Family: Epoxide-hydrolase_like

Block: X

Parent Family: No family


This family closely related to Abhydrolase_6 contains previously separated families (in Pfam they are partially included in Abhydrolase_6). In epoxide hydrolase, haloalkane dehalogenase, haloacetate_dehalogenase, the catalytic triad nucleophile is an invariable aspartate. Asp attacks a carbon of the epoxide moiety, opening the ring and forming an ester-linked substrate-enzyme intermediate complex. An activated water molecule, hydrolyzes the ester bond and releases diol as the product of catalysis. Two Tyr residues are located on the opposite side of the active site from the nucleophile. They hydrogen bond with the epoxide oxygen, positioning the substrate in the active site for nucleophilic attack. In Cif one of the Tyr is replaced by His


Interpro : IPR000639 Epoxide hydrolase-like , IPR016292 Epoxide hydrolase , IPR010497 Epoxide hydrolase, N-terminal


Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

No Genes Proteins

No fragment of genes

No fragment of genes

Substrates in Epoxide-hydrolase_like family (1)

No Inhibitor

References (3)

Title : alpha\/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase - Pusch_2022_Metabolites_12_761
Author(s) : Pusch LM , Riegler-Berket L , Oberer M , Zimmermann R , Taschler U
Ref : Metabolites , 12 : , 2022
PubMedID: 36005632
Gene_locus related to this paper: human-ABHD6

Title : Epoxide hydrolases: structure, function, mechanism, and assay - Arand_2005_Methods.Enzymol_400_569
Author(s) : Arand M , Cronin A , Adamska M , Oesch F
Ref : Methods Enzymol , 400 :569 , 2005
PubMedID: 16399371

Title : The telltale structures of epoxide hydrolases - Arand_2003_Drug.Metab.Rev_35_365
Author(s) : Arand M , Cronin A , Oesch F , Mowbray SL , Jones TA
Ref : Drug Metabolism Reviews , 35 :365 , 2003
PubMedID: 14705866