2-Chloroprocaine
Local anesthetic, the hydrochloride is Nesacaine || Chloroprocaine Hydrochloride is a synthetic, aminoester, local, anesthetic agent. Chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma. Chloroprocaine has a significantly shorter duration of action than lidocaine and is significantly less toxic.
General
Type : Local anesthetic, Not A\/B H target
Chemical_Nomenclature : 4-amino-2-chlorobenzoic acid 2-diethylaminoethyl ester hydrochlorid
Canonical SMILES : CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl || CC[NH+](CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.[Cl-] || CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl
InChI : InChI=1S\/C13H19ClN2O2\/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14\/h5-6,9H,3-4,7-8,15H2,1-2H3 || InChI=1S\/C13H19ClN2O2.ClH\/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14\;\/h5-6,9H,3-4,7-8,15H2,1-2H3\;1H
InChIKey : VDANGULDQQJODZ-UHFFFAOYSA-N || SZKQYDBPUCZLRX-UHFFFAOYSA-N
Other name(s) : Chlorprocain || Halestyn || Piocaine || Chlorprocaine || Chlorprocainum || Chlor-procaine || Nesacaine || Chloroprocaine hydrochloride || C07878 || D00732
MW : 270.755
Formula : C13H19ClN2O2
CAS_number : 3858-89-7
UniChem : VDANGULDQQJODZ-UHFFFAOYSA-N, SZKQYDBPUCZLRX-UHFFFAOYSA-N
IUPHAR : 7145
Wikipedia : Chloroprocaine
Target
Families : 2-Chloroprocaine ligand of proteins in family
BCHE
Protein :
human-BCHE
References (3)
| Title : Randomised controlled trial of spinal anaesthesia with bupivacaine or 2-chloroprocaine during caesarean section - Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642 |
| Author(s) : Maes S , Laubach M , Poelaert J |
| Ref : Acta Anaesthesiologica Scandinavica , 60 :642 , 2016 |
| Abstract : |
| PubMedSearch : Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642 |
| PubMedID: 26608876 |
| Title : Continuous caudal anesthesia for inguinal hernia repair in former preterm infants - Henderson_1993_J.Clin.Anesth_5_129 |
| Author(s) : Henderson K , Sethna NF , Berde CB |
| Ref : Journal of Clinical Anesthesia , 5 :129 , 1993 |
| Abstract : |
| PubMedSearch : Henderson_1993_J.Clin.Anesth_5_129 |
| PubMedID: 8476619 |
| Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
| Author(s) : Lockridge O |
| Ref : Pharmacol Ther , 47 :35 , 1990 |
| Abstract : |
| PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedID: 2195556 |
| Gene_locus related to this paper: human-BCHE |