Sixma TK

General

Full name : Sixma Titia K

First name : Titia K

Mail : Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Department of Molecular Carcinogenesis Amsterdam

Zip Code :

City :

Country : The Netherlands

Email : t.sixma@nki.nl

Phone :

Fax :

Website :

Directory :

References (21)

Title : Assembly of a pi-pi stack of ligands in the binding site of an acetylcholine-binding protein - Stornaiuolo_2013_Nat.Commun_4_1875
Author(s) : Stornaiuolo M , De Kloe GE , Rucktooa P , Fish A , van Elk R , Edink ES , Bertrand D , Smit AB , de Esch IJ , Sixma TK
Ref : Nat Commun , 4 :1875 , 2013
Abstract :
PubMedSearch : Stornaiuolo_2013_Nat.Commun_4_1875
PubMedID: 23695669

Title : Dimeric alpha-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors - Osipov_2012_J.Biol.Chem_287_6725
Author(s) : Osipov AV , Rucktooa P , Kasheverov IE , Filkin SY , Starkov VG , Andreeva TV , Sixma TK , Bertrand D , Utkin YN , Tsetlin VI
Ref : Journal of Biological Chemistry , 287 :6725 , 2012
Abstract :
PubMedSearch : Osipov_2012_J.Biol.Chem_287_6725
PubMedID: 22223648

Title : Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein - Rucktooa_2012_J.Biol.Chem_287_23283
Author(s) : Rucktooa P , Haseler CA , van Elk R , Smit AB , Gallagher T , Sixma TK
Ref : Journal of Biological Chemistry , 287 :23283 , 2012
Abstract :
PubMedSearch : Rucktooa_2012_J.Biol.Chem_287_23283
PubMedID: 22553201

Title : Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis - Edink_2011_J.Am.Chem.Soc_133_5363
Author(s) : Edink E , Rucktooa P , Retra K , Akdemir A , Nahar T , Zuiderveld O , van Elk R , Janssen E , van Nierop P , van Muijlwijk-Koezen J , Smit AB , Sixma TK , Leurs R , de Esch IJ
Ref : J Am Chem Soc , 133 :5363 , 2011
Abstract :
PubMedSearch : Edink_2011_J.Am.Chem.Soc_133_5363
PubMedID: 21322593

Title : Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors - Akdemir_2011_Bioorg.Med.Chem_19_6107
Author(s) : Akdemir A , Rucktooa P , Jongejan A , Elk R , Bertrand S , Sixma TK , Bertrand D , Smit AB , Leurs R , de Graaf C , de Esch IJ
Ref : Bioorganic & Medicinal Chemistry , 19 :6107 , 2011
Abstract :
PubMedSearch : Akdemir_2011_Bioorg.Med.Chem_19_6107
PubMedID: 21920761

Title : Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis - Ulens_2009_J.Med.Chem_52_2372
Author(s) : Ulens C , Akdemir A , Jongejan A , van Elk R , Bertrand S , Perrakis A , Leurs R , Smit AB , Sixma TK , Bertrand D , de Esch IJ
Ref : Journal of Medicinal Chemistry , 52 :2372 , 2009
Abstract :
PubMedSearch : Ulens_2009_J.Med.Chem_52_2372
PubMedID: 19331415

Title : Insight in nAChR subtype selectivity from AChBP crystal structures - Rucktooa_2009_Biochem.Pharmacol_78(7)_777
Author(s) : Rucktooa P , Smit AB , Sixma TK
Ref : Biochemical Pharmacology , 78 :777 , 2009
Abstract :
PubMedSearch : Rucktooa_2009_Biochem.Pharmacol_78(7)_777
PubMedID: 19576182

Title : Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor - Kasheverov_2009_J.Neurochem_111_934
Author(s) : Kasheverov IE , Zhmak MN , Fish A , Rucktooa P , Khruschov AY , Osipov AV , Ziganshin RH , D'Hoedt D , Bertrand D , Sixma TK , Smit AB , Tsetlin VI
Ref : Journal of Neurochemistry , 111 :934 , 2009
Abstract :
PubMedSearch : Kasheverov_2009_J.Neurochem_111_934
PubMedID: 19712060

Title : Nicotinic receptor structure emerging slowly -
Author(s) : Sixma TK
Ref : Nat Neurosci , 10 :937 , 2007
PubMedID: 17657233

Title : Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation - Knipscheer_2007_EMBO.J_26_2797
Author(s) : Knipscheer P , van Dijk WJ , Olsen JV , Mann M , Sixma TK
Ref : EMBO Journal , 26 :2797 , 2007
Abstract :
PubMedSearch : Knipscheer_2007_EMBO.J_26_2797
PubMedID: 17491593

Title : AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity - Dutertre_2007_EMBO.J_26_3858
Author(s) : Dutertre S , Ulens C , Buttner R , Fish A , van Elk R , Kendel Y , Hopping G , Alewood PF , Schroeder C , Nicke A , Smit AB , Sixma TK , Lewis RJ
Ref : EMBO Journal , 26 :3858 , 2007
Abstract :
PubMedSearch : Dutertre_2007_EMBO.J_26_3858
PubMedID: 17660751

Title : Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors - Smit_2006_J.Mol.Neurosci_30_9
Author(s) : Smit AB , Celie PH , Kasheverov IE , Mordvintsev DY , van Nierop P , Bertrand D , Tsetlin V , Sixma TK
Ref : Journal of Molecular Neuroscience , 30 :9 , 2006
Abstract :
PubMedSearch : Smit_2006_J.Mol.Neurosci_30_9
PubMedID: 17192605

Title : Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP - Ulens_2006_Proc.Natl.Acad.Sci.U.S.A_103_3615
Author(s) : Ulens C , Hogg RC , Celie PH , Bertrand D , Tsetlin V , Smit AB , Sixma TK
Ref : Proc Natl Acad Sci U S A , 103 :3615 , 2006
Abstract :
PubMedSearch : Ulens_2006_Proc.Natl.Acad.Sci.U.S.A_103_3615
PubMedID: 16505382

Title : Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant - Celie_2005_Nat.Struct.Mol.Biol_12_582
Author(s) : Celie PH , Kasheverov IE , Mordvintsev DY , Hogg RC , van Nierop P , van Elk R , van Rossum-Fikkert SE , Zhmak MN , Bertrand D , Tsetlin V , Sixma TK , Smit AB
Ref : Nat Struct Mol Biol , 12 :582 , 2005
Abstract :
PubMedSearch : Celie_2005_Nat.Struct.Mol.Biol_12_582
PubMedID: 15951818

Title : Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors - Celie_2005_J.Biol.Chem_280_26457
Author(s) : Celie PH , Klaassen RV , van Rossum-Fikkert SE , van Elk R , van Nierop P , Smit AB , Sixma TK
Ref : Journal of Biological Chemistry , 280 :26457 , 2005
Abstract :
PubMedSearch : Celie_2005_J.Biol.Chem_280_26457
PubMedID: 15899893

Title : Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures - Celie_2004_Neuron_41_907
Author(s) : Celie PH , van Rossum-Fikkert SE , van Dijk WJ , Brejc K , Smit AB , Sixma TK
Ref : Neuron , 41 :907 , 2004
Abstract :
PubMedSearch : Celie_2004_Neuron_41_907
PubMedID: 15046723

Title : Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels - Sixma_2003_Annu.Rev.Biophys.Biomol.Struct_32_311
Author(s) : Sixma TK , Smit AB
Ref : Annu Rev Biophys Biomol Struct , 32 :311 , 2003
Abstract :
PubMedSearch : Sixma_2003_Annu.Rev.Biophys.Biomol.Struct_32_311
PubMedID: 12695308

Title : Structure and function of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor - Smit_2003_Ann.N.Y.Acad.Sci_998_81
Author(s) : Smit AB , Brejc K , Syed N , Sixma TK
Ref : Annals of the New York Academy of Sciences , 998 :81 , 2003
Abstract :
PubMedSearch : Smit_2003_Ann.N.Y.Acad.Sci_998_81
PubMedID: 14592865

Title : The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor - Brejc_2002_Novartis.Found.Symp_245_22
Author(s) : Brejc K , van Dijk WJ , Smit AB , Sixma TK
Ref : Novartis Found Symp , 245 :22 , 2002
Abstract :
PubMedSearch : Brejc_2002_Novartis.Found.Symp_245_22
PubMedID: 12027010

Title : A glia-derived acetylcholine-binding protein that modulates synaptic transmission - Smit_2001_Nature_411_261
Author(s) : Smit AB , Syed NI , Schaap D , van Minnen J , Klumperman J , Kits KS , Lodder H , van der Schors RC , van Elk R , Sorgedrager B , Brejc K , Sixma TK , Geraerts WP
Ref : Nature , 411 :261 , 2001
Abstract :
PubMedSearch : Smit_2001_Nature_411_261
PubMedID: 11357121

Title : Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors - Brejc_2001_Nature_411_269
Author(s) : Brejc K , van Dijk WJ , Klaassen RV , Schuurmans M , Van der Oost J , Smit AB , Sixma TK
Ref : Nature , 411 :269 , 2001
Abstract :
PubMedSearch : Brejc_2001_Nature_411_269
PubMedID: 11357122