Freedman R

General

Full name : Freedman Robert

First name : Robert

Mail : Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, Colorado 80045

Zip Code :

City :

Country : USA

Email : Robert.Freedman@ucdenver.edu

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References (49)

Title : The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function - Sinkus_2015_Neuropharmacol_96_274
Author(s) : Sinkus ML , Graw S , Freedman R , Ross RG , Lester HA , Leonard S
Ref : Neuropharmacology , 96 :274 , 2015
Abstract :
PubMedSearch : Sinkus_2015_Neuropharmacol_96_274
PubMedID: 25701707

Title : The duplicated alpha7 subunits assemble and form functional nicotinic receptors with the full-length alpha7 - Wang_2014_J.Biol.Chem_289_26451
Author(s) : Wang Y , Xiao C , Indersmitten T , Freedman R , Leonard S , Lester HA
Ref : Journal of Biological Chemistry , 289 :26451 , 2014
Abstract :
PubMedSearch : Wang_2014_J.Biol.Chem_289_26451
PubMedID: 25056953

Title : Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk - Ross_2013_Am.J.Psychiatry_170_290
Author(s) : Ross RG , Hunter SK , McCarthy L , Beuler J , Hutchison AK , Wagner BD , Leonard S , Stevens KE , Freedman R
Ref : Am J Psychiatry , 170 :290 , 2013
Abstract :
PubMedSearch : Ross_2013_Am.J.Psychiatry_170_290
PubMedID: 23318559

Title : Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia - Stephens_2012_Psychiatr.Genet_22_1
Author(s) : Stephens SH , Franks A , Berger R , Palionyte M , Fingerlin TE , Wagner B , Logel J , Olincy A , Ross RG , Freedman R , Leonard S
Ref : Psychiatr Genet , 22 :1 , 2012
Abstract :
PubMedSearch : Stephens_2012_Psychiatr.Genet_22_1
PubMedID: 21970977

Title : Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the alpha7 nicotinic receptor - Olincy_2012_Handb.Exp.Pharmacol__211
Author(s) : Olincy A , Freedman R
Ref : Handbook of Experimental Pharmacology , :211 , 2012
Abstract :
PubMedSearch : Olincy_2012_Handb.Exp.Pharmacol__211
PubMedID: 23027417

Title : Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses - Miwa_2011_Neuron_70_20
Author(s) : Miwa JM , Freedman R , Lester HA
Ref : Neuron , 70 :20 , 2011
Abstract :
PubMedSearch : Miwa_2011_Neuron_70_20
PubMedID: 21482353

Title : Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia - Tregellas_2011_Biol.Psychiatry_69_7
Author(s) : Tregellas JR , Tanabe J , Rojas DC , Shatti S , Olincy A , Johnson L , Martin LF , Soti F , Kem WR , Leonard S , Freedman R
Ref : Biological Psychiatry , 69 :7 , 2011
Abstract :
PubMedSearch : Tregellas_2011_Biol.Psychiatry_69_7
PubMedID: 20728875

Title : Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia - Ross_2010_J.Child.Psychol.Psychiatry_51_535
Author(s) : Ross RG , Stevens KE , Proctor WR , Leonard S , Kisley MA , Hunter SK , Freedman R , Adams CE
Ref : J Child Psychol Psychiatry , 51 :535 , 2010
Abstract :
PubMedSearch : Ross_2010_J.Child.Psychol.Psychiatry_51_535
PubMedID: 19925602

Title : Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers - Mexal_2010_J.Mol.Neurosci_40_185
Author(s) : Mexal S , Berger R , Logel J , Ross RG , Freedman R , Leonard S
Ref : Journal of Molecular Neuroscience , 40 :185 , 2010
Abstract :
PubMedSearch : Mexal_2010_J.Mol.Neurosci_40_185
PubMedID: 19680823

Title : Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia - Tregellas_2010_Neuropsychopharmacology_35_938
Author(s) : Tregellas JR , Olincy A , Johnson L , Tanabe J , Shatti S , Martin LF , Singel D , Du YP , Soti F , Kem WR , Freedman R
Ref : Neuropsychopharmacology , 35 :938 , 2010
Abstract :
PubMedSearch : Tregellas_2010_Neuropsychopharmacology_35_938
PubMedID: 19956085

Title : Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia - Stephens_2009_Schizophr.Res_109_102
Author(s) : Stephens SH , Logel J , Barton A , Franks A , Schultz J , Short M , Dickenson J , James B , Fingerlin TE , Wagner B , Hodgkinson C , Graw S , Ross RG , Freedman R , Leonard S
Ref : Schizophr Res , 109 :102 , 2009
Abstract :
PubMedSearch : Stephens_2009_Schizophr.Res_109_102
PubMedID: 19181484

Title : A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia - Sinkus_2009_Brain.Res_1291_1
Author(s) : Sinkus ML , Lee MJ , Gault J , Logel J , Short M , Freedman R , Christian SL , Lyon J , Leonard S
Ref : Brain Research , 1291 :1 , 2009
Abstract :
PubMedSearch : Sinkus_2009_Brain.Res_1291_1
PubMedID: 19631623

Title : Initial phase 2 trial of a nicotinic agonist in schizophrenia - Freedman_2008_Am.J.Psychiatry_165_1040
Author(s) : Freedman R , Olincy A , Buchanan RW , Harris JG , Gold JM , Johnson L , Allensworth D , Guzman-Bonilla A , Clement B , Ball MP , Kutnick J , Pender V , Martin LF , Stevens KE , Wagner BD , Zerbe GO , Soti F , Kem WR
Ref : Am J Psychiatry , 165 :1040 , 2008
Abstract :
PubMedSearch : Freedman_2008_Am.J.Psychiatry_165_1040
PubMedID: 18381905

Title : Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type - Martin_2007_Am.J.Med.Genet.B.Neuropsychiatr.Genet_144B_611
Author(s) : Martin LF , Leonard S , Hall MH , Tregellas JR , Freedman R , Olincy A
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 144B :611 , 2007
Abstract :
PubMedSearch : Martin_2007_Am.J.Med.Genet.B.Neuropsychiatr.Genet_144B_611
PubMedID: 17192894

Title : Smoking, Genetics and Schizophrenia: Evidence for Self Medication - Leonard_2007_J.Dual.Diagn_3_43
Author(s) : Leonard S , Mexal S , Freedman R
Ref : J Dual Diagn , 3 :43 , 2007
Abstract :
PubMedSearch : Leonard_2007_J.Dual.Diagn_3_43
PubMedID: 19122786

Title : Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia - Olincy_2006_Arch.Gen.Psychiatry_63_630
Author(s) : Olincy A , Harris JG , Johnson LL , Pender V , Kongs S , Allensworth D , Ellis J , Zerbe GO , Leonard S , Stevens KE , Stevens JO , Martin L , Adler LE , Soti F , Kem WR , Freedman R
Ref : Arch Gen Psychiatry , 63 :630 , 2006
Abstract :
PubMedSearch : Olincy_2006_Arch.Gen.Psychiatry_63_630
PubMedID: 16754836

Title : Characterization of allelic variants at chromosome 15q14 in schizophrenia - Freedman_2006_Genes.Brain.Behav_5 Suppl 1_14
Author(s) : Freedman R , Leonard S , Waldo M , Gault J , Olincy A , Adler LE
Ref : Genes Brain Behav , 5 Suppl 1 :14 , 2006
Abstract :
PubMedSearch : Freedman_2006_Genes.Brain.Behav_5 Suppl 1_14
PubMedID: 16417613

Title : Early biomarkers of psychosis - Freedman_2005_Dialogues.Clin.Neurosci_7_17
Author(s) : Freedman R , Ross R , Leonard S , Myles-Worsley M , Adams CE , Waldo M , Tregellas J , Martin L , Olincy A , Tanabe J , Kisley MA , Hunter S , Stevens KE
Ref : Dialogues Clin Neurosci , 7 :17 , 2005
Abstract :
PubMedSearch : Freedman_2005_Dialogues.Clin.Neurosci_7_17
PubMedID: 16060593

Title : FMRI of response to nicotine during a smooth pursuit eye movement task in schizophrenia - Tregellas_2005_Am.J.Psychiatry_162_391
Author(s) : Tregellas JR , Tanabe JL , Martin LF , Freedman R
Ref : Am J Psychiatry , 162 :391 , 2005
Abstract :
PubMedSearch : Tregellas_2005_Am.J.Psychiatry_162_391
PubMedID: 15677609

Title : Effects of nicotine on cognitive deficits in schizophrenia - Harris_2004_Neuropsychopharmacology_29_1378
Author(s) : Harris JG , Kongs S , Allensworth D , Martin L , Tregellas J , Sullivan B , Zerbe G , Freedman R
Ref : Neuropsychopharmacology , 29 :1378 , 2004
Abstract :
PubMedSearch : Harris_2004_Neuropsychopharmacology_29_1378
PubMedID: 15138435

Title : Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects - Gault_2003_Am.J.Med.Genet.B.Neuropsychiatr.Genet_123B_39
Author(s) : Gault J , Hopkins J , Berger R , Drebing C , Logel J , Walton C , Short M , Vianzon R , Olincy A , Ross RG , Adler LE , Freedman R , Leonard S
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 123B :39 , 2003
Abstract :
PubMedSearch : Gault_2003_Am.J.Med.Genet.B.Neuropsychiatr.Genet_123B_39
PubMedID: 14582144

Title : The genetics of sensory gating deficits in schizophrenia - Freedman_2003_Curr.Psychiatry.Rep_5_155
Author(s) : Freedman R , Olincy A , Ross RG , Waldo MC , Stevens KE , Adler LE , Leonard S
Ref : Curr Psychiatry Rep , 5 :155 , 2003
Abstract :
PubMedSearch : Freedman_2003_Curr.Psychiatry.Rep_5_155
PubMedID: 12685995

Title : Recombination in a schizophrenic proband fails to exclude CHRNA7 at chromosome 15q14 -
Author(s) : Leonard S , Freedman R
Ref : Mol Psychiatry , 8 :145 , 2003
PubMedID: 12610645

Title : Input dysfunction, schizotypy, and genetic models of schizophrenia - Freedman_2002_Schizophr.Res_54_25
Author(s) : Freedman R , Adler LE , Olincy A , Waldo MC , Ross RG , Stevens KE , Leonard S
Ref : Schizophr Res , 54 :25 , 2002
Abstract :
PubMedSearch : Freedman_2002_Schizophr.Res_54_25
PubMedID: 11853975

Title : Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia - Leonard_2002_Arch.Gen.Psychiatry_59_1085
Author(s) : Leonard S , Gault J , Hopkins J , Logel J , Vianzon R , Short M , Drebing C , Berger R , Venn D , Sirota P , Zerbe G , Olincy A , Ross RG , Adler LE , Freedman R
Ref : Arch Gen Psychiatry , 59 :1085 , 2002
Abstract :
PubMedSearch : Leonard_2002_Arch.Gen.Psychiatry_59_1085
PubMedID: 12470124

Title : Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism - Adler_2001_Neuropsychopharmacology_24_671
Author(s) : Adler LE , Olincy A , Cawthra E , Hoffer M , Nagamoto HT , Amass L , Freedman R
Ref : Neuropsychopharmacology , 24 :671 , 2001
Abstract :
PubMedSearch : Adler_2001_Neuropsychopharmacology_24_671
PubMedID: 11331147

Title : Evidence for the multigenic inheritance of schizophrenia - Freedman_2001_Am.J.Med.Genet_105_794
Author(s) : Freedman R , Leonard S , Olincy A , Kaufmann CA , Malaspina D , Cloninger CR , Svrakic D , Faraone SV , Tsuang MT
Ref : American Journal of Medicine Genet , 105 :794 , 2001
Abstract :
PubMedSearch : Freedman_2001_Am.J.Med.Genet_105_794
PubMedID: 11803533

Title : Smoking and mental illness - Leonard_2001_Pharmacol.Biochem.Behav_70_561
Author(s) : Leonard S , Adler LE , Benhammou K , Berger R , Breese CR , Drebing C , Gault J , Lee MJ , Logel J , Olincy A , Ross RG , Stevens K , Sullivan B , Vianzon R , Virnich DE , Waldo M , Walton K , Freedman R
Ref : Pharmacol Biochem Behav , 70 :561 , 2001
Abstract :
PubMedSearch : Leonard_2001_Pharmacol.Biochem.Behav_70_561
PubMedID: 11796154

Title : Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7) - Freedman_2001_Am.J.Med.Genet_105_20
Author(s) : Freedman R , Leonard S , Gault JM , Hopkins J , Cloninger CR , Kaufmann CA , Tsuang MT , Farone SV , Malaspina D , Svrakic DM , Sanders A , Gejman P
Ref : American Journal of Medicine Genet , 105 :20 , 2001
Abstract :
PubMedSearch : Freedman_2001_Am.J.Med.Genet_105_20
PubMedID: 11424985

Title : Familial transmission of risk factors in the first-degree relatives of schizophrenic people - Waldo_2000_Biol.Psychiatry_47_231
Author(s) : Waldo MC , Adler LE , Leonard S , Olincy A , Ross RG , Harris JG , Freedman R
Ref : Biological Psychiatry , 47 :231 , 2000
Abstract :
PubMedSearch : Waldo_2000_Biol.Psychiatry_47_231
PubMedID: 10682220

Title : Smoking and schizophrenia: abnormal nicotinic receptor expression - Leonard_2000_Eur.J.Pharmacol_393_237
Author(s) : Leonard S , Breese C , Adams C , Benhammou K , Gault J , Stevens K , Lee M , Adler L , Olincy A , Ross R , Freedman R
Ref : European Journal of Pharmacology , 393 :237 , 2000
Abstract :
PubMedSearch : Leonard_2000_Eur.J.Pharmacol_393_237
PubMedID: 10771019

Title : Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia - Freedman_2000_Am.J.Med.Genet_97_58
Author(s) : Freedman R , Adams CE , Adler LE , Bickford PC , Gault J , Harris JG , Nagamoto HT , Olincy A , Ross RG , Stevens KE , Waldo M , Leonard S
Ref : American Journal of Medicine Genet , 97 :58 , 2000
Abstract :
PubMedSearch : Freedman_2000_Am.J.Med.Genet_97_58
PubMedID: 10813805

Title : The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia - Freedman_2000_J.Chem.Neuroanat_20_299
Author(s) : Freedman R , Adams CE , Leonard S
Ref : Journal of Chemical Neuroanatomy , 20 :299 , 2000
Abstract :
PubMedSearch : Freedman_2000_J.Chem.Neuroanat_20_299
PubMedID: 11207427

Title : Elementary phenotypes in the neurobiological and genetic study of schizophrenia - Adler_1999_Biol.Psychiatry_46_8
Author(s) : Adler LE , Freedman R , Ross RG , Olincy A , Waldo MC
Ref : Biological Psychiatry , 46 :8 , 1999
Abstract :
PubMedSearch : Adler_1999_Biol.Psychiatry_46_8
PubMedID: 10394470

Title : Decreased bombesin peptide response to cigarette smoking in schizophrenia - Olincy_1999_Neuropsychopharmacology_20_52
Author(s) : Olincy A , Leonard S , Young DA , Sullivan B , Freedman R
Ref : Neuropsychopharmacology , 20 :52 , 1999
Abstract :
PubMedSearch : Olincy_1999_Neuropsychopharmacology_20_52
PubMedID: 9885785

Title : Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) - Gault_1998_Genomics_52_173
Author(s) : Gault J , Robinson M , Berger R , Drebing C , Logel J , Hopkins J , Moore T , Jacobs S , Meriwether J , Choi MJ , Kim EJ , Walton K , Buiting K , Davis A , Breese C , Freedman R , Leonard S
Ref : Genomics , 52 :173 , 1998
Abstract :
PubMedSearch : Gault_1998_Genomics_52_173
PubMedID: 9782083

Title : Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative - Leonard_1998_Am.J.Med.Genet_81_308
Author(s) : Leonard S , Gault J , Moore T , Hopkins J , Robinson M , Olincy A , Adler LE , Cloninger CR , Kaufmann CA , Tsuang MT , Faraone SV , Malaspina D , Svrakic DM , Freedman R
Ref : American Journal of Medicine Genet , 81 :308 , 1998
Abstract :
PubMedSearch : Leonard_1998_Am.J.Med.Genet_81_308
PubMedID: 9674976

Title : Schizophrenia, sensory gating, and nicotinic receptors - Adler_1998_Schizophr.Bull_24_189
Author(s) : Adler LE , Olincy A , Waldo M , Harris JG , Griffith J , Stevens K , Flach K , Nagamoto H , Bickford P , Leonard S , Freedman R
Ref : Schizophr Bull , 24 :189 , 1998
Abstract :
PubMedSearch : Adler_1998_Schizophr.Bull_24_189
PubMedID: 9613620

Title : Nicotinic receptors, smoking and schizophrenia - Leonard_1998_Restor.Neurol.Neurosci_12_195
Author(s) : Leonard S , Gault J , Adams C , Breese CR , Rollins Y , Adler LE , Olincy A , Freedman R
Ref : Restor Neurol Neurosci , 12 :195 , 1998
Abstract :
PubMedSearch : Leonard_1998_Restor.Neurol.Neurosci_12_195
PubMedID: 12671315

Title : Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells - Frazier_1998_J.Neurosci_18_1187
Author(s) : Frazier CJ , Rollins YD , Breese CR , Leonard S , Freedman R , Dunwiddie TV
Ref : Journal of Neuroscience , 18 :1187 , 1998
Abstract :
PubMedSearch : Frazier_1998_J.Neurosci_18_1187
PubMedID: 9454829

Title : Improvement in smooth pursuit eye movements after cigarette smoking in schizophrenic patients - Olincy_1998_Neuropsychopharmacology_18_175
Author(s) : Olincy A , Ross RG , Young DA , Roath M , Freedman R
Ref : Neuropsychopharmacology , 18 :175 , 1998
Abstract :
PubMedSearch : Olincy_1998_Neuropsychopharmacology_18_175
PubMedID: 9471115

Title : Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain - Breese_1997_J.Comp.Neurol_387_385
Author(s) : Breese CR , Adams C , Logel J , Drebing C , Rollins Y , Barnhart M , Sullivan B , Demasters BK , Freedman R , Leonard S
Ref : Journal of Comparative Neurology , 387 :385 , 1997
Abstract :
PubMedSearch : Breese_1997_J.Comp.Neurol_387_385
PubMedID: 9335422

Title : Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus - Freedman_1997_Proc.Natl.Acad.Sci.U.S.A_94_587
Author(s) : Freedman R , Coon H , Myles-Worsley M , Orr-Urtreger A , Olincy A , Davis A , Polymeropoulos M , Holik J , Hopkins J , Hoff M , Rosenthal J , Waldo MC , Reimherr F , Wender P , Yaw J , Young DA , Breese CR , Adams C , Patterson D , Adler LE , Kruglyak L , Leonard S , Byerley W
Ref : Proc Natl Acad Sci U S A , 94 :587 , 1997
Abstract :
PubMedSearch : Freedman_1997_Proc.Natl.Acad.Sci.U.S.A_94_587
PubMedID: 9012828

Title : Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers - Olincy_1997_Biol.Psychiatry_42_1
Author(s) : Olincy A , Young DA , Freedman R
Ref : Biological Psychiatry , 42 :1 , 1997
Abstract :
PubMedSearch : Olincy_1997_Biol.Psychiatry_42_1
PubMedID: 9193735

Title : Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains - Stevens_1996_Neuropsychopharmacology_15_152
Author(s) : Stevens KE , Freedman R , Collins AC , Hall M , Leonard S , Marks MJ , Rose GM
Ref : Neuropsychopharmacology , 15 :152 , 1996
Abstract :
PubMedSearch : Stevens_1996_Neuropsychopharmacology_15_152
PubMedID: 8840351

Title : Nicotinic receptor function in schizophrenia - Leonard_1996_Schizophr.Bull_22_431
Author(s) : Leonard S , Adams C , Breese CR , Adler LE , Bickford P , Byerley W , Coon H , Griffith JM , Miller C , Myles-Worsley M , Nagamoto HT , Rollins Y , Stevens KE , Waldo M , Freedman R
Ref : Schizophr Bull , 22 :431 , 1996
Abstract :
PubMedSearch : Leonard_1996_Schizophr.Bull_22_431
PubMedID: 8873294

Title : Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia - Freedman_1995_Biol.Psychiatry_38_22
Author(s) : Freedman R , Hall M , Adler LE , Leonard S
Ref : Biological Psychiatry , 38 :22 , 1995
Abstract :
PubMedSearch : Freedman_1995_Biol.Psychiatry_38_22
PubMedID: 7548469

Title : Schizophrenia and nicotinic receptors - Freedman_1994_Harv.Rev.Psychiatry_2_179
Author(s) : Freedman R , Adler LE , Bickford P , Byerley W , Coon H , Cullum CM , Griffith JM , Harris JG , Leonard S , Miller C , Myles-Worsley M , Nagamoto HT , Rose G , Waldo M
Ref : Harvard Review of Psychiatry , 2 :179 , 1994
Abstract :
PubMedSearch : Freedman_1994_Harv.Rev.Psychiatry_2_179
PubMedID: 9384901

Title : Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression - Freedman_1993_J.Neurosci_13_1965
Author(s) : Freedman R , Wetmore C , Stromberg I , Leonard S , Olson L
Ref : Journal of Neuroscience , 13 :1965 , 1993
Abstract :
PubMedSearch : Freedman_1993_J.Neurosci_13_1965
PubMedID: 8478687