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2E(CF3)

IC50 eleelAChE 0.599 +/- 0.01 microM; horse BACE1 9.25 +/- 2.63 microM

General

Type : Azabicyclo, Trifluoro, Triazol, Carboxamide, Multitarget, BACE1-inhibitor

Chemical_Nomenclature : N-(2-(3-Oxo-9-azabicyclo [3.3.1]nonan-9-yl)ethyl)-1-(p-tolyl)-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxamide hydrochloride

Canonical SMILES : C(CN1C2CC(CC1CCC2)=O)NC(C3=C([N](N=N3)C4=CC=C(C=C4)C)C(F)(F)F)=O

InChI : InChI=1S\/C21H24F3N5O2\/c1-13-5-7-14(8-6-13)29-19(21(22,23)24)18(26-27-29)20(31)25-9-10-28-15-3-2-4-16(28)12-17(30)11-15\/h5-8,15-16H,2-4,9-12H2,1H3,(H,25,31)

InChIKey : ITTNAZXYPMDFJN-UHFFFAOYSA-N

Other name(s) :

MW : 435.448

Formula : C21H24F3N5O2

CAS_number :

PubChem :

UniChem : ITTNAZXYPMDFJN-UHFFFAOYSA-N

Target

Families : 2E(CF3) ligand of proteins in family
ACHE

References (1)

Title : Design, Synthesis, and Biological Evaluation of Novel Acetylcholinesterase and beta-Secretase 1 Inhibitors - Drozdowska_2026_Int.J.Mol.Sci_27_1008
Author(s) : Drozdowska D , Pawelski D , Wrobel-Talalaj A , Plonska-Brzezinska M , Kolesinska B , Lazny R , Seroka B , Parzych C , Ratkiewicz A
Ref : Int J Mol Sci , 27 :1008 , 2026
Abstract :
PubMedSearch : Drozdowska_2026_Int.J.Mol.Sci_27_1008
PubMedID: 41596653