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1,3-Dicyclohexylurea

Ki 26 nM mouse-hyes 47 nM human-EPHX2

General

Type : Urea derivative

Chemical_Nomenclature : 1,3-dicyclohexylurea

Canonical SMILES : C1CCC(CC1)NC(=O)NC2CCCCC2

InChI : InChI=1S\/C13H24N2O\/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12\/h11-12H,1-10H2,(H2,14,15,16)

InChIKey : ADFXKUOMJKEIND-UHFFFAOYSA-N

Other name(s) : 1,3-Dicyclohexylurea,n,n'-dicyclohexylurea,Dicyclohexylurea,Urea, N,N'-dicyclohexyl-

MW : 224.34

Formula : C13H24N2O

CAS_number : 2387-23-7

PubChem : 4277

UniChem : ADFXKUOMJKEIND-UHFFFAOYSA-N

Target

Families : 1,3-Dicyclohexylurea ligand of proteins in family
Epoxide_hydrolase

Protein :
human-EPHX2

References (2)

Title : Soluble epoxide hydrolase is a therapeutic target for acute inflammation - Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
Author(s) : Schmelzer KR , Kubala L , Newman JW , Kim IH , Eiserich JP , Hammock BD
Ref : Proc Natl Acad Sci U S A , 102 :9772 , 2005
Abstract : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
ESTHER : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
PubMedSearch : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
PubMedID: 15994227
Gene_locus related to this paper: human-EPHX2

Title : Potent urea and carbamate inhibitors of soluble epoxide hydrolases - Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
Author(s) : Morisseau C , Goodrow MH , Dowdy D , Zheng J , Greene JF , Sanborn JR , Hammock BD
Ref : Proc Natl Acad Sci U S A , 96 :8849 , 1999
Abstract : Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
ESTHER : Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
PubMedSearch : Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849
PubMedID: 10430859
Gene_locus related to this paper: mouse-hyes 
Array
(
    [id] => 3258
    [inhibitor] => 1,3-Dicyclohexylurea
    [type] => Array
        (
            [0] => Urea derivative
        )

    [other_name] => Array
        (
            [0] => 1,3-Dicyclohexylurea
            [1] => n,n'-dicyclohexylurea
            [2] => Dicyclohexylurea
            [3] => Urea, N,N'-dicyclohexyl-
        )

    [chemical_nomenclature] => 1,3-dicyclohexylurea
    [formula] => C13H24N2O
    [cas_number] => 2387-23-7
    [mw] => 224.34
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Morisseau_1999_Proc.Natl.Acad.Sci.U.S.A_96_8849 || Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772
    [comment] => Ki 26 nM mouse-hyes 47 nM human-EPHX2
    [gene_locus] => human-EPHX2
    [kin_inhibitor] => 
    [cid] => 4277
    [family] => Epoxide_hydrolase
    [inchikey] => ADFXKUOMJKEIND-UHFFFAOYSA-N
    [canonicalsmiles] => C1CCC(CC1)NC(=O)NC2CCCCC2
    [inchi] => InChI=1S\/C13H24N2O\/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12\/h11-12H,1-10H2,(H2,14,15,16)
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)