24D
General
Type : Piperidine, Pyrimidine, Carboxamide
Chemical_Nomenclature : N-[(2,4-dichlorophenyl)methyl]-4-pyrimidin-2-yloxypiperidine-1-carboxamide
Canonical SMILES : C1CN(CCC1OC2=NC=CC=N2)C(=O)NCC3=C(C=C(C=C3)Cl)Cl
InChI : InChI=1S\/C17H18Cl2N4O2\/c18-13-3-2-12(15(19)10-13)11-22-17(24)23-8-4-14(5-9-23)25-16-20-6-1-7-21-16\/h1-3,6-7,10,14H,4-5,8-9,11H2,(H,22,24)
InChIKey : UZEPPAOAIDTLTK-UHFFFAOYSA-N
Other name(s) : CHEMBL589136 || 3koo || SCHEMBL4109820 || BDBM50305629 || N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
MW : 381.25
Formula : C17H18Cl2N4O2
CAS_number :
PubChem : 24748513
UniChem : UZEPPAOAIDTLTK-UHFFFAOYSA-N
Target
Families : 24D ligand of proteins in family
Epoxide_hydrolase
Structure :
3KOO
Protein :
human-EPHX2
References (1)
| Title : Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase - Eldrup_2009_J.Med.Chem_52_5880 |
| Author(s) : Eldrup AB , Soleymanzadeh F , Taylor SJ , Muegge I , Farrow NA , Joseph D , McKellop K , Man CC , Kukulka A , De Lombaert S |
| Ref : Journal of Medicinal Chemistry , 52 :5880 , 2009 |
| Abstract : |
| PubMedSearch : Eldrup_2009_J.Med.Chem_52_5880 |
| PubMedID: 19746975 |
| Gene_locus related to this paper: human-EPHX2 |