| Title : Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV - Sheahan_2020_Nat.Commun_11_222 |
| Author(s) : Sheahan TP , Sims AC , Leist SR , Schafer A , Won J , Brown AJ , Montgomery SA , Hogg A , Babusis D , Clarke MO , Spahn JE , Bauer L , Sellers S , Porter D , Feng JY , Cihlar T , Jordan R , Denison MR , Baric RS |
| Ref : Nat Commun , 11 :222 , 2020 |
| Abstract : |
| PubMedSearch : Sheahan_2020_Nat.Commun_11_222 |
| PubMedID: 31924756 |
| Title : Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease - Agostini_2018_mBio_9_ |
| Author(s) : Agostini ML , Andres EL , Sims AC , Graham RL , Sheahan TP , Lu X , Smith EC , Case JB , Feng JY , Jordan R , Ray AS , Cihlar T , Siegel D , Mackman RL , Clarke MO , Baric RS , Denison MR |
| Ref : MBio , 9 : , 2018 |
| Abstract : |
| PubMedSearch : Agostini_2018_mBio_9_ |
| PubMedID: 29511076 |
| Title : Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys - Warren_2016_Nature_531_381 |
| Author(s) : Warren TK , Jordan R , Lo MK , Ray AS , Mackman RL , Soloveva V , Siegel D , Perron M , Bannister R , Hui HC , Larson N , Strickley R , Wells J , Stuthman KS , Van Tongeren SA , Garza NL , Donnelly G , Shurtleff AC , Retterer CJ , Gharaibeh D , Zamani R , Kenny T , Eaton BP , Grimes E , Welch LS , Gomba L , Wilhelmsen CL , Nichols DK , Nuss JE , Nagle ER , Kugelman JR , Palacios G , Doerffler E , Neville S , Carra E , Clarke MO , Zhang L , Lew W , Ross B , Wang Q , Chun K , Wolfe L , Babusis D , Park Y , Stray KM , Trancheva I , Feng JY , Barauskas O , Xu Y , Wong P , Braun MR , Flint M , McMullan LK , Chen SS , Fearns R , Swaminathan S , Mayers DL , Spiropoulou CF , Lee WA , Nichol ST , Cihlar T , Bavari S |
| Ref : Nature , 531 :381 , 2016 |
| Abstract : |
| PubMedSearch : Warren_2016_Nature_531_381 |
| PubMedID: 26934220 |
| Title : Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors - Birkus_2015_Antimicrob.Agents.Chemother_60_316 |
| Author(s) : Birkus G , Bam RA , Willkom M , Frey CR , Tsai L , Stray KM , Yant SR , Cihlar T |
| Ref : Antimicrobial Agents & Chemotherapy , 60 :316 , 2015 |
| Abstract : |
| PubMedSearch : Birkus_2015_Antimicrob.Agents.Chemother_60_316 |
| PubMedID: 26503655 |
| Gene_locus related to this paper: human-CES1 |
| Title : Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors - Bam_2014_Antivir.Ther_19_669 |
| Author(s) : Bam RA , Birkus G , Babusis D , Cihlar T , Yant SR |
| Ref : Antivir Ther , 19 :669 , 2014 |
| Abstract : |
| PubMedSearch : Bam_2014_Antivir.Ther_19_669 |
| PubMedID: 24625459 |
| Gene_locus related to this paper: human-CTSA |
| Title : Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases - Birkus_2008_Mol.Pharmacol_74_92 |
| Author(s) : Birkus G , Kutty N , He GX , Mulato A , Lee W , McDermott M , Cihlar T |
| Ref : Molecular Pharmacology , 74 :92 , 2008 |
| Abstract : |
| PubMedSearch : Birkus_2008_Mol.Pharmacol_74_92 |
| PubMedID: 18430788 |
| Gene_locus related to this paper: human-CTSA |