| Title : Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease - Hirano_2018_J.Alzheimers.Dis_62_1539 |
| Author(s) : Hirano S , Shinotoh H , Shimada H , Ota T , Sato K , Tanaka N , Zhang MR , Higuchi M , Fukushi K , Irie T , Kuwabara S , Suhara T |
| Ref : J Alzheimers Dis , 62 :1539 , 2018 |
| Abstract : |
| PubMedSearch : Hirano_2018_J.Alzheimers.Dis_62_1539 |
| PubMedID: 29562505 |
| Title : Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [(11) C]MP4A PET study - Shimada_2015_Int.J.Geriatr.Psychiatry_30_1105 |
| Author(s) : Shimada H , Hirano S , Sinotoh H , Ota T , Tanaka N , Sato K , Yamada M , Fukushi K , Irie T , Zhang MR , Higuchi M , Kuwabara S , Suhara T |
| Ref : Int J Geriatr Psychiatry , 30 :1105 , 2015 |
| Abstract : |
| PubMedSearch : Shimada_2015_Int.J.Geriatr.Psychiatry_30_1105 |
| PubMedID: 26280153 |
| Title : PET probes for imaging brain acetylcholinesterase - Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
| Author(s) : Kikuchi T , Okamura T , Zhang MR , Irie T |
| Ref : J Labelled Comp Radiopharm , 56 :172 , 2013 |
| Abstract : |
| PubMedSearch : Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
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| Title : A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluations - Ohya_2012_Nucl.Med.Commun_33_1019 |
| Author(s) : Ohya T , Zhang MR , Fukumura T , Fukushi K , Kikuchi T , Irie T |
| Ref : Nucl Med Commun , 33 :1019 , 2012 |
| Abstract : |
| PubMedSearch : Ohya_2012_Nucl.Med.Commun_33_1019 |
| PubMedID: 22850605 |
| Title : Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers - Ohya_2011_Neuroimage_56_1105 |
| Author(s) : Ohya T , Okamura T , Nagai Y , Fukushi K , Irie T , Suhara T , Zhang MR , Fukumura T , Kikuchi T |
| Ref : Neuroimage , 56 :1105 , 2011 |
| Abstract : |
| PubMedSearch : Ohya_2011_Neuroimage_56_1105 |
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| Title : Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders - Suzuki_2011_Arch.Gen.Psychiatry_68_306 |
| Author(s) : Suzuki K , Sugihara G , Ouchi Y , Nakamura K , Tsujii M , Futatsubashi M , Iwata Y , Tsuchiya KJ , Matsumoto K , Takebayashi K , Wakuda T , Yoshihara Y , Suda S , Kikuchi M , Takei N , Sugiyama T , Irie T , Mori N |
| Ref : Arch Gen Psychiatry , 68 :306 , 2011 |
| Abstract : |
| PubMedSearch : Suzuki_2011_Arch.Gen.Psychiatry_68_306 |
| PubMedID: 21383265 |
| Title : Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography - Ota_2010_Clin.Neuropharmacol_33_74 |
| Author(s) : Ota T , Shinotoh H , Fukushi K , Kikuchi T , Sato K , Tanaka N , Shimada H , Hirano S , Miyoshi M , Arai H , Suhara T , Irie T |
| Ref : Clinical Neuropharmacology , 33 :74 , 2010 |
| Abstract : |
| PubMedSearch : Ota_2010_Clin.Neuropharmacol_33_74 |
| PubMedID: 19935404 |
| Title : In vivo evaluation of N-[18F]fluoroethylpiperidin-4ylmethyl acetate in rats compared with MP4A as a probe for measuring cerebral acetylcholinesterase activity - Kikuchi_2010_Synapse_64_209 |
| Author(s) : Kikuchi T , Okamura T , Zhang MR , Fukushi K , Irie T |
| Ref : Synapse , 64 :209 , 2010 |
| Abstract : |
| PubMedSearch : Kikuchi_2010_Synapse_64_209 |
| PubMedID: 19862687 |
| Title : In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study - Miyoshi_2010_Parkinsonism.Relat.Disord_16_404 |
| Author(s) : Miyoshi M , Shinotoh H , Wszolek ZK , Strongosky AJ , Shimada H , Arakawa R , Higuchi M , Ikoma Y , Yasuno F , Fukushi K , Irie T , Ito H , Suhara T |
| Ref : Parkinsonism Relat Disord , 16 :404 , 2010 |
| Abstract : |
| PubMedSearch : Miyoshi_2010_Parkinsonism.Relat.Disord_16_404 |
| PubMedID: 20452812 |
| Title : Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples - Kikuchi_2010_Br.J.Pharmacol_159_1732 |
| Author(s) : Kikuchi T , Okamura T , Arai T , Obata T , Fukushi K , Irie T , Shiraishi T |
| Ref : British Journal of Pharmacology , 159 :1732 , 2010 |
| Abstract : |
| PubMedSearch : Kikuchi_2010_Br.J.Pharmacol_159_1732 |
| PubMedID: 20401964 |
| Title : Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay - Kikuchi_2010_Biol.Pharm.Bull_33_702 |
| Author(s) : Kikuchi T , Okamura T , Fukushi K , Irie T |
| Ref : Biol Pharm Bull , 33 :702 , 2010 |
| Abstract : |
| PubMedSearch : Kikuchi_2010_Biol.Pharm.Bull_33_702 |
| PubMedID: 20410609 |
| Title : Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia - Hirano_2010_Brain_133_2058 |
| Author(s) : Hirano S , Shinotoh H , Shimada H , Aotsuka A , Tanaka N , Ota T , Sato K , Ito H , Kuwabara S , Fukushi K , Irie T , Suhara T |
| Ref : Brain , 133 :2058 , 2010 |
| Abstract : |
| PubMedSearch : Hirano_2010_Brain_133_2058 |
| PubMedID: 20558417 |
| Title : Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET - Shimada_2009_Neurology_73_273 |
| Author(s) : Shimada H , Hirano S , Shinotoh H , Aotsuka A , Sato K , Tanaka N , Ota T , Asahina M , Fukushi K , Kuwabara S , Hattori T , Suhara T , Irie T |
| Ref : Neurology , 73 :273 , 2009 |
| Abstract : |
| PubMedSearch : Shimada_2009_Neurology_73_273 |
| PubMedID: 19474411 |
| Title : PET study of brain acetylcholinesterase in cerebellar degenerative disorders - Hirano_2008_Mov.Disord_23_1154 |
| Author(s) : Hirano S , Shinotoh H , Arai K , Aotsuka A , Yasuno F , Tanaka N , Ota T , Sato K , Fukushi K , Tanada S , Hattori T , Irie T |
| Ref : Movement Disorder , 23 :1154 , 2008 |
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| PubMedSearch : Hirano_2008_Mov.Disord_23_1154 |
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| Title : Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy - Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| Author(s) : Utsuki T , Uchimura N , Irikura M , Moriuchi H , Holloway HW , Yu QS , Spangler EL , Mamczarz J , Ingram DK , Irie T , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 321 :353 , 2007 |
| Abstract : |
| PubMedSearch : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedID: 17255466 |
| Title : Cerebral acetylcholinesterase imaging: development of the radioprobes - Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| Author(s) : Kikuchi T , Okamura T , Fukushi K , Takahashi K , Toyohara J , Okada M , Zhang MR , Irie T |
| Ref : Curr Top Med Chem , 7 :1790 , 2007 |
| Abstract : |
| PubMedSearch : Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| PubMedID: 17979787 |
| Title : Brain acetylcholinesterase activity in FTDP-17 studied by PET - |
| Author(s) : Hirano S , Shinotoh H , Kobayashi T , Tsuboi Y , Wszolek ZK , Aotsuka A , Tanaka N , Ota T , Fukushi K , Tanada S , Irie T |
| Ref : Neurology , 66 :1276 , 2006 |
| PubMedID: 16636254 |
| Title : N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity - Kikuchi_2005_J.Med.Chem_48_2577 |
| Author(s) : Kikuchi T , Zhang MR , Ikota N , Fukushi K , Okamura T , Suzuki K , Arano Y , Irie T |
| Ref : Journal of Medicinal Chemistry , 48 :2577 , 2005 |
| Abstract : |
| PubMedSearch : Kikuchi_2005_J.Med.Chem_48_2577 |
| PubMedID: 15801847 |
| Title : Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET - Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| Author(s) : Shiraishi T , Kikuchi T , Fukushi K , Shinotoh H , Nagatsuka S , Tanaka N , Ota T , Sato K , Hirano S , Tanada S , Iyo M , Irie T |
| Ref : Neuropsychopharmacology , 30 :2154 , 2005 |
| Abstract : |
| PubMedSearch : Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| PubMedID: 15920507 |
| Title : A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT - Ota_2004_Ann.Nucl.Med_18_187 |
| Author(s) : Ota T , Shinotoh H , Fukushi K , Nagatsuka S , Namba H , Iyo M , Aotsuka A , Tanaka N , Sato K , Shiraishi T , Tanada S , Arai H , Irie T |
| Ref : Ann Nucl Med , 18 :187 , 2004 |
| Abstract : |
| PubMedSearch : Ota_2004_Ann.Nucl.Med_18_187 |
| PubMedID: 15233279 |
| Title : N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography - Kikuchi_2004_Bioorg.Med.Chem.Lett_14_1927 |
| Author(s) : Kikuchi T , Zhang MR , Ikota N , Fukushi K , Okamura T , Suzuki K , Arano Y , Irie T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1927 , 2004 |
| Abstract : |
| PubMedSearch : Kikuchi_2004_Bioorg.Med.Chem.Lett_14_1927 |
| PubMedID: 15050629 |
| Title : Acetylcholinesterase imaging: its use in therapy evaluation and drug design - Shinotoh_2004_Curr.Pharm.Des_10_1505 |
| Author(s) : Shinotoh H , Fukushi K , Nagatsuka S , Irie T |
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| PubMedSearch : Shinotoh_2004_Curr.Pharm.Des_10_1505 |
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| Title : Evaluation of simplified kinetic analyses for measurement of brain acetylcholinesterase activity using N-[11C]Methylpiperidin-4-yl propionate and positron emission tomography - Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
| Author(s) : Sato K , Fukushi K , Shinotoh H , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Shiraishi T , Tanada S , Iyo M , Irie T |
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| Abstract : |
| PubMedSearch : Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
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| Title : N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo - Zhang_2003_Bioorg.Med.Chem_11_2519 |
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| PubMedSearch : Zhang_2003_Bioorg.Med.Chem_11_2519 |
| PubMedID: 12757720 |
| Title : The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system - Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
| Author(s) : Shinotoh H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Namba H , Tanada S , Irie T |
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| PubMedSearch : Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
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| Title : Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates - Namba_2002_Methods_27_242 |
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| Title : Synthesis and preliminary evaluation of [18F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo - Zhang_2002_Nucl.Med.Biol_29_463 |
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| Title : Involvement of calmodulin inhibition in analgesia induced with low doses of intrathecal trifluoperazine - Golbidi_2002_Jpn.J.Pharmacol_88_151 |
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| PubMedSearch : Golbidi_2002_Jpn.J.Pharmacol_88_151 |
| PubMedID: 11928715 |
| Title : Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET - Shinotoh_2001_Neurology_56_408 |
| Author(s) : Shinotoh H , Aotsuka A , Fukushi K , Nagatsuka S , Tanaka N , Ota T , Tanada S , Irie T |
| Ref : Neurology , 56 :408 , 2001 |
| Abstract : |
| PubMedSearch : Shinotoh_2001_Neurology_56_408 |
| PubMedID: 11171913 |
| Title : Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease - Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
| Author(s) : Tanaka N , Fukushi K , Shinotoh H , Nagatsuka S , Namba H , Iyo M , Aotsuka A , Ota T , Tanada S , Irie T |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 21 :295 , 2001 |
| Abstract : |
| PubMedSearch : Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
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| Title : Kinetic analysis of [(11)C]MP4A using a high-radioactivity brain region that represents an integrated input function for measurement of cerebral acetylcholinesterase activity without arterial blood sampling - Nagatsuka_2001_J.Cereb.Blood.Flow.Metab_21_1354 |
| Author(s) : Nagatsuka Si S , Fukushi K , Shinotoh H , Namba H , Iyo M , Tanaka N , Aotsuka A , Ota T , Tanada S , Irie T |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 21 :1354 , 2001 |
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| PubMedSearch : Nagatsuka_2001_J.Cereb.Blood.Flow.Metab_21_1354 |
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| Title : Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study - Shinotoh_2000_Ann.Neurol_48_194 |
| Author(s) : Shinotoh H , Namba H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Tanada S , Irie T |
| Ref : Annals of Neurology , 48 :194 , 2000 |
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| PubMedSearch : Shinotoh_2000_Ann.Neurol_48_194 |
| PubMedID: 10939570 |
| Title : Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography - Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
| Author(s) : Shinotoh H , Namba H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Tanada S , Irie T |
| Ref : Alzheimer Disease & Associated Disorders , 14 Suppl 1 :S114 , 2000 |
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| PubMedSearch : Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
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| Title : Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age - Namba_1999_Eur.J.Nucl.Med_26_135 |
| Author(s) : Namba H , Iyo M , Fukushi K , Shinotoh H , Nagatsuka S , Suhara T , Sudo Y , Suzuki K , Irie T |
| Ref : Eur J Nucl Med , 26 :135 , 1999 |
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| PubMedSearch : Namba_1999_Eur.J.Nucl.Med_26_135 |
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| Title : Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy - Shinotoh_1999_Ann.Neurol_46_62 |
| Author(s) : Shinotoh H , Namba H , Yamaguchi M , Fukushi K , Nagatsuka S , Iyo M , Asahina M , Hattori T , Tanada S , Irie T |
| Ref : Annals of Neurology , 46 :62 , 1999 |
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| PubMedSearch : Shinotoh_1999_Ann.Neurol_46_62 |
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| Title : Preserved acetylcholinesterase activity in aged cerebral cortex [letter] - |
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| Title : Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease - Iyo_1997_Lancet_349_1805 |
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| Author(s) : Irie T , Fukushi K , Akimoto Y , Tamagami H , Nozaki T |
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| Title : In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog - Namba_1994_Brain.Res_667_278 |
| Author(s) : Namba H , Irie T , Fukushi K , Iyo M |
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| Title : Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice - Okazaki_1990_Jpn.J.Pharmacol_53_211 |
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