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Family Report for: Prolylcarboxypeptidase


Block X


S28 peptidases in MEROPS database. These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase. In human the S28 family of peptidases consists of three enzymes, PRCP, TSSP and DPP7. DPP7 is also called dipeptidyl peptidase 2 and quiescent cell proline dipeptidase. TSSP is thymus-specific serine protease. PRCP is a lysosomal, serine carboxypeptidase that cleaves hydrophobic C-terminal amino acids adjacent to proline. In contrast, DPP7 is a serine dipeptidyl aminopeptidase that cleaves N-terminal amino acids adjacent to proline and is localized to intracellular vesicles

Interpro : IPR008758 (Peptidase_S28), IPR042269 (Serine carboxypeptidase S28, SKS domain)
Pdoc :
PFam : PF05577 (Peptidase_S28)
Prints :
Prosite :
EC at KEGG :
Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin : Text only/graphic display
Seed alignment with MAFFT : No colour/coloured with Mview
Alignment with MAFFT : No colour/coloured with Mview
Dendrogram : Graphical display, obtained with the dnd file produced by Clustalw
HMM profile : HMM profile

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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AcePerl Lincoln Stein Home Page

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