aspcl-CCSE

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) Hydrolyase ccsE

Comment

Cytochalasin biosynthesis protein E. Hydrolyase\; part of the gene cluster that mediates the biosynthesis of a family of the mycotoxins cytochalasins E and K. The hydrolyase ccsE may catalyze hydrolysis of epoxide bond in cytochalasin E to afford cytochalasin K

Relationship

Family : Duf_1100-S

Block : X

Position in NCBI Life Tree : Aspergillus clavatus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Aspergillus N E > Aspergillus clavatus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MHKLFKNAPF FDFEAIRILG TTCYGGADVA EVFEAVDQIK NNDPETWETA WRIQAERAEK LAAEALEHGD RDAALAGYLR ASNYTRASGY MYVSRAESSG EALVQDARAL PIAEKVGELF RKAIPLMKGS VHTLGIPYEE YALPGYLYLP PPWRRIPGRK IPILVNSGGA DSCQEELFYL NPAAGPGQGY AVVTFDGPGQ GIMLRKYGLE MRPDWEAVTG RVIDFLEEYA AENPHLELDL NCIAVSGASM GGYYALRAAA DQRVKACVSI DPFYDMWDFG TAHVSPIFIH AWTSGWISGG FVDNLMALLS RLSFQLRWEI SVTGTFFGLS SPSQILLHMK KYTLRSTEEE PEGFLSRVIC PVLLSGAGKS LYLDVDNHTR QCYDGLVNVA ERNKQLWIPE SEGQGSLQAK MGAFRLCNQR TYRFLDECFG IMRKSL

References (4)

Title : Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans - Zhang_2021_Chemistry_10_3106
Author(s) : Zhang H , Hantke V , Bruhnke P , Skellam E , Cox RJ
Ref : Chemistry , 10 :3106 , 2021
Abstract :
PubMedSearch : Zhang_2021_Chemistry_10_3106
PubMedID: 33146923
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis - Wang_2019_Org.Lett_21_8756
Author(s) : Wang C , Becker K , Pfutze S , Kuhnert E , Stadler M , Cox RJ , Skellam E
Ref : Org Lett , 21 :8756 , 2019
Abstract :
PubMedSearch : Wang_2019_Org.Lett_21_8756
PubMedID: 31644300
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae - Song_2015_Chem.Sci_6_4837
Author(s) : Song Z , Bakeer W , Marshall JW , Yakasai AA , Khalid RM , Collemare J , Skellam E , Tharreau D , Lebrun MH , Lazarus CM , Bailey AM , Simpson TJ , Cox RJ
Ref : Chem Sci , 6 :4837 , 2015
Abstract :
PubMedSearch : Song_2015_Chem.Sci_6_4837
PubMedID: 29142718
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB

Title : Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1 - Qiao_2011_Metab.Eng_13_723
Author(s) : Qiao K , Chooi YH , Tang Y
Ref : Metab Eng , 13 :723 , 2011
Abstract :
PubMedSearch : Qiao_2011_Metab.Eng_13_723
PubMedID: 21983160
Gene_locus related to this paper: aspcl-CCSE