1,3-Dicyclohexylurea

Ki 26 nM mouse-hyes 47 nM human-EPHX2

General

Type : Urea derivative

Chemical_Nomenclature : 1,3-dicyclohexylurea

Canonical SMILES : C1CCC(CC1)NC(=O)NC2CCCCC2

InChI : InChI=1S\/C13H24N2O\/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12\/h11-12H,1-10H2,(H2,14,15,16)

InChIKey : ADFXKUOMJKEIND-UHFFFAOYSA-N

Other name(s) : 1,3-Dicyclohexylurea, n,n'-dicyclohexylurea, Dicyclohexylurea, Urea, N,N'-dicyclohexyl-


MW : 224.34

Formula : C13H24N2O

CAS_number : 2387-23-7

PubChem : 4277

UniChem : ADFXKUOMJKEIND-UHFFFAOYSA-N

Target

Families : 1,3-Dicyclohexylurea ligand of proteins in family
Epoxide_hydrolase

Protein :
human-EPHX2

References (2)

Title : Soluble epoxide hydrolase is a therapeutic target for acute inflammation - Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
Author(s) : Schmelzer KR , Kubala L , Newman JW , Kim IH , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 102 :9772 , 2005
PubMedID: 15994227
Gene_locus related to this paper: human-EPHX2

Title : Potent urea and carbamate inhibitors of soluble epoxide hydrolases - Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
Author(s) : Morisseau C , Goodrow MH , Dowdy D , Zheng J , Greene JF , Sanborn JR , Hammock BD
Ref : Proc Natl Acad Sci U S A , 96 :8849 , 1999
PubMedID: 10430859
Gene_locus related to this paper: mouse-hyes