author(s) : Bradley SJ , Bourgognon JM , Sanger HE , Verity N , Mogg AJ , White DJ , Butcher AJ , Moreno JA , Molloy C , Macedo-Hatch T , Edwards JM , Wess J , Pawlak R , Read DJ , Sexton PM , Broad LM , Steinert JR , Mallucci GR , Christopoulos A , Felder CC , Tobin AB |
| Ref : J Clinical Investigation , 127 :487 , 2017 |
| Abstract : |
| PubMedSearch : Bradley_2017_J.Clin.Invest_127_487 |
| PubMedID: 27991860 |
| Title : Characterization of PCS1055, a novel muscarinic M4 receptor antagonist - Croy_2016_Eur.J.Pharmacol_782_70 |
| Author(s) : Croy CH , Chan WY , Castetter AM , Watt ML , Quets AT , Felder CC |
| Ref : European Journal of Pharmacology , 782 :70 , 2016 |
| Abstract : |
| PubMedSearch : Croy_2016_Eur.J.Pharmacol_782_70 |
| PubMedID: 27085897 |
| Title : M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine - Witkin_2014_J.Pharmacol.Exp.Ther_351_448 |
| Author(s) : Witkin JM , Overshiner C , Li X , Catlow JT , Wishart GN , Schober DA , Heinz BA , Nikolayev A , Tolstikov VV , Anderson WH , Higgs RE , Kuo MS , Felder CC |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 351 :448 , 2014 |
| Abstract : |
| PubMedSearch : Witkin_2014_J.Pharmacol.Exp.Ther_351_448 |
| PubMedID: 25187432 |
| Title : Activation and allosteric modulation of a muscarinic acetylcholine receptor - Kruse_2013_Nature_504_101 |
| Author(s) : Kruse AC , Ring AM , Manglik A , Hu J , Hu K , Eitel K , Hubner H , Pardon E , Valant C , Sexton PM , Christopoulos A , Felder CC , Gmeiner P , Steyaert J , Weis WI , Garcia KC , Wess J , Kobilka BK |
| Ref : Nature , 504 :101 , 2013 |
| Abstract : |
| PubMedSearch : Kruse_2013_Nature_504_101 |
| PubMedID: 24256733 |
| Title : Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects - Valant_2012_Mol.Pharmacol_81_41 |
| Author(s) : Valant C , Felder CC , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 81 :41 , 2012 |
| Abstract : |
| PubMedSearch : Valant_2012_Mol.Pharmacol_81_41 |
| PubMedID: 21989256 |
| Title : The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor - Leach_2011_Mol.Pharmacol_79_855 |
| Author(s) : Leach K , Davey AE , Felder CC , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 79 :855 , 2011 |
| Abstract : |
| PubMedSearch : Leach_2011_Mol.Pharmacol_79_855 |
| PubMedID: 21300722 |
| Title : Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor - Suratman_2011_Br.J.Pharmacol_162_1659 |
| Author(s) : Suratman S , Leach K , Sexton P , Felder CC , Loiacono R , Christopoulos A |
| Ref : British Journal of Pharmacology , 162 :1659 , 2011 |
| Abstract : |
| PubMedSearch : Suratman_2011_Br.J.Pharmacol_162_1659 |
| PubMedID: 21198541 |
| Title : Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms - Nawaratne_2010_J.Biol.Chem_285_19012 |
| Author(s) : Nawaratne V , Leach K , Felder CC , Sexton PM , Christopoulos A |
| Ref : Journal of Biological Chemistry , 285 :19012 , 2010 |
| Abstract : |
| PubMedSearch : Nawaratne_2010_J.Biol.Chem_285_19012 |
| PubMedID: 20406819 |
| Title : Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties - Leach_2010_Neuropsychopharmacology_35_855 |
| Author(s) : Leach K , Loiacono RE , Felder CC , McKinzie DL , Mogg A , Shaw DB , Sexton PM , Christopoulos A |
| Ref : Neuropsychopharmacology , 35 :855 , 2010 |
| Abstract : |
| PubMedSearch : Leach_2010_Neuropsychopharmacology_35_855 |
| PubMedID: 19940843 |
| Title : New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug) - Nawaratne_2008_Mol.Pharmacol_74_1119 |
| Author(s) : Nawaratne V , Leach K , Suratman N , Loiacono RE , Felder CC , Armbruster BN , Roth BL , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 74 :1119 , 2008 |
| Abstract : |
| PubMedSearch : Nawaratne_2008_Mol.Pharmacol_74_1119 |
| PubMedID: 18628403 |
| Title : Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia - Chan_2008_Proc.Natl.Acad.Sci.U.S.A_105_10978 |
| Author(s) : Chan WY , McKinzie DL , Bose S , Mitchell SN , Witkin JM , Thompson RC , Christopoulos A , Lazareno S , Birdsall NJ , Bymaster FP , Felder CC |
| Ref : Proc Natl Acad Sci U S A , 105 :10978 , 2008 |
| Abstract : |
| PubMedSearch : Chan_2008_Proc.Natl.Acad.Sci.U.S.A_105_10978 |
| PubMedID: 18678919 |
| Title : Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia - Shekhar_2008_Am.J.Psychiatry_165_1033 |
| Author(s) : Shekhar A , Potter WZ , Lightfoot J , Lienemann J , Dube S , Mallinckrodt C , Bymaster FP , McKinzie DL , Felder CC |
| Ref : Am J Psychiatry , 165 :1033 , 2008 |
| Abstract : |
| PubMedSearch : Shekhar_2008_Am.J.Psychiatry_165_1033 |
| PubMedID: 18593778 |
| Title : New evidence for the involvement of muscarinic cholinergic receptors in psychoses. - |
| Author(s) : Bymaster FP , McKinzie DL , Felder CC |
| Ref : Cholinergic Mechanisms, CRC Press :331 , 2004 |
| PubMedID: |
| Title : Generation and analysis of muscarinic acetylcholine receptor knockout mice. - |
| Author(s) : Duttaroy A , Yamada M , Gomeza J , Zhang W , Miyakawa T , Makita R , Bymaster FP , Felder CC , Deng CX , Wess J |
| Ref : Cholinergic Mechanisms, CRC Press :63 , 2004 |
| PubMedID: |
| Title : Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review - Wess_2003_Life.Sci_72_2047 |
| Author(s) : Wess J , Duttaroy A , Gomeza J , Zhang W , Yamada M , Felder CC , Bernardini N , Reeh PW |
| Ref : Life Sciences , 72 :2047 , 2003 |
| Abstract : |
| PubMedSearch : Wess_2003_Life.Sci_72_2047 |
| PubMedID: 12628455 |
| Title : Muscarinic mechanisms of antipsychotic atypicality - Bymaster_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_1125 |
| Author(s) : Bymaster FP , Felder CC , Tzavara E , Nomikos GG , Calligaro DO , McKinzie DL |
| Ref : Prog Neuropsychopharmacol Biological Psychiatry , 27 :1125 , 2003 |
| Abstract : |
| PubMedSearch : Bymaster_2003_Prog.Neuropsychopharmacol.Biol.Psychiatry_27_1125 |
| PubMedID: 14642972 |
| Title : Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity - Bymaster_2003_Eur.J.Neurosci_17_1403 |
| Author(s) : Bymaster FP , Carter PA , Yamada M , Gomeza J , Wess J , Hamilton SE , Nathanson NM , McKinzie DL , Felder CC |
| Ref : European Journal of Neuroscience , 17 :1403 , 2003 |
| Abstract : |
| PubMedSearch : Bymaster_2003_Eur.J.Neurosci_17_1403 |
| PubMedID: 12713643 |
| Title : Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents - Bymaster_2002_Mol.Psychiatry_7 Suppl 1_S57 |
| Author(s) : Bymaster FP , Felder CC |
| Ref : Mol Psychiatry , 7 Suppl 1 :S57 , 2002 |
| Abstract : |
| PubMedSearch : Bymaster_2002_Mol.Psychiatry_7 Suppl 1_S57 |
| PubMedID: 11986996 |
| Title : M1 muscarinic receptor signaling in mouse hippocampus and cortex - Porter_2002_Brain.Res_944_82 |
| Author(s) : Porter AC , Bymaster FP , DeLapp NW , Yamada M , Wess J , Hamilton SE , Nathanson NM , Felder CC |
| Ref : Brain Research , 944 :82 , 2002 |
| Abstract : |
| PubMedSearch : Porter_2002_Brain.Res_944_82 |
| PubMedID: 12106668 |
| Title : Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice - Duttaroy_2002_Mol.Pharmacol_62_1084 |
| Author(s) : Duttaroy A , Gomeza J , Gan JW , Siddiqui N , Basile AS , Harman WD , Smith PL , Felder CC , Levey AI , Wess J |
| Ref : Molecular Pharmacology , 62 :1084 , 2002 |
| Abstract : |
| PubMedSearch : Duttaroy_2002_Mol.Pharmacol_62_1084 |
| PubMedID: 12391271 |
| Title : The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex - Perry_2001_Biol.Psychiatry_49_716 |
| Author(s) : Perry KW , Nisenbaum LK , George CA , Shannon HE , Felder CC , Bymaster FP |
| Ref : Biological Psychiatry , 49 :716 , 2001 |
| Abstract : |
| PubMedSearch : Perry_2001_Biol.Psychiatry_49_716 |
| PubMedID: 11313039 |
| Title : Elucidating the role of muscarinic receptors in psychosis - Felder_2001_Life.Sci_68(22-23)_2605 |
| Author(s) : Felder CC , Porter AC , Skillman TL , Zhang L , Bymaster FP , Nathanson NM , Hamilton SE , Gomeza J , Wess J , McKinzie DL |
| Ref : Life Sciences , 68 :2605 , 2001 |
| Abstract : |
| PubMedSearch : Felder_2001_Life.Sci_68(22-23)_2605 |
| PubMedID: 11392633 |
| Title : A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data - Kennedy_2001_Int.J.Geriatr.Psychiatry_16 Suppl 1_S33 |
| Author(s) : Kennedy JS , Bymaster FP , Schuh L , Calligaro DO , Nomikos G , Felder CC , Bernauer M , Kinon BJ , Baker RW , Hay D , Roth HJ , Dossenbach M , Kaiser C , Beasley CM , Holcombe JH , Effron MB , Breier A |
| Ref : Int J Geriatr Psychiatry , 16 Suppl 1 :S33 , 2001 |
| Abstract : |
| PubMedSearch : Kennedy_2001_Int.J.Geriatr.Psychiatry_16 Suppl 1_S33 |
| PubMedID: 11748788 |
| Title : Poster: The M1 muscarinic receptor subtype mediates Gq coupling in mouse hippocampus and pre-frontal cortex - |
| Author(s) : Porter AC , Bymaster FP , Nathanson NM , Hamilton SE , Carter PA , DeLapp NW , Felder CC |
| Ref : Life Sciences , 68 :2624 , 2001 |
| PubMedID: |
| Title : Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice - Gomeza_2001_Life.Sci_68(22-23)_2457 |
| Author(s) : Gomeza J , Zhang L , Kostenis E , Felder CC , Bymaster FP , Brodkin J , Shannon HE , Xia B , Duttaroy A , Deng CX , Wess J |
| Ref : Life Sciences , 68 :2457 , 2001 |
| Abstract : |
| PubMedSearch : Gomeza_2001_Life.Sci_68(22-23)_2457 |
| PubMedID: 11392613 |
| Title : Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo - Bymaster_2001_Brain.Res_916_165 |
| Author(s) : Bymaster FP , Carter PA , DeLapp NW , Calligaro DO , Felder CC |
| Ref : Brain Research , 916 :165 , 2001 |
| Abstract : |
| PubMedSearch : Bymaster_2001_Brain.Res_916_165 |
| PubMedID: 11597604 |
| Title : Poster: Enhanced sensitivity to the locomotor-activating and disrupting effects of phencyclidine in M4 muscarinic receptor knock-out mice - |
| Author(s) : Felder CC , Bymaster FP , Wess J , Zhang L , Shaw DB , McKinzie DL |
| Ref : Life Sciences , 68 :2636 , 2001 |
| PubMedID: |
| Title : Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism - Salamone_2001_Life.Sci_68(22-23)_2579 |
| Author(s) : Salamone JD , Correa M , Carlson BB , Wisniecki A , Mayorga AJ , Nisenbaum E , Nisenbaum L , Felder CC |
| Ref : Life Sciences , 68 :2579 , 2001 |
| Abstract : |
| PubMedSearch : Salamone_2001_Life.Sci_68(22-23)_2579 |
| PubMedID: 11392629 |
| Title : Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice - Bymaster_2001_Life.Sci_68(22-23)_2473 |
| Author(s) : Bymaster FP , Carter PA , Zhang L , Falcone JF , Stengel PW , Cohen ML , Shannon HE , Gomeza J , Wess J , Felder CC |
| Ref : Life Sciences , 68 :2473 , 2001 |
| Abstract : |
| PubMedSearch : Bymaster_2001_Life.Sci_68(22-23)_2473 |
| PubMedID: 11392615 |
| Title : Therapeutic opportunities for muscarinic receptors in the central nervous system - |
| Author(s) : Felder CC , Bymaster FP , Ward JS , DeLapp NC |
| Ref : Journal of Medicinal Chemistry , 43 :4333 , 2000 |
| PubMedID: 11087557 |
| Title : Poster: New potent muscarinic 1,2,5-thiadiazole-azacycles and dimers hereof - |
| Author(s) : Jeppesen L , Sauerberg P , Olesen PH , Sheardown MJ , Thomsen C , Rasmussen T , Fink-Jensen A , Christensen MS , Ward JS , Whitesitt C , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE |
| Ref : Life Sciences , 64 :555 , 1999 |
| PubMedID: |
| Title : 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives - Jeppesen_1999_J.Med.Chem_42_1999 |
| Author(s) : Jeppesen L , Olesen PH , Hansen L , Sheardown MJ , Thomsen C , Rasmussen T , Jensen AF , Christensen MS , Rimvall K , Ward JS , Whitesitt CA , Calligaro DO , Bymaster FP , DeLapp NW , Felder CC , Shannon HE , Sauerberg P |
| Ref : Journal of Medicinal Chemistry , 42 :1999 , 1999 |
| Abstract : |
| PubMedSearch : Jeppesen_1999_J.Med.Chem_42_1999 |
| PubMedID: 10354408 |
| Title : Poster: Comparison of GTP-gamma-35S and 3H-NMS binding in CHO cells stably expressing human M1-M5 muscarinic receptors using scintillation proximity assays - |
| Author(s) : Sawyer BD , Silbernagel A , McKinzie JB , Falcone J , DeLapp NW , Felder CC |
| Ref : Life Sciences , 64 :568 , 1999 |
| PubMedID: |
| Title : Poster: A study of M1 receptor coupling to inhibitory G proteins in CHO cells via GTPS binding determined with anti-G protein antibodies - |
| Author(s) : DeLapp NW , McClure D , McKinzie J , Silbernagel A , Sawyer BD , Felder CC |
| Ref : Life Sciences , 64 :569 , 1999 |
| PubMedID: |
| Title : Poster: An anti-G protein scintillation proximity assay for M1-M5 receptor-mediated GTPS binding - |
| Author(s) : McKinzie JH , Sawyer BD , Felder CC , Falcone J , Silbernagel A , McClure D , DeLapp NW |
| Ref : Life Sciences , 64 :570 , 1999 |
| PubMedID: |
| Title : Cytosolic phospholipase A2 (cPLA2) distribution in murine brain and functional studies indicate that cPLA2 does not participate in muscarinic receptor-mediated signaling in neurons - |
| Author(s) : Lamar T , Lautens LL , Chiou XG , Sharp JD , Young III WS , Sprague DL , Ross LS , Felder CC |
| Ref : Journal de Physiologie (Paris) , 92 :454 , 1998 |
| PubMedID: |
| Title : Muscarinic receptor activated Ca2+ channels in non-excitable cells - Singer-Lahat_1996_Prog.Brain.Res_109_195 |
| Author(s) : Singer-Lahat D , Rojas E , Felder CC |
| Ref : Prog Brain Res , 109 :195 , 1996 |
| Abstract : |
| PubMedSearch : Singer-Lahat_1996_Prog.Brain.Res_109_195 |
| PubMedID: 9009707 |
| Title : Independent induction of morphological transformation of CHO cells by receptor-activated cyclic AMP synthesis or by receptor-operated calcium influx - Singer-Lahat_1996_Biochem.Pharmacol_51_495 |
| Author(s) : Singer-Lahat D , Ma AL , Felder CC |
| Ref : Biochemical Pharmacology , 51 :495 , 1996 |
| Abstract : |
| PubMedSearch : Singer-Lahat_1996_Biochem.Pharmacol_51_495 |
| PubMedID: 8619896 |
| Title : Muscarinic acetylcholine receptor subtypes associated with release of Alzheimer amyloid precursor derivatives activate multiple signal transduction pathways - Felder_1993_Ann.N.Y.Acad.Sci_695_15 |
| Author(s) : Felder CC , Ma AL , Briley EM , Axelrod J |
| Ref : Annals of the New York Academy of Sciences , 695 :15 , 1993 |
| Abstract : |
| PubMedSearch : Felder_1993_Ann.N.Y.Acad.Sci_695_15 |
| PubMedID: 8239275 |
| Title : Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx - Felder_1993_Proc.Natl.Acad.Sci.U.S.A_90_1706 |
| Author(s) : Felder CC , MacArthur L , Ma AL , Gusovsky F , Kohn EC |
| Ref : Proc Natl Acad Sci U S A , 90 :1706 , 1993 |
| Abstract : |
| PubMedSearch : Felder_1993_Proc.Natl.Acad.Sci.U.S.A_90_1706 |
| PubMedID: 7680475 |
| Title : Receptor-coupled amyloid precursor protein processing - Nitsch_1993_Ann.N.Y.Acad.Sci_695_122 |
| Author(s) : Nitsch RM , Slack BE , Farber SA , Borghesani PR , Schulz JG , Kim C , Felder CC , Growdon JH , Wurtman RJ |
| Ref : Annals of the New York Academy of Sciences , 695 :122 , 1993 |
| Abstract : |
| PubMedSearch : Nitsch_1993_Ann.N.Y.Acad.Sci_695_122 |
| PubMedID: 8239269 |
| Title : The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release - Felder_1991_J.Pharmacol.Exp.Ther_257_967 |
| Author(s) : Felder CC , Ma AL , Liotta LA , Kohn EC |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 257 :967 , 1991 |
| Abstract : |
| PubMedSearch : Felder_1991_J.Pharmacol.Exp.Ther_257_967 |
| PubMedID: 1646332 |
| Title : Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture - Kanterman_1990_Neurosci.Lett_118_235 |
| Author(s) : Kanterman RY , Ma AL , Briley EM , Axelrod J , Felder CC |
| Ref : Neuroscience Letters , 118 :235 , 1990 |
| Abstract : |
| PubMedSearch : Kanterman_1990_Neurosci.Lett_118_235 |
| PubMedID: 2125713 |
| Title : A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis - Felder_1989_J.Biol.Chem_264_20356 |
| Author(s) : Felder CC , Kanterman RY , Ma AL , Axelrod J |
| Ref : Journal of Biological Chemistry , 264 :20356 , 1989 |
| Abstract : |
| PubMedSearch : Felder_1989_J.Biol.Chem_264_20356 |
| PubMedID: 2555356 |
| Title : Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor - Felder_1989_FEBS.Lett_245_75 |
| Author(s) : Felder CC , Ma AL , Conklin BR |
| Ref : FEBS Letters , 245 :75 , 1989 |
| Abstract : |
| PubMedSearch : Felder_1989_FEBS.Lett_245_75 |
| PubMedID: 2466702 |
| Title : Poster: Carbachol stimulation causes inhibition of mitogenesis and cell elongation in CHO cells transfected with muscarinrc receptor genes - |
| Author(s) : Conklin BR , Brann MR , Buckley NJ , Bonner TI , Ma AL , Felder CC , Axelrod J |
| Ref : Trends in Pharmacological Sciences , Suppl :117 , 1989 |
| PubMedID: |