5NN0

Name : Human butyrylcholinesterase in complex with inhibitor with picomolar activity

Revelation date : 14-Mar-2018

Family : BCHE

Gene_locus : human-BCHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Kosak U, Brus B, Knez D, akelj S, Trontelj J, Pilar A, Sink R, Jukic M, Zivin M, Podkowa A, Nachon F, Brazzolotto X, Stojan J, Kos J, Coquelle N, Salat K, Colletier JP, Gobec S

Ligand :

References (1)

Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119
Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 61 :119 , 2018
PubMedID: 29227101
Gene_locus related to this paper: human-BCHE

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 5NN0 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 5NN0 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 5NN0 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 5NN0 3D, interactive encyclopedia of proteins - PROTEOPEDIA server