burxl-bphD
Burkholderia xenovorans 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase gene bphD
Comment
Relationship
Family : Carbon-carbon_bond_hydrolase
Block : X
Position in NCBI Life Tree : Burkholderia xenovorans LB400
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Betaproteobacteria N E > Burkholderiales N E > Burkholderiaceae N E > Paraburkholderia N E > Paraburkholderia xenovorans N E > Paraburkholderia xenovorans LB400 N EMolecular evidence
No mutation
2OG1 - Crystal Structure of BphD, a C-C hydrolase from Burkholderia xenovorans LB400
2PU5 - Crystal Structure of a C-C bond hydrolase, BphD, from Burkholderia xenovorans LB400
2PU7 - Crystal Structure of S112A\/H265A double mutant of a C-C hydrolase, BphD, from Burkholderia xenovorans LB400
2PUH - Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with its substrate HOPDA
2PUJ - Crystal Structure of the S112A\/H265A double mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with its substrate HOPDA
2RHT - Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3-Cl HOPDA
2RHW - Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3,10-Di-Fluoro HOPDA
2RI6 - Crystal Structure of S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400 (replaced 2PU6)
3V1K - Crystal Structure of the H265Q mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400.
3V1L - Crystal Structure of the S112A\/H265Q mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400
3V1M - Crystal Structure of the S112A\/H265Q mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, after exposure to its substrate HOPDA
3V1N - Crystal Structure of the H265Q mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, after exposure to its substrate HOPDA
No kinetic
No disease
No inhibitor
Sequence
Peptide
MTALTESSTS KFVKINEKGF SDFNIHYNEA GNGETVIMLH GGGPGAGGWS NYYRNVGPFV DAGYRVILKD SPGFNKSDAV VMDEQRGLVN ARAVKGLMDA LDIDRAHLVG NSMGGATALN FALEYPDRIG KLILMGPGGL GPSMFAPMPM EGIKLLFKLY AEPSYETLKQ MLQVFLYDQS LITEELLQGR WEAIQRQPEH LKNFLISAQK APLSTWDVTA RLGEIKAKTF ITWGRDDRFV PLDHGLKLLW NIDDARLHVF SKCGHWAQWE HADEFNRLVI DFLRHA
References (8)
| Title : A water-assisted nucleophilic mechanism utilized by BphD, the meta-cleavage product hydrolase in biphenyl degradation - Dong_2017_J.Mol.Graph.Model_76_448 |
| Author(s) : Dong L , Zhang S , Liu Y |
| Ref : J Mol Graph Model , 76 :448 , 2017 |
| Abstract : |
| PubMedSearch : Dong_2017_J.Mol.Graph.Model_76_448 |
| PubMedID: 28783597 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad - Ruzzini_2012_J.Am.Chem.Soc_134_4615 |
| Author(s) : Ruzzini AC , Ghosh S , Horsman GP , Foster LJ , Bolin JT , Eltis LD |
| Ref : J Am Chem Soc , 134 :4615 , 2012 |
| Abstract : |
| PubMedSearch : Ruzzini_2012_J.Am.Chem.Soc_134_4615 |
| PubMedID: 22339283 |
| Gene_locus related to this paper: burxl-bphD |
| Title : The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization - Bhowmik_2007_J.Biol.Chem_282_36377 |
| Author(s) : Bhowmik S , Horsman GP , Bolin JT , Eltis LD |
| Ref : Journal of Biological Chemistry , 282 :36377 , 2007 |
| Abstract : |
| PubMedSearch : Bhowmik_2007_J.Biol.Chem_282_36377 |
| PubMedID: 17932031 |
| Gene_locus related to this paper: burxl-bphD |
| Title : The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad - Horsman_2007_J.Biol.Chem_282_19894 |
| Author(s) : Horsman GP , Bhowmik S , Seah SY , Kumar P , Bolin JT , Eltis LD |
| Ref : Journal of Biological Chemistry , 282 :19894 , 2007 |
| Abstract : |
| PubMedSearch : Horsman_2007_J.Biol.Chem_282_19894 |
| PubMedID: 17442675 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway - Horsman_2006_Biochemistry_45_11071 |
| Author(s) : Horsman GP , Ke J , Dai S , Seah SY , Bolin JT , Eltis LD |
| Ref : Biochemistry , 45 :11071 , 2006 |
| Abstract : |
| PubMedSearch : Horsman_2006_Biochemistry_45_11071 |
| PubMedID: 16964968 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls - Seah_2000_J.Biol.Chem_275_15701 |
| Author(s) : Seah SY , Labbe G , Nerdinger S , Johnson MR , Snieckus V , Eltis LD |
| Ref : Journal of Biological Chemistry , 275 :15701 , 2000 |
| Abstract : |
| PubMedSearch : Seah_2000_J.Biol.Chem_275_15701 |
| PubMedID: 10821847 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Purification and preliminary characterization of a serine hydrolase involved in the microbial degradation of polychlorinated biphenyls - Seah_1998_J.Biol.Chem_273_22943 |
| Author(s) : Seah SY , Terracina G , Bolin JT , Riebel P , Snieckus V , Eltis LD |
| Ref : Journal of Biological Chemistry , 273 :22943 , 1998 |
| Abstract : |
| PubMedSearch : Seah_1998_J.Biol.Chem_273_22943 |
| PubMedID: 9722515 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl\/polychlorinated biphenyl degradation - Hofer_1993_Gene_130_47 |
| Author(s) : Hofer B , Eltis LD , Dowling DN , Timmis KN |
| Ref : Gene , 130 :47 , 1993 |
| Abstract : |
| PubMedSearch : Hofer_1993_Gene_130_47 |
| PubMedID: 8344527 |
| Gene_locus related to this paper: burxl-bphD |