Magee BB

References (2)

Title : Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome - Chibana_2005_Genetics_170_1525
Author(s) : Chibana H , Oka N , Nakayama H , Aoyama T , Magee BB , Magee PT , Mikami Y
Ref : Genetics , 170 :1525 , 2005
Abstract : The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to sequence polymorphism between homologous chromosomes. Chromosome 7 is 1 Mb in size and the best characterized of the 8 chromosomes in C. albicans. We assigned 16 of the contigs, ranging in length from 7309 to 267,590 bp, to chromosome 7 and determined sequences of 16 regions. These regions included four gaps, a misassembled sequence, and two major repeat sequences (MRS) of >16 kb. The length of the continuous sequence attained was 949,626 bp and provided complete coverage of chromosome 7 except for telomeric regions. Sequence analysis was carried out and predicted 404 genes, 11 of which included at least one intron. A 7-kb indel, which might be caused by a retrotransposon, was identified as the largest difference between the homologous chromosomes. Synteny analysis revealed that the degree of synteny between C. albicans and Saccharomyces cerevisiae is too weak to use for completion of the genomic sequence in C. albicans.
ESTHER : Chibana_2005_Genetics_170_1525
PubMedSearch : Chibana_2005_Genetics_170_1525
PubMedID: 15937140
Gene_locus related to this paper: canal-cbpy , canal-LIP5 , canal-LIP8 , canal-LIP9 , canal-q5a0c9 , canal-q5afp8 , canal-q5ah37

Title : The diploid genome sequence of Candida albicans - Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329
Author(s) : Jones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N , Magee PT , Davis RW , Scherer S
Ref : Proc Natl Acad Sci U S A , 101 :7329 , 2004
Abstract : We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
ESTHER : Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329
PubMedSearch : Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329
PubMedID: 15123810
Gene_locus related to this paper: canal-apth1 , canal-ATG15 , canal-bna7 , canal-c4yl13 , canal-cbpy , canal-LIP1 , canal-LIP2 , canal-LIP3 , canal-LIP4 , canal-LIP5 , canal-LIP6 , canal-LIP7 , canal-LIP8 , canal-LIP9 , canal-LIP10 , canal-ppme1 , canal-q5a0c9 , canal-q5a0i7 , canal-q5a2i9 , canal-q5a2u7 , canal-q5a6l4 , canal-q5a042 , canal-q5a948 , canal-q5aa97 , canal-q5abf2 , canal-q5acl5 , canal-q5ad17 , canal-q5adx4 , canal-q5ady2 , canal-q5aeu3 , canal-q5afp8 , canal-q5ag57 , canal-q5ah37 , canal-q5ai09 , canal-q5ai12 , canal-q5ai87 , canal-q5ajt3 , canal-q5ak09 , canal-q5ak29 , canal-q5ak96 , canal-q5akr2 , canal-q5akz5 , canal-q5amg8 , canal-q5amn4 , canal-q5amn7 , canal-q5ams2 , canal-q5ams7 , canal-q5apu4 , canal-q59k70 , canal-q59kl3 , canal-q59l46 , canal-q59ln6 , canal-q59m48 , canal-q59ng0 , canal-q59nl9 , canal-q59nw6 , canal-q59nx4 , canal-q59nx8 , canal-q59s22 , canal-q59tt5 , canal-q59u61 , canal-q59u64 , canal-q59vf1 , canal-q59vp0 , canal-q59we9 , canal-q59xq6 , canal-q59y42 , canal-q59y97 , canaw-c4yrr3 , canal-hda1