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Mbeg1-like

Relationship

Family: Mbeg1-like

Block: X

Parent Family: No family

Comment

This bacterial family of proteins has no known function. Should be in L Block PS00120. Few Plant proteins (Selaginella moellendorffii) and Plastid group (Trypanosoma) Phospholipase A1 activity was identified as the gene product of plaA of Serratia liquefaciens Serratia sp MK1 (Givskov Molin 1993, Song et al. 1999) Phospholipase A of Yersinia enterocolitica contributes to pathogenesis in a mouse model (Schmiel et al. 1998) Gemella sanguinis 9bacl-a0a2n6sev5 protein identified as Mbeg1 in a functional multigenomic screening of human-associated bacteria for NF-kappaB-inducing bioactive effectors (Estrela et al.) since then family called Mbeg1-like (previously DUF_2974)

Database

Interpro : IPR024499 Mbeg1-like

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF11187 Mbeg1-like DUF2974

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
7UBZ Chymotrypsin digested toxin\/immunity complex for a T6SS lipase effector from E. cloacae entcl-a0a0m7ene2
7UC0 WITHDRAWN Toxin\/immunity complex for a T6SS lipase effector from E. cloacae entcl-a0a0m7ene2
7UC1 WITHDRAWN Toxin S289A mutant\/immunity complex for a T6SS lipase effector from E. cloacae entcl-a0a0m7ene2
9CYS Toxin\/immunity complex for a T6SS lipase effector from E. cloacae entcl-a0a0m7ene2

Gene_locus Name Species
9actn-a4e7n0 Collinsella aerofaciens ATCC 25986 Putative uncharacterized protein Collinsella aerofaciens ATCC 25986
9actn-b6gbh9 Collinsella stercoris DSM 13279 Putative uncharacterized protein Collinsella stercoris DSM 13279
9actn-b9ck47 Atopobium rimae ATCC 49626 Putative uncharacterized protein Atopobium rimae ATCC 49626
9actn-c4f994 Collinsella intestinalis DSM 13280 Putative uncharacterized protein Collinsella intestinalis DSM 13280
9acto-a7bat0 Actinomyces odontolyticus ATCC 17982 Putative uncharacterized protein Actinomyces odontolyticus ATCC 17982
9bace-b7ar17 Bacteroides pectinophilus ATCC 43243 Putative uncharacterized protein Bacteroides pectinophilus ATCC 43243
9bacl-a0a2n6sev5 Gemella sanguinis NF-kappaB-Inducing Bioactive Effector Gemella sanguinis
9bacl-b7dps0 Alicyclobacillus acidocaldarius LAA1 Putative uncharacterized protein Alicyclobacillus acidocaldarius LAA1
9bact-b0fb14 uncultured bacterium pFosPlaG Phospholipase A1 uncultured bacterium pFosPlaG
9bifi-b1s7a0 Bifidobacterium dentium, Putative uncharacterized protein Bifidobacterium dentium ATCC 27678
9bifi-b1s7a2 Bifidobacterium dentium, Putative uncharacterized protein Bifidobacterium dentium ATCC 27678
9bifi-b6xwn9 Bifidobacterium catenulatum DSM 16992 Putative uncharacterized protein Bifidobacterium catenulatum DSM 16992
9bifi-c0bqy6 Bifidobacterium pseudocatenulatum DSM 20438 Putative uncharacterized protein Bifidobacterium pseudocatenulatum DSM 20438
9bifi-c0bqy7 Bifidobacterium pseudocatenulatum DSM 20438 DSM 16992 Putative uncharacterized protein Bifidobacterium pseudocatenulatum DSM 20438
9bifi-c4feq0 Bifidobacterium angulatum DSM 20098 Putative uncharacterized protein Bifidobacterium angulatum DSM 20098
9bifi-c4fgw1 Bifidobacterium angulatum DSM 20098 Putative uncharacterized protein Bifidobacterium angulatum DSM 20098
9burk-b5wmp6 Burkholderia sp. H160 Putative uncharacterized protein Burkholderia sp. H160
9clot-a7vep4 Clostridium sp. L2-50 Putative uncharacterized protein Clostridium sp. L2-50
9clot-b6fnm2 Clostridium nexile DSM 1787 Putative uncharacterized protein Clostridium nexile DSM 1787
9entr-PLAA Serratia sp. MK1 phospholipase a1 Serratia sp. MK1
9entr-a9x3m0 Serratia sp. XJF1 Phospholipase A Serratia sp. XJF1
9entr-b6xeg3 Providencia alcalifaciens DSM 30120 Putative uncharacterized protein Providencia alcalifaciens DSM 30120
9entr-q54889 Serratia proteamaculans Lipase Serratia proteamaculans
9firm-a5zpa7 Ruminococcus obeum ATCC 29174 Putative uncharacterized protein Ruminococcus obeum ATCC 29174
9firm-a8rb13 Eubacterium dolichum DSM 3991 Putative uncharacterized protein Eubacterium dolichum DSM 3991
9firm-a8sie6 Parvimonas micra ATCC 33270 Putative uncharacterized protein Parvimonas micra ATCC 33270
9firm-b0mef0 Anaerostipes caccae DSM 14662 Putative uncharacterized protein Anaerostipes caccae DSM 14662
9firm-b0n5t8 Clostridium ramosum DSM 1402 Putative uncharacterized protein Clostridium ramosum DSM 1402
9firm-b1c295 Clostridium spiroforme DSM 1552 Putative uncharacterized protein Clostridium spiroforme DSM 1552
9firm-b7c8m3 Eubacterium biforme DSM 3989 Putative uncharacterized protein Eubacterium biforme DSM 3989
9firm-b7cbt4 Eubacterium biforme DSM 3989 Putative uncharacterized protein Eubacterium biforme DSM 3989
9firm-c0frk4 Roseburia inulinivorans DSM 16841 Putative uncharacterized protein Roseburia inulinivorans DSM 16841
9firm-c2ky88 Oribacterium sinus F0268 Putative uncharacterized protein Oribacterium sinus F0268
9firm-c4fwx0 Catonella morbi ATCC 51271 Putative uncharacterized protein Catonella morbi ATCC 51271
9firm-c4gby7 Shuttleworthia satelles DSM 14600 Putative uncharacterized protein Shuttleworthia satelles DSM 14600
9heli-c3xin5 Helicobacter bilis ATCC 43879 Lipase Helicobacter bilis ATCC 43879
9laco-c0xd53 Lactobacillus gasseri JV-V03 Putative uncharacterized protein Lactobacillus gasseri JV-V03
9laco-c0xef2 Lactobacillus gasseri JV-V03 (strain ATCC 33323 \/ DSM 20243) 202-4 Putative uncharacterized protein Lactobacillus gasseri JV-V03
9laco-c2elr4 Lactobacillus ultunensis DSM 16047 Putative uncharacterized protein Lactobacillus ultunensis DSM 16047
9laco-c2eml8 Lactobacillus ultunensis DSM 16047 Putative uncharacterized protein Lactobacillus ultunensis DSM 16047
9laco-c2enu7 Lactobacillus ultunensis DSM 16047 Putative uncharacterized protein Lactobacillus ultunensis DSM 16047
9laco-c2esh2 Lactobacillus vaginalis ATCC 49540 Putative uncharacterized protein Lactobacillus vaginalis ATCC 49540
9laco-c2kc76 Lactobacillus crispatus JV-V01 Putative uncharacterized protein Lactobacillus crispatus JV-V01
9laco-c2kdb5 Lactobacillus crispatus JV-V01 Putative uncharacterized protein Lactobacillus crispatus JV-V01
9laco-c4vne8 Lactobacillus jensenii 269-3 and 1153 JV-V16 Putative uncharacterized protein Lactobacillus jensenii 269-3
9laco-c4vpp3 Lactobacillus gasseri 202-4 Putative uncharacterized protein Lactobacillus gasseri 202-4
9molu-c3rqh3 Mollicutes bacterium D7 Putative uncharacterized protein Mollicutes bacterium D7
9stre-b1sfy1 Streptococcus infantarius subsp. infantarius ATCC BAA-102 Putative uncharacterized protein Streptococcus infantarius subsp. infantarius ATCC BAA-102
amoa5-b3erb7 Amoebophilus asiaticus (strain 5a2) Putative uncharacterized protein Amoebophilus asiaticus
amoa5-b3esw9 Amoebophilus asiaticus (strain 5a2) Putative uncharacterized protein Amoebophilus asiaticus
amoa5-b3esx2 Amoebophilus asiaticus (strain 5a2) Putative uncharacterized protein Amoebophilus asiaticus
amoa5-b3et14 Amoebophilus asiaticus (strain 5a2) Putative uncharacterized protein Amoebophilus asiaticus
bacce-q4mwb5 Bacillus cereus G9241 Putative peptidoglycan binding domain protein Bacillus cereus G9241
bacpu-b4ak00 Bacillus pumilus ATCC 7061 Putative uncharacterized protein Bacillus pumilus ATCC 7061
bifaa-a0zzu1 Bifidobacterium adolescentis (strain ATCC 15703 \/ DSM 20083) L2-32 Putative uncharacterized protein Bifidobacterium adolescentis
bifaa-a0zzu2 Bifidobacterium adolescentis (strain ATCC 15703 \/ DSM 20083) L2-32 Putative uncharacterized protein Bifidobacterium adolescentis
bifan-b2ea73 Bifidobacterium animalis subsp. lactis, Putative uncharacterized protein Bifidobacterium animalis subsp. lactis HN019
biflo-BL0336 Bifidobacterium longum (and subsp. infantis longum), Bifidobacterium sp. hypothetical protein Bifidobacterium longum
biflo-BL0787 Bifidobacterium longum (and subsp.: infantis, longum), Bifidobacterium breve, Bifidobacterium sp. narrowly conserved hypothetical protein Bifidobacterium longum
camco-q4hd54 Campylobacter coli RM2228 Putative uncharacterized protein Campylobacter coli RM2228
camhc-a7i2l0 Campylobacter hominis (strain ATCC BAA-381 \/ LMG 19568 \/ NCTC 13146 CH001A) Putative uncharacterized protein Campylobacter hominis
camjr-q5huc7 Campylobacter jejuni (strain RM1221) Conserved domain protein Campylobacter jejuni
celju-b3pfb5 Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp cellulosa) Putative lipoprotein Cellvibrio japonicus
clob1-a7fv94 Clostridium botulinum Thrombospondin type 3 repeat protein Clostridium botulinum
clob8-a6lub8 Clostridium beijerinckii (strain ATCC 51743 \/ NCIMB 8052) (Clostridium acetobutylicum) Putative uncharacterized protein Clostridium beijerinckii
cloba-b2v2f0 Clostridium botulinum (strain Alaska E43 \/ Type E3) (strain Eklund 17B \/ Type B) Putative uncharacterized protein Clostridium botulinum
clobu-b1qya0 Clostridium butyricum (5521) (E4 str. BoNT E BL5262) Putative uncharacterized protein Clostridium butyricum
cloth-a3dbb5 Clostridium thermocellum (strain ATCC 27405 \/ DSM 1237) Putative uncharacterized protein Clostridium thermocellum
deshd-b8fx43 Desulfitobacterium hafniense (strain DCB-2 \/ DSM 10664) Putative uncharacterized protein Desulfitobacterium hafniense
deshy-q24nz6 Desulfitobacterium hafniense (strain Y51) Putative uncharacterized protein Desulfitobacterium hafniense
desmr-c4xq70 Desulfovibrio magneticus (strain ATCC 700980 \/ DSM 13731 \/ RS-1) Putative uncharacterized protein Desulfovibrio magneticus
edwi9-c5bd69 Edwardsiella ictaluri (strain 93-146) Putative uncharacterized protein Edwardsiella ictaluri
entcl-a0a0m7ene2 Enterobacter cloacae T6SS lipase effector (162-380 domain) Enterobacter cloacae
erwct-q6d1l9 Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) Putative phospholipase Erwinia carotovora subsp. atroseptica
eube2-c4z2j4 Eubacterium eligens (strain ATCC 27750 \/ VPI C15-48) Putative uncharacterized protein Eubacterium eligens
eubr3-c4z8a6 Eubacterium rectale (strain ATCC 33656 \/ VPI 0990) Putative uncharacterized protein Eubacterium rectale
garva-c2cus2 Gardnerella vaginalis ATCC 14019 Putative uncharacterized protein Gardnerella vaginalis ATCC 14019
lacac-c2hnv3 Lactobacillus acidophilus ATCC 4796 Putative uncharacterized protein Lactobacillus acidophilus ATCC 4796
lacac-q5fkq4 Lactobacillus acidophilus Putative uncharacterized protein Lactobacillus acidophilus
lacac-q5flg1 Lactobacillus acidophilus (and ATCC 4796) Putative uncharacterized protein Lactobacillus acidophilus
lacac-q5fmz8 Lactobacillus acidophilus Putative uncharacterized protein Lactobacillus acidophilus
lacc3-q035l1 Lactobacillus casei, Putative uncharacterized protein Lactobacillus casei
laccs-d5h0d3 Lactobacillus crispatus, Putative uncharacterized protein Lactobacillus crispatus JV-V01
lacdb-q04b33 Lactobacillus delbrueckii Putative uncharacterized protein Lactobacillus delbrueckii subsp. bulgaricus
lacdb-q04cw3 Lactobacillus delbrueckii subsp. bulgaricus\; lactis, Putative uncharacterized protein Lactobacillus delbrueckii subsp. bulgaricus
lacga-q043a3 Lactobacillus gasseri, Lactobacillus johnsonii, Putative uncharacterized protein Lactobacillus gasseri
lacga-q045l3 Lactobacillus gasseri (strain ATCC 33323 \/ DSM 20243) Putative uncharacterized protein Lactobacillus gasseri
lach4-a8yut9 Lactobacillus helveticus (strain DPC 4571) Putative uncharacterized protein Lactobacillus helveticus
lach4-a8yw60 Lactobacillus helveticus, Putative uncharacterized protein Lactobacillus helveticus
lache-a4zgx8 Lactobacillus helveticus CNRZ32 Putative triacylglycerol lipase Lactobacillus helveticus CNRZ32
lacjo-c2e7u2 Lactobacillus johnsonii ATCC 33200 Putative uncharacterized protein Lactobacillus johnsonii ATCC 33200
lacjo-q74kr9 Lactobacillus johnsonii Putative uncharacterized protein Lactobacillus johnsonii
lacjo-q74m20 Lactobacillus johnsonii (and ATCC 33200) Putative uncharacterized protein Lactobacillus johnsonii
lacpa-c2fbf7 Lactobacillus paracasei (subsp. paracasei ATCC 25302) (subsp. paracasei 8700:2) (strain BL23) Putative uncharacterized protein Lactobacillus paracasei
lacrh-c2jyu5 Lactobacillus rhamnosus (LMS2-1) (HN001) Putative uncharacterized protein Lactobacillus rhamnosus
pedpa-q03hj2 Pediococcus pentosaceus (strain ATCC 25745 \/ 183-1w) Putative uncharacterized protein Pediococcus pentosaceus
pholl-q7n8a5 Photorhabdus luminescens subsp. laumondii Similar to phospholipase A1 Photorhabdus luminescens subsp. laumondii
prost-b2q175 Providencia stuartii ATCC 25827 Putative uncharacterized protein Providencia stuartii ATCC 25827
ricpr-y165 Rickettsia prowazekii Uncharacterized protein RP165 Rickettsia prowazekii
serli-pa1 Serratia liquefaciens Extracellular phospholipase A1 Serratia liquefaciens
serma-PHLA Serratia marcescens phospholipase Serratia marcescens
serp5-a8gi37 Serratia proteamaculans (strain 568) Phospholipase A(1) Serratia proteamaculans
shewm-b1kgs0 Shewanella woodyi (strain ATCC 51908 \/ MS32) PAAR repeat-containing protein Shewanella woodyi
sodgm-q2nqt2 Sodalis glossinidius (strain morsitans) Putative phospholipase A Sodalis glossinidius
strag-SAG0246 Streptococcus agalactiae (serotype V) (COH1) (18RS21) (H36B)(serotype Ia) (CJB111) hypothetical protein Streptococcus agalactiae
strag-SAG0912 Streptococcus agalactiae (serotype V) (serotype III) (H36B) (CJB111)(serotype Ia) (515) (18RS21) (COH1) conserved hypothetical protein Streptococcus agalactiae
strgc-a8ayc6 Streptococcus gordonii (strain Challis \/ ATCC 35105 \/ CH1 \/ DL1 V288) Putative uncharacterized protein Streptococcus gordonii
strpn-b2dz20 Streptococcus pneumoniae Putative uncharacterized protein Streptococcus pneumoniae
strsl-c2luh7 Streptococcus salivarius SK126 Putative uncharacterized protein Streptococcus salivarius SK126
strsu-a4vws4 Streptococcus suis, Putative uncharacterized protein Streptococcus suis
strsv-a3cpg5 Streptococcus sanguinis, Putative uncharacterized protein Streptococcus sanguinis
stru0-b9dsd7 Streptococcus uberis (strain ATCC BAA-854 \/ 0140J) Putative uncharacterized protein Streptococcus uberis
tryb2-b2zwb5 Trypanosoma brucei TREU927 Putative uncharacterized protein Trypanosoma brucei TREU927
xanca-XCC2722 Xanthomonas campestris, Xanthomonas axonopodis, Xanthomonas perforans, Xanthomonas fuscans, phospholipase a1 Xanthomonas campestris
xenne-xlpA Xenorhabdus nematophilus (Achromobacter nematophilus) XlpA Xenorhabdus nematophila
yeral-c4ubg9 Yersinia aldovae ATCC 35236 Extracellular phospholipase A1 Yersinia aldovae ATCC 35236
yeren-YPLA Yersinia enterocolitica (and serotype O:8 \/ biotype 1B (strain 8081))phospholipase a Yersinia enterocolitica
yerfr-c4snb7 Yersinia frederiksenii ATCC 33641 Extracellular phospholipase A1 Yersinia frederiksenii ATCC 33641
yerin-c4t3r0 Yersinia intermedia ATCC 29909 Extracellular phospholipase A1 Yersinia intermedia ATCC 29909
yerkr-c4tvg1 Yersinia kristensenii ATCC 33638 Extracellular phospholipase A1 Yersinia kristensenii ATCC 33638
yerpe-YPLA Yersinia pestis, Yersinia pseudotuberculosis, phospholipase a Yersinia pestis
yerru-c4ugl2 Yersinia ruckeri ATCC 29473 Extracellular phospholipase A1 Yersinia ruckeri ATCC 29473

Gene_locus_frgt Name Species
amoa5-b3erb8 Amoebophilus asiaticus (strain 5a2) Putative uncharacterized protein Amoebophilus asiaticus
braso-a4z1w8 Bradyrhizobium sp. (strain ORS278) Putative uncharacterized protein Bradyrhizobium sp.
camc1-a7zbx5 Campylobacter concisus (strain 13826) Putative uncharacterized protein Campylobacter concisus
strt2-q5m508 Streptococcus thermophilus (strain ATCC BAA-250 \/ LMG 18311) (strain CNRZ 1066) Putative uncharacterized protein Streptococcus thermophilus

Substrate Chemical Nomenclature Proteins
4-nitro-3-(octanoyloxy)benzoic-acid 4-nitro-3-octanoyloxybenzoic acid yeren-YPLA    human-PLA2G7
POPC [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate 9entr-PLAA

References (4)

Title : Functional Multigenomic Screening of Human-Associated Bacteria for NF-B-Inducing Bioactive Effectors - Estrela_2019_mBio_10_e02587
Author(s) : Estrela AB , Nakashige TG , Lemetre C , Woodworth ID , Weisman JL , Cohen LJ , Brady SF
Ref : MBio , 10 : , 2019
Abstract :
PubMedSearch : Estrela_2019_mBio_10_e02587
PubMedID: 31744921
Gene_locus related to this paper: 9bacl-a0a2n6sev5

Title : Cloning and expression of the gene encoding phospholipase A1 from Serratia sp. MK1 in Escherichia coli - Song_1999_J.Biotechnol_72_103
Author(s) : Song JK , Kim MK , Rhee JS
Ref : J Biotechnol , 72 :103 , 1999
Abstract :
PubMedSearch : Song_1999_J.Biotechnol_72_103
PubMedID: 10406101
Gene_locus related to this paper: 9entr-PLAA

Title : Phospholipase A of Yersinia enterocolitica contributes to pathogenesis in a mouse model - Schmiel_1998_Infect.Immun_66_3941
Author(s) : Schmiel DH , Wagar E , Karamanou L , Weeks D , Miller VL
Ref : Infect Immun , 66 :3941 , 1998
Abstract :
PubMedSearch : Schmiel_1998_Infect.Immun_66_3941
PubMedID: 9673284
Gene_locus related to this paper: yeren-YPLA

Title : Secretion of Serratia liquefaciens phospholipase from Escherichia coli - Givskov_1993_Mol.Microbiol_8_229
Author(s) : Givskov M , Molin S
Ref : Molecular Microbiology , 8 :229 , 1993
Abstract :
PubMedSearch : Givskov_1993_Mol.Microbiol_8_229
PubMedID: 8316077
Gene_locus related to this paper: serli-pa1