DUF1100 UPF0255. The family was split in two. Duf_1100-S with active site (S217 in (GXSXG) D300 H329) as in artni-Q93NG6, and Duf_1100-R with active site (R53, D203, R 272 (in GXRXG)) as in FrsA. This family is represented by a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation: 2,6-dihydroxy-pseudo-oxynicotine hydrolase from the nicotine-degradation pathway of Arthrobacter nicotinovorans (artni-Q93NG6a) (Schleberger et al.). The family also includes the hydrolytic polyketide shortening protein Ayg1 from fungi (Fujii et al.), and Fus2 from Gibberella species, which is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8 (Niehaus et al.). Other members of this family are still uncharacterised
Interpro : IPR010520 Esterase FrsA-like Protein of unknown function DUF1100 UPF0255, hydrolase-like
PIRSF : PIRSF004493 YafA protein
Pdoc : No Pdoc
Pfam : PF06500 FrsA-like DUF1100
Prints : No Print
EC Number : No EC Number
Structures (18)
Genes Proteins in Duf_1100-S family (79)
Fragments of genes in Duf_1100-S family (2)
Structures in Duf_1100-S family (18)Substrates in Duf_1100-S family (5)
Inhibitors in Duf_1100-S family (4)
Title : Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase - Kellett_2013_Biochemistry_52_1842 |
Author(s) : Kellett WF , Brunk E , Desai BJ , Fedorov AA , Almo SC , Gerlt JA , Rothlisberger U , Richards NG |
Ref : Biochemistry , 52 :1842 , 2013 |
Abstract : Kellett_2013_Biochemistry_52_1842 |
ESTHER : Kellett_2013_Biochemistry_52_1842 |
PubMedSearch : Kellett_2013_Biochemistry_52_1842 |
PubMedID: 23452154 |
Gene_locus related to this paper: vibvy-y856 |
Title : Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway - Niehaus_2013_Chem.Biol_20_1055 |
Author(s) : Niehaus EM , Kleigrewe K , Wiemann P , Studt L , Sieber CM , Connolly LR , Freitag M , Guldener U , Tudzynski B , Humpf HU |
Ref : Chemical Biology , 20 :1055 , 2013 |
Abstract : Niehaus_2013_Chem.Biol_20_1055 |
ESTHER : Niehaus_2013_Chem.Biol_20_1055 |
PubMedSearch : Niehaus_2013_Chem.Biol_20_1055 |
PubMedID: 23932525 |
Gene_locus related to this paper: gibf5-fus2 , gibf5-fus5 |
Title : FrsA functions as a cofactor-independent decarboxylase to control metabolic flux - Lee_2011_Nat.Chem.Biol_7_434 |
Author(s) : Lee KJ , Jeong CS , An YJ , Lee HJ , Park SJ , Seok YJ , Kim P , Lee JH , Lee KH , Cha SS |
Ref : Nat Chemical Biology , 7 :434 , 2011 |
Abstract : Lee_2011_Nat.Chem.Biol_7_434 |
ESTHER : Lee_2011_Nat.Chem.Biol_7_434 |
PubMedSearch : Lee_2011_Nat.Chem.Biol_7_434 |
PubMedID: 21623357 |
Gene_locus related to this paper: vibvy-y856 |
Title : Structure and action of a C-C bond cleaving alpha\/beta-hydrolase involved in nicotine degradation - Schleberger_2007_J.Mol.Biol_367_409 |
Author(s) : Schleberger C , Sachelaru P , Brandsch R , Schulz GE |
Ref : Journal of Molecular Biology , 367 :409 , 2007 |
Abstract : Schleberger_2007_J.Mol.Biol_367_409 |
ESTHER : Schleberger_2007_J.Mol.Biol_367_409 |
PubMedSearch : Schleberger_2007_J.Mol.Biol_367_409 |
PubMedID: 17275835 |
Gene_locus related to this paper: artni-Q93NG6 |
Title : A novel fermentation\/respiration switch protein regulated by enzyme IIAGlc in Escherichia coli - Koo_2004_J.Biol.Chem_279_31613 |
Author(s) : Koo BM , Yoon MJ , Lee CR , Nam TW , Choe YJ , Jaffe H , Peterkofsky A , Seok YJ |
Ref : Journal of Biological Chemistry , 279 :31613 , 2004 |
Abstract : Koo_2004_J.Biol.Chem_279_31613 |
ESTHER : Koo_2004_J.Biol.Chem_279_31613 |
PubMedSearch : Koo_2004_J.Biol.Chem_279_31613 |
PubMedID: 15169777 |
Gene_locus related to this paper: vibvy-y856 |
Title : Hydrolytic polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis - Fujii_2004_J.Biol.Chem_279_44613 |
Author(s) : Fujii I , Yasuoka Y , Tsai HF , Chang YC , Kwon-Chung KJ , Ebizuka Y |
Ref : Journal of Biological Chemistry , 279 :44613 , 2004 |
Abstract : Fujii_2004_J.Biol.Chem_279_44613 |
ESTHER : Fujii_2004_J.Biol.Chem_279_44613 |
PubMedSearch : Fujii_2004_J.Biol.Chem_279_44613 |
PubMedID: 15310761 |
Gene_locus related to this paper: aspfu-AYG1 |