Asp2

Relationship

Family: Asp2

Block: X

Parent Family: No family

Comment

(from Interpro) Accessory Sec protein Asp2. Proteins in this entry form part of an accessory Sec system which is involved in the export of serine-rich repeat (SRR) glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. Asp2 and Asp3 interact directly with GspB and may function in part as chaperones in the early phase of GspB transport. Asp2 is a bifunctional protein that is essential for both GspB transport and correct glycosylation. A subset of this family is XcbB_CpsF_sero family

Database

Interpro : IPR022267 Accessory Sec system protein Asp2

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF16929 Asp2

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (2)

Genes Proteins in Asp2 family (287)

Fragments of genes in Asp2 family (6)

Structures in Asp2 family (2)

No substrate

No Inhibitor

References (6)

Title : Structural and functional insights into the Asp1\/2\/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP - Guo_2020_Biochem.Biophys.Res.Commun_524_784
Author(s) : Guo C , Feng Z , Zuo G , Jiang YL , Zhou CZ , Chen Y , Hou WT
Ref : Biochemical & Biophysical Research Communications , 524 :784 , 2020
PubMedID: 32037091
Gene_locus related to this paper: stree-a0a0b7mbs7

Title : Gap2 promotes the formation of a stable protein complex required for mature Fap1 biogenesis - Echlin_2013_J.Bacteriol_195_2166
Author(s) : Echlin H , Zhu F , Li Y , Peng Z , Ruiz T , Bedwell GJ , Prevelige PE, Jr. , Wu H
Ref : Journal of Bacteriology , 195 :2166 , 2013
PubMedID: 23475979
Gene_locus related to this paper: 9stre-e7s950

Title : Differential localization of the streptococcal accessory sec components and implications for substrate export - Yen_2013_J.Bacteriol_195_682
Author(s) : Yen YT , Cameron TA , Bensing BA , Seepersaud R , Zambryski PC , Sullam PM
Ref : Journal of Bacteriology , 195 :682 , 2013
PubMedID: 23204472

Title : The accessory Sec protein Asp2 modulates GlcNAc deposition onto the serine-rich repeat glycoprotein GspB - Seepersaud_2012_J.Bacteriol_194_5564
Author(s) : Seepersaud R , Bensing BA , Yen YT , Sullam PM
Ref : Journal of Bacteriology , 194 :5564 , 2012
PubMedID: 22885294
Gene_locus related to this paper: strag-a0a076z217 , strgn-asp2

Title : Asp2 and Asp3 interact directly with GspB, the export substrate of the Streptococcus gordonii accessory Sec System - Yen_2011_J.Bacteriol_193_3165
Author(s) : Yen YT , Seepersaud R , Bensing BA , Sullam PM
Ref : Journal of Bacteriology , 193 :3165 , 2011
PubMedID: 21531800
Gene_locus related to this paper: strgn-asp2

Title : Genes in the accessory sec locus of Streptococcus gordonii have three functionally distinct effects on the expression of the platelet-binding protein GspB - Takamatsu_2004_Mol.Microbiol_52_189
Author(s) : Takamatsu D , Bensing BA , Sullam PM
Ref : Molecular Microbiology , 52 :189 , 2004
PubMedID: 15049820
Gene_locus related to this paper: strgn-asp2