Karakousis PC

Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311

Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE

Ref : Eur J Med Chem Rep , 15 :100311 , 2025

Abstract :

PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311

PubMedID:

Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249

Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC

Ref : Cell , 170 :249 , 2017

Abstract :

PubMedSearch : Aggarwal_2017_Cell_170_249

PubMedID: 28669536

Gene_locus related to this paper: myctu-PKS13

Karakousis PC

References (2)

1. Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311

2. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249