Alternative name(s) : anti-DPPX autoimmunity, DPPX autoimmune encephalitis
Gene_locus : human-DPP6
Mutation : No mutation
Comment
Dipeptidyl-peptidase-like protein-6 (DPPX) encephalitis is a rare autoimmune disorder characterized by the presence of antibodies directed against DPPX, a subunit of the Kv4.2 potassium channel. Most patients demonstrate a classic triad of chronic diarrhea\/weight loss, cognitive dysfunction, and central nervous system (CNS) hyperexcitability
| Title : Neuropsychiatric Presentation of Anti-DPPX Progressive Encephalomyelitis with Rigidity and Myoclonus - |
| Author(s) : Neo RJ , Mehta AR , Weston M , Magrinelli F , Quattrone A , Gandhi S , Joyce EM , Bhatia KP |
| Ref : Movement Disordersord Clin Pract , 11 :97 , 2024 |
| PubMedID: 38291842 |
| Gene_locus related to this paper: human-DPP6 |
| Title : The effect of double filtration plasmapheresis and corticosteroids on patients with anti-dipeptidyl-peptidase-like protein 6 encephalitis - Wan_2024_Ther.Apher.Dial_28_141 |
| Author(s) : Wan W , Pan Y , Chen Y , Bai S , Yao X , Lin Y , Wu J , Ni L , Mei Y , Qiu H , Zhou Y , Hao Y , Guan Y |
| Ref : Ther Apher Dial , 28 :141 , 2024 |
| Abstract : Wan_2024_Ther.Apher.Dial_28_141 |
| ESTHER : Wan_2024_Ther.Apher.Dial_28_141 |
| PubMedSearch : Wan_2024_Ther.Apher.Dial_28_141 |
| PubMedID: 37461148 |
| Gene_locus related to this paper: human-DPP6 |
| Title : A rare case of anti-DPPX encephalitis combined with neuroleptospirosis - Jin_2024_BMC.Neurol_24_34 |
| Author(s) : Jin Y , Lan W , Chen X , Liu W , Luo W , Chen S |
| Ref : BMC Neurol , 24 :34 , 2024 |
| Abstract : Jin_2024_BMC.Neurol_24_34 |
| ESTHER : Jin_2024_BMC.Neurol_24_34 |
| PubMedSearch : Jin_2024_BMC.Neurol_24_34 |
| PubMedID: 38243162 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Colocalization of Increased Midbrain Signals in Neuroinflammation and Tau PET Imaging Suggests the Diagnosis of Progressive Supranuclear Palsy - Lu_2024_Clin.Nucl.Med__ |
| Author(s) : Lu J , Ge J , Yu H , Zhao G , Chen X |
| Ref : Clin Nucl Med , : , 2024 |
| Abstract : Lu_2024_Clin.Nucl.Med__ |
| ESTHER : Lu_2024_Clin.Nucl.Med__ |
| PubMedSearch : Lu_2024_Clin.Nucl.Med__ |
| PubMedID: 38271226 |
| Gene_locus related to this paper: human-DPP6 |
| Title : A Devastating Neurological Disorder: Anti-Dipeptidyl-Peptidase-Like Protein 6 (DPPX) Encephalitis Causing Rapidly Progressive Dementia - Esechie_2023_Cureus_15_e51123 |
| Author(s) : Esechie A , Thottempudi N , Patel C , Shanina E , Li X |
| Ref : Cureus , 15 :e51123 , 2023 |
| Abstract : Esechie_2023_Cureus_15_e51123 |
| ESTHER : Esechie_2023_Cureus_15_e51123 |
| PubMedSearch : Esechie_2023_Cureus_15_e51123 |
| PubMedID: 38274926 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Long term outcomes in patients with anti-DPPX autoimmunity - Dominguez_2023_J.Neuroimmunol_384_578214 |
| Author(s) : Dominguez L , McKeon A , Tobin WO , Lopez-Chiriboga S |
| Ref : Journal of Neuroimmunology , 384 :578214 , 2023 |
| Abstract : Dominguez_2023_J.Neuroimmunol_384_578214 |
| ESTHER : Dominguez_2023_J.Neuroimmunol_384_578214 |
| PubMedSearch : Dominguez_2023_J.Neuroimmunol_384_578214 |
| PubMedID: 37806046 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Case report: Pain in anti-DPPX encephalitis - Bjerknes_2022_Front.Neurol_13_1091688 |
| Author(s) : Bjerknes TL , Steihaug OM , Haugen M , Hjelland IE , Vedeler CA |
| Ref : Front Neurol , 13 :1091688 , 2022 |
| Abstract : Bjerknes_2022_Front.Neurol_13_1091688 |
| ESTHER : Bjerknes_2022_Front.Neurol_13_1091688 |
| PubMedSearch : Bjerknes_2022_Front.Neurol_13_1091688 |
| PubMedID: 36588910 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report - Lin_2022_BMC.Neurol_22_242 |
| Author(s) : Lin J , Zhu M , Mao X , Jin Z , Zhou M , Hong D |
| Ref : BMC Neurol , 22 :242 , 2022 |
| Abstract : Lin_2022_BMC.Neurol_22_242 |
| ESTHER : Lin_2022_BMC.Neurol_22_242 |
| PubMedSearch : Lin_2022_BMC.Neurol_22_242 |
| PubMedID: 35778696 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy - Xiao_2022_BMC.Neurol_22_129 |
| Author(s) : Xiao J , Fu PC , Li ZJ |
| Ref : BMC Neurol , 22 :129 , 2022 |
| Abstract : Xiao_2022_BMC.Neurol_22_129 |
| ESTHER : Xiao_2022_BMC.Neurol_22_129 |
| PubMedSearch : Xiao_2022_BMC.Neurol_22_129 |
| PubMedID: 35382765 |
| Gene_locus related to this paper: human-DPP6 |
| Title : [Weakness and weight loss in a 62 year-old patient] - |
| Author(s) : Legendre P , Couture P , Ponsoye M , Marroun I , Ackermann F , Comarmond C |
| Ref : Rev Med Interne , 43 :444 , 2022 |
| PubMedID: 35606201 |
| Title : Treatable Rapid Progressive Dementia: A First Case Report of Anti-dipeptidyl-peptidase-like Protein 6 Encephalitis in Taiwan - Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| Author(s) : Tsai MC , Shih HK , Lin HH , Tsai MY , Sung YF |
| Ref : Acta Neurol Taiwan , 30(3) :118 , 2021 |
| Abstract : Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| ESTHER : Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| PubMedSearch : Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| PubMedID: 34841508 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Clinical Features and Prognosis in Chinese Patients With Dipeptidyl-Peptidase-Like Protein 6 Antibody-Associated Encephalitis - Miao_2021_Front.Neurol_12_817896 |
| Author(s) : Miao A , Shi Y , Wang X , Ge J , Yu C |
| Ref : Front Neurol , 12 :817896 , 2021 |
| Abstract : Miao_2021_Front.Neurol_12_817896 |
| ESTHER : Miao_2021_Front.Neurol_12_817896 |
| PubMedSearch : Miao_2021_Front.Neurol_12_817896 |
| PubMedID: 35095748 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX autoimmune encephalitis: A short report on two patients presenting with classic features of this rare but treatable disease - |
| Author(s) : Mbonde AA , Gritsch D , Arca K , Blech B , McKeon A , Carter J |
| Ref : Mult Scler Relat Disord , 52 :102934 , 2021 |
| PubMedID: 33901970 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-dipeptidyl-peptidase-like protein 6 encephalitis, a rare cause of reversible rapid progressive dementia and insomnia - Zhou_2020_J.Neuroimmunol_339_577114 |
| Author(s) : Zhou Q , Zhu X , Meng H , Zhang M , Chen S |
| Ref : Journal of Neuroimmunology , 339 :577114 , 2020 |
| Abstract : Zhou_2020_J.Neuroimmunol_339_577114 |
| ESTHER : Zhou_2020_J.Neuroimmunol_339_577114 |
| PubMedSearch : Zhou_2020_J.Neuroimmunol_339_577114 |
| PubMedID: 31775073 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Utilization of video oculography to quantify oculomotor dysfunction in anti-DPPX encephalitis: A case study - Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| Author(s) : Blackburn K , Vernino S , Sguigna P |
| Ref : Mult Scler Relat Disord , 46 :102460 , 2020 |
| Abstract : Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| ESTHER : Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| PubMedSearch : Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| PubMedID: 32932166 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Oro-Bucco-Lingual Dyskinesia, Weight Loss, and Cognitive Decline in Anti-DPPX Antibody-Mediated Encephalitis - |
| Author(s) : Deuel LM , Yu CH , Vaughan CL , Piquet AL |
| Ref : Movement Disordersord Clin Pract , 7 :S80 , 2020 |
| PubMedID: 33015231 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Co-occurrence of antibodies against dipeptidyl-peptidase-like protein-6 and aquaporin-4 during a case of paraneoplastic encephalitis - |
| Author(s) : Bien CG , Schanzer A , Dargvainiene J , Dogan-Onugoren M , Woermann F , Strickler A |
| Ref : Clin Neurol Neurosurg , 197 :106093 , 2020 |
| PubMedID: 32702576 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Dipeptidyl-peptidase-like protein 6 encephalitis treated with immunotherapy - Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| Author(s) : Ye L , Schnegelsberg M , Obermann M |
| Ref : Proc (Bayl Univ Med Cent) , 34 :114 , 2020 |
| Abstract : Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| ESTHER : Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| PubMedSearch : Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| PubMedID: 33456166 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Teaching Video NeuroImages: Opsoclonus in anti-DPPX encephalitis - |
| Author(s) : Micieli JA , Newman NJ , Kase CS , Biousse V |
| Ref : Neurology , 92 :e2298 , 2019 |
| PubMedID: 31061220 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Pruritus in anti-DPPX encephalitis - |
| Author(s) : Wijntjes J , Bechakra M , Schreurs MWJ , Jongen JLM , Koppenaal A , Titulaer MJ |
| Ref : Neurol Neuroimmunol Neuroinflamm , 5 :e455 , 2018 |
| PubMedID: 29616232 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX antibody-associated encephalitis: Main syndrome and antibody effects - Hara_2017_Neurology_88_1340 |
| Author(s) : Hara M , Arino H , Petit-Pedrol M , Sabater L , Titulaer MJ , Martinez-Hernandez E , Schreurs MW , Rosenfeld MR , Graus F , Dalmau J |
| Ref : Neurology , 88 :1340 , 2017 |
| Abstract : Hara_2017_Neurology_88_1340 |
| ESTHER : Hara_2017_Neurology_88_1340 |
| PubMedSearch : Hara_2017_Neurology_88_1340 |
| PubMedID: 28258082 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-DPPX encephalitis: prominent nystagmus reflected by extraocular muscle FDG-PET avidity - |
| Author(s) : Doherty L , Gold D , Solnes L , Probasco J , Venkatesan A |
| Ref : Neurol Neuroimmunol Neuroinflamm , 4 :e361 , 2017 |
| PubMedID: 28626782 |
| Gene_locus related to this paper: human-DPP6 |
| Title : [Progressive encephalitis due to anti-DPPX antibodies: a case with good response to treatment with rituximab] - |
| Author(s) : Valero-Lopez G , Martin-Fernandez JJ , Hernandez-Clares R , Baidez-Guerrero AE , Martinez-Hernandez E |
| Ref : Rev Neurol , 65 :525 , 2017 |
| PubMedID: 29178111 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-DPPX encephalitis: Pathogenic effects of antibodies on gut and brain neurons - Piepgras_2015_Neurology_85_890 |
| Author(s) : Piepgras J , Holtje M , Michel K , Li Q , Otto C , Drenckhahn C , Probst C , Schemann M , Jarius S , Stocker W , Balint B , Meinck HM , Buchert R , Dalmau J , Ahnert-Hilger G , Ruprecht K |
| Ref : Neurology , 85 :890 , 2015 |
| Abstract : Piepgras_2015_Neurology_85_890 |
| ESTHER : Piepgras_2015_Neurology_85_890 |
| PubMedSearch : Piepgras_2015_Neurology_85_890 |
| PubMedID: 26291285 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Prednisolone and azathioprine are effective in DPPX antibody-positive autoimmune encephalitis - |
| Author(s) : Stoeck K , Carstens PO , Jarius S , Raddatz D , Stocker W , Wildemann B , Schmidt J |
| Ref : Neurol Neuroimmunol Neuroinflamm , 2 :e86 , 2015 |
| PubMedID: 25798450 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Progressive encephalomyelitis with rigidity and myoclonus: a new variant with DPPX antibodies - Balint_2014_Neurology_82_1521 |
| Author(s) : Balint B , Jarius S , Nagel S , Haberkorn U , Probst C , Blocker IM , Bahtz R , Komorowski L , Stocker W , Kastrup A , Kuthe M , Meinck HM |
| Ref : Neurology , 82 :1521 , 2014 |
| Abstract : Balint_2014_Neurology_82_1521 |
| ESTHER : Balint_2014_Neurology_82_1521 |
| PubMedSearch : Balint_2014_Neurology_82_1521 |
| PubMedID: 24696508 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients - Tobin_2014_Neurology_83_1797 |
| Author(s) : Tobin WO , Lennon VA , Komorowski L , Probst C , Clardy SL , Aksamit AJ , Appendino JP , Lucchinetti CF , Matsumoto JY , Pittock SJ , Sandroni P , Tippmann-Peikert M , Wirrell EC , McKeon A |
| Ref : Neurology , 83 :1797 , 2014 |
| Abstract : Tobin_2014_Neurology_83_1797 |
| ESTHER : Tobin_2014_Neurology_83_1797 |
| PubMedSearch : Tobin_2014_Neurology_83_1797 |
| PubMedID: 25320100 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels - Boronat_2013_Ann.Neurol_73_120 |
| Author(s) : Boronat A , Gelfand JM , Gresa-Arribas N , Jeong HY , Walsh M , Roberts K , Martinez-Hernandez E , Rosenfeld MR , Balice-Gordon R , Graus F , Rudy B , Dalmau J |
| Ref : Annals of Neurology , 73 :120 , 2013 |
| Abstract : Boronat_2013_Ann.Neurol_73_120 |
| ESTHER : Boronat_2013_Ann.Neurol_73_120 |
| PubMedSearch : Boronat_2013_Ann.Neurol_73_120 |
| PubMedID: 23225603 |
| Gene_locus related to this paper: human-DPP6 |