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agrra-echA

Agrobacterium radiobacter echA gene AraEchA

Comment

Relationship

Family : Epoxide_hydrolase

Block : X

Position in NCBI Life Tree : Agrobacterium radiobacter

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Proteobacteria N E > Alphaproteobacteria N E > Rhizobiales N E > Rhizobiaceae N E > Rhizobium\/Agrobacterium group N E > Agrobacterium N E > Agrobacterium tumefaciens complex N E > Agrobacterium tumefaciens N E

Molecular evidence

No mutation

No kinetic

No disease

Database

Sequence

Peptide

MTIRRPEDFK HYEVQLPDVK IHYVREGAGP TLLLLHGWPG FWWEWSKVIG PLAEHYDVIV PDLRGFGDSE KPDLNDLSKY SLDKAADDQA ALLDALGIEK AYVVGHDFAA IVLHKFIRKY SDRVIKAAIF DPIQPDFGPV YFGLGHVHES WYSQFHQLDM AVEVVGSSRE VCKKYFKHFF DHWSYRDELL TEEELEVHVD NCMKPDNIHG GFNYYRANIR PDAALWTDLD HTMSDLPVTM IWGLGDTCVP YAPLIEFVPK YYSNYTMETI EDCGHFLMVE KPEIAIDRIK TAFR

References (11)

Title : Enhanced catalytic efficiency and enantioselectivity of epoxide hydrolase from Agrobacterium radiobacter AD1 by iterative saturation mutagenesis for (R)-epichlorohydrin synthesis - Zou_2018_Appl.Microbiol.Biotechnol_102_733
Author(s) : Zou SP , Zheng YG , Wu Q , Wang ZC , Xue YP , Liu ZQ
Ref : Applied Microbiology & Biotechnology , 102 :733 , 2018
Abstract :
PubMedSearch : Zou_2018_Appl.Microbiol.Biotechnol_102_733
PubMedID: 29151159
Gene_locus related to this paper: agrra-echA

Title : Biosynthesis of (R)-epichlorohydrin at high substrate concentration by kinetic resolution of racemic epichlorohydrin with a recombinant epoxide hydrolase - Jin_2013_Eng.Life.Sci_13_385
Author(s) : Jin HX , Liu ZQ , Hu ZC , Zheng YG
Ref : Eng Life Sciences , 13 :385 , 2013
Abstract :
PubMedSearch : Jin_2013_Eng.Life.Sci_13_385
PubMedID:
Gene_locus related to this paper: agrra-echA

Title : Improved enantioselective conversion of styrene epoxides and meso-epoxides through epoxide hydrolases with a mutated nucleophile-flanking residue - van Loo_2009_Enz.Microb.Technol_44_145
Author(s) : van Loo B , Kingma J , Heyman G , Wittenaar A , Spelberg JHL , Sonke T , Janssen DB
Ref : Enzyme and Microbial Technology , 44 :145 , 2009
Abstract :
PubMedSearch : van Loo_2009_Enz.Microb.Technol_44_145
PubMedID:
Gene_locus related to this paper: agrra-echA

Title : Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis - van Loo_2006_Appl.Environ.Microbiol_72_2905
Author(s) : van Loo B , Kingma J , Arand M , Wubbolts MG , Janssen DB
Ref : Applied Environmental Microbiology , 72 :2905 , 2006
Abstract :
PubMedSearch : van Loo_2006_Appl.Environ.Microbiol_72_2905
PubMedID: 16597997
Gene_locus related to this paper: agrra-echA , bacsu-yfhM , corsp-cEH , deira-DR2549 , myctu-ephF , nosp7-b2j4w6 , nosp7-b2iv02 , psepu-PP4624 , rhopa-q6n645 , strco-2SCG4.13 , thefy-q47qj2

Title : Protein engineering of epoxide hydrolase from Agrobacterium radiobacter AD1 for enhanced activity and enantioselective production of (R)-1-phenylethane-1,2-diol - Rui_2005_Appl.Environ.Microbiol_71_3995
Author(s) : Rui L , Cao L , Chen W , Reardon KF , Wood TK
Ref : Applied Environmental Microbiology , 71 :3995 , 2005
Abstract :
PubMedSearch : Rui_2005_Appl.Environ.Microbiol_71_3995
PubMedID: 16000814
Gene_locus related to this paper: agrra-echA

Title : Active site engineering of the epoxide hydrolase from Agrobacterium radiobacter AD1 to enhance aerobic mineralization of cis-1,2-dichloroethylene in cells expressing an evolved toluene ortho-monooxygenase - Rui_2004_J.Biol.Chem_279_46810
Author(s) : Rui L , Cao L , Chen W , Reardon KF , Wood TK
Ref : Journal of Biological Chemistry , 279 :46810 , 2004
Abstract :
PubMedSearch : Rui_2004_J.Biol.Chem_279_46810
PubMedID: 15347647
Gene_locus related to this paper: agrra-echA

Title : Directed evolution of epoxide hydrolase from A. radiobacter toward higher enantioselectivity by error-prone PCR and DNA shuffling - van Loo_2004_Chem.Biol_11_981
Author(s) : van Loo B , Spelberg JH , Kingma J , Sonke T , Wubbolts MG , Janssen DB
Ref : Chemical Biology , 11 :981 , 2004
Abstract :
PubMedSearch : van Loo_2004_Chem.Biol_11_981
PubMedID: 15271356
Gene_locus related to this paper: agrra-echA

Title : The x-ray structure of epoxide hydrolase from Agrobacterium radiobacter AD1. An enzyme to detoxify harmful epoxides - Nardini_1999_J.Biol.Chem_274_14579
Author(s) : Nardini M , Ridder IS , Rozeboom HJ , Kalk KH , Rink R , Janssen DB , Dijkstra BW
Ref : Journal of Biological Chemistry , 274 :14579 , 1999
Abstract :
PubMedSearch : Nardini_1999_J.Biol.Chem_274_14579
PubMedID: 10329649
Gene_locus related to this paper: agrra-echA

Title : Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity - Rink_1999_J.Am.Chem.Soc_121_7417
Author(s) : Rink R , Lutje Spelberg JH , Pieters RJ , Kingma J , Nardini M , Kellogg RM , Dijkstra BW , Janssen DB
Ref : Journal of the American Chemical Society , 121 :7417 , 1999
Abstract :
PubMedSearch : Rink_1999_J.Am.Chem.Soc_121_7417
PubMedID:
Gene_locus related to this paper: agrra-echA

Title : Kinetic mechanism of the enantioselective conversion of styrene oxide by epoxide hydrolase from Agrobacterium radiobacter AD1 - Rink_1998_Biochemistry_37_18119
Author(s) : Rink R , Janssen DB
Ref : Biochemistry , 37 :18119 , 1998
Abstract :
PubMedSearch : Rink_1998_Biochemistry_37_18119
PubMedID: 9922181
Gene_locus related to this paper: agrra-echA

Title : Primary structure and catalytic mechanism of the epoxide hydrolase from Agrobacterium radiobacter AD1 - Rink_1997_J.Biol.Chem_272_14650
Author(s) : Rink R , Fennema M , Smids M , Dehmel U , Janssen DB
Ref : Journal of Biological Chemistry , 272 :14650 , 1997
Abstract :
PubMedSearch : Rink_1997_J.Biol.Chem_272_14650
PubMedID: 9169427
Gene_locus related to this paper: agrra-echA