ratno-thyro

Rattus norvegicus (Rat) Thyroglobulin

Comment

only c-term Pfam A COesterase 2180 2719 here only homologous region starting with first G in cholinesterase 424

Relationship

Family : Thyroglobulin

Block : C

Position in NCBI Life Tree : Rattus norvegicus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Rattus N E > Rattus norvegicus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

FGQLQGGSQV VKVGTAWKQV YQFLGVPYAA PPLAENRFQA PEVLNWTGSW DATKLRSSCW QPGTRTPTPP QISEDCLYLN VFVPENLVSN ASVLVFFHNT VEMEGSGGQL NIDGSILAAV GNLIVVTANY RLGVFGFLSS GSDEVAGNWG LLDQVAALTW VQTHIGAFGG DPQRVTLAAD RGGADVASIH LLITRPTRLQ LFRKALLMGG SALSPAAIIS PDRAQQQAAA LAKEVGCPNS SVQEVVSCFR QKPANILNEA QTKLLAVSGP FHYWGPVVDG QYLRELPSRR LKRPLPVKVD LLIGGSQDDG LINRAKAVKQ FEESQGRTNS KTAFYQALQN SLGGEDSDAR ILAAAIWYYS LEHSTDDYAS FSRALENATR DYFIICPIVN MASLWARRTR GNVFMYHVPE SYGHGSLELL ADVQYAFGLP FYSAYQGYFS TEEQSLSLKV MQYFSNFIRS GNPNYPHEFS QKAAEFATPW PDFVPGAGGE SYKELSAQLP NRQGLKKADC SFWSKYIQTL KDADGAKDAQ LTKSGEEDLE VGPGSEEDFS GSLEPVPKSY SK

References (10)

Title : A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth - Gualeni_2013_Dis.Model.Mech_6_1414
Author(s) : Gualeni B , Rajpar MH , Kellogg A , Bell PA , Arvan P , Boot-Handford RP , Briggs MD
Ref : Dis Model Mech , 6 :1414 , 2013
PubMedID: 24046357
Gene_locus related to this paper: ratno-thyro

Title : Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw\/rdw rat dwarf - Menon_2007_J.Biol.Chem_282_6183
Author(s) : Menon S , Lee J , Abplanalp WA , Yoo SE , Agui T , Furudate S , Kim PS , Arvan P
Ref : Journal of Biological Chemistry , 282 :6183 , 2007
PubMedID: 17200118
Gene_locus related to this paper: ratno-thyro

Title : Genome sequence of the Brown Norway rat yields insights into mammalian evolution - Gibbs_2004_Nature_428_493
Author(s) : Gibbs RA , Weinstock GM , Metzker ML , Muzny DM , Sodergren EJ , Scherer S , Scott G , Steffen D , Worley KC , Burch PE , Okwuonu G , Hines S , Lewis L , DeRamo C , Delgado O , Dugan-Rocha S , Miner G , Morgan M , Hawes A , Gill R , Celera , Holt RA , Adams MD , Amanatides PG , Baden-Tillson H , Barnstead M , Chin S , Evans CA , Ferriera S , Fosler C , Glodek A , Gu Z , Jennings D , Kraft CL , Nguyen T , Pfannkoch CM , Sitter C , Sutton GG , Venter JC , Woodage T , Smith D , Lee HM , Gustafson E , Cahill P , Kana A , Doucette-Stamm L , Weinstock K , Fechtel K , Weiss RB , Dunn DM , Green ED , Blakesley RW , Bouffard GG , de Jong PJ , Osoegawa K , Zhu B , Marra M , Schein J , Bosdet I , Fjell C , Jones S , Krzywinski M , Mathewson C , Siddiqui A , Wye N , McPherson J , Zhao S , Fraser CM , Shetty J , Shatsman S , Geer K , Chen Y , Abramzon S , Nierman WC , Havlak PH , Chen R , Durbin KJ , Egan A , Ren Y , Song XZ , Li B , Liu Y , Qin X , Cawley S , Cooney AJ , D'Souza LM , Martin K , Wu JQ , Gonzalez-Garay ML , Jackson AR , Kalafus KJ , McLeod MP , Milosavljevic A , Virk D , Volkov A , Wheeler DA , Zhang Z , Bailey JA , Eichler EE , Tuzun E , Birney E , Mongin E , Ureta-Vidal A , Woodwark C , Zdobnov E , Bork P , Suyama M , Torrents D , Alexandersson M , Trask BJ , Young JM , Huang H , Wang H , Xing H , Daniels S , Gietzen D , Schmidt J , Stevens K , Vitt U , Wingrove J , Camara F , Mar Alba M , Abril JF , Guigo R , Smit A , Dubchak I , Rubin EM , Couronne O , Poliakov A , Hubner N , Ganten D , Goesele C , Hummel O , Kreitler T , Lee YA , Monti J , Schulz H , Zimdahl H , Himmelbauer H , Lehrach H , Jacob HJ , Bromberg S , Gullings-Handley J , Jensen-Seaman MI , Kwitek AE , Lazar J , Pasko D , Tonellato PJ , Twigger S , Ponting CP , Duarte JM , Rice S , Goodstadt L , Beatson SA , Emes RD , Winter EE , Webber C , Brandt P , Nyakatura G , Adetobi M , Chiaromonte F , Elnitski L , Eswara P , Hardison RC , Hou M , Kolbe D , Makova K , Miller W , Nekrutenko A , Riemer C , Schwartz S , Taylor J , Yang S , Zhang Y , Lindpaintner K , Andrews TD , Caccamo M , Clamp M , Clarke L , Curwen V , Durbin R , Eyras E , Searle SM , Cooper GM , Batzoglou S , Brudno M , Sidow A , Stone EA , Payseur BA , Bourque G , Lopez-Otin C , Puente XS , Chakrabarti K , Chatterji S , Dewey C , Pachter L , Bray N , Yap VB , Caspi A , Tesler G , Pevzner PA , Haussler D , Roskin KM , Baertsch R , Clawson H , Furey TS , Hinrichs AS , Karolchik D , Kent WJ , Rosenbloom KR , Trumbower H , Weirauch M , Cooper DN , Stenson PD , Ma B , Brent M , Arumugam M , Shteynberg D , Copley RR , Taylor MS , Riethman H , Mudunuri U , Peterson J , Guyer M , Felsenfeld A , Old S , Mockrin S , Collins F
Ref : Nature , 428 :493 , 2004
PubMedID: 15057822
Gene_locus related to this paper: rat-abhea , rat-abheb , rat-cd029 , rat-d3zaw4 , rat-dpp9 , rat-d3zhq1 , rat-d3zkp8 , rat-d3zuq1 , rat-d3zxw8 , rat-d4a4w4 , rat-d4a7w1 , rat-d4a9l7 , rat-d4a071 , rat-d4aa31 , rat-d4aa33 , rat-d4aa61 , rat-dglb , rat-f1lz91 , rat-Kansl3 , rat-nceh1 , rat-Tex30 , ratno-1hlip , ratno-1neur , ratno-1plip , ratno-2neur , ratno-3neur , ratno-3plip , ratno-ABH15 , ratno-ACHE , ratno-balip , ratno-BCHE , ratno-cauxin , ratno-Ces1d , ratno-Ces1e , ratno-Ces2f , ratno-d3ze31 , ratno-d3zp14 , ratno-d3zxi3 , ratno-d3zxq0 , ratno-d3zxq1 , ratno-d4a3d4 , ratno-d4aa05 , ratno-dpp4 , ratno-dpp6 , ratno-est8 , ratno-FAP , ratno-hyep , ratno-hyes , ratno-kmcxe , ratno-lmcxe , ratno-LOC246252 , ratno-MGLL , ratno-pbcxe , ratno-phebest , ratno-Ppgb , ratno-q4qr68 , ratno-q6ayr2 , ratno-q6q629 , ratno-SPG21 , ratno-thyro , rat-m0rc77 , rat-a0a0g2k9y7 , rat-a0a0g2kb83 , rat-d3zba8 , rat-d3zbj1 , rat-d3zcr8 , rat-d3zxw5 , rat-d4a340 , rat-f1lvg7 , rat-m0r509 , rat-m0r5d4 , rat-b5den3 , rat-d3zxk4 , rat-d4a1b6 , rat-d3zmg4 , rat-ab17c

Title : A missense mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat - Kim_2000_Mol.Endocrinol_14_1944
Author(s) : Kim PS , Ding M , Menon S , Jung CG , Cheng JM , Miyamoto T , Li B , Furudate S , Agui T
Ref : Mol Endocrinol , 14 :1944 , 2000
PubMedID: 11117525
Gene_locus related to this paper: ratno-thyro

Title : A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats - Hishinuma_2000_Endocrinology_141_4050
Author(s) : Hishinuma A , Furudate S , Oh-Ishi M , Nagakubo N , Namatame T , Ieiri T
Ref : Endocrinology , 141 :4050 , 2000
PubMedID: 11089535
Gene_locus related to this paper: ratno-thyro

Title : A second thyroglobulin messenger RNA species (rTg-2) in rat thyrocytes - Graves_1990_Mol.Endocrinol_4_155
Author(s) : Graves PN , Davies TF
Ref : Mol Endocrinol , 4 :155 , 1990
PubMedID: 2325666
Gene_locus related to this paper: ratno-thyro

Title : The complete structure of the rat thyroglobulin gene - Musti_1986_Proc.Natl.Acad.Sci.U.S.A_83_323
Author(s) : Musti AM , Avvedimento EV , Polistina C , Ursini VM , Obici S , Nitsch L , Cocozza S , Di Lauro R
Ref : Proc Natl Acad Sci U S A , 83 :323 , 1986
PubMedID: 3455768
Gene_locus related to this paper: ratno-thyro

Title : The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites - Di.Lauro_1985_Eur.J.Biochem_148_7
Author(s) : Di Lauro R , Obici S , Condliffe D , Ursini VM , Musti AM , Moscatelli C , Avvedimento VE
Ref : European Journal of Biochemistry , 148 :7 , 1985
PubMedID: 3838512
Gene_locus related to this paper: ratno-thyro

Title : Structural organization of the 3' half of the rat thyroglobulin gene - Avvedimento_1984_Nucleic.Acids.Res_12_3461
Author(s) : Avvedimento VE , Musti AM , Obici S , Cocozza S , Di Lauro R
Ref : Nucleic Acids Research , 12 :3461 , 1984
PubMedID: 6328423
Gene_locus related to this paper: ratno-thyro