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Family Report for: Bacterial_lip_FamI.3


Block L
Parent Family : Bacterial_lipase

This family corresponds to family I.3 of the classification of Arpigny and Jaeger (1999) The N-catalytic domain (residues 1370) contains the active site residues, Ser207, Asp255, and His313 4, 5. The C-domain contains several repeats of the RTX motif and a putative secretion signal near the C-terminus. The Cdomain contains two beta-roll motifs, laterally stacked together forming the so called beta-roll sandwich. The first beta-roll motif consists of residues 373417, containing five RTX repeats and binds three Ca2+ ions. The second beta-roll motif consists of residues 493-568, containing eight RTX repeats and binds five Ca2+ ions. HemolysinCabind (PF00353). This family contains Polyurethanases (PURase)

no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

3 more
    Title: X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids
    Angkawidjaja C, Matsumura H, Koga Y, Takano K, Kanaya S
    Ref: Journal of Molecular Biology, 400:82, 2010 : PubMed


    Title: Lipases for biotechnology
    Jaeger KE, Eggert T
    Ref: Curr Opin Biotechnol, 13:390, 2002 : PubMed


    Title: Bacterial lipolytic enzymes: classification and properties
    Arpigny JL, Jaeger KE
    Ref: Biochemical Journal, 343:177, 1999 : PubMed


Other Papers

Structure scheme for Bacterial_lip_FamI.3

Structures in Bacterial_lip_FamI.3 family (9)

Genes Proteins in Bacterial_lip_FamI.3 family (32)

No fragments
Substrates of some enzymes in the Bacterial_lip_FamI.3 family (8)

Inhibitors of some enzymes in the Bacterial_lip_FamI.3 family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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