Family: Thyroglobulin

Block: C

Parent Family: Non-catalytic_C


Only the C-terminal part of thyroglobulin is a member of the alpha/beta hydrolase family, here starting with the first G in cholinesterase 2206 (aa numbering in human thyroglobulin). The N-terminal part of thyroglobulin is made of three domains, labeled I to III, that encompass 10 repeats of a ca. 65 amino acid residues known as the Tg type-1 repeat PF00086 PS00484 IPR011641 IPR000716 not included in ESTHER. Thyroglobulin is the glycoprotein precursor to the thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). It has a molecular mass of 660 kD, with 2 identical subunits, yet its complete hydrolysis yields only 2 to 4 molecules of T3 and T4. The protein contains a 19-amino acid signal peptide followed by 2,748 residues. Van Ommen (1987) suggested that defects in the TG gene can cause either dominant or recessive disorders depending on the nature of the defect. When the gene is absent or at least when no thyroglobulin is synthesized, the disorder is likely to be recessive, whereas the presence of an abnormal subunit leads to a dominantly inherited disorder. The explanation for this is that in a dimeric protein such as thyroglobulin, 75% of the dimers in heterozygotes will contain 1 or more abnormal subunits. This should profoundly disturb thyroglobulin metabolism, since this protein fulfills a dual storage/catalytic role as a dimer, is present in bulk quantities (100 mg Tg/g thyroid mass), and needs to be exocytosed, iodinated, endocytosed, and degraded. EnsemblClone AF230666, EnsemblContig AC079020.2.132816.152274, AF235100_2 gene chromosome 8 clone PAC 98A24 map 8q24.3. there is a small gene with only a little bit of thyroglobuline just 3' of the real gene AC069434.7.189089.192039 ENST00000254617 ENSG00000132287. Three out of five iodination sites are in the cholinesterase homologous domain 2573 (In T4), 2587 (In T4),2766 (In T3)


Interpro : IPR016324 Thyroglobulin , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
7QTQ Structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids. bovin-thyro
7N4Y Structure of bovine thyroglobulin with iodinated tyrosines bovin-thyro
7B75 Cryo-EM structure of native human thyroglobulin human-TG
6SCJ The structure of human thyroglobulin human-TG

Gene_locus Name Species
ailme-d2h794 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
anapl-r0m5n4 Anas platyrhynchos (Domestic duck) (Anas boschas) Thyroglobulin Anas platyrhynchos
anoca-g1kl79 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
bovin-thyro Bos taurus (Bovine) Thyroglobulin Bos taurus
calja-f7id21 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
canfa-q1ert3 Canis familiaris (Dog) thyroglobulin Canis lupus familiaris
cavpo-h0vf67 Cavia porcellus (Guinea pig) Uncharacterized protein Cavia porcellus
chick-thyro Gallus gallus (Chicken) Thyroglobulin Gallus gallus
danre-f1qfr0 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein Danio rerio
gorgo-g3s7h8 Gorilla gorilla gorilla (Lowland gorilla) Uncharacterized protein Gorilla gorilla gorilla
hetga-g5c6q5 Heterocephalus glaber (Naked mole rat) Thyroglobulin Heterocephalus glaber
horse-f6qsc5 Equus caballus (Horse) Uncharacterized protein Equus caballus
human-TG Homo sapiens (Human) Thyroglobulin TG Tg Homo sapiens
loxaf-g3t9h6 Loxodonta africana (African elephant) Uncharacterized protein Loxodonta africana
macfa-g7pd01 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)\; Macaca nemestrina (Pig-tailed macaque) Thyroglobulin Macaca fascicularis
macmu-g7n054 Macaca mulatta (Rhesus macaque) Thyroglobulin Macaca mulatta
mondo-f7ckd0 Monodelphis domestica (Gray short-tailed opossum) Uncharacterized protein Monodelphis domestica
mouse-thyro Mus musculus thyroglobulin cDNA Mus musculus
muspf-m3xr80 Mustela putorius furo (European domestic ferret) (Mustela furo) Uncharacterized protein Mustela putorius furo
myods-l5mij9 Myotis davidii (David's myotis) Thyroglobulin Myotis davidii
myolu-g1nvv4 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
nomle-g1r1g0 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobate leucogenys) Uncharacterized protein Nomascus leucogenys
oreni-i3j1d2 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) Uncharacterized protein Oreochromis niloticus
ornan-f7ejp8 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
oryla-h2mqz5 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
otoga-h0x190 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Uncharacterized protein Otolemur garnettii
pantr-h2qwr1 Pan troglodytes (Chimpanzee) Uncharacterized protein Pan troglodytes
ponab-h2pr87 Pongo abelii (Sumatran orangutan) Uncharacterized protein Pongo abelii
pteal-l5kjy3 Pteropus alecto (Black flying fox) Thyroglobulin Pteropus alecto
rabit-g1siu8 Oryctolagus cuniculus (Rabbit) Uncharacterized protein Oryctolagus cuniculus
ratno-thyro Rattus norvegicus (Rat) Thyroglobulin Rattus norvegicus
sheep-thyro Ovis aries (Sheep) thyroglobulin (fragment) Ovis aries
spetr-i3mj61 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) Uncharacterized protein Spermophilus tridecemlineatus
pig-d1kkb3 Sus scrofa (Pig) Thyroglobulin Sus scrofa
taegu-h0zqp3 Taeniopygia guttata (Zebra finch) (Poephila guttata) Uncharacterized protein Taeniopygia guttata
takru-h2uxa9 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein Takifugu rubripes
xentr-f6v3z1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein Xenopus tropicalis
pelsi-k7fb89 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) Uncharacterized protein Pelodiscus sinensis
xipma-m3zzc8 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
fical-u3jj73 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) Uncharacterized protein Ficedula albicollis
lepoc-w5mke1 Lepisosteus oculatus (Spotted gar). Uncharacterized protein Lepisosteus oculatus
aptfo-a0a087qrv1 Aptenodytes forsteri (Emperor penguin). Thyroglobulin Aptenodytes forsteri
fukda-a0a091dfp4 Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Thyroglobulin Fukomys damarensis
corbr-a0a091eyj6 Corvus brachyrhynchos (American crow). Thyroglobulin Corvus brachyrhynchos
9pass-a0a091p5t6 Acanthisitta chloris (rifleman). Thyroglobulin Acanthisitta chloris
apavi-a0a091pl33 Apaloderma vittatum (Bar-tailed trogon). Thyroglobulin Apaloderma vittatum
opiho-a0a091wkv7 Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). Thyroglobulin Opisthocomus hoazin
picpb-a0a093i4r0 Picoides pubescens (Downy woodpecker) (Dryobates pubescens). Thyroglobulin Picoides pubescens
9pass-a0a093pjh2 Manacus vitellinus (golden-collared manakin). Thyroglobulin Manacus vitellinus
tingu-a0a099z4l8 Tinamus guttatus (White-throated tinamou). Thyroglobulin Tinamus guttatus
chavo-a0a0a0aat2 Charadrius vociferus (Killdeer) (Aegialitis vocifera). Thyroglobulin Charadrius vociferus
9hyst-a0a0a1ec83 Fukomys anselli (Ansell's mole-rat). Thyroglobulin Fukomys anselli
larcr-a0a0f8d1j2 Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). Thyroglobulin Larimichthys crocea
9tele-a0a0p7v4l2 Scleropages formosus (Asian bonytongue) Uncharacterized protein Scleropages formosus
chlsb-a0a0d9rbx5 Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). Uncharacterized protein Chlorocebus sabaeus
funhe-a0a146p2f8 Fundulus heteroclitus (Killifish) (Mummichog). Thyroglobulin-like protein Fundulus heteroclitus
erieu-a0a1s2zn70 Erinaceus europaeus (Western European hedgehog). thyroglobulin Erinaceus europaeus
dipor-a0a1s3fvq3 Dipodomys ordii (Ord's kangaroo rat). thyroglobulin Dipodomys ordii
tarsy-a0a1u7tup6 Tarsius syrichta (Philippine tarsier). thyroglobulin Tarsius syrichta
felca-a0a2i2ugd3 Felis catus (Cat) (Felis silvestris catus). Thyroglobulin Felis catus
aotna-a0a2k5f0h3 Aotus nancymaae (Ma's night monkey). Thyroglobulin Aotus nancymaae
colap-a0a2k5j544 Colobus angolensis palliatus (Peters' Angolan colobus). Thyroglobulin Colobus angolensis palliatus
cerat-a0a2k5nb12 Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Thyroglobulin Cercocebus atys
cebca-a0a2k5r1q1 Cebus capucinus imitator. Thyroglobulin Cebus capucinus imitator
manle-a0a2k6a1b1 Mandrillus leucophaeus (Drill) (Papio leucophaeus). Thyroglobulin Mandrillus leucophaeus
proco-a0a2k6erk8 Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli). Thyroglobulin Propithecus coquereli
rhibe-a0a2k6lev4 Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)\; Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana). Thyroglobulin Rhinopithecus bieti
saibb-a0a2k6tid6 Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Thyroglobulin Saimiri boliviensis boliviensis

Gene_locus_frgt Name Species
crigr-g3in46 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Thyroglobulin Cricetulus griseus
gasac-g3n792 Gasterosteus aculeatus (Three-spined stickleback) Uncharacterized protein Gasterosteus aculeatus
melga-g1njl6 Meleagris gallopavo (Common turkey) Uncharacterized protein Meleagris gallopavo
melga-g1njl8 Meleagris gallopavo (Common turkey) Uncharacterized protein Meleagris gallopavo
sarha-g3wk69 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Uncharacterized protein Sarcophilus harrisii
solse-a3kfc4 Solea senegalensis (Sole) thyroglobulin (fragment) Solea senegalensis
tetng-h3cac5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein Tetraodon nigroviridis
tetng-q4tbn1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Thyroglobulin (fragment) Tetraodon nigroviridis
tupch-l9k367 Tupaia chinensis (Chinese tree shrew) Thyroglobulin Tupaia chinensis
9perc-j7hbe9 Sebastiscus marmoratus (false kelpfish) Thyroglobulin (fragment) Sebastiscus marmoratus
9ceta-s9xrj3 Camelus ferus (Wild Bactrian camel) Uncharacterized protein Camelus ferus
chemy-m7aut9 Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Thyroglobulin Chelonia mydas
petma-s4r814 Petromyzon marinus (Sea lamprey) Uncharacterized protein Petromyzon marinus
tupch-l9k3p6 Tupaia chinensis (Chinese tree shrew) Thyroglobulin Tupaia chinensis
myobr-s7pll1 Myotis brandtii (Brandt's bat) Thyroglobulin Myotis brandtii
neovi-u6dy00 Neovison vison (American mink) (Mustela vison) Thyroglobulin Neovison vison
astmx-w5lgw0 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein Astyanax mexicanus
ophha-v8nnw7 Ophiophagus hannah (King cobra) (Naja hannah). Thyroglobulin Ophiophagus hannah
poefo-a0a087xac3 Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein Poecilia formosa
oncmy-a0a060zij9 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Oncorhynchus mykiss genomic scaffold, scaffold_61656 Oncorhynchus mykiss
colst-a0a091k8v2 Colius striatus (Speckled mousebird). Thyroglobulin Colius striatus
papan-a0a096n7z5 Papio anubis (Olive baboon). Uncharacterized protein Papio anubis
amaae-a0a0q3lug9 Amazona aestiva Uncharacterized protein Amazona aestiva
amaae-a0a0q3t0y6 Amazona aestiva Uncharacterized protein Amazona aestiva
9tele-a0a0s7glw8 Poeciliopsis prolifica (blackstripe livebearer). THYG Poeciliopsis prolifica
9tele-a0a0s7m1k5 Poeciliopsis prolifica (blackstripe livebearer). THYG Poeciliopsis prolifica
funhe-a0a146s5t0 Fundulus heteroclitus (Killifish) (Mummichog). Neuroligin-3 Fundulus heteroclitus
funhe-a0a146y0f0 Fundulus heteroclitus (Killifish) (Mummichog). Thyroglobulin-like protein Fundulus heteroclitus
allmi-a0a151p7z1 Alligator mississippiensis (American alligator). Uncharacterized protein Alligator mississippiensis
allmi-a0a151p833 Alligator mississippiensis (American alligator). Thyroglobulin isoform B Alligator mississippiensis
allmi-a0a151p8h6 Alligator mississippiensis (American alligator). Thyroglobulin isoform C Alligator mississippiensis
allmi-a0a151p7y4 Alligator mississippiensis (American alligator). Thyroglobulin isoform A Alligator mississippiensis
neole-a0a1a6hmw2 Neotoma lepida (Desert woodrat). Uncharacterized protein Neotoma lepida
neole-a0a1a6hnm4 Neotoma lepida (Desert woodrat). Uncharacterized protein Neotoma lepida
mesau-a0a1u8ch28 Mesocricetus auratus (Golden hamster). thyroglobulin Mesocricetus auratus
cereh-a0a212ceg4 Cervus elaphus hippelaphus (European red deer). TG Cervus elaphus hippelaphus
papan-a0a2i3m8w2 Papio anubis (Olive baboon). Thyroglobulin Papio anubis

References (31)

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Gene_locus related to this paper: bovin-thyro

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Gene_locus related to this paper: human-TG

Title : The role of thyroglobulin in thyroid hormonogenesis - Citterio_2019_Nat.Rev.Endocrinol_15_323
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Gene_locus related to this paper: human-TG

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Gene_locus related to this paper: human-TG

Title : Haplotype analysis reveals founder effects of thyroglobulin gene mutations C1058R and C1977S in Japan - Hishinuma_2006_J.Clin.Endocrinol.Metab_91_3100
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Gene_locus related to this paper: human-TG

Title : Compound heterozygous mutations in the thyroglobulin gene (1143delC and 6725G-->A [R2223H]) resulting in fetal goitrous hypothyroidism - Caron_2003_J.Clin.Endocrinol.Metab_88_3546
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Gene_locus related to this paper: human-TG

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Gene_locus related to this paper: human-TG

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Gene_locus related to this paper: ratno-thyro

Title : A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog\/cog mouse: a model of human endoplasmic reticulum storage diseases - Kim_1998_Proc.Natl.Acad.Sci.U.S.A_95_9909
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PubMedSearch : Kim_1998_Proc.Natl.Acad.Sci.U.S.A_95_9909
PubMedID: 9707574
Gene_locus related to this paper: mouse-thyro

Title : The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells - van de Graaf_1997_Eur.J.Endocrinol_136_508
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Abstract :
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PubMedID: 9186272
Gene_locus related to this paper: human-TG

Title : A 138-nucleotide deletion in the thyroglobulin ribonucleic acid messenger in a congenital goiter with defective thyroglobulin synthesis - Targovnik_1995_J.Clin.Endocrinol.Metab_80_3356
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Abstract :
PubMedSearch : Targovnik_1995_J.Clin.Endocrinol.Metab_80_3356
PubMedID: 7593451
Gene_locus related to this paper: human-TG

Title : A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger - Targovnik_1993_J.Clin.Endocrinol.Metab_77_210
Author(s) : Targovnik HM , Medeiros-Neto G , Varela V , Cochaux P , Wajchenberg BL , Vassart G
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Abstract :
PubMedSearch : Targovnik_1993_J.Clin.Endocrinol.Metab_77_210
PubMedID: 8325944
Gene_locus related to this paper: human-TG

Title : A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism - Ieiri_1991_J.Clin.Invest_88_1901
Author(s) : Ieiri T , Cochaux P , Targovnik HM , Suzuki M , Shimoda S , Perret J , Vassart G
Ref : J Clinical Investigation , 88 :1901 , 1991
Abstract :
PubMedSearch : Ieiri_1991_J.Clin.Invest_88_1901
PubMedID: 1752952

Title : Mutant gene-induced disorders of structure, function and thyroglobulin synthesis in congenital goitre (cog\/cog) in mice - Adkison_1990_J.Endocrinol_126_51
Author(s) : Adkison LR , Taylor S , Beamer WG
Ref : J Endocrinol , 126 :51 , 1990
Abstract :
PubMedSearch : Adkison_1990_J.Endocrinol_126_51
PubMedID: 1696305

Title : Consensus sequences for early iodination and hormonogenesis in human thyroglobulin - Lamas_1989_J.Biol.Chem_264_13541
Author(s) : Lamas L , Anderson PC , Fox JW , Dunn JT
Ref : Journal of Biological Chemistry , 264 :13541 , 1989
Abstract :
PubMedSearch : Lamas_1989_J.Biol.Chem_264_13541
PubMedID: 2760035
Gene_locus related to this paper: human-TG

Title : Low levels of thyroglobulin messenger ribonucleic acid in congenital goitrous hypothyroidism with defective thyroglobulin synthesis - Targovnik_1989_J.Clin.Endocrinol.Metab_69_1137
Author(s) : Targovnik H , Propato F , Varela V , Wajchenberg B , Knobel M , D'Abronzo HF , Medeiros-Neto G
Ref : J Clinical Endocrinology Metab , 69 :1137 , 1989
Abstract :
PubMedSearch : Targovnik_1989_J.Clin.Endocrinol.Metab_69_1137
PubMedID: 2584351

Title : Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA - Malthiery_1987_Eur.J.Biochem_165_491
Author(s) : Malthiery Y , Lissitzky S
Ref : European Journal of Biochemistry , 165 :491 , 1987
Abstract :
PubMedSearch : Malthiery_1987_Eur.J.Biochem_165_491
PubMedID: 3595599
Gene_locus related to this paper: human-TG

Title : A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts - Ricketts_1987_Proc.Natl.Acad.Sci.U.S.A_84_3181
Author(s) : Ricketts MH , Simons MJ , Parma J , Mercken L , Dong Q , Vassart G
Ref : Proc Natl Acad Sci U S A , 84 :3181 , 1987
Abstract :
PubMedSearch : Ricketts_1987_Proc.Natl.Acad.Sci.U.S.A_84_3181
PubMedID: 3472203

Title : Autosomal recessive inheritance of goiter in Dutch goats - Kok_1987_J.Hered_78_298
Author(s) : Kok K , van Dijk JE , Sterk A , Baas F , van Ommen GJ , de Vijlder JJ
Ref : Journal of Heredity , 78 :298 , 1987
Abstract :
PubMedSearch : Kok_1987_J.Hered_78_298
PubMedID: 3680925

Title : Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and exonization during evolution - Parma_1987_J.Mol.Biol_196_769
Author(s) : Parma J , Christophe D , Pohl V , Vassart G
Ref : Journal of Molecular Biology , 196 :769 , 1987
Abstract :
PubMedSearch : Parma_1987_J.Mol.Biol_196_769
PubMedID: 3681978
Gene_locus related to this paper: bovin-thyro , human-TG

Title : The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb - Baas_1986_Nucleic.Acids.Res_14_5171
Author(s) : Baas F , van Ommen GJ , Bikker H , Arnberg AC , de Vijlder JJ
Ref : Nucleic Acids Research , 14 :5171 , 1986
Abstract :
PubMedSearch : Baas_1986_Nucleic.Acids.Res_14_5171
PubMedID: 3016640

Title : The thyroglobulin gene resides on chromosome 8 in man and on chromosome 7 in the rat - Brocas_1985_Cytogenet.Cell.Genet_39_150
Author(s) : Brocas H , Szpirer J , Lebo RV , Levan G , Szpirer C , Cheung MC , Vassart G
Ref : Cytogenet Cell Genet , 39 :150 , 1985
Abstract :
PubMedSearch : Brocas_1985_Cytogenet.Cell.Genet_39_150
PubMedID: 4006519

Title : Mapping of human thyroglobulin gene on the long arm of chromosome 8 by in situ hybridization - Avvedimento_1985_Hum.Genet_71_163
Author(s) : Avvedimento VE , Di Lauro R , Monticelli A , Bernardi F , Patracchini P , Calzolari E , Martini G , Varrone S
Ref : Hum Genet , 71 :163 , 1985
Abstract :
PubMedSearch : Avvedimento_1985_Hum.Genet_71_163
PubMedID: 4043966

Title : Defective splicing of thyroglobulin gene transcripts in the congenital goitre of the Afrikander cattle - Ricketts_1985_EMBO.J_4_731
Author(s) : Ricketts MH , Pohl V , de Martynoff G , Boyd CD , Bester AJ , Van Jaarsveld PP , Vassart G
Ref : EMBO Journal , 4 :731 , 1985
Abstract :
PubMedSearch : Ricketts_1985_EMBO.J_4_731
PubMedID: 2988933

Title : Autosomal dominant inheritance of a thyroglobulin abnormality suggests cooperation of sub-units in hormone formation -
Author(s) : De Vijlder JJM , Baas F , Koch CAM , Kok K , Gons M
Ref : Ann Endocrinol (Paris) , 44 :36 , 1983

Title : Defective thyroglobulin export as a cause of congenital goitre - Lissitzky_1975_Clin.Endocrinol.(Oxf)_4_363
Author(s) : Lissitzky S , Torresani J , Burrow GN , Bouchilloux S , Chabaud O
Ref : Clinical Endocrinology (Oxf) , 4 :363 , 1975
Abstract :
PubMedSearch : Lissitzky_1975_Clin.Endocrinol.(Oxf)_4_363
PubMedID: 1157342

Title : A goitrous subject with structural abnormality of thyroglobulin -
Author(s) : Kusakabe T
Ref : J Clinical Endocrinology Metab , 35 :785 , 1972
PubMedID: 4628864