5NN0
Name : Human butyrylcholinesterase in complex with inhibitor with picomolar activity
Revelation date : 14-Mar-2018
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Kosak U, Brus B, Knez D, akelj S, Trontelj J, Pilar A, Sink R, Jukic M, Zivin M, Podkowa A, Nachon F, Brazzolotto X, Stojan J, Kos J, Coquelle N, Salat K, Colletier JP, Gobec S
References (1)
| Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119 |
| Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 61 :119 , 2018 |
| Abstract : |
| PubMedSearch : Kosak_2018_J.Med.Chem_61_119 |
| PubMedID: 29227101 |
| Gene_locus related to this paper: human-BCHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 5NN0 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 5NN0 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 5NN0 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 5NN0 3D, interactive encyclopedia of proteins - PROTEOPEDIA server