malgo-a8puy1
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) SMG1, LIP1, secretory lipase (Family 3)
Comment
Malassezia globosa belongs to Malassezia, associated with common skin disorders like dandruff and seborrheic dermatitis (D\/SD). SMG1 hydrolyses diolein but not triolein. The mutant SMG1-F278N with a 6-fold increased enzyme activity than that of the wide type
Relationship
Family : Lipase_3
Block : L
Position in NCBI Life Tree : Malassezia globosa
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Basidiomycota N E > Ustilaginomycotina N E > Malasseziomycetes N E > Malasseziales N E > Malasseziaceae N E > Malassezia N E > Malassezia globosa N EMolecular evidence
No mutation
3UUE - Mono- and diacylglycerol lipase from Malassezia globosa SMG1
3UUF - Crystal structure of mono- and diacylglycerol lipase from Malassezia globosa SMG1
4ZRD - Crystal structure of SMG1 F278N mutant
4ZRE - Crystal structure of SMG1 F278D mutant
7SPR - Malassezia globosa SMG1, LIP1, secretory lipase mutant (G28C\/P206C\/Q34P\/A37P\/M176V\/G177A\/M294R\/F278N)
No kinetic
No disease
Sequence
Peptide
MLFSRFVLLA FGSVAAVSAS SIYARGRGGS STDQPVANPY NTKEISLAAG LVQQTYCDST ENGLKIGDSE LLYTMGEGYA RQRVNIYHSP SLGIAVAIEG TNLFSLNSDL HDAKFWQEDP NERYIQYYPK GTKLMHGFQQ AYNDLMDDIF TAVKKYKKEK NEKRVTVIGH SLGAAMGLLC AMDIELRMDG GLYKTYLFGL PRLGNPTFAS FVDQKIGDKF HSIINGRDWV PTVPPRALGY QHPSDYVWIY PGNSTSAKLY PGQENVHGIL TVAREFNFDD HQGIYFHTQI GAVMGECPAQ VGAH
References (19)
| Title : Engineering the Thermostability of the Mono- and Diacylglycerol Lipase SMG1 for the Synthesis of Diacylglycerols - Li_2022_Foods_11_4069 |
| Author(s) : Li L , Wang Y , Cui R , Wang F , Lan D |
| Ref : Foods , 11 :4069 , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Foods_11_4069 |
| PubMedID: 36553811 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Synthesis and Characterization of Epoxidized Silkworm Pupae Oil and Its Application as Polyvinyl Chloride - Ji_2022_Appl.Biochem.Biotechnol_194_1290 |
| Author(s) : Ji Y , Xu L , Xu Q , Liu X , Lin S , Liao S , Wang W , Lan D |
| Ref : Appl Biochem Biotechnol , 194 :1290 , 2022 |
| Abstract : |
| PubMedSearch : Ji_2022_Appl.Biochem.Biotechnol_194_1290 |
| PubMedID: 34677760 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : The enhancement of rice bran oil quality through a novel moderate biorefining process - Li_2021_LWT_151_112118 |
| Author(s) : Li D , Zhang J , Faiza M , Shi L , Wang W , Liu N , Wang Y |
| Ref : LWT , 151 :112118 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_LWT_151_112118 |
| PubMedID: |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Enhancing the thermostability of a mono- and diacylglycerol lipase from Malassizia globose by stabilizing a flexible loop in the catalytic pocket - Xing_2021_Enzyme.Microb.Technol_149_109849 |
| Author(s) : Xing YN , Tan J , Wang Y , Wang J |
| Ref : Enzyme Microb Technol , 149 :109849 , 2021 |
| Abstract : |
| PubMedSearch : Xing_2021_Enzyme.Microb.Technol_149_109849 |
| PubMedID: 34311886 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Highly Efficient Deacidification of High-Acid Rice Bran Oil Using Methanol as a Novel Acyl Acceptor - Li_2018_Appl.Biochem.Biotechnol_184_1061 |
| Author(s) : Li D , Faiza M , Ali S , Wang W , Tan CP , Yang B , Wang Y |
| Ref : Appl Biochem Biotechnol , 184 :1061 , 2018 |
| Abstract : |
| PubMedSearch : Li_2018_Appl.Biochem.Biotechnol_184_1061 |
| PubMedID: 28948493 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Simplified Enzymatic Upgrading of High-Acid Rice Bran Oil Using Ethanol as a Novel Acyl Acceptor - Li_2016_J.Agric.Food.Chem_64_6730 |
| Author(s) : Li D , Wang W , Durrani R , Li X , Yang B , Wang Y |
| Ref : Journal of Agricultural and Food Chemistry , 64 :6730 , 2016 |
| Abstract : |
| PubMedSearch : Li_2016_J.Agric.Food.Chem_64_6730 |
| PubMedID: 27571030 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : A Novel Process for the Synthesis of Highly Pure n-3 Polyunsaturated Fatty Acid (PUFA)-Enriched Triglycerides by Combined Transesterification and Ethanolysis - Li_2016_J.Agric.Food.Chem_64_6533 |
| Author(s) : Li D , Wang W , Qin X , Li X , Yang B , Wang Y |
| Ref : Journal of Agricultural and Food Chemistry , 64 :6533 , 2016 |
| Abstract : |
| PubMedSearch : Li_2016_J.Agric.Food.Chem_64_6533 |
| PubMedID: 27540752 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Lid mobility in lipase SMG1 validated using a thiol\/disulfide redox potential probe - Guo_2016_FEBS.Open.Bio_6_477 |
| Author(s) : Guo S , Popowicz GM , Li D , Yuan D , Wang Y |
| Ref : FEBS Open Bio , 6 :477 , 2016 |
| Abstract : |
| PubMedSearch : Guo_2016_FEBS.Open.Bio_6_477 |
| PubMedID: 27419053 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Novel inhibitor against Malassezia globosa LIP1 (SMG1), a potential anti-dandruff target - Guo_2015_Bioorg.Med.Chem.Lett_25_3464 |
| Author(s) : Guo S , Huang W , Zhang J , Wang Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :3464 , 2015 |
| Abstract : |
| PubMedSearch : Guo_2015_Bioorg.Med.Chem.Lett_25_3464 |
| PubMedID: 26199121 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : A mechanistic study into the epoxidation of carboxylic acid and alkene in a mono, di-acylglycerol lipase - Wang_2015_Biochem.Biophys.Res.Commun_460_392 |
| Author(s) : Wang X , Tang Q , Popowicz GM , Yang B , Wang Y |
| Ref : Biochemical & Biophysical Research Communications , 460 :392 , 2015 |
| Abstract : |
| PubMedSearch : Wang_2015_Biochem.Biophys.Res.Commun_460_392 |
| PubMedID: 25783054 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Structure of product-bound SMG1 lipase: active site gating implications - Guo_2015_FEBS.J_282_4538 |
| Author(s) : Guo S , Xu J , Pavlidis IV , Lan D , Bornscheuer UT , Liu J , Wang Y |
| Ref : Febs J , 282 :4538 , 2015 |
| Abstract : |
| PubMedSearch : Guo_2015_FEBS.J_282_4538 |
| PubMedID: 26365206 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Residue Asn277 Affects the Stability and Substrate Specificity of the SMG1 Lipase from Malassezia globosa - Lan_2015_Int.J.Mol.Sci_16_7273 |
| Author(s) : Lan D , Wang Q , Xu J , Zhou P , Yang B , Wang Y |
| Ref : Int J Mol Sci , 16 :7273 , 2015 |
| Abstract : |
| PubMedSearch : Lan_2015_Int.J.Mol.Sci_16_7273 |
| PubMedID: 25837472 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Conversion of a Mono- and Diacylglycerol Lipase into a Triacylglycerol Lipase by Protein Engineering - Lan_2015_Chembiochem_16_1431 |
| Author(s) : Lan D , Popowicz GM , Pavlidis IV , Zhou P , Bornscheuer UT , Wang Y |
| Ref : Chembiochem , 16 :1431 , 2015 |
| Abstract : |
| PubMedSearch : Lan_2015_Chembiochem_16_1431 |
| PubMedID: 25955297 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : The Role of Residues 103, 104, and 278 in the Activity of SMG1 Lipase from Malassezia globosa: A Site-Directed Mutagenesis Study - Lan_2015_J.Microbiol.Biotechnol_25_1827 |
| Author(s) : Lan D , Wang Q , Popowicz GM , Yang B , Tang Q , Wang Y |
| Ref : J Microbiol Biotechnol , 25 :1827 , 2015 |
| Abstract : |
| PubMedSearch : Lan_2015_J.Microbiol.Biotechnol_25_1827 |
| PubMedID: 26239010 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Site-directed mutagenesis studies of the aromatic residues at the active site of a lipase from Malassezia globosa - Gao_2014_Biochimie_102_29 |
| Author(s) : Gao C , Lan D , Liu L , Zhang H , Yang B , Wang Y |
| Ref : Biochimie , 102 :29 , 2014 |
| Abstract : |
| PubMedSearch : Gao_2014_Biochimie_102_29 |
| PubMedID: 24556587 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Molecular basis for substrate selectivity of a mono- and diacylglycerol lipase from Malassezia globosa - Liu_2012_Biochem.Biophys.Res.Commun_424_285 |
| Author(s) : Liu L , Gao C , Lan D , Yang B , Wang Y |
| Ref : Biochemical & Biophysical Research Communications , 424 :285 , 2012 |
| Abstract : |
| PubMedSearch : Liu_2012_Biochem.Biophys.Res.Commun_424_285 |
| PubMedID: 22750000 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity - Xu_2012_J.Struct.Biol_178_363 |
| Author(s) : Xu T , Liu L , Hou S , Xu J , Yang B , Wang Y , Liu J |
| Ref : J Struct Biol , 178 :363 , 2012 |
| Abstract : |
| PubMedSearch : Xu_2012_J.Struct.Biol_178_363 |
| PubMedID: 22484238 |
| Gene_locus related to this paper: malgo-a8puy1 |
| Title : Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens - Xu_2007_Proc.Natl.Acad.Sci.U.S.A_104_18730 |
| Author(s) : Xu J , Saunders CW , Hu P , Grant RA , Boekhout T , Kuramae EE , Kronstad JW , Deangelis YM , Reeder NL , Johnstone KR , Leland M , Fieno AM , Begley WM , Sun Y , Lacey MP , Chaudhary T , Keough T , Chu L , Sears R , Yuan B , Dawson TL, Jr. |
| Ref : Proc Natl Acad Sci U S A , 104 :18730 , 2007 |
| Abstract : |
| PubMedSearch : Xu_2007_Proc.Natl.Acad.Sci.U.S.A_104_18730 |
| PubMedID: 18000048 |
| Gene_locus related to this paper: malgo-a8puy5 , malgo-a8puy1 , malgo-a8pvh8 , malgo-a8pwh6 , malgo-a8pwm2 , malgo-a8pwr6 , malgo-a8px35 , malgo-a8pzh3 , malgo-a8q1i5 , malgo-a8q4e6 , malgo-a8q7d0 , malgo-a8q8v5 , malgo-a8q9m3 , malgo-a8q9n0 , malgo-a8q902 , malgo-a8qcr1 , malgo-a8qcv4 , malgo-a8qcv7 , malgo-a8qcw4 , malgo-a8qdf0 |
| Title : Isolation and expression of a Malassezia globosa lipase gene, LIP1 - DeAngelis_2007_J.Invest.Dermatol_127_2138 |
| Author(s) : Deangelis YM , Saunders CW , Johnstone KR , Reeder NL , Coleman CG , Kaczvinsky JR, Jr. , Gale C , Walter R , Mekel M , Lacey MP , Keough TW , Fieno A , Grant RA , Begley B , Sun Y , Fuentes G , Youngquist RS , Xu J , Dawson TL, Jr. |
| Ref : Journal of Investigative Dermatology , 127 :2138 , 2007 |
| Abstract : |
| PubMedSearch : DeAngelis_2007_J.Invest.Dermatol_127_2138 |
| PubMedID: 17460728 |
| Gene_locus related to this paper: malgo-a8puy1 |