Author Report for: Zhan SNo contact information in database for Zhan S
Gao H, Bai L, Jiang Y, Huang W, Wang L, Li S, Zhu G, Wang D, Huang Z and Wang S <5 more author(s)> Gao H, Bai L, Jiang Y, Huang W, Wang L, Li S, Zhu G, Wang D, Huang Z, Li X, Cao J, Jiang L, Jacobs-Lorena M, Zhan S, Wang S (- 5) Ref: Nat Microbiol, :, 2021 : PubMed ESTHER: Gao_2021_Nat.Microbiol__ PubMedSearch: Gao 2021 Nat.Microbiol PubMedID: 33958765 Abstract The stalling global progress in the fight against malaria prompts the urgent need to develop new intervention strategies. Whilst engineered symbiotic bacteria have been shown to confer mosquito resistance to parasite infection, a major challenge for field implementation is to address regulatory concerns. Here, we report the identification of a Plasmodium-blocking symbiotic bacterium, Serratia ureilytica Su_YN1, isolated from the midgut of wild Anopheles sinensis in China that inhibits malaria parasites via secretion of an antimalarial lipase. Analysis of Plasmodium vivax epidemic data indicates that local malaria cases in Tengchong (Yunnan province, China) are significantly lower than imported cases and importantly, that the local vector A. sinensis is more resistant to infection by P. vivax than A. sinensis from other regions. Analysis of the gut symbiotic bacteria of mosquitoes from Yunnan province led to the identification of S. ureilytica Su_YN1. This bacterium renders mosquitoes resistant to infection by the human parasite Plasmodium falciparum or the rodent parasite Plasmodium berghei via secretion of a lipase that selectively kills parasites at various stages. Importantly, Su_YN1 rapidly disseminates through mosquito populations by vertical and horizontal transmission, providing a potential tool for blocking malaria transmission in the field. Title: Divergent and Convergent Evolution of Fungal Pathogenicity Shang Y, Xiao G, Zheng P, Cen K, Zhan S, Wang C Ref: Genome Biol Evol, 8:1374, 2016 : PubMed ESTHER: Shang_2016_Genome.Biol.Evol_8_1374 PubMedSearch: Shang 2016 Genome.Biol.Evol 8 1374 PubMedID: 27071652 Gene_locus related to this paper: 9hypo-a0a162hs49, 9hypo-a0a162hub8, 9hypo-a0a162i1u8, 9euro-a0a162iix1, 9hypo-a0a162ima8, 9hypo-a0a162jas9, 9hypo-a0a162jfj3, 9hypo-a0a162jhb9, 9hypo-a0a162jmg2, cordf-a0a162k2a2, 9hypo-a0a162k3b2, 9hypo-a0a162k3t2, cordf-a0a162kne2, cordf-a0a162kwz0, 9hypo-a0a162m4x7, cordf-a0a162mwk4, 9hypo-a0a166nct4, 9euro-a0a166nl14, 9hypo-a0a166v6u3, 9hypo-a0a166wlx9, 9hypo-a0a166wxz0, 9hypo-a0a166yda3, 9hypo-a0a166ymi5, 9hypo-a0a166z511, 9hypo-a0a167fcg1, 9hypo-a0a167gu64, 9hypo-a0a167gyk2, 9hypo-a0a167kjz5, 9hypo-a0a167m3a6, 9pezi-a0a167nge5, 9hypo-a0a167qnf7, 9pezi-a0a167qz56, 9pezi-a0a167sfr8, 9pezi-a0a167snk4, 9hypo-a0a167tjx1, 9hypo-a0a167tm61, 9pezi-a0a167u5l8, 9pezi-a0a167uqx6, 9hypo-a0a167v4i2, 9euro-a0a167vcq2, 9pezi-a0a167vqe2, 9hypo-a0a167vzl7, 9euro-a0a167w192, cordf-a0a167wrl9, 9pezi-a0a167wyb6, 9euro-a0a167xzp3, 9euro-a0a167y0h7, 9hypo-a0a167yg81, 9pezi-a0a167z9i1, cordf-a0a167zqi5, 9hypo-a0a168are5, cordf-a0a168bcu5, 9hypo-a0a168bsl8, cordf-a0a168cqs1, cordf-a0a168crk3, 9hypo-a0a168d6j2, 9hypo-a0a168enh0, 9hypo-a0a168eu39, cordf-a0a168g0e1, cordf-a0a168g1t1, cordf-a0a168g678, cordf-a0a168hsg3, cordf-a0a168j527, cordf-a0a168jr90, cordf-a0a168l178, 9hypo-a0a167x7j9, beaba-a0a2s7xwt2, 9hypo-a0a167xk24, cordf-a0a168j0y7, 9hypo-a0a167es80, 9pezi-a0a162mh01, 9hypo-a0a168b790, 9hypo-a0a166uph8, 9hypo-a0a168enk0, 9hypo-a0a167dlr2, cordf-a0a168hsf0, 9hypo-a0a167hq40, metrr-a0a166ygn0, cordf-a0a179ib68, corfa-a0a167q5m2, metrr-a0a162jas4, cordf-a0a168fit9 Abstract Fungal pathogens of plants and animals have multifarious effects; they cause devastating damages to agricultures, lead to life-threatening diseases in humans, or induce beneficial effects by reducing insect pest populations. Many virulence factors have been determined in different fungal pathogens; however, the molecular determinants contributing to fungal host selection and adaptation are largely unknown. In this study, we sequenced the genomes of seven ascomycete insect pathogens and performed the genome-wide analyses of 33 species of filamentous ascomycete pathogenic fungi that infect insects (12 species), plants (12), and humans (9). Our results revealed that the genomes of plant pathogens encode more proteins and protein families than the insect and human pathogens. Unexpectedly, more common orthologous protein groups are shared between the insect and plant pathogens than between the two animal group pathogens. We also found that the pathogenicity of host-adapted fungi evolved multiple times, and that both divergent and convergent evolutions occurred during pathogen-host cospeciation thus resulting in protein families with similar features in each fungal group. However, the role of phylogenetic relatedness on the evolution of protein families and therefore pathotype formation could not be ruled out due to the effect of common ancestry. The evolutionary correlation analyses led to the identification of different protein families that correlated with alternate pathotypes. Particularly, the effector-like proteins identified in plant and animal pathogens were strongly linked to fungal host adaptation, suggesting the existence of similar gene-for-gene relationships in fungus-animal interactions that has not been established before. These results well advance our understanding of the evolution of fungal pathogenicity and the factors that contribute to fungal pathotype formation. Title: Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation Hu X, Xiao G, Zheng P, Shang Y, Su Y, Zhang X, Liu X, Zhan S, St Leger RJ, Wang C Ref: Proc Natl Acad Sci U S A, 111:16796, 2014 : PubMed ESTHER: Hu_2014_Proc.Natl.Acad.Sci.U.S.A_111_16796 PubMedSearch: Hu 2014 Proc.Natl.Acad.Sci.U.S.A 111 16796 PubMedID: 25368161 Gene_locus related to this paper: metan-a0a086npb7, 9hypo-a0a0b2wj22, 9hypo-a0a0b2wjv9, 9hypo-a0a0b2wph9, 9hypo-a0a0b2wpk8, 9hypo-a0a0b2wpu7, 9hypo-a0a0b2wwt8, 9hypo-a0a0b2wyt3, 9hypo-a0a0b2x1p9, metan-a0a0b4es34, 9hypo-a0a0b4g6h7, 9hypo-a0a0b4gae9, 9hypo-a0a0b4gyw4, 9hypo-a0a0b4gzy5, 9hypo-a0a0b4hfr4, 9hypo-a0a0b4hi37, 9hypo-a0a0b4hin0, 9hypo-a0a0b4fk47, 9hypo-a0a0b4g7m5, 9hypo-a0a0b4i0i8, 9hypo-a0a0b4ie69, 9hypo-a0a0b4if28, 9hypo-a0a0b4h1h6, 9hypo-a0a0b4hlm2, metan-a0a0d9pev7, metas-a0a0b2wy97, metas-a0a0b2wk60, metra-e9ewg3, metaq-pks1, metra-pks2, metmf-pks2, metaf-pks1, metbs-pks2, metas-pks1 Abstract Much remains unknown regarding speciation. Host-pathogen interactions are a major driving force for diversification, but the genomic basis for speciation and host shifting remains unclear. The fungal genus Metarhizium contains species ranging from specialists with very narrow host ranges to generalists that attack a wide range of insects. By genomic analyses of seven species, we demonstrated that generalists evolved from specialists via transitional species with intermediate host ranges and that this shift paralleled insect evolution. We found that specialization was associated with retention of sexuality and rapid evolution of existing protein sequences whereas generalization was associated with protein-family expansion, loss of genome-defense mechanisms, genome restructuring, horizontal gene transfer, and positive selection that accelerated after reinforcement of reproductive isolation. These results advance understanding of speciation and genomic signatures that underlie pathogen adaptation to hosts. Title: The monarch butterfly genome yields insights into long-distance migration Zhan S, Merlin C, Boore JL, Reppert SM Ref: Cell, 147:1171, 2011 : PubMed ESTHER: Zhan_2011_Cell_147_1171 PubMedSearch: Zhan 2011 Cell 147 1171 PubMedID: 22118469 Gene_locus related to this paper: danpl-a0a212fjb0, danpl-ACHE2, danpl-g6ci98, danpl-g6ckz1, danpl-g6clm2, danpl-g6cm19, danpl-g6cm20, danpl-g6cm21, danpl-g6cm38, danpl-g6cma6, danpl-g6cnf9, danpl-g6cqk1, danpl-g6cqk2, danpl-g6cqk3, danpl-g6cqm7, danpl-g6cqm8, danpl-g6cqp3, danpl-g6cqs2, danpl-g6ctg8, danpl-g6ctk9, danpl-g6ctw4, danpl-g6cvv8, danpl-g6cxc2, danpl-g6d2e6, danpl-g6d2t6, danpl-g6d3i9, danpl-g6d4m3, danpl-g6d8w2, danpl-g6d125, danpl-g6d455, danpl-g6da07, danpl-g6da31, danpl-g6dal9, danpl-g6db68, danpl-g6dec2, danpl-g6dec3, danpl-g6dej6, danpl-g6dgy4, danpl-g6dk77, danpl-g6dke0, danpl-g6dl80, danpl-g6dmj2, danpl-g6dq10.1, danpl-g6dq10.2, danpl-g6dq11, danpl-g6dq12, danpl-g6dsd7, danpl-g6dsv4, danpl-g6dt17, danpl-g6dt18.1, danpl-g6dt18.2, danpl-g6dt19, danpl-g6cv50, danpl-g6dej9, danpl-g6chs3, danpl-g6dix4, danpl-a0a212ek15, danpl-a0a212eqw0, danpl-a0a212f5w2, danpl-a0a212ey73, danpl-a0a212ekj2 Abstract We present the draft 273 Mb genome of the migratory monarch butterfly (Danaus plexippus) and a set of 16,866 protein-coding genes. Orthology properties suggest that the Lepidoptera are the fastest evolving insect order yet examined. Compared to the silkmoth Bombyx mori, the monarch genome shares prominent similarity in orthology content, microsynteny, and protein family sizes. The monarch genome reveals a vertebrate-like opsin whose existence in insects is widespread; a full repertoire of molecular components for the monarch circadian clockwork; all members of the juvenile hormone biosynthetic pathway whose regulation shows unexpected sexual dimorphism; additional molecular signatures of oriented flight behavior; microRNAs that are differentially expressed between summer and migratory butterflies; monarch-specific expansions of chemoreceptors potentially important for long-distance migration; and a variant of the sodium/potassium pump that underlies a valuable chemical defense mechanism. The monarch genome enhances our ability to better understand the genetic and molecular basis of long-distance migration. | |||||||
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