Carbon-carbon_bond_hydrolase

Relationship

Family: Carbon-carbon_bond_hydrolase

Block: X

Parent Family: No family

Comment

"2-hydroxymuconic semialdehyde hydrolase PIRSF037174. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself (environmental pollutants: BP/PCB). 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. The purified enzyme is a dimeric protein requiring no cofactors for catalytic activity"

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (10)

Title : The Lid Domain of the MCP Hydrolase DxnB2 Contributes to the Reactivity toward Recalcitrant PCB Metabolites - Ruzzini_2013_Biochemistry_52_5685
Author(s) : Ruzzini AC , Bhowmik S , Yam KC , Ghosh S , Bolin JT , Eltis LD
Ref : Biochemistry , 52 :5685 , 2013
Abstract : Ruzzini_2013_Biochemistry_52_5685
ESTHER : Ruzzini_2013_Biochemistry_52_5685
PubMedSearch : Ruzzini_2013_Biochemistry_52_5685
PubMedID: 23879719
Gene_locus related to this paper: sphww-a5j2a5

Title : Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism - Lack_2010_J.Biol.Chem_285_434
Author(s) : Lack NA , Yam KC , Lowe ED , Horsman GP , Owen RL , Sim E , Eltis LD
Ref : Journal of Biological Chemistry , 285 :434 , 2010
Abstract : Lack_2010_J.Biol.Chem_285_434
ESTHER : Lack_2010_J.Biol.Chem_285_434
PubMedSearch : Lack_2010_J.Biol.Chem_285_434
PubMedID: 19875455
Gene_locus related to this paper: myctu-Rv3569c

Title : The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization - Bhowmik_2007_J.Biol.Chem_282_36377
Author(s) : Bhowmik S , Horsman GP , Bolin JT , Eltis LD
Ref : Journal of Biological Chemistry , 282 :36377 , 2007
Abstract : Bhowmik_2007_J.Biol.Chem_282_36377
ESTHER : Bhowmik_2007_J.Biol.Chem_282_36377
PubMedSearch : Bhowmik_2007_J.Biol.Chem_282_36377
PubMedID: 17932031
Gene_locus related to this paper: burxl-bphD

Title : The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad - Horsman_2007_J.Biol.Chem_282_19894
Author(s) : Horsman GP , Bhowmik S , Seah SY , Kumar P , Bolin JT , Eltis LD
Ref : Journal of Biological Chemistry , 282 :19894 , 2007
Abstract : Horsman_2007_J.Biol.Chem_282_19894
ESTHER : Horsman_2007_J.Biol.Chem_282_19894
PubMedSearch : Horsman_2007_J.Biol.Chem_282_19894
PubMedID: 17442675
Gene_locus related to this paper: burxl-bphD

Title : Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway - Horsman_2006_Biochemistry_45_11071
Author(s) : Horsman GP , Ke J , Dai S , Seah SY , Bolin JT , Eltis LD
Ref : Biochemistry , 45 :11071 , 2006
Abstract : Horsman_2006_Biochemistry_45_11071
ESTHER : Horsman_2006_Biochemistry_45_11071
PubMedSearch : Horsman_2006_Biochemistry_45_11071
PubMedID: 16964968
Gene_locus related to this paper: burxl-bphD

Title : A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products - Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491
Author(s) : Fushinobu S , Jun SY , Hidaka M , Nojiri H , Yamane H , Shoun H , Omori T , Wakagi T
Ref : Biosci Biotechnol Biochem , 69 :491 , 2005
Abstract : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491
ESTHER : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491
PubMedSearch : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491
PubMedID: 15784976
Gene_locus related to this paper: psefl-cumD

Title : Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls - Seah_2000_J.Biol.Chem_275_15701
Author(s) : Seah SY , Labbe G , Nerdinger S , Johnson MR , Snieckus V , Eltis LD
Ref : Journal of Biological Chemistry , 275 :15701 , 2000
Abstract : Seah_2000_J.Biol.Chem_275_15701
ESTHER : Seah_2000_J.Biol.Chem_275_15701
PubMedSearch : Seah_2000_J.Biol.Chem_275_15701
PubMedID: 10821847
Gene_locus related to this paper: burxl-bphD

Title : The bphDEF meta-cleavage pathway genes involved in biphenyl\/polychlorinated biphenyl degradation are located on a linear plasmid and separated from the initial bphACB genes in Rhodococcus sp. strain RHA1 - Masai_1997_Gene_187_141
Author(s) : Masai E , Sugiyama K , Iwashita N , Shimizu S , Hauschild JE , Hatta T , Kimbara K , Yano K , Fukuda M
Ref : Gene , 187 :141 , 1997
Abstract : Masai_1997_Gene_187_141
ESTHER : Masai_1997_Gene_187_141
PubMedSearch : Masai_1997_Gene_187_141
PubMedID: 9073078
Gene_locus related to this paper: rhosp-bphd

Title : Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12 - Ferrandez_1997_J.Bacteriol_179_2573
Author(s) : Ferrandez A , Garcia JL , Diaz E
Ref : Journal of Bacteriology , 179 :2573 , 1997
Abstract : Ferrandez_1997_J.Bacteriol_179_2573
ESTHER : Ferrandez_1997_J.Bacteriol_179_2573
PubMedSearch : Ferrandez_1997_J.Bacteriol_179_2573
PubMedID: 9098055
Gene_locus related to this paper: ecoli-mhpc

Title : Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase - Lam_1997_Biochemistry_36_12242
Author(s) : Lam WW , Bugg TD
Ref : Biochemistry , 36 :12242 , 1997
Abstract : Lam_1997_Biochemistry_36_12242
ESTHER : Lam_1997_Biochemistry_36_12242
PubMedSearch : Lam_1997_Biochemistry_36_12242
PubMedID: 9315862
Gene_locus related to this paper: ecoli-mhpc

Structures (47)

Genes Proteins in Carbon-carbon_bond_hydrolase family (334)

Fragments of genes in Carbon-carbon_bond_hydrolase family (10)

Structures in Carbon-carbon_bond_hydrolase family (47)

Substrates in Carbon-carbon_bond_hydrolase family (23)

Inhibitors in Carbon-carbon_bond_hydrolase family (11)