5NN0-92H
The compound has a picomolar inhibition constant versus BChE, inhibits BChE ex vivo, and is non-cytotoxic. It crosses the blood-brain barrier, and improves memory, cognitive functions, and learning abilities of mice in a scopolamine model of dementia
General
Type : Piperidine, Inden, Naphthalene, Carboxamide
Chemical_Nomenclature : N-[[(3R)-1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl]methyl]-N-[2-(dimethylamino)ethyl]naphthalene-2-carboxamide
Canonical SMILES : CN(C)CCN(C[C@@H]1CCCN(C1)C2CC3=CC=CC=C3C2)C(=O)C4=CC5=CC=CC=C5C=C4
InChI : InChI=1S\/C30H37N3O\/c1-31(2)16-17-33(30(34)28-14-13-24-9-3-4-10-25(24)18-28)22-23-8-7-15-32(21-23)29-19-26-11-5-6-12-27(26)20-29\/h3-6,9-14,18,23,29H,7-8,15-17,19-22H2,1-2H3\/t23-\/m1\/s1
InChIKey : OFDHKZMZEXORRX-HSZRJFAPSA-N
Other name(s) : 92H
MW : 455.6
Formula : C30H37N3O
CAS_number :
PubChem : 132471735
UniChem : OFDHKZMZEXORRX-HSZRJFAPSA-N
Target
References
No reference