human-PRSS16

Homo sapiens (Human) PRSS16 protease, serine, 16 (thymus) TSSP thymus-specific serine protease precursor (EC 3.4.-.-)

Comment

old human-tssp TSSP_HUMAN || also old Gene_locus human-q5w1c0 Trembl Q5W1C0 Homo sapiens (Human) otthump00000039491

Relationship

Family : Prolylcarboxypeptidase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

MAVWLAQWLG PLLLVSLWGL LAPASLLRRL GEHIQQFQES SAQGLGLSLG PGAAALPKVG WLEQLLDPFN VSDRRSFLQR YWVNDQHWVG QDGPIFLHLG GEGSLGPGSV MRGHPAALAP AWGALVISLE HRFYGLSIPA GGLEMAQLRF LSSRLALADV VSARLALSRL FNISSSSPWI CFGGSYAGSL AAWARLKFPH LIFASVASSA PVRAVLDFSE YNDVVSRSLM STAIGGSLEC RAAVSVAFAE VERRLRSGGA AQAALRTELS ACGPLGRAEN QAELLGALQA LVGGVVQYDG QTGAPLSVRQ LCGLLLGGGG NRSHSTPYCG LRRAVQIVLH SLGQKCLSFS RAETVAQLRS TEPQLSGVGD RQWLYQTCTE FGFYVTCENP RCPFSQLPAL PSQLDLCEQV FGLSALSVAQ AVAQTNSYYG GQTPGANKVL FVNGDTDPWH VLSVTQALGS SESTLLIRTG SHCLDMAPER PSDSPSLRLG RQNIFQQLQT WLKLAKESQI KGEV

References (18)

Title : Schizophreniaassociated microRNA148b3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells - Wu_2020_Mol.Med.Rep_22_1429
Author(s) : Wu S , Wang P , Tao R , Yang P , Yu X , Li Y , Shao Q , Nie F , Ha J , Zhang R , Tian Y , Ma J
Ref : Mol Med Rep , 22 :1429 , 2020
PubMedID: 32626976
Gene_locus related to this paper: human-PRSS16

Title : The thymus-specific serine protease TSSP\/PRSS16 is crucial for the antitumoral role of CD4(+) T cells - Brisson_2015_Cell.Rep_10_39
Author(s) : Brisson L , Pouyet L , N'Guessan P , Garcia S , Lopes N , Warcollier G , Iovanna JL , Carrier A
Ref : Cell Rep , 10 :39 , 2015
PubMedID: 25543139
Gene_locus related to this paper: human-PRSS16

Title : A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP\/PRSS16 involved in CD4 T-cell maturation - Brisson_2015_Oncoimmunology_4_e1026536
Author(s) : Brisson L , Carrier A
Ref : Oncoimmunology , 4 :e1026536 , 2015
PubMedID: 26405595
Gene_locus related to this paper: human-PRSS16

Title : The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens - Viret_2015_J.Immunol_195_1964
Author(s) : Viret C , Mahiddine K , Baker RL , Haskins K , Guerder S
Ref : J Immunol , 195 :1964 , 2015
PubMedID: 26209627
Gene_locus related to this paper: human-PRSS16

Title : No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia - Kitazawa_2012_Am.J.Med.Genet.B.Neuropsychiatr.Genet_159B_456
Author(s) : Kitazawa M , Ohnuma T , Takebayashi Y , Shibata N , Baba H , Ohi K , Yasuda Y , Nakamura Y , Aleksic B , Yoshimi A , Okochi T , Ikeda M , Naitoh H , Hashimoto R , Iwata N , Ozaki N , Takeda M , Arai H
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 159B :456 , 2012
PubMedID: 22488895
Gene_locus related to this paper: human-PRSS16

Title : Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice - Viret_2011_J.Clin.Invest_121_1810
Author(s) : Viret C , Leung-Theung-Long S , Serre L , Lamare C , Vignali DA , Malissen B , Carrier A , Guerder S
Ref : J Clinical Investigation , 121 :1810 , 2011
PubMedID: 21505262
Gene_locus related to this paper: human-PRSS16

Title : Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire - Viret_2011_J.Exp.Med_208_3
Author(s) : Viret C , Lamare C , Guiraud M , Fazilleau N , Bour A , Malissen B , Carrier A , Guerder S
Ref : J Exp Med , 208 :3 , 2011
PubMedID: 21173102
Gene_locus related to this paper: human-PRSS16

Title : Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex - Viken_2009_Genes.Immun_10_323
Author(s) : Viken MK , Blomhoff A , Olsson M , Akselsen HE , Pociot F , Nerup J , Kockum I , Cambon-Thomsen A , Thorsby E , Undlien DE , Lie BA
Ref : Genes Immun , 10 :323 , 2009
PubMedID: 19295542
Gene_locus related to this paper: human-PRSS16

Title : Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes - Gommeaux_2009_Eur.J.Immunol_39_956
Author(s) : Gommeaux J , Gregoire C , Nguessan P , Richelme M , Malissen M , Guerder S , Malissen B , Carrier A
Ref : European Journal of Immunology , 39 :956 , 2009
PubMedID: 19283781
Gene_locus related to this paper: human-PRSS16

Title : Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease - Lie_2007_Hum.Immunol_68_592
Author(s) : Lie BA , Viken MK , Akselsen HE , Flam ST , Pociot F , Nerup J , Kockum I , Cambon-Thomsen A , Thorsby E , Undlien DE
Ref : Hum Immunol , 68 :592 , 2007
PubMedID: 17584581
Gene_locus related to this paper: human-PRSS16

Title : Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus - Luther_2005_Genes.Immun_6_1
Author(s) : Luther C , Wienhold W , Oehlmann R , Heinemann MK , Melms A , Tolosa E
Ref : Genes Immun , 6 :1 , 2005
PubMedID: 15592422
Gene_locus related to this paper: human-PRSS16

Title : Prss16 is not required for T-cell development - Cheunsuk_2005_Mol.Cell.Biol_25_789
Author(s) : Cheunsuk S , Lian ZX , Yang GX , Gershwin ME , Gruen JR , Bowlus CL
Ref : Molecular & Cellular Biology , 25 :789 , 2005
PubMedID: 15632078
Gene_locus related to this paper: human-PRSS16

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53

Title : The DNA sequence and analysis of human chromosome 6 - Mungall_2003_Nature_425_805
Author(s) : Mungall AJ , Palmer SA , Sims SK , Edwards CA , Ashurst JL , Wilming L , Jones MC , Horton R , Hunt SE , Scott CE , Gilbert JG , Clamp ME , Bethel G , Milne S , Ainscough R , Almeida JP , Ambrose KD , Andrews TD , Ashwell RI , Babbage AK , Bagguley CL , Bailey J , Banerjee R , Barker DJ , Barlow KF , Bates K , Beare DM , Beasley H , Beasley O , Bird CP , Blakey S , Bray-Allen S , Brook J , Brown AJ , Brown JY , Burford DC , Burrill W , Burton J , Carder C , Carter NP , Chapman JC , Clark SY , Clark G , Clee CM , Clegg S , Cobley V , Collier RE , Collins JE , Colman LK , Corby NR , Coville GJ , Culley KM , Dhami P , Davies J , Dunn M , Earthrowl ME , Ellington AE , Evans KA , Faulkner L , Francis MD , Frankish A , Frankland J , French L , Garner P , Garnett J , Ghori MJ , Gilby LM , Gillson CJ , Glithero RJ , Grafham DV , Grant M , Gribble S , Griffiths C , Griffiths M , Hall R , Halls KS , Hammond S , Harley JL , Hart EA , Heath PD , Heathcott R , Holmes SJ , Howden PJ , Howe KL , Howell GR , Huckle E , Humphray SJ , Humphries MD , Hunt AR , Johnson CM , Joy AA , Kay M , Keenan SJ , Kimberley AM , King A , Laird GK , Langford C , Lawlor S , Leongamornlert DA , Leversha M , Lloyd CR , Lloyd DM , Loveland JE , Lovell J , Martin S , Mashreghi-Mohammadi M , Maslen GL , Matthews L , Mccann OT , McLaren SJ , McLay K , McMurray A , Moore MJ , Mullikin JC , Niblett D , Nickerson T , Novik KL , Oliver K , Overton-Larty EK , Parker A , Patel R , Pearce AV , Peck AI , Phillimore B , Phillips S , Plumb RW , Porter KM , Ramsey Y , Ranby SA , Rice CM , Ross MT , Searle SM , Sehra HK , Sheridan E , Skuce CD , Smith S , Smith M , Spraggon L , Squares SL , Steward CA , Sycamore N , Tamlyn-Hall G , Tester J , Theaker AJ , Thomas DW , Thorpe A , Tracey A , Tromans A , Tubby B , Wall M , Wallis JM , West AP , White SS , Whitehead SL , Whittaker H , Wild A , Willey DJ , Wilmer TE , Wood JM , Wray PW , Wyatt JC , Young L , Younger RM , Bentley DR , Coulson A , Durbin R , Hubbard T , Sulston JE , Dunham I , Rogers J , Beck S
Ref : Nature , 425 :805 , 2003
PubMedID: 14574404
Gene_locus related to this paper: human-ABHD16A , human-BPHL , human-FAM135A , human-PRSS16 , human-SERAC1

Title : Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility - Cheunsuk_2002_J.Autoimmun_18_311
Author(s) : Cheunsuk S , Sparks R , Noveroske JK , Hsu T , Justice MJ , Gershwin ME , Gruen JR , Bowlus CL
Ref : J Autoimmun , 18 :311 , 2002
PubMedID: 12144812
Gene_locus related to this paper: human-PRSS16

Title : Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases - Lie_2002_Genes.Immun_3_306
Author(s) : Lie BA , Akselsen HE , Bowlus CL , Gruen JR , Thorsby E , Undlien DE
Ref : Genes Immun , 3 :306 , 2002
PubMedID: 12140752
Gene_locus related to this paper: human-PRSS16

Title : Analysis of the IDDM candidate gene Prss16 in NOD and NON mice - Cheunsuk_2002_Dev.Immunol_9_183
Author(s) : Cheunsuk S , Hsu T , Gershwin ME , Bowlus CL
Ref : Dev Immunol , 9 :183 , 2002
PubMedID: 15144014
Gene_locus related to this paper: human-PRSS16

Title : Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus - Bowlus_1999_Cell.Immunol_196_80
Author(s) : Bowlus CL , Ahn J , Chu T , Gruen JR
Ref : Cell Immunol , 196 :80 , 1999
PubMedID: 10527559
Gene_locus related to this paper: human-PRSS16