aspfu-psoB

Neosartorya fumigata (Aspergillus fumigatus) Alpha/beta hydrolase psoB

Comment

Pseurotin biosynthesis protein B. Alpha\/beta hydrolase\; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation. FUS2 hydrolase family. Other strains: Neosartorya fumigata (strain ATCC MYA-4609 \/ Af293 \/ CBS 101355 \/ FGSC A1100\; CEA10 \/ CBS 144.89 \/ FGSC A1163\; Z5) (Aspergillus fumigatus)

Relationship

Family : Duf_1100-S

Block : X

Position in NCBI Life Tree : Aspergillus fumigatus Af293

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Aspergillus N E > Aspergillus fumigatus N E > Aspergillus fumigatus Af293 N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MATIHKLFKS PFFDFEFLRL LAMAPYEGAE IGEVLEAAAK IKDQDPESWY STLLETGGKA EAIAKQAEAS GDRVGARRAY LRSSNYLRAA QFMLNEGPIG HDERVLPTLE RAIANFRKGV QYRDGKTIFL EIPYEGGKTL PGYLYLPPAA RRIPGRKIPI LLNSGGGDST QEEIYFVNPA YGPDLGYAVL TFEGPGQGIV LRRDKLPMRP DWESVTGPVL DHLFDLATRH PELELDLDHI AVTGASMGGY FALRAAADPR IKACVSVDGF YSLSSFVGGR MPGPLFNGFM SGWLSDWMFN GILGVLKKLA FQARWEFNHL RWATGSTTDA DVMRSFGAYT LQKADGTEYL ADVKCPTLVT GAGASFYFDP ATTTDKIYDC LTSLQDGVDK EKWIATDVAY GGLQAKIGAF GYSAQKTFEW LDQRFGIQRE PLAASSRLED LVSRL

References (5)

Title : Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans - Zhang_2021_Chemistry_10_3106
Author(s) : Zhang H , Hantke V , Bruhnke P , Skellam E , Cox RJ
Ref : Chemistry , 10 :3106 , 2021
PubMedID: 33146923
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis - Wang_2019_Org.Lett_21_8756
Author(s) : Wang C , Becker K , Pfutze S , Kuhnert E , Stadler M , Cox RJ , Skellam E
Ref : Org Lett , 21 :8756 , 2019
PubMedID: 31644300
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB , maggr-pyie

Title : Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae - Song_2015_Chem.Sci_6_4837
Author(s) : Song Z , Bakeer W , Marshall JW , Yakasai AA , Khalid RM , Collemare J , Skellam E , Tharreau D , Lebrun MH , Lazarus CM , Bailey AM , Simpson TJ , Cox RJ
Ref : Chem Sci , 6 :4837 , 2015
PubMedID: 29142718
Gene_locus related to this paper: phano-phmG , aspcl-CCSE , aspfu-psoB , mago7-ORFZB

Title : Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity - Tsunematsu_2014_Angew.Chem.Int.Ed.Engl_53_8475
Author(s) : Tsunematsu Y , Fukutomi M , Saruwatari T , Noguchi H , Hotta K , Tang Y , Watanabe K
Ref : Angew Chem Int Ed Engl , 53 :8475 , 2014
PubMedID: 24939566
Gene_locus related to this paper: aspfu-psoB

Title : Prototype of an intertwined secondary-metabolite supercluster - Wiemann_2013_Proc.Natl.Acad.Sci.U.S.A_110_17065
Author(s) : Wiemann P , Guo CJ , Palmer JM , Sekonyela R , Wang CC , Keller NP
Ref : Proc Natl Acad Sci U S A , 110 :17065 , 2013
PubMedID: 24082142
Gene_locus related to this paper: aspfu-psoB , aspfu-fmac