Bacterial_lip_FamI.3

Relationship

Family: Bacterial_lip_FamI.3

Block: L

Parent Family: Bacterial_lipase

Comment

This family corresponds to family I.3 of the classification of Arpigny and Jaeger (1999) The N-catalytic domain (residues 1-370) contains the active site residues, Ser207, Asp255, and His313 4, 5. The C-domain contains several repeats of the RTX motif and a putative secretion signal near the C-terminus. The C-domain contains two beta-roll motifs, laterally stacked together forming the so called beta-roll sandwich. The first beta-roll motif consists of residues 373-417, containing five RTX repeats and binds three Ca2+ ions. The second beta-roll motif consists of residues 493-568, containing eight RTX repeats and binds five Ca2+ ions. HemolysinCabind (PF00353). This family contains Polyurethanases (PURase)

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (9)

Genes Proteins in Bacterial_lip_FamI.3 family (34)

No fragment of genes

Structures in Bacterial_lip_FamI.3 family (9)

Substrates in Bacterial_lip_FamI.3 family (8)

Inhibitors in Bacterial_lip_FamI.3 family (1)

References (7)

Title : Enhanced enzyme thermostability of a family I.3 lipase LipSR1 by T118A mutation at the calcium-binding site - Jiang_2023_Biotechnol.Lett__
Author(s) : Jiang S , Zhou Z , Han J , Fan Q , Long Z , Wang J
Ref : Biotechnol Lett , : , 2023
PubMedID: 37439931
Gene_locus related to this paper: lacac-q5fi30

Title : X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids - Angkawidjaja_2010_J.Mol.Biol_400_82
Author(s) : Angkawidjaja C , Matsumura H , Koga Y , Takano K , Kanaya S
Ref : Journal of Molecular Biology , 400 :82 , 2010
PubMedID: 20438738
Gene_locus related to this paper: psesp-Q9RBY1

Title : Importance of the Ca2+-binding sites in the N-catalytic domain of a family I.3 lipase for activity and stability - Kuwahara_2008_Protein.Eng.Des.Sel_21_737
Author(s) : Kuwahara K , Angkawidjaja C , Matsumura H , Koga Y , Takano K , Kanaya S
Ref : Protein Engineering Des Sel , 21 :737 , 2008
PubMedID: 18987131
Gene_locus related to this paper: psesp-Q9RBY1

Title : Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation - Angkawidjaja_2007_FEBS.Lett_581_5060
Author(s) : Angkawidjaja C , You DJ , Matsumura H , Kuwahara K , Koga Y , Takano K , Kanaya S
Ref : FEBS Letters , 581 :5060 , 2007
PubMedID: 17923123
Gene_locus related to this paper: psesp-Q9RBY1

Title : A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens - Meier_2007_J.Biol.Chem_282_31477
Author(s) : Meier R , Drepper T , Svensson V , Jaeger KE , Baumann U
Ref : Journal of Biological Chemistry , 282 :31477 , 2007
PubMedID: 17728256
Gene_locus related to this paper: serma-lipasA

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
PubMedID: 12323363

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
Author(s) : Arpigny JL , Jaeger KE
Ref : Biochemical Journal , 343 :177 , 1999
PubMedID: 10493927