2-Chloroprocaine

"Local anesthetic, the hydrochloride is Nesacaine" || "Chloroprocaine Hydrochloride is a synthetic, aminoester, local, anesthetic agent. Chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma. Chloroprocaine has a significantly shorter duration of action than lidocaine and is significantly less toxic."

General

Type : Local anesthetic,Not A\/B H target

Chemical_Nomenclature : 4-amino-2-chlorobenzoic acid 2-diethylaminoethyl ester hydrochlorid

Canonical SMILES : CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl || CC[NH+](CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.[Cl-] || CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl

InChI : InChI=1S\/C13H19ClN2O2\/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14\/h5-6,9H,3-4,7-8,15H2,1-2H3 || InChI=1S\/C13H19ClN2O2.ClH\/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14\;\/h5-6,9H,3-4,7-8,15H2,1-2H3\;1H

InChIKey : VDANGULDQQJODZ-UHFFFAOYSA-N || SZKQYDBPUCZLRX-UHFFFAOYSA-N

Other name(s) : Chlorprocain,Halestyn,Piocaine,Chlorprocaine,Chlorprocainum,Chlor-procaine,Nesacaine,Chloroprocaine hydrochloride,C07878,D00732


MW : 270.755

Formula : C13H19ClN2O2

CAS_number : 3858-89-7

PubChem : 8612, 441348, 19727

UniChem : VDANGULDQQJODZ-UHFFFAOYSA-N || SZKQYDBPUCZLRX-UHFFFAOYSA-N

IUPHAR : 7145

Wikipedia : Chloroprocaine

Target

Families : 2-Chloroprocaine ligand of proteins in family: BCHE

Stucture :

Protein : human-BCHE

References (3)

Title : Randomised controlled trial of spinal anaesthesia with bupivacaine or 2-chloroprocaine during caesarean section - Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642
Author(s) : Maes S , Laubach M , Poelaert J
Ref : Acta Anaesthesiologica Scandinavica , 60 :642 , 2016
Abstract : Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642
ESTHER : Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642
PubMedSearch : Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642
PubMedID: 26608876

Title : Continuous caudal anesthesia for inguinal hernia repair in former preterm infants - Henderson_1993_J.Clin.Anesth_5_129
Author(s) : Henderson K , Sethna NF , Berde CB
Ref : Journal of Clinical Anesthesia , 5 :129 , 1993
Abstract : Henderson_1993_J.Clin.Anesth_5_129
ESTHER : Henderson_1993_J.Clin.Anesth_5_129
PubMedSearch : Henderson_1993_J.Clin.Anesth_5_129
PubMedID: 8476619

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract : Lockridge_1990_Pharmacol.Ther_47_35
ESTHER : Lockridge_1990_Pharmacol.Ther_47_35
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE