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human-OLAH

Homo sapiens (Human) s-acyl fatty acid synthase thioesterase, medium chain OLAH THEDC1 SAST (EC 3.1.2.14) human-SAST

Comment

Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). oleoyl-acyl-carrier-protein hydrolase. S-acyl fatty acid synthase thioesterase, medium chain

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MERGDQPKRT RNENIFNCLY KNPEATFKLI CFPWMGGGST HFAKWGQDTH DLLEVHSLRL PGRESRVEEP LENDISQLVD EVVCALQPVI QDKPFAFFGH SMGSYIAFRT ALGLKENNQP EPLHLFLSSA TPVHSKAWHR IPKDDELSEE QISHYLMEFG GTPKHFAEAK EFVKQCSPII RADLNIVRSC TSNVPSKAVL SCDLTCFVGS EDIAKDMEAW KDVTSGNAKI YQLPGGHFYL LDPANEKLIK NYIIKCLEVS SISNF

References (3)

Title : Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase - Ritchie_2016_J.Biol.Chem_291_3520
Author(s) : Ritchie MK , Johnson LC , Clodfelter JE , Pemble CWt , Fulp BE , Furdui CM , Kridel SJ , Lowther WT
Ref : Journal of Biological Chemistry , 291 :3520 , 2016
Abstract :
PubMedSearch : Ritchie_2016_J.Biol.Chem_291_3520
PubMedID: 26663084
Gene_locus related to this paper: human-OLAH

Title : Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase - Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852
Author(s) : Tai MH , Chirala SS , Wakil SJ
Ref : Proc Natl Acad Sci U S A , 90 :1852 , 1993
Abstract :
PubMedSearch : Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852
PubMedID: 8446599
Gene_locus related to this paper: human-OLAH , ratno-sast

Title : Thioesterase II, a new marker enzyme for human cells of breast epithelial origin - Smith_1984_J.Natl.Cancer.Inst_73_323
Author(s) : Smith S , Pasco D , Pawlak J , Thompson BJ , Stampfer M , Nandi S
Ref : J Natl Cancer Inst , 73 :323 , 1984
Abstract :
PubMedSearch : Smith_1984_J.Natl.Cancer.Inst_73_323
PubMedID: 6589427
Gene_locus related to this paper: human-OLAH