Peptidase_S15
Relationship
Comment
This entry represents a domain found peptidases Xaa-Pro dipeptidyl-peptidase and glutaryl-7-aminocephalosporanic-acid acylase, which belong to MEROPS peptidase families S15. It is also found in hydrolases from the CocE/NonD family. Cocaine esterase (CocE) hydrolyzes cocaine endowing the bacteria with the ability to utilise cocaine as a sole source of carbon and energy. YcjY-like are bacterial cell division gene and LipSM54-like_FamXVI belongs also to this larger family
Database
Interpro : IPR000383 X-Pro dipeptidyl-peptidase-like domain Peptidase_S15 , IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal Xaa-Pro_dipept_C
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF02129 Peptidase_S15 , PF08530 PepX_C
Prints : No Print
EC Number : 3.4.14.11
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Ampicillin | (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | xanax-GAA acepa-AEHA pig-EST1 pig-a0a1s6l967 |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| DFP | Diisopropylphosphorofluoridate | arcfu-AF1763 human-DPP4 human-ACHE human-BCHE human-PLA2G7 bacce-BC3734 ecoli-IROE fusso-cutas human-FAP human-CTSA aspni-FAEA |
| PMSF | Phenylmethylsulfonyl fluoride | theet-q3ch51 emeni-q5avy9 human-ABHD10 human-PREPL myctu-Rv1430 psefl-cxest 9bact-E40 thefu-q6a0i4 ecoli-Aes orysj-Q10QA5 bac25-mglp 9bact-Q0GMU2 bacsu-FENB psepu-clcd1 thema-TM0077 bacsu-RsbQ ecoli-bioh drome-CG9542 human-FAP tubmm-TmEst2 human-NOTUM cutac-e6dae5 9gamm-urc15994 9baci-EstD9 geost-est30 pholl-AntI |
| Phenylboronic-acid | phenylboronic acid | rhosm-cocE |
References (3)
| Title : The Structural Basis for Catalysis and Specificity of the X-Prolyl Dipeptidyl Aminopeptidase from Lactococcus lactis - Rigolet_2002_Structure.(Camb)_10_1383 |
| Author(s) : Rigolet P , Mechin I , Delage M , Chich J |
| Ref : Structure (Camb) , 10 :1383 , 2002 |
| Abstract : |
| PubMedSearch : Rigolet_2002_Structure.(Camb)_10_1383 |
| PubMedID: 12377124 |
| Gene_locus related to this paper: lacla-pepx |
| Title : Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1 - Bresler_2000_Appl.Environ.Microbiol_66_904 |
| Author(s) : Bresler MM , Rosser SJ , Basran A , Bruce NC |
| Ref : Applied Environmental Microbiology , 66 :904 , 2000 |
| Abstract : |
| PubMedSearch : Bresler_2000_Appl.Environ.Microbiol_66_904 |
| PubMedID: 10698749 |
| Gene_locus related to this paper: rhosm-cocE |