human-DPP6
Homo sapiens (Human) (dipeptidylpeptidase VI) (dppx)
Comment
also called DPPX. Not to be confounded with DPP-10 (human-DPP10). Ventricular fibrillation, paroxysmal familial 2. Alders et al. (2009) identified a C-to-T transition 340 bases upstream from the ATG start site of the DPP6 gene (rs3807218). All 10 probands carried the same haplotype. The mutation was not present in a control group of 350 Dutch individuals of European descent. The mutation is associated with 20-fold increased expression in DPP6 mRNA levels in the myocardium of carriers as compared to controls. Gilles de la Tourette syndrome (GTS). DPP6 gene disruption in a family with Gilles de la Tourette syndrome (Prontera et al.2014 ) Evidence suggests that mutations in more than one gene can cause Gilles de la Tourette syndrome Mental retardation, autosomal dominant 33: A missense mutation in the DPP6 gene (M385L\; 126141.0002) was identified in a family segregating microcephaly and autosomal dominant mental retardation.(Liao et al 2013). Dipeptidyl-peptidase-like protein-6 (DPPX) encephalitis is a rare autoimmune disorder characterized by the presence of antibodies directed against DPPX. Most patients demonstrate a classic triad of chronic diarrhea\/weight loss, cognitive dysfunction, and central nervous system (CNS) hyperexcitability. The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels. Structures of the complex are available (Kise et al.)
Relationship
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
1XFD - Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family
7E87 - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2 (Kv4.2DPP6S-TM and cyto) complex
7E89 - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2, (Kv4.2DPP6S-EC) complex
7E8B - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2 (Kv4.2DPP6S-whole) complex
7E8E - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2, Kv channel-interacting proteins (KChIP1) (Kv4.2DPP6SKChIP1-TM and cyto)
7E8G - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2, Kv channel-interacting proteins (KChIP1) (Kv4.2DPP6SKChIP1-EC)
7E8H - DPP6S, Voltage-gated potassium (Kv) channel Kv4.2, Kv channel-interacting proteins (KChIP1) (Kv4.2DPP6SKChIP1-whole) complex
7UKG - Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
7UKH - Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region
No kinetic
No substrate
No inhibitor
Database
Sequence
Peptide
MASLYQRFTG KINTSRSFPA PPEASHLLGG QGPEEDGGAG AKPLGPRAQA AAPRERGGGG GGAGGRPRFQ YQGRSDGDEE DELVGSNPPQ RNWKGIAIAL LVILVICSLI VTSVILLTPA EDNSLSQKKK VTVEDLFSED FKIHDPEAKW ISDTEFIYRE QKGTVRLWNV ETNTSTVLIE GKKIESLRAI RYEISPDREY ALFSYNVEPI YQHSYTGYYV LSKIPHGDPQ SLDPPEVSNA KLQYAGWGPK GQQLIFIFEN NIYYCAHVGK QAIRVVSTGK EGVIYNGLSD WLYEEEILKT HIAHWWSPDG TRLAYAAIND SRVPIMELPT YTGSIYPTVK PYHYPKAGSE NPSISLHVIG LNGPTHDLEM MPPDDPRMRE YYITMVKWAT STKVAVTWLN RAQNVSILTL CDATTGVCTK KHEDESEAWL HRQNEEPVFS KDGRKFFFIR AIPQGGRGKF YHITVSSSQP NSSNDNIQSI TSGDWDVTKI LAYDEKGNKI YFLSTEDLPR RRQLYSANTE GNFNRQCLSC DLVENCTYFS ASFSHSMDFF LLKCEGPGVP MVTVHNTTDK KKMFDLETNE HVKKAINDRQ MPKVEYRDIE IDDYNLPMQI LKPATFTDTT HYPLLLVVDG TPGSQSVAEK FEVSWETVMV SSHGAVVVKC DGRGSGFQGT KLLHEVRRRL GLLEEKDQME AVRTMLKEQY IDRTRVAVFG KDYGGYLSTY ILPAKGENQG QTFTCGSALS PITDFKLYAS AFSERYLGLH GLDNRAYEMT KVAHRVSALE EQQFLIIHPT ADEKIHFQHT AELITQLIRG KANYSLQIYP DESHYFTSSS LKQHLYRSII NFFVECFRIQ DKLPTVTAKE DEEED
References (54)
| Title : Anti-dipeptidyl-peptidase-like protein-6 encephalitis with late-onset gastric cancer: A case report and 2-year follow-up - Wu_2025_Medicine.(Baltimore)_104_e41534 |
| Author(s) : Wu G , Shi Y , Sun J , Wu F , Jiang M , Li Q |
| Ref : Medicine (Baltimore) , 104 :e41534 , 2025 |
| Abstract : |
| PubMedSearch : Wu_2025_Medicine.(Baltimore)_104_e41534 |
| PubMedID: 39960935 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Expanding the clinical spectrum of anti-DPPX encephalitis: a multicenter retrospective study - Gao_2024_Front.Neurosci_18_1379933 |
| Author(s) : Gao Y , Zhang Y , Chunyu H , Xu Y , Wang Y , Liu S , Chang J , Tang B , Xu C , Lu Y , Zhou J , Kong X , Zhu X , Chen S , Zhou Q , Meng H |
| Ref : Front Neurosci , 18 :1379933 , 2024 |
| Abstract : |
| PubMedSearch : Gao_2024_Front.Neurosci_18_1379933 |
| PubMedID: 38756408 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Neuropsychiatric Presentation of Anti-DPPX Progressive Encephalomyelitis with Rigidity and Myoclonus - |
| Author(s) : Neo RJ , Mehta AR , Weston M , Magrinelli F , Quattrone A , Gandhi S , Joyce EM , Bhatia KP |
| Ref : Movement Disorder Clin Pract , 11 :97 , 2024 |
| PubMedID: 38291842 |
| Gene_locus related to this paper: human-DPP6 |
| Title : The effect of double filtration plasmapheresis and corticosteroids on patients with anti-dipeptidyl-peptidase-like protein 6 encephalitis - Wan_2024_Ther.Apher.Dial_28_141 |
| Author(s) : Wan W , Pan Y , Chen Y , Bai S , Yao X , Lin Y , Wu J , Ni L , Mei Y , Qiu H , Zhou Y , Hao Y , Guan Y |
| Ref : Ther Apher Dial , 28 :141 , 2024 |
| Abstract : |
| PubMedSearch : Wan_2024_Ther.Apher.Dial_28_141 |
| PubMedID: 37461148 |
| Gene_locus related to this paper: human-DPP6 |
| Title : A rare case of anti-DPPX encephalitis combined with neuroleptospirosis - Jin_2024_BMC.Neurol_24_34 |
| Author(s) : Jin Y , Lan W , Chen X , Liu W , Luo W , Chen S |
| Ref : BMC Neurol , 24 :34 , 2024 |
| Abstract : |
| PubMedSearch : Jin_2024_BMC.Neurol_24_34 |
| PubMedID: 38243162 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Colocalization of Increased Midbrain Signals in Neuroinflammation and Tau PET Imaging Suggests the Diagnosis of Progressive Supranuclear Palsy - Lu_2024_Clin.Nucl.Med__ |
| Author(s) : Lu J , Ge J , Yu H , Zhao G , Chen X |
| Ref : Clin Nucl Med , : , 2024 |
| Abstract : |
| PubMedSearch : Lu_2024_Clin.Nucl.Med__ |
| PubMedID: 38271226 |
| Gene_locus related to this paper: human-DPP6 |
| Title : A Devastating Neurological Disorder: Anti-Dipeptidyl-Peptidase-Like Protein 6 (DPPX) Encephalitis Causing Rapidly Progressive Dementia - Esechie_2023_Cureus_15_e51123 |
| Author(s) : Esechie A , Thottempudi N , Patel C , Shanina E , Li X |
| Ref : Cureus , 15 :e51123 , 2023 |
| Abstract : |
| PubMedSearch : Esechie_2023_Cureus_15_e51123 |
| PubMedID: 38274926 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Long term outcomes in patients with anti-DPPX autoimmunity - Dominguez_2023_J.Neuroimmunol_384_578214 |
| Author(s) : Dominguez L , McKeon A , Tobin WO , Lopez-Chiriboga S |
| Ref : Journal of Neuroimmunology , 384 :578214 , 2023 |
| Abstract : |
| PubMedSearch : Dominguez_2023_J.Neuroimmunol_384_578214 |
| PubMedID: 37806046 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Case report: Pain in anti-DPPX encephalitis - Bjerknes_2022_Front.Neurol_13_1091688 |
| Author(s) : Bjerknes TL , Steihaug OM , Haugen M , Hjelland IE , Vedeler CA |
| Ref : Front Neurol , 13 :1091688 , 2022 |
| Abstract : |
| PubMedSearch : Bjerknes_2022_Front.Neurol_13_1091688 |
| PubMedID: 36588910 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6) - Malloy_2022_Int.J.Mol.Sci_23_9184 |
| Author(s) : Malloy C , Ahern M , Lin L , Hoffman DA |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Malloy_2022_Int.J.Mol.Sci_23_9184 |
| PubMedID: 36012450 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report - Lin_2022_BMC.Neurol_22_242 |
| Author(s) : Lin J , Zhu M , Mao X , Jin Z , Zhou M , Hong D |
| Ref : BMC Neurol , 22 :242 , 2022 |
| Abstract : |
| PubMedSearch : Lin_2022_BMC.Neurol_22_242 |
| PubMedID: 35778696 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Activation and closed-state inactivation mechanisms of the human voltage-gated K(V)4 channel complexes - Ye_2022_Mol.Cell_S1097-2765_00395 |
| Author(s) : Ye W , Zhao H , Dai Y , Wang Y , Lo YH , Jan LY , Lee CH |
| Ref : Mol Cell , : , 2022 |
| Abstract : |
| PubMedSearch : Ye_2022_Mol.Cell_S1097-2765_00395 |
| PubMedID: 35597238 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy - Xiao_2022_BMC.Neurol_22_129 |
| Author(s) : Xiao J , Fu PC , Li ZJ |
| Ref : BMC Neurol , 22 :129 , 2022 |
| Abstract : |
| PubMedSearch : Xiao_2022_BMC.Neurol_22_129 |
| PubMedID: 35382765 |
| Gene_locus related to this paper: human-DPP6 |
| Title : The Molecular Genetics of Dissociative Symptomatology: A Transdiagnostic Literature Review - Rajkumar_2022_Genes.(Basel)_13_843 |
| Author(s) : Rajkumar RP |
| Ref : Genes (Basel) , 13 : , 2022 |
| Abstract : |
| PubMedSearch : Rajkumar_2022_Genes.(Basel)_13_843 |
| PubMedID: 35627228 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Structural basis of gating modulation of Kv4 channel complexes - Kise_2021_Nature__ |
| Author(s) : Kise Y , Kasuya G , Okamoto HH , Yamanouchi D , Kobayashi K , Kusakizako T , Nishizawa T , Nakajo K , Nureki O |
| Ref : Nature , : , 2021 |
| Abstract : |
| PubMedSearch : Kise_2021_Nature__ |
| PubMedID: 34552243 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Treatable Rapid Progressive Dementia: A First Case Report of Anti-dipeptidyl-peptidase-like Protein 6 Encephalitis in Taiwan - Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| Author(s) : Tsai MC , Shih HK , Lin HH , Tsai MY , Sung YF |
| Ref : Acta Neurol Taiwan , 30(3) :118 , 2021 |
| Abstract : |
| PubMedSearch : Tsai_2021_Acta.Neurol.Taiwan_30(3)_118 |
| PubMedID: 34841508 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Psychiatric Sequelae of Anti-Dipeptidyl Peptidase-Like Protein-6 Encephalitis: A Case Report and Review of the Literature - |
| Author(s) : Dean EA , Sola CL |
| Ref : J Acad Consult Liaison Psychiatry , 62 :449 , 2021 |
| PubMedID: 34210404 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Clinical Features and Prognosis in Chinese Patients With Dipeptidyl-Peptidase-Like Protein 6 Antibody-Associated Encephalitis - Miao_2021_Front.Neurol_12_817896 |
| Author(s) : Miao A , Shi Y , Wang X , Ge J , Yu C |
| Ref : Front Neurol , 12 :817896 , 2021 |
| Abstract : |
| PubMedSearch : Miao_2021_Front.Neurol_12_817896 |
| PubMedID: 35095748 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX autoimmune encephalitis: A short report on two patients presenting with classic features of this rare but treatable disease - |
| Author(s) : Mbonde AA , Gritsch D , Arca K , Blech B , McKeon A , Carter J |
| Ref : Mult Scler Relat Disord , 52 :102934 , 2021 |
| PubMedID: 33901970 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-dipeptidyl-peptidase-like protein 6 encephalitis, a rare cause of reversible rapid progressive dementia and insomnia - Zhou_2020_J.Neuroimmunol_339_577114 |
| Author(s) : Zhou Q , Zhu X , Meng H , Zhang M , Chen S |
| Ref : Journal of Neuroimmunology , 339 :577114 , 2020 |
| Abstract : |
| PubMedSearch : Zhou_2020_J.Neuroimmunol_339_577114 |
| PubMedID: 31775073 |
| Gene_locus related to this paper: human-DPP6 |
| Title : A novel structure associated with aging is augmented in the DPP6-KO mouse brain - Lin_2020_Acta.Neuropathol.Commun_8_197 |
| Author(s) : Lin L , Petralia RS , Lake R , Wang YX , Hoffman DA |
| Ref : Acta Neuropathologica Commun , 8 :197 , 2020 |
| Abstract : |
| PubMedSearch : Lin_2020_Acta.Neuropathol.Commun_8_197 |
| PubMedID: 33225987 |
| Gene_locus related to this paper: human-DPP6 , mouse-DPP6 |
| Title : Utilization of video oculography to quantify oculomotor dysfunction in anti-DPPX encephalitis: A case study - Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| Author(s) : Blackburn K , Vernino S , Sguigna P |
| Ref : Mult Scler Relat Disord , 46 :102460 , 2020 |
| Abstract : |
| PubMedSearch : Blackburn_2020_Mult.Scler.Relat.Disord_46_102460 |
| PubMedID: 32932166 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Oro-Bucco-Lingual Dyskinesia, Weight Loss, and Cognitive Decline in Anti-DPPX Antibody-Mediated Encephalitis - |
| Author(s) : Deuel LM , Yu CH , Vaughan CL , Piquet AL |
| Ref : Movement Disorder Clin Pract , 7 :S80 , 2020 |
| PubMedID: 33015231 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Co-occurrence of antibodies against dipeptidyl-peptidase-like protein-6 and aquaporin-4 during a case of paraneoplastic encephalitis - |
| Author(s) : Bien CG , Schanzer A , Dargvainiene J , Dogan-Onugoren M , Woermann F , Strickler A |
| Ref : Clin Neurol Neurosurg , 197 :106093 , 2020 |
| PubMedID: 32702576 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Dipeptidyl-peptidase-like protein 6 encephalitis treated with immunotherapy - Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| Author(s) : Ye L , Schnegelsberg M , Obermann M |
| Ref : Proc (Bayl Univ Med Cent) , 34 :114 , 2020 |
| Abstract : |
| PubMedSearch : Ye_2020_Proc.(Bayl.Univ.Med.Cent)_34_114 |
| PubMedID: 33456166 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Teaching Video NeuroImages: Opsoclonus in anti-DPPX encephalitis - |
| Author(s) : Micieli JA , Newman NJ , Kase CS , Biousse V |
| Ref : Neurology , 92 :e2298 , 2019 |
| PubMedID: 31061220 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Pruritus in anti-DPPX encephalitis - |
| Author(s) : Wijntjes J , Bechakra M , Schreurs MWJ , Jongen JLM , Koppenaal A , Titulaer MJ |
| Ref : Neurol Neuroimmunol Neuroinflamm , 5 :e455 , 2018 |
| PubMedID: 29616232 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX antibody-associated encephalitis: Main syndrome and antibody effects - Hara_2017_Neurology_88_1340 |
| Author(s) : Hara M , Arino H , Petit-Pedrol M , Sabater L , Titulaer MJ , Martinez-Hernandez E , Schreurs MW , Rosenfeld MR , Graus F , Dalmau J |
| Ref : Neurology , 88 :1340 , 2017 |
| Abstract : |
| PubMedSearch : Hara_2017_Neurology_88_1340 |
| PubMedID: 28258082 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-DPPX encephalitis: prominent nystagmus reflected by extraocular muscle FDG-PET avidity - |
| Author(s) : Doherty L , Gold D , Solnes L , Probasco J , Venkatesan A |
| Ref : Neurol Neuroimmunol Neuroinflamm , 4 :e361 , 2017 |
| PubMedID: 28626782 |
| Gene_locus related to this paper: human-DPP6 |
| Title : [Progressive encephalitis due to anti-DPPX antibodies: a case with good response to treatment with rituximab] - |
| Author(s) : Valero-Lopez G , Martin-Fernandez JJ , Hernandez-Clares R , Baidez-Guerrero AE , Martinez-Hernandez E |
| Ref : Rev Neurol , 65 :525 , 2017 |
| PubMedID: 29178111 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Implication of LRRC4C and DPP6 in neurodevelopmental disorders - Maussion_2017_Am.J.Med.Genet.A_173_395 |
| Author(s) : Maussion G , Cruceanu C , Rosenfeld JA , Bell SC , Jollant F , Szatkiewicz J , Collins RL , Hanscom C , Kolobova I , de Champfleur NM , Blumenthal I , Chiang C , Ota V , Hultman C , O'Dushlaine C , McCarroll S , Alda M , Jacquemont S , Ordulu Z , Marshall CR , Carter MT , Shaffer LG , Sklar P , Girirajan S , Morton CC , Gusella JF , Turecki G , Stavropoulos DJ , Sullivan PF , Scherer SW , Talkowski ME , Ernst C |
| Ref : American Journal of Medicine Genet A , 173 :395 , 2017 |
| Abstract : |
| PubMedSearch : Maussion_2017_Am.J.Med.Genet.A_173_395 |
| PubMedID: 27759917 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex - Kitazawa_2015_J.Biol.Chem_290_22724 |
| Author(s) : Kitazawa M , Kubo Y , Nakajo K |
| Ref : Journal of Biological Chemistry , 290 :22724 , 2015 |
| Abstract : |
| PubMedSearch : Kitazawa_2015_J.Biol.Chem_290_22724 |
| PubMedID: 26209633 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Anti-DPPX encephalitis: Pathogenic effects of antibodies on gut and brain neurons - Piepgras_2015_Neurology_85_890 |
| Author(s) : Piepgras J , Holtje M , Michel K , Li Q , Otto C , Drenckhahn C , Probst C , Schemann M , Jarius S , Stocker W , Balint B , Meinck HM , Buchert R , Dalmau J , Ahnert-Hilger G , Ruprecht K |
| Ref : Neurology , 85 :890 , 2015 |
| Abstract : |
| PubMedSearch : Piepgras_2015_Neurology_85_890 |
| PubMedID: 26291285 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Prednisolone and azathioprine are effective in DPPX antibody-positive autoimmune encephalitis - |
| Author(s) : Stoeck K , Carstens PO , Jarius S , Raddatz D , Stocker W , Wildemann B , Schmidt J |
| Ref : Neurol Neuroimmunol Neuroinflamm , 2 :e86 , 2015 |
| PubMedID: 25798450 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPP6 gene disruption in a family with Gilles de la Tourette syndrome - Prontera_2014_Neurogenetics_15_237 |
| Author(s) : Prontera P , Napolioni V , Ottaviani V , Rogaia D , Fusco C , Augello B , Serino D , Parisi V , Bernardini L , Merla G , Cavanna AE , Donti E |
| Ref : Neurogenetics , 15 :237 , 2014 |
| Abstract : |
| PubMedSearch : Prontera_2014_Neurogenetics_15_237 |
| PubMedID: 25129042 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Progressive encephalomyelitis with rigidity and myoclonus: a new variant with DPPX antibodies - Balint_2014_Neurology_82_1521 |
| Author(s) : Balint B , Jarius S , Nagel S , Haberkorn U , Probst C , Blocker IM , Bahtz R , Komorowski L , Stocker W , Kastrup A , Kuthe M , Meinck HM |
| Ref : Neurology , 82 :1521 , 2014 |
| Abstract : |
| PubMedSearch : Balint_2014_Neurology_82_1521 |
| PubMedID: 24696508 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients - Tobin_2014_Neurology_83_1797 |
| Author(s) : Tobin WO , Lennon VA , Komorowski L , Probst C , Clardy SL , Aksamit AJ , Appendino JP , Lucchinetti CF , Matsumoto JY , Pittock SJ , Sandroni P , Tippmann-Peikert M , Wirrell EC , McKeon A |
| Ref : Neurology , 83 :1797 , 2014 |
| Abstract : |
| PubMedSearch : Tobin_2014_Neurology_83_1797 |
| PubMedID: 25320100 |
| Gene_locus related to this paper: human-DPP6 |
| Title : The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6 - Mercer_2013_J.Biol.Chem_288_37241 |
| Author(s) : Mercer RC , Ma L , Watts JC , Strome R , Wohlgemuth S , Yang J , Cashman NR , Coulthart MB , Schmitt-Ulms G , Jhamandas JH , Westaway D |
| Ref : Journal of Biological Chemistry , 288 :37241 , 2013 |
| Abstract : |
| PubMedSearch : Mercer_2013_J.Biol.Chem_288_37241 |
| PubMedID: 24225951 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Loss-of-function variation in the DPP6 gene is associated with autosomal dominant microcephaly and mental retardation - Liao_2013_Eur.J.Med.Genet_56_484 |
| Author(s) : Liao C , Fu F , Li R , Yang WQ , Liao HY , Yan JR , Li J , Li SY , Yang X , Li DZ |
| Ref : Eur Journal of Medical Genetics , 56 :484 , 2013 |
| Abstract : |
| PubMedSearch : Liao_2013_Eur.J.Med.Genet_56_484 |
| PubMedID: 23832105 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia - Tanaka_2013_Pharmacogenomics.J_13_27 |
| Author(s) : Tanaka S , Syu A , Ishiguro H , Inada T , Horiuchi Y , Ishikawa M , Koga M , Noguchi E , Ozaki N , Someya T , Kakita A , Takahashi H , Nawa H , Arinami T |
| Ref : Pharmacogenomics J , 13 :27 , 2013 |
| Abstract : |
| PubMedSearch : Tanaka_2013_Pharmacogenomics.J_13_27 |
| PubMedID: 21826085 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels - Boronat_2013_Ann.Neurol_73_120 |
| Author(s) : Boronat A , Gelfand JM , Gresa-Arribas N , Jeong HY , Walsh M , Roberts K , Martinez-Hernandez E , Rosenfeld MR , Balice-Gordon R , Graus F , Rudy B , Dalmau J |
| Ref : Annals of Neurology , 73 :120 , 2013 |
| Abstract : |
| PubMedSearch : Boronat_2013_Ann.Neurol_73_120 |
| PubMedID: 23225603 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6 - Postema_2011_Neth.Heart.J_19_290 |
| Author(s) : Postema PG , Christiaans I , Hofman N , Alders M , Koopmann TT , Bezzina CR , Loh P , Zeppenfeld K , Volders PG , Wilde AA |
| Ref : Neth Heart J , 19 :290 , 2011 |
| Abstract : |
| PubMedSearch : Postema_2011_Neth.Heart.J_19_290 |
| PubMedID: 21512816 |
| Gene_locus related to this paper: human-DPP6 |
| Title : DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons - Sun_2011_Neuron_71_1102 |
| Author(s) : Sun W , Maffie JK , Lin L , Petralia RS , Rudy B , Hoffman DA |
| Ref : Neuron , 71 :1102 , 2011 |
| Abstract : |
| PubMedSearch : Sun_2011_Neuron_71_1102 |
| PubMedID: 21943606 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. - Alders_2009_Am.J.Hum.Genet_84_468 |
| Author(s) : Alders M , Koopmann TT , Christiaans I , Postema PG , Beekman L , Tanck MW , Zeppenfeld K , Loh P , Koch KT , Demolombe S , Mannens MM , Bezzina CR , Wilde AA |
| Ref : American Journal of Human Genetics , 84 :468 , 2009 |
| Abstract : |
| PubMedSearch : Alders_2009_Am.J.Hum.Genet_84_468 |
| PubMedID: 19285295 |
| Gene_locus related to this paper: human-DPP6 |
| Title : The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels - Dougherty_2009_Channels.(Austin)_3_122 |
| Author(s) : Dougherty K , Tu L , Deutsch C , Covarrubias M |
| Ref : Channels (Austin) , 3 :122 , 2009 |
| Abstract : |
| PubMedSearch : Dougherty_2009_Channels.(Austin)_3_122 |
| PubMedID: 19372736 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3 - Radicke_2005_J.Physiol_565_751 |
| Author(s) : Radicke S , Cotella D , Graf EM , Ravens U , Wettwer E |
| Ref : Journal of Physiology , 565 :751 , 2005 |
| Abstract : |
| PubMedSearch : Radicke_2005_J.Physiol_565_751 |
| PubMedID: 15890703 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family - Strop_2004_J.Mol.Biol_343_1055 |
| Author(s) : Strop P , Bankovich AJ , Hansen KC , Garcia KC , Brunger AT |
| Ref : Journal of Molecular Biology , 343 :1055 , 2004 |
| Abstract : |
| PubMedSearch : Strop_2004_J.Mol.Biol_343_1055 |
| PubMedID: 15476821 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10) - Jerng_2004_Biophys.J_87_2380 |
| Author(s) : Jerng HH , Qian Y , Pfaffinger PJ |
| Ref : Biophysical Journal , 87 :2380 , 2004 |
| Abstract : |
| PubMedSearch : Jerng_2004_Biophys.J_87_2380 |
| PubMedID: 15454437 |
| Gene_locus related to this paper: human-DPP6 , human-DPP10 |
| Title : The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels - Nadal_2003_Neuron_37_449 |
| Author(s) : Nadal MS , Ozaita A , Amarillo Y , Vega-Saenz de Miera E , Ma Y , Mo W , Goldberg EM , Misumi Y , Ikehara Y , Neubert TA , Rudy B |
| Ref : Neuron , 37 :449 , 2003 |
| Abstract : |
| PubMedSearch : Nadal_2003_Neuron_37_449 |
| PubMedID: 12575952 |
| Gene_locus related to this paper: human-DPP6 , human-DPP10 |
| Title : Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein - Kin_2001_J.Biochem_129_289 |
| Author(s) : Kin Y , Misumi Y , Ikehara Y |
| Ref : J Biochem , 129 :289 , 2001 |
| Abstract : |
| PubMedSearch : Kin_2001_J.Biochem_129_289 |
| PubMedID: 11173531 |
| Gene_locus related to this paper: human-DPP6 , human-DPP10 |
| Title : Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7 - |
| Author(s) : Yokotani N , Doi K , Wenthold RJ , Wada K |
| Ref : Hum Mol Genet , 2 :1037 , 1993 |
| PubMedID: 8103397 |
| Gene_locus related to this paper: human-DPP6 |
| Title : Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family - Wada_1992_Proc.Natl.Acad.Sci.U.S.A_89_197 |
| Author(s) : Wada K , Yokotani N , Hunter C , Doi K , Wenthold RJ , Shimasaki S |
| Ref : Proc Natl Acad Sci U S A , 89 :197 , 1992 |
| Abstract : |
| PubMedSearch : Wada_1992_Proc.Natl.Acad.Sci.U.S.A_89_197 |
| PubMedID: 1729689 |
| Gene_locus related to this paper: bovin-dpp6 , human-DPP6 , human-DPP10 , ratno-dpp6 |