Khurana JP

References (15)

Title : Draft Genome Sequence of Sphingobium sp. Strain HDIPO4, an Avid Degrader of Hexachlorocyclohexane - Mukherjee_2013_Genome.Announc_1_e00749
Author(s) : Mukherjee U , Kumar R , Mahato NK , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Sphingobium sp. strain HDIPO4 was isolated from a hexachlorocyclohexane (HCH) dumpsite and degraded HCH isomers rapidly. The draft genome sequence of HDIPO4 (~4.7 Mbp) contains 143 contigs and 4,646 coding sequences with a G+C content of 65%.
ESTHER : Mukherjee_2013_Genome.Announc_1_e00749
PubMedSearch : Mukherjee_2013_Genome.Announc_1_e00749
PubMedID: 24051321
Gene_locus related to this paper: sphju-d4z7y1 , sphju-d4z363 , sphpi-linb

Title : Draft Genome Sequence of Sphingobium chinhatense Strain IP26T, Isolated from a Hexachlorocyclohexane Dumpsite - Niharika_2013_Genome.Announc_1_e00680
Author(s) : Niharika N , Sangwan N , Ahmad S , Singh P , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Sphingobium chinhatense strain IP26(T) is a conducive hexachlorocyclohexane (HCH) degrader isolated from a heavily contaminated (450 mg HCH/g soil) HCH dumpsite. IP26(T) degrades alpha-, beta-, gamma-, and delta-HCH, which are highly persistent in the environment. Here we report the draft genome sequence (~5.8 Mbp) of this strain.
ESTHER : Niharika_2013_Genome.Announc_1_e00680
PubMedSearch : Niharika_2013_Genome.Announc_1_e00680
PubMedID: 23990581
Gene_locus related to this paper: sphju-d4z7y1 , sphju-d4z363

Title : Genome Sequence of Novosphingobium lindaniclasticum LE124T, Isolated from a Hexachlorocyclohexane Dumpsite - Saxena_2013_Genome.Announc_1_e00715
Author(s) : Saxena A , Nayyar N , Sangwan N , Kumari R , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Novosphingobium lindaniclasticum LE124(T) is a hexachlorocyclohexane (HCH)-degrading bacterium isolated from a high-dosage-point HCH dumpsite (450 mg HCH/g soil) located in Lucknow, India (27 degrees 00'N and 81 degrees 09'E). Here, we present the annotated draft genome sequence of strain LE124(T), which has an estimated size of 4.86 Mb and is comprised of 4,566 coding sequences.
ESTHER : Saxena_2013_Genome.Announc_1_e00715
PubMedSearch : Saxena_2013_Genome.Announc_1_e00715
PubMedID: 24029761
Gene_locus related to this paper: 9sphn-t0hqb1 , 9sphn-t0hmn5 , 9sphn-t0iya6 , 9sphn-t0gy64 , 9sphn-t0hhu1 , 9sphn-t0i5p8 , 9sphn-t0hp61

Title : Draft Genome Sequence of Sphingobium lactosutens Strain DS20T, Isolated from a Hexachlorocyclohexane Dumpsite - Kumar_2013_Genome.Announc_1_e00753
Author(s) : Kumar R , Dwivedi V , Negi V , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Sphingobium lactosutens DS20(T) has been isolated from the hexachlorocyclohexane (HCH) dumpsite in Lucknow, India, but does not degrade any of the HCH isomers. Here, we present the ~5.36-Mb draft genome sequence of strain DS20(T), which consists of 110 contigs and 5,288 coding sequences, with a G+C content of 63.1%.
ESTHER : Kumar_2013_Genome.Announc_1_e00753
PubMedSearch : Kumar_2013_Genome.Announc_1_e00753
PubMedID: 24051323
Gene_locus related to this paper: 9sphn-q1n750 , 9sphn-t0hf11 , 9sphn-t0him9 , 9sphn-t0i493

Title : Draft Genome Sequence of Sphingobium ummariense Strain RL-3, a Hexachlorocyclohexane-Degrading Bacterium - Kohli_2013_Genome.Announc_1_e00956
Author(s) : Kohli P , Dua A , Sangwan N , Oldach P , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Here, we report the draft genome sequence of the hexachlorocyclohexane (HCH)-degrading bacterium Sphingobium ummariense strain RL-3, which was isolated from the HCH dumpsite located in Lucknow, India (27 degrees 00'N and 81 degrees 09'E). The annotated draft genome sequence (4.75 Mb) of strain RL-3 consisted of 139 contigs, 4,645 coding sequences, and 65% G+C content.
ESTHER : Kohli_2013_Genome.Announc_1_e00956
PubMedSearch : Kohli_2013_Genome.Announc_1_e00956
PubMedID: 24233594
Gene_locus related to this paper: sphpi-linb , 9sphn-t0kby4 , 9sphn-t0kfu7 , sphpi-a0a197bwy5 , 9sphn-t0jaw2

Title : Draft Genome Sequence of a Hexachlorocyclohexane-Degrading Bacterium, Sphingobium baderi Strain LL03T - Kaur_2013_Genome.Announc_1_e00751
Author(s) : Kaur J , Verma H , Tripathi C , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Sphingobium baderi strain LL03(T) was isolated from hexachlorocyclohexane (HCH)-contaminated soil from Spolana, Czech Republic. Strain LL03(T) is a mutant that is deficient in linB and linC (genes that encode hexachlorocyclohexane haloalkane dehalogenase and dehydrogenase, respectively). The draft genome sequence of LL03(T) (~4.85 Mb) consists of 92 contigs and 4,914 coding sequences, with a G+C content of 63.5%.
ESTHER : Kaur_2013_Genome.Announc_1_e00751
PubMedSearch : Kaur_2013_Genome.Announc_1_e00751
PubMedID: 24051322
Gene_locus related to this paper: 9sphn-t0g9p6 , 9sphn-t0g1r2

Title : Draft Genome Sequence of Sphingobium quisquiliarum Strain P25T, a Novel Hexachlorocyclohexane (HCH)-Degrading Bacterium Isolated from an HCH Dumpsite - Kumar_2013_Genome.Announc_1_e00717
Author(s) : Kumar Singh A , Sangwan N , Sharma A , Gupta V , Khurana JP , Lal R
Ref : Genome Announc , 1 : , 2013
Abstract : Here, we report the draft genome sequence (4.2 Mb) of Sphingobium quisquiliarum strain P25(T), a natural lin (genes involved in degradation of hexachlorocyclohexane [HCH] isomers) variant genotype, isolated from a heavily contaminated (450 mg HCH/g of soil) HCH dumpsite.
ESTHER : Kumar_2013_Genome.Announc_1_e00717
PubMedSearch : Kumar_2013_Genome.Announc_1_e00717
PubMedID: 24029763
Gene_locus related to this paper: 9sphn-t0gfp3 , 9sphn-t0gjp1 , 9sphn-t0iek2

Title : Genome sequence of Sphingobium indicum B90A, a hexachlorocyclohexane-degrading bacterium - Anand_2012_J.Bacteriol_194_4471
Author(s) : Anand S , Sangwan N , Lata P , Kaur J , Dua A , Singh AK , Verma M , Khurana JP , Khurana P , Mathur S , Lal R
Ref : Journal of Bacteriology , 194 :4471 , 2012
Abstract : Sphingobium indicum B90A, an efficient degrader of hexachlorocyclohexane (HCH) isomers, was isolated in 1990 from sugarcane rhizosphere soil in Cuttack, India. Here we report the draft genome sequence of this bacterium, which has now become a model system for understanding the genetics, biochemistry, and physiology of HCH degradation.
ESTHER : Anand_2012_J.Bacteriol_194_4471
PubMedSearch : Anand_2012_J.Bacteriol_194_4471
PubMedID: 22843598
Gene_locus related to this paper: sphju-d4z363 , sphpi-linb

Title : Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution - Saini_2012_Nucleic.Acids.Res_40_10832
Author(s) : Saini V , Raghuvanshi S , Khurana JP , Ahmed N , Hasnain SE , Tyagi AK
Ref : Nucleic Acids Research , 40 :10832 , 2012
Abstract : Understanding the evolutionary and genomic mechanisms responsible for turning the soil-derived saprophytic mycobacteria into lethal intracellular pathogens is a critical step towards the development of strategies for the control of mycobacterial diseases. In this context, Mycobacterium indicus pranii (MIP) is of specific interest because of its unique immunological and evolutionary significance. Evolutionarily, it is the progenitor of opportunistic pathogens belonging to M. avium complex and is endowed with features that place it between saprophytic and pathogenic species. Herein, we have sequenced the complete MIP genome to understand its unique life style, basis of immunomodulation and habitat diversification in mycobacteria. As a case of massive gene acquisitions, 50.5% of MIP open reading frames (ORFs) are laterally acquired. We show, for the first time for Mycobacterium, that MIP genome has mosaic architecture. These gene acquisitions have led to the enrichment of selected gene families critical to MIP physiology. Comparative genomic analysis indicates a higher antigenic potential of MIP imparting it a unique ability for immunomodulation. Besides, it also suggests an important role of genomic fluidity in habitat diversification within mycobacteria and provides a unique view of evolutionary divergence and putative bottlenecks that might have eventually led to intracellular survival and pathogenic attributes in mycobacteria.
ESTHER : Saini_2012_Nucleic.Acids.Res_40_10832
PubMedSearch : Saini_2012_Nucleic.Acids.Res_40_10832
PubMedID: 22965120
Gene_locus related to this paper: mycia-h8ivh5 , 9myco-j9waw2 , mycia-h8iug5 , 9myco-i2acb5

Title : Genome sequence of Acinetobacter sp. strain HA, isolated from the gut of the polyphagous insect pest Helicoverpa armigera - Malhotra_2012_J.Bacteriol_194_5156
Author(s) : Malhotra J , Dua A , Saxena A , Sangwan N , Mukherjee U , Pandey N , Rajagopal R , Khurana P , Khurana JP , Lal R
Ref : Journal of Bacteriology , 194 :5156 , 2012
Abstract : In this study, Acinetobacter sp. strain HA was isolated from the midgut of a fifth-instar larva of Helicoverpa armigera. Here, we report the draft genome sequence (3,125,085 bp) of this strain that consists of 102 contigs, 2,911 predicted coding sequences, and a G+C content of 41%.
ESTHER : Malhotra_2012_J.Bacteriol_194_5156
PubMedSearch : Malhotra_2012_J.Bacteriol_194_5156
PubMedID: 22933775
Gene_locus related to this paper: 9gamm-i4zrl8 , 9gamm-i4zpd5

Title : Draft genome sequence of Thermus sp. strain RL, isolated from a hot water spring located atop the Himalayan ranges at Manikaran, India - Dwivedi_2012_J.Bacteriol_194_3534
Author(s) : Dwivedi V , Sangwan N , Nigam A , Garg N , Niharika N , Khurana P , Khurana JP , Lal R
Ref : Journal of Bacteriology , 194 :3534 , 2012
Abstract : Thermus sp. strain RL was isolated from a hot water spring (90 degreesC to 98 degreesC) at Manikaran, Himachal Pradesh, India. Here we report the draft genome sequence (20,36,600 bp) of this strain. The draft genome sequence consists of 17 contigs and 1,986 protein-coding sequences and has an average G+C content of 68.77%.
ESTHER : Dwivedi_2012_J.Bacteriol_194_3534
PubMedSearch : Dwivedi_2012_J.Bacteriol_194_3534
PubMedID: 22689228
Gene_locus related to this paper: 9dein-h7ghr8

Title : Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699 - Verma_2011_J.Bacteriol_193_5562
Author(s) : Verma M , Kaur J , Kumar M , Kumari K , Saxena A , Anand S , Nigam A , Ravi V , Raghuvanshi S , Khurana P , Tyagi AK , Khurana JP , Lal R
Ref : Journal of Bacteriology , 193 :5562 , 2011
Abstract : Amycolatopsis mediterranei S699 is an actinomycete that produces an important antibiotic, rifamycin B. Semisynthetic derivatives of rifamycin B are used for the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections. Here, we report the complete genome sequence (10.2 Mb) of A. mediterranei S699, with 9,575 predicted coding sequences.
ESTHER : Verma_2011_J.Bacteriol_193_5562
PubMedSearch : Verma_2011_J.Bacteriol_193_5562
PubMedID: 21914879
Gene_locus related to this paper: amymu-d8hka5 , amymu-d8hpp2 , amymu-d8hu68 , amymu-d8hy73 , amymu-d8i2j5 , amymu-d8i8i8 , amyms-g0fkj6 , amyms-g0g7f0 , amyms-g0fps5

Title : The Rice Annotation Project Database (RAP-DB): 2008 update - Tanaka_2008_Nucleic.Acids.Res_36_D1028
Author(s) : Tanaka T , Antonio BA , Kikuchi S , Matsumoto T , Nagamura Y , Numa H , Sakai H , Wu J , Itoh T , Sasaki T , Aono R , Fujii Y , Habara T , Harada E , Kanno M , Kawahara Y , Kawashima H , Kubooka H , Matsuya A , Nakaoka H , Saichi N , Sanbonmatsu R , Sato Y , Shinso Y , Suzuki M , Takeda J , Tanino M , Todokoro F , Yamaguchi K , Yamamoto N , Yamasaki C , Imanishi T , Okido T , Tada M , Ikeo K , Tateno Y , Gojobori T , Lin YC , Wei FJ , Hsing YI , Zhao Q , Han B , Kramer MR , McCombie RW , Lonsdale D , O'Donovan CC , Whitfield EJ , Apweiler R , Koyanagi KO , Khurana JP , Raghuvanshi S , Singh NK , Tyagi AK , Haberer G , Fujisawa M , Hosokawa S , Ito Y , Ikawa H , Shibata M , Yamamoto M , Bruskiewich RM , Hoen DR , Bureau TE , Namiki N , Ohyanagi H , Sakai Y , Nobushima S , Sakata K , Barrero RA , Souvorov A , Smith-White B , Tatusova T , An S , An G , S OO , Fuks G , Messing J , Christie KR , Lieberherr D , Kim H , Zuccolo A , Wing RA , Nobuta K , Green PJ , Lu C , Meyers BC , Chaparro C , Piegu B , Panaud O , Echeverria M
Ref : Nucleic Acids Research , 36 :D1028 , 2008
Abstract : The Rice Annotation Project Database (RAP-DB) was created to provide the genome sequence assembly of the International Rice Genome Sequencing Project (IRGSP), manually curated annotation of the sequence, and other genomics information that could be useful for comprehensive understanding of the rice biology. Since the last publication of the RAP-DB, the IRGSP genome has been revised and reassembled. In addition, a large number of rice-expressed sequence tags have been released, and functional genomics resources have been produced worldwide. Thus, we have thoroughly updated our genome annotation by manual curation of all the functional descriptions of rice genes. The latest version of the RAP-DB contains a variety of annotation data as follows: clone positions, structures and functions of 31 439 genes validated by cDNAs, RNA genes detected by massively parallel signature sequencing (MPSS) technology and sequence similarity, flanking sequences of mutant lines, transposable elements, etc. Other annotation data such as Gnomon can be displayed along with those of RAP for comparison. We have also developed a new keyword search system to allow the user to access useful information. The RAP-DB is available at: http://rapdb.dna.affrc.go.jp/ and http://rapdb.lab.nig.ac.jp/.
ESTHER : Tanaka_2008_Nucleic.Acids.Res_36_D1028
PubMedSearch : Tanaka_2008_Nucleic.Acids.Res_36_D1028
PubMedID: 18089549
Gene_locus related to this paper: orysa-Q9FW17 , orysa-Q0JK71 , orysa-B9EWJ8 , orysa-Q5N7L1 , orysa-pir7a , orysa-q2qyj1 , orysj-q6yse8 , orysa-q6yzk1 , orysa-Q8S0U8 , orysa-q33aq0 , orysa-Q0J0A4 , orysi-a2z179 , orysi-a2zef2 , orysi-b8a7e6 , orysi-b8a7e7 , orysi-b8bfe5 , orysi-b8bhp9 , orysj-b9fi05 , orysj-b9fkb0 , orysj-cgep , orysj-q0djj0 , orysj-q0dud7 , orysj-q0jaf0 , orysj-q0jga1 , orysj-q5jl22 , orysj-q5jlw7 , orysj-q6h7q9 , orysj-q6yvk6 , orysj-q7f8x1 , orysj-q7xcx3 , orysj-q9fwm6 , orysj-q10j20 , orysj-q10ss2 , orysj-q69uw6 , orysj-q94d71 , orysj-q0iq98 , orysj-b9gbs4 , orysj-b9gbs1 , orysj-pla4 , orysj-pla1

Title : Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana - Itoh_2007_Genome.Res_17_175
Author(s) : Itoh T , Tanaka T , Barrero RA , Yamasaki C , Fujii Y , Hilton PB , Antonio BA , Aono H , Apweiler R , Bruskiewich R , Bureau T , Burr F , Costa de Oliveira A , Fuks G , Habara T , Haberer G , Han B , Harada E , Hiraki AT , Hirochika H , Hoen D , Hokari H , Hosokawa S , Hsing YI , Ikawa H , Ikeo K , Imanishi T , Ito Y , Jaiswal P , Kanno M , Kawahara Y , Kawamura T , Kawashima H , Khurana JP , Kikuchi S , Komatsu S , Koyanagi KO , Kubooka H , Lieberherr D , Lin YC , Lonsdale D , Matsumoto T , Matsuya A , McCombie WR , Messing J , Miyao A , Mulder N , Nagamura Y , Nam J , Namiki N , Numa H , Nurimoto S , O'Donovan C , Ohyanagi H , Okido T , Oota S , Osato N , Palmer LE , Quetier F , Raghuvanshi S , Saichi N , Sakai H , Sakai Y , Sakata K , Sakurai T , Sato F , Sato Y , Schoof H , Seki M , Shibata M , Shimizu Y , Shinozaki K , Shinso Y , Singh NK , Smith-White B , Takeda J , Tanino M , Tatusova T , Thongjuea S , Todokoro F , Tsugane M , Tyagi AK , Vanavichit A , Wang A , Wing RA , Yamaguchi K , Yamamoto M , Yamamoto N , Yu Y , Zhang H , Zhao Q , Higo K , Burr B , Gojobori T , Sasaki T
Ref : Genome Res , 17 :175 , 2007
Abstract : We present here the annotation of the complete genome of rice Oryza sativa L. ssp. japonica cultivar Nipponbare. All functional annotations for proteins and non-protein-coding RNA (npRNA) candidates were manually curated. Functions were identified or inferred in 19,969 (70%) of the proteins, and 131 possible npRNAs (including 58 antisense transcripts) were found. Almost 5000 annotated protein-coding genes were found to be disrupted in insertional mutant lines, which will accelerate future experimental validation of the annotations. The rice loci were determined by using cDNA sequences obtained from rice and other representative cereals. Our conservative estimate based on these loci and an extrapolation suggested that the gene number of rice is approximately 32,000, which is smaller than previous estimates. We conducted comparative analyses between rice and Arabidopsis thaliana and found that both genomes possessed several lineage-specific genes, which might account for the observed differences between these species, while they had similar sets of predicted functional domains among the protein sequences. A system to control translational efficiency seems to be conserved across large evolutionary distances. Moreover, the evolutionary process of protein-coding genes was examined. Our results suggest that natural selection may have played a role for duplicated genes in both species, so that duplication was suppressed or favored in a manner that depended on the function of a gene.
ESTHER : Itoh_2007_Genome.Res_17_175
PubMedSearch : Itoh_2007_Genome.Res_17_175
PubMedID: 17210932
Gene_locus related to this paper: orysa-Q7XTC5 , orysa-Q852M6 , orysa-Q8GSE8 , orysa-Q9FYP7 , orysa-Q5ZA26 , orysa-Q5JLP6 , orysa-Q8H5P5 , orysa-Q7F1Y5 , orysa-cbp3 , orysa-cbpx , orysa-Q6YSZ8 , orysa-Q9FW17 , orysa-Q84QZ6 , orysa-Q0JK71 , orysa-B9EWJ8 , orysa-Q6ZDG6 , orysa-Q6ZDG5 , orysa-Q658B2 , orysa-Q5N7L1 , orysa-Q8RYV9 , orysa-Q8H3R3 , orysa-Q5SNH3 , orysa-pir7a , orysa-q2qnj4 , orysa-q2qyj1 , orysa-q2r077 , orysa-Q4VWY7 , orysa-q5smv5 , orysa-q5z901 , orysa-Q5ZBI5 , orysa-q6atz0 , orysa-q6i5q3 , orysa-q6j657 , orysa-q6k4q2 , orysj-q6yse8 , orysa-q6yy42 , orysa-q6yzk1 , orysa-q6z8b1 , orysa-q6z995 , orysa-q6zjq6 , orysa-q7x7y5 , orysa-Q7XC50 , orysa-q7xr62 , orysa-q7xr63 , orysa-q7xsg1 , orysa-q7xsq2 , orysa-q7xts6 , orysa-q7xv53 , orysa-Q8LQS5 , orysa-Q8RZ79 , orysa-Q8S0U8 , orysa-Q8W3C6 , orysa-Q9LHX5 , orysa-q53m20 , orysa-q53nd8 , orysa-q60e79 , orysa-q67iz2 , orysa-q67iz3 , orysa-q67iz7 , orysa-q67iz8 , orysa-q67j02 , orysa-q67j05 , orysa-q67j09 , orysa-q67j10 , orysa-q67tr6 , orysa-q67tv0 , orysa-q69j38 , orysa-q69y21 , orysa-q75hy1 , orysa-q75hy2 , orysa-Q0J0A4 , orysa-q651a8 , orysa-q652g4 , orysa-q688m8 , orysa-Q6H8G1 , orysi-a2z179 , orysi-a2zef2 , orysi-b8a7e6 , orysi-b8a7e7 , orysi-b8bfe5 , orysi-b8bhp9 , orysj-b9fi05 , orysj-q0djj0 , orysj-q0jaf0 , orysj-q0jga1 , orysj-q0jhi5 , orysj-q5jl22 , orysj-q5jlw7 , orysj-q6h7q9 , orysj-q6yvk6 , orysj-q7f8x1 , orysj-q7xcx3 , orysj-q9fwm6 , orysj-q10j20 , orysj-q10ss2 , orysj-q69uw6 , orysj-q94d71 , orysj-q0iq98 , orysj-b9gbs4 , orysj-b9gbs1

Title : Molecular analysis of a leprosy immunotherapeutic bacillus provides insights into Mycobacterium evolution - Ahmed_2007_PLoS.One_2_e968
Author(s) : Ahmed N , Saini V , Raghuvanshi S , Khurana JP , Tyagi AK , Hasnain SE
Ref : PLoS ONE , 2 :e968 , 2007
Abstract : BACKGROUND: Evolutionary dynamics plays a central role in facilitating the mechanisms of species divergence among pathogenic and saprophytic mycobacteria. The ability of mycobacteria to colonize hosts, to proliferate and to cause diseases has evolved due to its predisposition to various evolutionary forces acting over a period of time. Mycobacterium indicus pranii (MIP), a taxonomically unknown 'generalist' mycobacterium, acts as an immunotherapeutic against leprosy and is approved for use as a vaccine against it. The large-scale field trials of this MIP based leprosy vaccine coupled with its demonstrated immunomodulatory and adjuvant property has led to human clinical evaluations of MIP in interventions against HIV-AIDS, psoriasis and bladder cancer. MIP, commercially available as 'Immuvac', is currently the focus of advanced phase III clinical trials for its antituberculosis efficacy. Thus a comprehensive analysis of MIP vis-a-vis evolutionary path, underpinning its immanent immunomodulating properties is of the highest desiderata. PRINCIPAL FINDINGS: Genome wide comparisons together with molecular phylogenetic analyses by fluorescent amplified fragment length polymorphism (FAFLP), enterobacterial repetitive intergenic consensus (ERIC) based genotyping and candidate orthologues sequencing revealed that MIP has been the predecessor of highly pathogenic Mycobacterium avium intracellulare complex (MAIC) that did not resort to parasitic adaptation by reductional gene evolution and therefore, preferred a free living life-style. Further analysis suggested a shared aquatic phase of MAIC bacilli with the early pathogenic forms of Mycobacterium, well before the latter diverged as 'specialists'. CONCLUSIONS/SIGNIFICANCE: This evolutionary paradigm possibly affirms to marshall our understanding about the acquisition and optimization of virulence in mycobacteria and determinants of boundaries therein.
ESTHER : Ahmed_2007_PLoS.One_2_e968
PubMedSearch : Ahmed_2007_PLoS.One_2_e968
PubMedID: 17912347
Gene_locus related to this paper: myca1-a0q9c0 , mycia-h8ivh5 , 9myco-j9waw2 , mycia-h8iug5 , 9myco-i2acb5